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sentences

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps.
T2 106-169 Sentence denotes Importance of DNA end phosphorylation and camptothecin effects.
T3 170-392 Sentence denotes We used purified mammalian topoisomerases I (top1) and oligonucleotides containing a unique top1 cleavage site to study top1-mediated cleavage and recombination in the presence of nicks and short gaps mimicking DNA damage.
T4 393-530 Sentence denotes In general, top1 cleavage was not induced opposite to the nicks, and nicks upstream from the top1 cleavage site suppressed top1 activity.
T5 531-711 Sentence denotes Irreversible top1 cleavage complexes ("suicide products" or "aborted complexes") were produced in DNA containing nicks or short gaps just opposite to the normal top1 cleavage site.
T6 712-827 Sentence denotes Camptothecin enhanced the formation of the aborted top1 complexes only for nicks downstream from the cleavage site.
T7 828-1001 Sentence denotes These aborted (suicide) complexes can mediate DNA recombination and promote illegitimate recombination by catalyzing the ligation of nonhomologous DNA fragments (acceptors).
T8 1002-1174 Sentence denotes We report for the first time that top1-mediated recombination is greatly enhanced by the presence of a phosphate at the 5' terminus of the top1 aborted complex (donor DNA).
T9 1175-1263 Sentence denotes By contrast, phosphorylation of the 3' terminus of the gap did not affect recombination.
T10 1264-1470 Sentence denotes At concentrations that strongly enhanced inhibition of intramolecular religation, resulting in an increase of top1 cleavable complexes, camptothecin did not reduce recombination (intermolecular religation).
T11 1471-1685 Sentence denotes Nicks or gaps with 5'-phosphate termini would be expected to be produced directly by ionizing radiations or by processing of abasic sites and DNA lesions induced by carcinogens or drugs used in cancer chemotherapy.
T12 1686-1832 Sentence denotes Thus, these results further demonstrate that DNA damage can efficiently trap top1-cleavable complexes and enhance top1-mediated DNA recombination.
T1 0-105 Sentence denotes Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps.
T2 106-169 Sentence denotes Importance of DNA end phosphorylation and camptothecin effects.
T3 170-392 Sentence denotes We used purified mammalian topoisomerases I (top1) and oligonucleotides containing a unique top1 cleavage site to study top1-mediated cleavage and recombination in the presence of nicks and short gaps mimicking DNA damage.
T4 393-530 Sentence denotes In general, top1 cleavage was not induced opposite to the nicks, and nicks upstream from the top1 cleavage site suppressed top1 activity.
T5 531-711 Sentence denotes Irreversible top1 cleavage complexes ("suicide products" or "aborted complexes") were produced in DNA containing nicks or short gaps just opposite to the normal top1 cleavage site.
T6 712-827 Sentence denotes Camptothecin enhanced the formation of the aborted top1 complexes only for nicks downstream from the cleavage site.
T7 828-1001 Sentence denotes These aborted (suicide) complexes can mediate DNA recombination and promote illegitimate recombination by catalyzing the ligation of nonhomologous DNA fragments (acceptors).
T8 1002-1174 Sentence denotes We report for the first time that top1-mediated recombination is greatly enhanced by the presence of a phosphate at the 5' terminus of the top1 aborted complex (donor DNA).
T9 1175-1263 Sentence denotes By contrast, phosphorylation of the 3' terminus of the gap did not affect recombination.
T10 1264-1470 Sentence denotes At concentrations that strongly enhanced inhibition of intramolecular religation, resulting in an increase of top1 cleavable complexes, camptothecin did not reduce recombination (intermolecular religation).
T11 1471-1685 Sentence denotes Nicks or gaps with 5'-phosphate termini would be expected to be produced directly by ionizing radiations or by processing of abasic sites and DNA lesions induced by carcinogens or drugs used in cancer chemotherapy.
T12 1686-1832 Sentence denotes Thus, these results further demonstrate that DNA damage can efficiently trap top1-cleavable complexes and enhance top1-mediated DNA recombination.

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1665-1671 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1665-1671 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992