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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
T2 100-215 Sentence denotes Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.
T3 216-330 Sentence denotes This study tested the hypothesis that anti-LPS Abs neutralize endotoxin by blocking cellular uptake through mCD14.
T4 331-590 Sentence denotes Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.
T5 591-712 Sentence denotes LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.
T6 713-961 Sentence denotes O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).
T7 962-1125 Sentence denotes Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.
T8 1126-1435 Sentence denotes The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.
T9 1436-1641 Sentence denotes LPS-specific Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.
T1 0-99 Sentence denotes Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
T2 100-215 Sentence denotes Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.
T3 216-330 Sentence denotes This study tested the hypothesis that anti-LPS Abs neutralize endotoxin by blocking cellular uptake through mCD14.
T4 331-590 Sentence denotes Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.
T5 591-712 Sentence denotes LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.
T6 713-961 Sentence denotes O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).
T7 962-1125 Sentence denotes Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.
T8 1126-1435 Sentence denotes The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.
T9 1436-1641 Sentence denotes LPS-specific Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 16-30 protein denotes LPS antibodies
T2 100-116 cell_type denotes Human phagocytes
T3 161-174 protein denotes membrane CD14
T4 176-181 protein denotes mCD14
T5 186-214 protein denotes proinflammatory LPS receptor
T6 254-266 protein denotes anti-LPS Abs
T7 324-329 protein denotes mCD14
T8 479-535 cell_line denotes human CD14-transfected Chinese hamster ovary fibroblasts
T9 537-551 cell_line denotes CHO-CD14 cells
T10 557-589 cell_type denotes human peripheral blood monocytes
T11 595-631 protein denotes core- and O-side chain-specific mAbs
T12 642-647 protein denotes mCD14
T13 713-738 protein denotes O-side chain-specific mAb
T14 814-835 protein denotes complement receptor-1
T15 837-840 protein denotes CR1
T16 856-870 cell_line denotes CHO-CD14 cells
T17 889-913 protein denotes heat-labile serum factor
T18 921-957 protein denotes cell-associated recognition molecule
T19 962-979 protein denotes Core-specific mAb
T20 990-995 protein denotes mCD14
T21 1099-1104 protein denotes mCD14
T22 1144-1157 protein denotes anti-LPS mAbs
T23 1161-1166 protein denotes mCD14
T24 1221-1254 protein denotes LPS-induced nuclear factor-kappaB
T25 1256-1265 protein denotes NF-kappaB
T26 1285-1294 protein denotes TNF-alpha
T27 1308-1322 cell_line denotes CHO-CD14 cells
T28 1381-1386 protein denotes mCD14
T29 1436-1452 protein denotes LPS-specific Abs
T30 1577-1582 protein denotes mCD14
T31 1613-1616 protein denotes CR1
T32 1626-1640 protein denotes cell receptors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-99 Sentence denotes Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
S2 100-215 Sentence denotes Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.
S3 216-330 Sentence denotes This study tested the hypothesis that anti-LPS Abs neutralize endotoxin by blocking cellular uptake through mCD14.
S4 331-590 Sentence denotes Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.
S5 591-712 Sentence denotes LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.
S6 713-961 Sentence denotes O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).
S7 962-1125 Sentence denotes Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.
S8 1126-1435 Sentence denotes The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.
S9 1436-1641 Sentence denotes LPS-specific Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 53-56 NP denotes LPS
C2 127-152 NP denotes bacterial LPS (endotoxin)
C3 161-182 NP denotes membrane CD14 (mCD14)
C4 184-214 NP denotes a proinflammatory LPS receptor
C5 234-248 NP denotes the hypothesis
C6 249-253 NP denotes that
C7 278-287 NP denotes endotoxin
C9 324-329 NP denotes mCD14
C8 300-329 NP denotes cellular uptake through mCD14
C11 479-552 NP denotes human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells)
C12 557-589 NP denotes human peripheral blood monocytes
C10 479-589 NP denotes human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes
C13 671-686 NP denotes both cell types
C15 796-805 NP denotes monocytes
C16 814-841 NP denotes complement receptor-1 (CR1)
C17 856-870 NP denotes CHO-CD14 cells
C14 761-960 NP denotes complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s)
C19 1015-1046 NP denotes homologous and heterologous LPS
C18 990-1046 NP denotes mCD14-mediated uptake of homologous and heterologous LPS
C20 1095-1124 NP denotes non-mCD14-mediated LPS uptake
C21 1161-1186 NP denotes mCD14-mediated LPS uptake
C23 1308-1322 NP denotes CHO-CD14 cells
C24 1327-1336 NP denotes monocytes
C22 1207-1350 NP denotes inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively
C25 1377-1406 NP denotes non-mCD14-mediated LPS uptake
C26 1418-1434 NP denotes these activities
C28 1565-1568 NP denotes LPS
C29 1577-1582 NP denotes mCD14
C27 1543-1582 NP denotes target cell uptake of LPS through mCD14
C30 1613-1616 NP denotes CR1
R1 C2 C1 coref-ident bacterial LPS (endotoxin),LPS
R2 C4 C3 coref-appos a proinflammatory LPS receptor,membrane CD14 (mCD14)
R3 C6 C5 coref-relat that,the hypothesis
R4 C7 C2 coref-ident endotoxin,bacterial LPS (endotoxin)
R5 C9 C3 coref-ident mCD14,membrane CD14 (mCD14)
R6 C13 C10 coref-ident both cell types,human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes
R7 C15 C12 coref-ident monocytes,human peripheral blood monocytes
R8 C17 C11 coref-ident CHO-CD14 cells,human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells)
R9 C19 C7 coref-ident homologous and heterologous LPS,endotoxin
R10 C18 C8 coref-ident mCD14-mediated uptake of homologous and heterologous LPS,cellular uptake through mCD14
R11 C20 C14 coref-ident non-mCD14-mediated LPS uptake,complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s)
R12 C21 C18 coref-ident mCD14-mediated LPS uptake,mCD14-mediated uptake of homologous and heterologous LPS
R13 C23 C17 coref-ident CHO-CD14 cells,CHO-CD14 cells
R14 C24 C15 coref-ident monocytes,monocytes
R15 C25 C20 coref-ident non-mCD14-mediated LPS uptake,non-mCD14-mediated LPS uptake
R16 C26 C22 coref-ident these activities,"inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively"
R17 C28 C19 coref-ident LPS,homologous and heterologous LPS
R18 C29 C9 coref-ident mCD14,mCD14
R19 C27 C21 coref-ident target cell uptake of LPS through mCD14,mCD14-mediated LPS uptake
R20 C30 C16 coref-ident CR1,complement receptor-1 (CR1)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 16-19 lipid denotes LPS
T2 53-56 lipid denotes LPS
T3 61-64 lipid denotes LPS
T4 100-116 cell_type denotes Human phagocytes
T5 127-136 lipid denotes bacterial
T6 137-140 lipid denotes LPS
T7 161-174 protein_molecule denotes membrane CD14
T8 176-181 protein_molecule denotes mCD14
T9 186-201 protein_family_or_group denotes proinflammatory
T10 202-205 lipid denotes LPS
T11 254-259 protein_family_or_group denotes anti-
T12 259-262 lipid denotes LPS
T13 324-329 protein_molecule denotes mCD14
T14 331-352 other_name denotes Ab-associated changes
T15 396-401 lipid denotes FITC-
T16 401-404 lipid denotes LPS
T17 422-436 other_name denotes flow cytometry
T18 441-475 other_name denotes laser scanning confocal microscopy
T19 479-535 cell_line denotes human CD14-transfected Chinese hamster ovary fibroblasts
T20 537-551 cell_line denotes CHO-CD14 cells
T21 557-589 cell_type denotes human peripheral blood monocytes
T22 591-594 lipid denotes LPS
T23 642-647 protein_molecule denotes mCD14
T24 657-660 lipid denotes LPS
T25 713-738 protein_family_or_group denotes O-side chain-specific mAb
T26 782-785 lipid denotes LPS
T27 814-835 protein_molecule denotes complement receptor-1
T28 837-840 protein_molecule denotes CR1
T29 856-870 cell_line denotes CHO-CD14 cells
T30 889-913 protein_family_or_group denotes heat-labile serum factor
T31 921-957 protein_family_or_group denotes cell-associated recognition molecule
T32 962-979 protein_family_or_group denotes Core-specific mAb
T33 990-995 protein_molecule denotes mCD14
T34 1043-1046 lipid denotes LPS
T35 1095-1099 other_name denotes non-
T36 1099-1104 protein_molecule denotes mCD14
T37 1114-1117 lipid denotes LPS
T38 1144-1149 protein_family_or_group denotes anti-
T39 1149-1152 lipid denotes LPS
T40 1161-1166 protein_molecule denotes mCD14
T41 1176-1179 lipid denotes LPS
T42 1221-1224 lipid denotes LPS
T43 1256-1265 protein_complex denotes NF-kappaB
T44 1285-1294 protein_molecule denotes TNF-alpha
T45 1308-1322 cell_line denotes CHO-CD14 cells
T46 1377-1381 other_name denotes non-
T47 1381-1386 protein_molecule denotes mCD14
T48 1396-1399 lipid denotes LPS
T49 1436-1439 lipid denotes LPS
T50 1543-1561 other_name denotes target cell uptake
T51 1565-1568 lipid denotes LPS
T52 1577-1582 protein_molecule denotes mCD14
T53 1613-1616 protein_molecule denotes CR1
T54 1626-1640 protein_family_or_group denotes cell receptors