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PubMed:9317131 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-28 protein denotes binding sites
T2 33-38 protein denotes STAT6
T3 43-57 protein denotes NF kappa B/rel
T4 65-69 protein denotes IL-4
T5 99-126 DNA denotes human IgE germline promoter
T6 128-142 protein denotes Ig heavy chain
T7 174-183 protein denotes cytokines
T8 225-233 DNA denotes CH genes
T9 254-266 cell_type denotes primed cells
T10 352-355 protein denotes IgE
T11 373-377 protein denotes IL-4
T12 392-413 DNA denotes IgE germline promoter
T13 449-469 protein denotes transcription factor
T14 470-475 protein denotes STAT6
T15 477-485 protein denotes IL-4STAT
T16 494-516 DNA denotes responsive DNA element
T17 524-539 DNA denotes proximal region
T18 547-555 DNA denotes promoter
T19 617-636 DNA denotes cis-acting elements
T20 671-713 protein denotes NF kappa B/rel transcription factor family
T21 720-724 protein denotes IL-4
T22 798-819 protein denotes nucleoprotein complex
T23 834-847 DNA denotes upstream site
T24 849-860 protein denotes NF kappa B1
T25 875-904 protein denotes classical p50/p65 heterodimer
T26 925-938 DNA denotes proximal site
T27 940-951 protein denotes NF kappa B2
T28 979-982 protein denotes p50
T29 987-991 protein denotes relB
T30 993-1039 DNA denotes IgE germline promoter reporter gene constructs
T31 1072-1083 protein denotes NF kappa B2
T32 1118-1122 protein denotes IL-4
T33 1219-1230 protein denotes NF kappa B1
T34 1249-1257 protein denotes cytokine
T35 1286-1304 DNA denotes wild-type promoter
T36 1310-1321 protein denotes NF kappa B2
T37 1366-1384 DNA denotes STAT6 binding site
T38 1409-1426 protein denotes NF kappa B2 motif
T39 1473-1481 protein denotes cytokine
T40 1531-1558 DNA denotes NF kappa B/rel binding site
T41 1567-1589 DNA denotes STAT6 response element
T42 1600-1604 protein denotes IL-4
T43 1623-1652 DNA denotes heterologous minimal promoter
T44 1732-1765 protein denotes NF kappa B2 nucleoprotein complex
T45 1785-1800 protein denotes DNA-bound STAT6
T46 1812-1816 protein denotes IL-4
T47 1845-1868 DNA denotes human IgE germline gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-127 Sentence denotes Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter.
S2 128-234 Sentence denotes Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.
S3 235-336 Sentence denotes Subsequently, such primed cells can undergo switch recombination to express the selected new isotype.
S4 337-556 Sentence denotes In the case of IgE class switching, IL-4 activates the IgE germline promoter by inducing the interaction of the transcription factor STAT6 (IL-4STAT) with a responsive DNA element in the proximal region of the promoter.
S5 557-745 Sentence denotes This study describes the characterization of two additional cis-acting elements that interact with members of the NF kappa B/rel transcription factor family in an IL-4-independent fashion.
S6 746-905 Sentence denotes Electrophoretic mobility shift assays show that the nucleoprotein complex formed on the upstream site (NF kappa B1) contains the classical p50/p65 heterodimer.
S7 906-992 Sentence denotes The complex on the proximal site (NF kappa B2) appears to be composed of p50 and relB.
S8 993-1305 Sentence denotes IgE germline promoter reporter gene constructs carrying point mutations in the NF kappa B2 site were largely unresponsive to IL-4 stimulation in transient transfection experiments, while plasmids with similar mutations in the NF kappa B1 site responded to cytokine stimulation better than the wild-type promoter.
S9 1306-1496 Sentence denotes The NF kappa B2 effect was dependent on the presence of the STAT6 binding site, demonstrating that the NF kappa B2 motif is necessary but not sufficient for mediating cytokine up-regulation.
S10 1497-1695 Sentence denotes In addition, the combination of a NF kappa B/rel binding site and the STAT6 response element conferred IL-4 inducibility to a heterologous minimal promoter, while the individual sites had no effect.
S11 1696-1869 Sentence denotes The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 33-38 NP denotes STAT6
C3 95-126 NP denotes the human IgE germline promoter
C2 61-126 NP denotes the IL-4-induced up-regulation of the human IgE germline promoter
C4 388-413 NP denotes the IgE germline promoter
C5 445-475 NP denotes the transcription factor STAT6
C6 543-555 NP denotes the promoter
C7 602-636 NP denotes two additional cis-acting elements
C8 637-641 NP denotes that
C9 830-847 NP denotes the upstream site
C11 921-938 NP denotes the proximal site
C10 906-952 NP denotes The complex on the proximal site (NF kappa B2)
C12 1068-1088 NP denotes the NF kappa B2 site
C13 1118-1134 NP denotes IL-4 stimulation
C14 1215-1235 NP denotes the NF kappa B1 site
C15 1249-1269 NP denotes cytokine stimulation
C16 1473-1495 NP denotes cytokine up-regulation
C17 1728-1765 NP denotes the NF kappa B2 nucleoprotein complex
R1 C4 C3 coref-ident the IgE germline promoter,the human IgE germline promoter
R2 C5 C1 coref-ident the transcription factor STAT6,STAT6
R3 C6 C4 coref-ident the promoter,the IgE germline promoter
R4 C8 C7 coref-relat that,two additional cis-acting elements
R5 C12 C11 coref-ident the NF kappa B2 site,the proximal site
R6 C14 C9 coref-ident the NF kappa B1 site,the upstream site
R7 C15 C13 coref-ident cytokine stimulation,IL-4 stimulation
R8 C16 C2 coref-ident cytokine up-regulation,the IL-4-induced up-regulation of the human IgE germline promoter
R9 C17 C10 coref-ident the NF kappa B2 nucleoprotein complex,The complex on the proximal site (NF kappa B2)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-28 protein_domain_or_region denotes binding sites
T2 33-38 protein_molecule denotes STAT6
T3 43-57 protein_complex denotes NF kappa B/rel
T4 65-69 protein_molecule denotes IL-4
T5 99-126 DNA_domain_or_region denotes human IgE germline promoter
T6 128-142 protein_family_or_group denotes Ig heavy chain
T7 174-183 protein_family_or_group denotes cytokines
T8 225-233 DNA_family_or_group denotes CH genes
T9 254-266 cell_type denotes primed cells
T10 352-355 protein_family_or_group denotes IgE
T11 373-377 protein_molecule denotes IL-4
T12 392-395 protein_family_or_group denotes IgE
T13 449-469 protein_family_or_group denotes transcription factor
T14 470-475 protein_molecule denotes STAT6
T15 477-485 protein_molecule denotes IL-4STAT
T16 494-516 DNA_domain_or_region denotes responsive DNA element
T17 524-539 DNA_domain_or_region denotes proximal region
T18 547-555 DNA_domain_or_region denotes promoter
T19 617-636 DNA_family_or_group denotes cis-acting elements
T20 671-685 protein_complex denotes NF kappa B/rel
T21 720-724 protein_molecule denotes IL-4
T22 746-783 other_name denotes Electrophoretic mobility shift assays
T23 798-819 protein_complex denotes nucleoprotein complex
T24 834-847 DNA_domain_or_region denotes upstream site
T25 849-860 protein_complex denotes NF kappa B1
T26 875-904 protein_complex denotes classical p50/p65 heterodimer
T27 925-938 DNA_domain_or_region denotes proximal site
T28 940-951 protein_complex denotes NF kappa B2
T29 979-982 protein_subunit denotes p50
T30 987-991 protein_subunit denotes relB
T31 993-996 protein_family_or_group denotes IgE
T32 1049-1064 other_name denotes point mutations
T33 1072-1083 protein_complex denotes NF kappa B2
T34 1118-1122 protein_molecule denotes IL-4
T35 1219-1230 protein_complex denotes NF kappa B1
T36 1249-1257 protein_family_or_group denotes cytokine
T37 1286-1304 DNA_domain_or_region denotes wild-type promoter
T38 1310-1321 protein_complex denotes NF kappa B2
T39 1366-1371 protein_molecule denotes STAT6
T40 1409-1420 protein_complex denotes NF kappa B2
T41 1473-1481 protein_family_or_group denotes cytokine
T42 1531-1545 protein_complex denotes NF kappa B/rel
T43 1567-1572 protein_molecule denotes STAT6
T44 1600-1604 protein_molecule denotes IL-4
T45 1623-1652 DNA_domain_or_region denotes heterologous minimal promoter
T46 1732-1743 protein_complex denotes NF kappa B2
T47 1744-1765 protein_complex denotes nucleoprotein complex
T48 1785-1794 protein_molecule denotes DNA-bound
T49 1795-1800 protein_molecule denotes STAT6
T50 1812-1816 protein_molecule denotes IL-4
T51 1845-1850 DNA_domain_or_region denotes human
T52 1851-1854 protein_family_or_group denotes IgE