PubMed:9326236
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-13 | protein | denotes | Interleukin-7 |
| T2 | 30-48 | DNA | denotes | interleukin-2-gene |
| T3 | 63-92 | cell_type | denotes | activated human T lymphocytes |
| T4 | 188-205 | cell_type | denotes | activated T cells |
| T5 | 210-229 | protein | denotes | activator protein-1 |
| T6 | 281-319 | protein | denotes | stromal-derived cytokine interleukin-7 |
| T7 | 321-325 | protein | denotes | IL-7 |
| T8 | 334-343 | DNA | denotes | IL-2-gene |
| T9 | 358-381 | cell_type | denotes | activated T lymphocytes |
| T10 | 397-401 | protein | denotes | IL-2 |
| T11 | 428-449 | protein | denotes | transcription factors |
| T12 | 466-475 | DNA | denotes | IL-2-gene |
| T13 | 488-503 | protein | denotes | T-cell receptor |
| T14 | 504-513 | protein | denotes | (TCR)/CD3 |
| T15 | 572-589 | cell_type | denotes | activated T cells |
| T16 | 591-595 | protein | denotes | NFAT |
| T17 | 598-617 | protein | denotes | activator protein-1 |
| T18 | 619-623 | protein | denotes | AP-1 |
| T19 | 630-651 | protein | denotes | nuclear factor kappaB |
| T20 | 653-661 | protein | denotes | NFkappaB |
| T21 | 676-699 | protein | denotes | CD28 responsive complex |
| T22 | 701-707 | protein | denotes | CD28RC |
| T23 | 741-745 | protein | denotes | CD28 |
| T24 | 771-823 | cell_line | denotes | phytohemagglutinin/anti-CD28 activated T lymphocytes |
| T25 | 829-833 | protein | denotes | IL-7 |
| T26 | 862-866 | protein | denotes | IL-2 |
| T27 | 932-941 | DNA | denotes | IL-2-gene |
| T28 | 1014-1018 | protein | denotes | IL-7 |
| T29 | 1109-1113 | protein | denotes | IL-7 |
| T30 | 1177-1181 | protein | denotes | NFAT |
| T31 | 1192-1196 | protein | denotes | AP-1 |
| T32 | 1241-1249 | protein | denotes | NFkappaB |
| T33 | 1254-1260 | protein | denotes | CD28RC |
| T34 | 1328-1332 | protein | denotes | IL-7 |
| T35 | 1360-1364 | protein | denotes | AP-1 |
| T36 | 1424-1428 | protein | denotes | AP-1 |
| T37 | 1444-1456 | protein | denotes | NFAT complex |
| T38 | 1479-1483 | protein | denotes | IL-7 |
| T39 | 1539-1559 | protein | denotes | fos and jun proteins |
| T40 | 1569-1573 | protein | denotes | AP-1 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-230 | Sentence | denotes | Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. |
| S2 | 231-382 | Sentence | denotes | In the present report, we studied the role of the stromal-derived cytokine interleukin-7 (IL-7) in the IL-2-gene regulation in activated T lymphocytes. |
| S3 | 383-487 | Sentence | denotes | Production of IL-2 requires the formation of transcription factors involved in the IL-2-gene regulation. |
| S4 | 488-753 | Sentence | denotes | T-cell receptor (TCR)/CD3 engagement results in the activation of nuclear factor of activated T cells (NFAT), activator protein-1 (AP-1), and nuclear factor kappaB (NFkappaB), whereas the CD28 responsive complex (CD28RC) is activated in response to the CD28 signal. |
| S5 | 754-927 | Sentence | denotes | Costimulation of phytohemagglutinin/anti-CD28 activated T lymphocytes with IL-7 induces a fivefold enhanced IL-2-mRNA accumulation and a 2.5-fold enhanced protein secretion. |
| S6 | 928-1068 | Sentence | denotes | The IL-2-gene transcription rate is increased 3.4-fold, indicating that the effect of IL-7 is in part mediated at the transcriptional level. |
| S7 | 1069-1305 | Sentence | denotes | The molecular mechanisms underlying the IL-7 effect involve the upregulation of the DNA binding activity of NFAT (60%) and AP-1 (120%), without affecting the activities of NFkappaB and CD28RC, which was confirmed by transfection assays. |
| S8 | 1306-1417 | Sentence | denotes | We also show that the IL-7-induced enhancement of the AP-1-DNA binding activity is not cyclosporin A-sensitive. |
| S9 | 1418-1583 | Sentence | denotes | Since AP-1 is part of the NFAT complex, we conclude that the IL-7-signaling pathway is involved in the activation of the fos and jun proteins of which AP-1 consists. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-13 | NP | denotes | Interleukin-7 |
| C2 | 63-92 | NP | denotes | activated human T lymphocytes |
| C3 | 96-121 | NP | denotes | the transcriptional level |
| C4 | 277-326 | NP | denotes | the stromal-derived cytokine interleukin-7 (IL-7) |
| C5 | 330-354 | NP | denotes | the IL-2-gene regulation |
| C6 | 358-381 | NP | denotes | activated T lymphocytes |
| C7 | 462-486 | NP | denotes | the IL-2-gene regulation |
| C8 | 554-596 | NP | denotes | nuclear factor of activated T cells (NFAT) |
| C9 | 598-624 | NP | denotes | activator protein-1 (AP-1) |
| C10 | 630-662 | NP | denotes | nuclear factor kappaB (NFkappaB) |
| C11 | 672-708 | NP | denotes | the CD28 responsive complex (CD28RC) |
| C12 | 829-833 | NP | denotes | IL-7 |
| C14 | 1014-1018 | NP | denotes | IL-7 |
| C13 | 1000-1018 | NP | denotes | the effect of IL-7 |
| C15 | 1042-1067 | NP | denotes | the transcriptional level |
| C16 | 1105-1120 | NP | denotes | the IL-7 effect |
| C17 | 1177-1181 | NP | denotes | NFAT |
| C18 | 1192-1196 | NP | denotes | AP-1 |
| C19 | 1241-1249 | NP | denotes | NFkappaB |
| C20 | 1254-1260 | NP | denotes | CD28RC |
| C21 | 1424-1428 | NP | denotes | AP-1 |
| C22 | 1535-1559 | NP | denotes | the fos and jun proteins |
| C23 | 1563-1568 | NP | denotes | which |
| C24 | 1569-1573 | NP | denotes | AP-1 |
| R1 | C4 | C1 | coref-ident | the stromal-derived cytokine interleukin-7 (IL-7),Interleukin-7 |
| R2 | C6 | C2 | coref-ident | activated T lymphocytes,activated human T lymphocytes |
| R3 | C7 | C5 | coref-ident | the IL-2-gene regulation,the IL-2-gene regulation |
| R4 | C12 | C4 | coref-ident | IL-7,the stromal-derived cytokine interleukin-7 (IL-7) |
| R5 | C14 | C12 | coref-ident | IL-7,IL-7 |
| R6 | C15 | C3 | coref-ident | the transcriptional level,the transcriptional level |
| R7 | C16 | C13 | coref-ident | the IL-7 effect,the effect of IL-7 |
| R8 | C17 | C8 | coref-ident | NFAT,nuclear factor of activated T cells (NFAT) |
| R9 | C18 | C9 | coref-ident | AP-1,activator protein-1 (AP-1) |
| R10 | C19 | C10 | coref-ident | NFkappaB,nuclear factor kappaB (NFkappaB) |
| R11 | C20 | C11 | coref-ident | CD28RC,the CD28 responsive complex (CD28RC) |
| R12 | C21 | C18 | coref-ident | AP-1,AP-1 |
| R13 | C23 | C22 | coref-relat | which,the fos and jun proteins |
| R14 | C24 | C21 | coref-ident | AP-1,AP-1 |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-13 | protein_molecule | denotes | Interleukin-7 |
| T2 | 30-48 | DNA_domain_or_region | denotes | interleukin-2-gene |
| T3 | 63-92 | cell_type | denotes | activated human T lymphocytes |
| T4 | 139-161 | other_name | denotes | DNA binding activities |
| T5 | 188-205 | cell_type | denotes | activated T cells |
| T6 | 210-229 | protein_molecule | denotes | activator protein-1 |
| T7 | 281-305 | protein_family_or_group | denotes | stromal-derived cytokine |
| T8 | 306-319 | protein_molecule | denotes | interleukin-7 |
| T9 | 321-325 | protein_molecule | denotes | IL-7 |
| T10 | 334-343 | DNA_domain_or_region | denotes | IL-2-gene |
| T11 | 358-381 | cell_type | denotes | activated T lymphocytes |
| T12 | 397-401 | protein_molecule | denotes | IL-2 |
| T13 | 428-449 | protein_family_or_group | denotes | transcription factors |
| T14 | 466-470 | protein_molecule | denotes | IL-2 |
| T15 | 488-503 | protein_family_or_group | denotes | T-cell receptor |
| T16 | 504-513 | protein_complex | denotes | (TCR)/CD3 |
| T17 | 572-589 | cell_type | denotes | activated T cells |
| T18 | 591-595 | protein_family_or_group | denotes | NFAT |
| T19 | 598-617 | protein_molecule | denotes | activator protein-1 |
| T20 | 619-623 | protein_molecule | denotes | AP-1 |
| T21 | 630-651 | protein_complex | denotes | nuclear factor kappaB |
| T22 | 653-661 | protein_complex | denotes | NFkappaB |
| T23 | 676-699 | protein_complex | denotes | CD28 responsive complex |
| T24 | 701-707 | protein_complex | denotes | CD28RC |
| T25 | 741-745 | protein_molecule | denotes | CD28 |
| T26 | 771-789 | protein_molecule | denotes | phytohemagglutinin |
| T27 | 800-823 | cell_type | denotes | activated T lymphocytes |
| T28 | 829-833 | protein_molecule | denotes | IL-7 |
| T29 | 862-866 | protein_molecule | denotes | IL-2 |
| T30 | 900-926 | other_name | denotes | enhanced protein secretion |
| T31 | 932-936 | protein_molecule | denotes | IL-2 |
| T32 | 1014-1018 | protein_molecule | denotes | IL-7 |
| T33 | 1109-1113 | protein_molecule | denotes | IL-7 |
| T34 | 1177-1181 | protein_family_or_group | denotes | NFAT |
| T35 | 1192-1196 | protein_molecule | denotes | AP-1 |
| T36 | 1241-1249 | protein_complex | denotes | NFkappaB |
| T37 | 1254-1260 | protein_complex | denotes | CD28RC |
| T38 | 1285-1304 | other_name | denotes | transfection assays |
| T39 | 1328-1332 | protein_molecule | denotes | IL-7 |
| T40 | 1360-1364 | protein_molecule | denotes | AP-1 |
| T41 | 1393-1416 | other_name | denotes | cyclosporin A-sensitive |
| T42 | 1424-1428 | protein_molecule | denotes | AP-1 |
| T43 | 1444-1456 | protein_complex | denotes | NFAT complex |
| T44 | 1479-1483 | protein_molecule | denotes | IL-7 |
| T45 | 1569-1573 | protein_molecule | denotes | AP-1 |