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PubMed:9315663 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 72-99 protein denotes retinoblastoma gene product
T2 103-121 cell_line denotes promonocytic cells
T3 148-175 protein denotes retinoblastoma gene product
T4 177-180 protein denotes pRB
T5 324-327 protein denotes pRB
T6 390-393 protein denotes tTG
T7 561-564 protein denotes pRB
T8 597-607 cell_line denotes U937 cells
T9 688-698 cell_line denotes U937 cells
T10 787-790 protein denotes pRB
T11 931-934 protein denotes pRB
T12 1033-1043 cell_line denotes U937 cells
T13 1128-1131 protein denotes pRB
T14 1216-1221 protein denotes E2F-1
T15 1265-1280 cell_line denotes pRB-null clones
T16 1286-1296 cell_line denotes U937 cells
T17 1319-1322 protein denotes pRB
T18 1332-1351 cell_line denotes U937-derived clones
T19 1366-1380 cell_line denotes p53-null cells
T20 1508-1511 protein denotes tTG
T21 1527-1538 protein denotes pRB protein

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-143 Sentence denotes Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis.
S2 144-271 Sentence denotes The retinoblastoma gene product (pRB) plays an important role in controlling both cell release from the G1 phase and apoptosis.
S3 272-414 Sentence denotes We show here that in the early phases of apoptosis, pRB is posttranslationally modified by a tissue transglutaminase (tTG)-catalyzed reaction.
S4 415-629 Sentence denotes In fact, by employing a novel haptenized lysis synthetic substrate which allows the isolation of glutaminyl-tTG substrates in vivo, we identified pRB as a potential tTG substrate in U937 cells undergoing apoptosis.
S5 630-917 Sentence denotes In keeping with this finding, we showed that apoptosis of U937 cells is characterized by the rapid disappearance of the 105,000- to 110,000-molecular-weight pRB forms concomitantly with the appearance of a smear of immunoreactive products with a molecular weight of greater than 250,000.
S6 918-1109 Sentence denotes The shift in pRB molecular weight was reproduced by adding exogenous purified tTG to extracts obtained from viable U937 cells and was prevented by dansylcadaverine, a potent enzyme inhibitor.
S7 1110-1297 Sentence denotes The effect of the pRB posttranslational modification during apoptosis was investigated by determining the E2F-1 levels and by isolating and characterizing pRB-null clones from U937 cells.
S8 1298-1467 Sentence denotes Notably, the lack of pRB in these U937-derived clones renders these p53-null cells highly resistant to apoptosis induced by serum withdrawal, calphostin C, and ceramide.
S9 1468-1619 Sentence denotes Taken together, these data suggest that tTG, acting on the pRB protein, might play an important role in the cell progression through the death program.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 68-99 NP denotes the retinoblastoma gene product
C2 133-142 NP denotes apoptosis
C3 144-181 NP denotes The retinoblastoma gene product (pRB)
C4 261-270 NP denotes apoptosis
C5 313-322 NP denotes apoptosis
C6 324-327 NP denotes pRB
C7 437-481 NP denotes a novel haptenized lysis synthetic substrate
C8 482-487 NP denotes which
C9 561-564 NP denotes pRB
C10 619-628 NP denotes apoptosis
C11 688-698 NP denotes U937 cells
C12 1065-1081 NP denotes dansylcadaverine
C13 1083-1108 NP denotes a potent enzyme inhibitor
C14 1170-1179 NP denotes apoptosis
C15 1265-1280 NP denotes pRB-null clones
C16 1286-1296 NP denotes U937 cells
C17 1319-1322 NP denotes pRB
C18 1326-1351 NP denotes these U937-derived clones
C19 1360-1380 NP denotes these p53-null cells
C20 1523-1538 NP denotes the pRB protein
C21 1601-1618 NP denotes the death program
R1 C3 C1 coref-ident The retinoblastoma gene product (pRB),the retinoblastoma gene product
R2 C4 C2 coref-ident apoptosis,apoptosis
R3 C5 C4 coref-ident apoptosis,apoptosis
R4 C6 C3 coref-ident pRB,The retinoblastoma gene product (pRB)
R5 C8 C7 coref-relat which,a novel haptenized lysis synthetic substrate
R6 C9 C6 coref-ident pRB,pRB
R7 C10 C5 coref-ident apoptosis,apoptosis
R8 C13 C12 coref-appos a potent enzyme inhibitor,dansylcadaverine
R9 C14 C10 coref-ident apoptosis,apoptosis
R10 C16 C11 coref-ident U937 cells,U937 cells
R11 C17 C9 coref-ident pRB,pRB
R12 C18 C15 coref-ident these U937-derived clones,pRB-null clones
R13 C19 C18 coref-ident these p53-null cells,these U937-derived clones
R14 C20 C17 coref-ident the pRB protein,pRB
R15 C21 C14 coref-ident the death program,apoptosis

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-64 other_name denotes Tissue transglutaminase-dependent posttranslational modification
T2 72-99 protein_molecule denotes retinoblastoma gene product
T3 103-121 cell_line denotes promonocytic cells
T4 133-142 other_name denotes apoptosis
T5 148-175 protein_molecule denotes retinoblastoma gene product
T6 177-180 protein_molecule denotes pRB
T7 226-238 other_name denotes cell release
T8 248-256 other_name denotes G1 phase
T9 261-270 other_name denotes apoptosis
T10 313-322 other_name denotes apoptosis
T11 324-327 protein_molecule denotes pRB
T12 365-390 other_name denotes tissue transglutaminase (
T13 390-393 protein_molecule denotes tTG
T14 439-481 other_organic_compound denotes novel haptenized lysis synthetic substrate
T15 512-537 other_organic_compound denotes glutaminyl-tTG substrates
T16 561-564 protein_molecule denotes pRB
T17 570-593 other_organic_compound denotes potential tTG substrate
T18 597-607 cell_line denotes U937 cells
T19 619-628 other_name denotes apoptosis
T20 675-684 other_name denotes apoptosis
T21 688-698 cell_line denotes U937 cells
T22 787-790 protein_molecule denotes pRB
T23 931-934 protein_molecule denotes pRB
T24 977-999 other_organic_compound denotes exogenous purified tTG
T25 1033-1043 cell_line denotes U937 cells
T26 1065-1081 other_organic_compound denotes dansylcadaverine
T27 1085-1108 other_organic_compound denotes potent enzyme inhibitor
T28 1128-1131 protein_molecule denotes pRB
T29 1170-1179 other_name denotes apoptosis
T30 1216-1221 protein_molecule denotes E2F-1
T31 1265-1268 protein_molecule denotes pRB
T32 1286-1296 cell_line denotes U937 cells
T33 1319-1322 protein_molecule denotes pRB
T34 1332-1351 cell_line denotes U937-derived clones
T35 1366-1380 cell_line denotes p53-null cells
T36 1401-1410 other_name denotes apoptosis
T37 1422-1438 other_name denotes serum withdrawal
T38 1440-1452 other_organic_compound denotes calphostin C
T39 1458-1466 other_organic_compound denotes ceramide
T40 1508-1511 protein_molecule denotes tTG
T41 1527-1530 protein_molecule denotes pRB