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sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Purification and characterization of the human SR 31747A-binding protein.
T2 74-135 Sentence denotes A nuclear membrane protein related to yeast sterol isomerase.
T3 136-266 Sentence denotes SR 31747A, defined as a sigma ligand, is a novel immunosuppressive agent that blocks proliferation of human and mouse lymphocytes.
T4 267-391 Sentence denotes Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP).
T5 392-501 Sentence denotes Purified SR-BP retained its binding properties and migrated on SDS-polyacrylamide gel as a Mr 28,000 protein.
T6 502-661 Sentence denotes Cloning of the cDNA encoding human SR-BP shows an open reading frame for a 223-amino acid protein, which is homologous to the recently cloned sigma 1 receptor.
T7 662-792 Sentence denotes Interestingly, the deduced amino acid sequence was found to be related to fungal C8-C7 sterol isomerase, encoded by the ERG2 gene.
T8 793-942 Sentence denotes The ERG2 gene product has been identified recently as the molecular target of SR 31747A that mediates antiproliferative effects of the drug in yeast.
T9 943-1146 Sentence denotes Northern blot analysis of SR-BP gene expression revealed a single transcript of 2 kilobases which was widely expressed among organs, with the highest abundance in liver and the lowest abundance in brain.
T10 1147-1330 Sentence denotes Subcellular localization analysis in various cells, using a specific monoclonal antibody raised against SR-BP, demonstrated that this protein was associated with the nuclear envelope.
T11 1331-1616 Sentence denotes When studying the binding of SR 31747A on membranes from yeast expressing SR-BP, we found a pharmacological profile of sigma 1 receptors; binding was displaced by (+)-pentazocine, haloperidol, and (+)-SKF 10,047, with (+)-SKF 10, 047 being a more potent competitor than (-)-SKF 10,047.
T12 1617-1813 Sentence denotes Scatchard plot analysis revealed Kd values of 7.1 nM and 0.15 nM for (+)-pentazocine and SR 31747A, respectively, indicating an affinity of SR-BP 50-fold higher for SR 31747A than for pentazocine.
T13 1814-1958 Sentence denotes Additionally, we showed that pentazocine, a competitive inhibitor of SR 31747A binding, also prevents the immunosuppressive effect of SR 31747A.
T14 1959-2135 Sentence denotes Taken together, these findings strongly suggest that SR-BP represents the molecular target for SR 31747A in mammalian tissues, which could be critical for T cell proliferation.
T1 0-73 Sentence denotes Purification and characterization of the human SR 31747A-binding protein.
T2 74-135 Sentence denotes A nuclear membrane protein related to yeast sterol isomerase.
T3 136-266 Sentence denotes SR 31747A, defined as a sigma ligand, is a novel immunosuppressive agent that blocks proliferation of human and mouse lymphocytes.
T4 267-391 Sentence denotes Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP).
T5 392-501 Sentence denotes Purified SR-BP retained its binding properties and migrated on SDS-polyacrylamide gel as a Mr 28,000 protein.
T6 502-661 Sentence denotes Cloning of the cDNA encoding human SR-BP shows an open reading frame for a 223-amino acid protein, which is homologous to the recently cloned sigma 1 receptor.
T7 662-792 Sentence denotes Interestingly, the deduced amino acid sequence was found to be related to fungal C8-C7 sterol isomerase, encoded by the ERG2 gene.
T8 793-942 Sentence denotes The ERG2 gene product has been identified recently as the molecular target of SR 31747A that mediates antiproliferative effects of the drug in yeast.
T9 943-1146 Sentence denotes Northern blot analysis of SR-BP gene expression revealed a single transcript of 2 kilobases which was widely expressed among organs, with the highest abundance in liver and the lowest abundance in brain.
T10 1147-1330 Sentence denotes Subcellular localization analysis in various cells, using a specific monoclonal antibody raised against SR-BP, demonstrated that this protein was associated with the nuclear envelope.
T11 1331-1616 Sentence denotes When studying the binding of SR 31747A on membranes from yeast expressing SR-BP, we found a pharmacological profile of sigma 1 receptors; binding was displaced by (+)-pentazocine, haloperidol, and (+)-SKF 10,047, with (+)-SKF 10, 047 being a more potent competitor than (-)-SKF 10,047.
T12 1617-1813 Sentence denotes Scatchard plot analysis revealed Kd values of 7.1 nM and 0.15 nM for (+)-pentazocine and SR 31747A, respectively, indicating an affinity of SR-BP 50-fold higher for SR 31747A than for pentazocine.
T13 1814-1958 Sentence denotes Additionally, we showed that pentazocine, a competitive inhibitor of SR 31747A binding, also prevents the immunosuppressive effect of SR 31747A.
T14 1959-2135 Sentence denotes Taken together, these findings strongly suggest that SR-BP represents the molecular target for SR 31747A in mammalian tissues, which could be critical for T cell proliferation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1106-1111 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1140-1145 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 41-72 protein denotes human SR 31747A-binding protein
T2 76-100 protein denotes nuclear membrane protein
T3 112-134 protein denotes yeast sterol isomerase
T4 238-265 cell_type denotes human and mouse lymphocytes
T5 357-382 protein denotes SR 31747A-binding protein
T6 384-389 protein denotes SR-BP
T7 392-406 protein denotes Purified SR-BP
T8 483-500 protein denotes Mr 28,000 protein
T9 517-521 DNA denotes cDNA
T10 531-542 protein denotes human SR-BP
T11 552-570 DNA denotes open reading frame
T12 577-599 protein denotes 223-amino acid protein
T13 644-660 protein denotes sigma 1 receptor
T14 736-765 protein denotes fungal C8-C7 sterol isomerase
T15 782-791 DNA denotes ERG2 gene
T16 797-814 protein denotes ERG2 gene product
T17 969-974 protein denotes SR-BP
T18 1023-1034 RNA denotes 2 kilobases
T19 1207-1235 protein denotes specific monoclonal antibody
T20 1251-1256 protein denotes SR-BP
T21 1405-1410 protein denotes SR-BP
T22 1450-1467 protein denotes sigma 1 receptors
T23 1757-1762 protein denotes SR-BP
T24 2012-2017 protein denotes SR-BP

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-73 Sentence denotes Purification and characterization of the human SR 31747A-binding protein.
S2 74-135 Sentence denotes A nuclear membrane protein related to yeast sterol isomerase.
S3 136-266 Sentence denotes SR 31747A, defined as a sigma ligand, is a novel immunosuppressive agent that blocks proliferation of human and mouse lymphocytes.
S4 267-391 Sentence denotes Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP).
S5 392-501 Sentence denotes Purified SR-BP retained its binding properties and migrated on SDS-polyacrylamide gel as a Mr 28,000 protein.
S6 502-661 Sentence denotes Cloning of the cDNA encoding human SR-BP shows an open reading frame for a 223-amino acid protein, which is homologous to the recently cloned sigma 1 receptor.
S7 662-792 Sentence denotes Interestingly, the deduced amino acid sequence was found to be related to fungal C8-C7 sterol isomerase, encoded by the ERG2 gene.
S8 793-942 Sentence denotes The ERG2 gene product has been identified recently as the molecular target of SR 31747A that mediates antiproliferative effects of the drug in yeast.
S9 943-1146 Sentence denotes Northern blot analysis of SR-BP gene expression revealed a single transcript of 2 kilobases which was widely expressed among organs, with the highest abundance in liver and the lowest abundance in brain.
S10 1147-1330 Sentence denotes Subcellular localization analysis in various cells, using a specific monoclonal antibody raised against SR-BP, demonstrated that this protein was associated with the nuclear envelope.
S11 1331-1616 Sentence denotes When studying the binding of SR 31747A on membranes from yeast expressing SR-BP, we found a pharmacological profile of sigma 1 receptors; binding was displaced by (+)-pentazocine, haloperidol, and (+)-SKF 10,047, with (+)-SKF 10, 047 being a more potent competitor than (-)-SKF 10,047.
S12 1617-1813 Sentence denotes Scatchard plot analysis revealed Kd values of 7.1 nM and 0.15 nM for (+)-pentazocine and SR 31747A, respectively, indicating an affinity of SR-BP 50-fold higher for SR 31747A than for pentazocine.
S13 1814-1958 Sentence denotes Additionally, we showed that pentazocine, a competitive inhibitor of SR 31747A binding, also prevents the immunosuppressive effect of SR 31747A.
S14 1959-2135 Sentence denotes Taken together, these findings strongly suggest that SR-BP represents the molecular target for SR 31747A in mammalian tissues, which could be critical for T cell proliferation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 37-72 NP denotes the human SR 31747A-binding protein
C2 112-134 NP denotes yeast sterol isomerase
C3 136-145 NP denotes SR 31747A
C4 177-208 NP denotes a novel immunosuppressive agent
C5 209-213 NP denotes that
C6 221-265 NP denotes proliferation of human and mouse lymphocytes
C8 333-342 NP denotes SR 31747A
C7 321-342 NP denotes a target of SR 31747A
C9 354-356 NP denotes it
C10 357-390 NP denotes SR 31747A-binding protein (SR-BP)
C11 392-406 NP denotes Purified SR-BP
C12 416-419 NP denotes its
C13 531-542 NP denotes human SR-BP
C14 575-599 NP denotes a 223-amino acid protein
C15 601-606 NP denotes which
C16 677-708 NP denotes the deduced amino acid sequence
C17 736-765 NP denotes fungal C8-C7 sterol isomerase
C18 793-814 NP denotes The ERG2 gene product
C20 871-880 NP denotes SR 31747A
C19 847-880 NP denotes the molecular target of SR 31747A
C21 881-885 NP denotes that
C22 924-932 NP denotes the drug
C23 1000-1034 NP denotes a single transcript of 2 kilobases
C24 1035-1040 NP denotes which
C25 1251-1256 NP denotes SR-BP
C26 1276-1288 NP denotes this protein
C27 1360-1369 NP denotes SR 31747A
C28 1405-1410 NP denotes SR-BP
C29 1494-1509 NP denotes (+)-pentazocine
C30 1686-1701 NP denotes (+)-pentazocine
C31 1706-1715 NP denotes SR 31747A
C32 1757-1762 NP denotes SR-BP
C33 1782-1791 NP denotes SR 31747A
C34 1801-1812 NP denotes pentazocine
C35 1843-1854 NP denotes pentazocine
C36 1856-1900 NP denotes a competitive inhibitor of SR 31747A binding
C37 1948-1957 NP denotes SR 31747A
C38 2012-2017 NP denotes SR-BP
C39 2054-2063 NP denotes SR 31747A
C40 2114-2134 NP denotes T cell proliferation
R1 C5 C4 coref-relat that,a novel immunosuppressive agent
R2 C8 C3 coref-ident SR 31747A,SR 31747A
R3 C7 C1 coref-ident a target of SR 31747A,the human SR 31747A-binding protein
R4 C9 C7 coref-pron it,a target of SR 31747A
R5 C12 C11 coref-pron its,Purified SR-BP
R6 C13 C10 coref-ident human SR-BP,SR 31747A-binding protein (SR-BP)
R7 C15 C14 coref-relat which,a 223-amino acid protein
R8 C16 C14 coref-ident the deduced amino acid sequence,a 223-amino acid protein
R9 C17 C2 coref-ident fungal C8-C7 sterol isomerase,yeast sterol isomerase
R10 C18 C17 coref-ident The ERG2 gene product,fungal C8-C7 sterol isomerase
R11 C20 C8 coref-ident SR 31747A,SR 31747A
R12 C21 C19 coref-relat that,the molecular target of SR 31747A
R13 C22 C18 coref-ident the drug,The ERG2 gene product
R14 C24 C23 coref-relat which,a single transcript of 2 kilobases
R15 C25 C13 coref-ident SR-BP,human SR-BP
R16 C26 C25 coref-ident this protein,SR-BP
R17 C27 C20 coref-ident SR 31747A,SR 31747A
R18 C28 C26 coref-ident SR-BP,this protein
R19 C30 C29 coref-ident (+)-pentazocine,(+)-pentazocine
R20 C31 C27 coref-ident SR 31747A,SR 31747A
R21 C32 C28 coref-ident SR-BP,SR-BP
R22 C33 C31 coref-ident SR 31747A,SR 31747A
R23 C34 C30 coref-ident pentazocine,(+)-pentazocine
R24 C35 C34 coref-ident pentazocine,pentazocine
R25 C36 C35 coref-appos a competitive inhibitor of SR 31747A binding,pentazocine
R26 C37 C33 coref-ident SR 31747A,SR 31747A
R27 C38 C32 coref-ident SR-BP,SR-BP
R28 C39 C37 coref-ident SR 31747A,SR 31747A
R29 C40 C6 coref-ident T cell proliferation,proliferation of human and mouse lymphocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 41-72 protein_molecule denotes human SR 31747A-binding protein
T2 76-100 protein_molecule denotes nuclear membrane protein
T3 112-134 protein_molecule denotes yeast sterol isomerase
T4 136-145 other_organic_compound denotes SR 31747A
T5 185-208 other_organic_compound denotes immunosuppressive agent
T6 275-302 other_organic_compound denotes radiolabeled chemical probe
T7 333-342 other_organic_compound denotes SR 31747A
T8 357-366 other_organic_compound denotes SR 31747A
T9 384-389 protein_molecule denotes SR-BP
T10 392-400 protein_molecule denotes Purified
T11 401-406 protein_molecule denotes SR-BP
T12 455-477 other_organic_compound denotes SDS-polyacrylamide gel
T13 483-500 protein_molecule denotes Mr 28,000 protein
T14 517-521 DNA_family_or_group denotes cDNA
T15 531-536 protein_molecule denotes human
T16 537-542 protein_molecule denotes SR-BP
T17 552-570 DNA_domain_or_region denotes open reading frame
T18 577-599 protein_molecule denotes 223-amino acid protein
T19 644-660 protein_molecule denotes sigma 1 receptor
T20 736-765 protein_molecule denotes fungal C8-C7 sterol isomerase
T21 782-791 DNA_domain_or_region denotes ERG2 gene
T22 797-806 DNA_domain_or_region denotes ERG2 gene
T23 851-867 other_name denotes molecular target
T24 871-880 other_organic_compound denotes SR 31747A
T25 895-920 other_name denotes antiproliferative effects
T26 936-941 mono_cell denotes yeast
T27 969-974 protein_molecule denotes SR-BP
T28 975-990 other_name denotes gene expression
T29 1023-1034 RNA_molecule denotes 2 kilobases
T30 1068-1074 body_part denotes organs
T31 1106-1111 body_part denotes liver
T32 1140-1145 body_part denotes brain
T33 1207-1235 protein_molecule denotes specific monoclonal antibody
T34 1251-1256 protein_molecule denotes SR-BP
T35 1313-1329 cell_component denotes nuclear envelope
T36 1360-1369 other_organic_compound denotes SR 31747A
T37 1373-1382 cell_component denotes membranes
T38 1388-1393 mono_cell denotes yeast
T39 1405-1410 protein_molecule denotes SR-BP
T40 1423-1446 other_name denotes pharmacological profile
T41 1450-1467 protein_family_or_group denotes sigma 1 receptors
T42 1494-1509 other_organic_compound denotes (+)-pentazocine
T43 1511-1522 other_organic_compound denotes haloperidol
T44 1528-1542 other_organic_compound denotes (+)-SKF 10,047
T45 1549-1564 other_organic_compound denotes (+)-SKF 10, 047
T46 1601-1615 other_organic_compound denotes (-)-SKF 10,047
T47 1617-1640 other_name denotes Scatchard plot analysis
T48 1686-1701 other_organic_compound denotes (+)-pentazocine
T49 1706-1715 other_organic_compound denotes SR 31747A
T50 1757-1762 protein_molecule denotes SR-BP
T51 1782-1791 other_organic_compound denotes SR 31747A
T52 1801-1812 other_organic_compound denotes pentazocine
T53 1843-1854 other_organic_compound denotes pentazocine
T54 1858-1879 other_organic_compound denotes competitive inhibitor
T55 1883-1892 other_organic_compound denotes SR 31747A
T56 1920-1944 other_name denotes immunosuppressive effect
T57 1948-1957 other_organic_compound denotes SR 31747A
T58 2012-2017 protein_molecule denotes SR-BP
T59 2054-2063 other_organic_compound denotes SR 31747A
T60 2067-2084 tissue denotes mammalian tissues
T61 2114-2134 other_name denotes T cell proliferation

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 41-46 OrganismTaxon denotes human 9606
T2 238-243 OrganismTaxon denotes human 9606
T3 248-253 OrganismTaxon denotes mouse 10088|10090
T5 531-536 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1106-1111 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1140-1145 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 76-92 Body_part denotes nuclear membrane http://purl.obolibrary.org/obo/GO_0031965
T2 254-265 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T3 1106-1111 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 1140-1145 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T6 1313-1329 Body_part denotes nuclear envelope http://purl.obolibrary.org/obo/GO_0005635
T7 1373-1382 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T10 2114-2120 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 254-265 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T2 2114-2120 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084