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PubMed:9312192 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 225-240 DNA denotes lymphocyte gene
T2 270-281 protein denotes phosphatase
T3 294-305 protein denotes calcineurin
T4 307-309 protein denotes CN
T5 362-364 protein denotes CN
T6 377-399 cell_type denotes circulating leukocytes
T7 427-429 protein denotes CN
T8 444-468 cell_type denotes primary human leukocytes
T9 518-520 protein denotes CN
T10 600-622 cell_line denotes CsA-treated leukocytes
T11 683-685 protein denotes CN
T12 788-831 protein denotes nuclear factor of activated T cell proteins
T13 870-905 DNA denotes transfected reporter gene construct
T14 949-958 protein denotes IFN-gamma
T15 998-1000 protein denotes CN
T16 1091-1100 protein denotes IFN-gamma
T17 1119-1155 cell_line denotes allogeneic mixed lymphocyte cultures
T18 1196-1198 protein denotes CN
T19 1247-1274 cell_type denotes primary human T lymphocytes
T20 1299-1301 protein denotes CN
T21 1395-1410 DNA denotes lymphocyte gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-83 Sentence denotes Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.
S2 84-201 Sentence denotes Cyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways.
S3 202-311 Sentence denotes In vitro, CsA inhibits lymphocyte gene activation by inhibiting the phosphatase activity of calcineurin (CN).
S4 312-400 Sentence denotes In clinical use, CsA treatment inhibits 50-75% of CN activity in circulating leukocytes.
S5 401-596 Sentence denotes We modeled this degree of CN inhibition in primary human leukocytes in vitro in order to study the effect of partial CN inhibition on the downstream signaling events that lead to gene activation.
S6 597-970 Sentence denotes In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production.
S7 971-1156 Sentence denotes Furthermore, the degree of CN inhibition was reflected by a similar degree of reduction in lymphocyte proliferation and IFN-gamma production in the allogeneic mixed lymphocyte cultures.
S8 1157-1275 Sentence denotes These data support the conclusion that CN activity is rate-limiting for the activation of primary human T lymphocytes.
S9 1276-1471 Sentence denotes Thus, the reduction of CN activity observed in CsA-treated patients is accompanied by a similar degree of reduction in lymphocyte gene activation, and accounts for the immunosuppression observed.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-8 NP denotes Evidence
C2 9-13 NP denotes that
C3 14-25 NP denotes calcineurin
C4 47-82 NP denotes primary human lymphocyte activation
C5 84-102 NP denotes Cyclosporine (CsA)
C6 212-215 NP denotes CsA
C7 225-251 NP denotes lymphocyte gene activation
C9 294-310 NP denotes calcineurin (CN)
C8 266-310 NP denotes the phosphatase activity of calcineurin (CN)
C10 362-373 NP denotes CN activity
C11 427-440 NP denotes CN inhibition
C12 535-566 NP denotes the downstream signaling events
C13 567-571 NP denotes that
C14 580-595 NP denotes gene activation
C15 683-694 NP denotes CN activity
C16 998-1011 NP denotes CN inhibition
C17 1176-1190 NP denotes the conclusion
C18 1191-1195 NP denotes that
C19 1196-1207 NP denotes CN activity
C20 1229-1274 NP denotes the activation of primary human T lymphocytes
C21 1299-1310 NP denotes CN activity
C22 1395-1421 NP denotes lymphocyte gene activation
R1 C2 C1 coref-relat that,Evidence
R2 C6 C5 coref-ident CsA,Cyclosporine (CsA)
R3 C9 C3 coref-ident calcineurin (CN),calcineurin
R4 C10 C8 coref-ident CN activity,the phosphatase activity of calcineurin (CN)
R5 C13 C12 coref-relat that,the downstream signaling events
R6 C14 C7 coref-ident gene activation,lymphocyte gene activation
R7 C15 C10 coref-ident CN activity,CN activity
R8 C16 C11 coref-ident CN inhibition,CN inhibition
R9 C18 C17 coref-relat that,the conclusion
R10 C19 C15 coref-ident CN activity,CN activity
R11 C20 C4 coref-ident the activation of primary human T lymphocytes,primary human lymphocyte activation
R12 C21 C19 coref-ident CN activity,CN activity
R13 C22 C14 coref-ident lymphocyte gene activation,gene activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 47-82 other_name denotes primary human lymphocyte activation
T2 84-96 other_organic_compound denotes Cyclosporine
T3 98-101 other_organic_compound denotes CsA
T4 113-144 other_organic_compound denotes clinical immunosuppressive drug
T5 168-200 other_name denotes intracellular signaling pathways
T6 212-215 other_organic_compound denotes CsA
T7 225-240 DNA_family_or_group denotes lymphocyte gene
T8 270-281 protein_family_or_group denotes phosphatase
T9 294-305 protein_molecule denotes calcineurin
T10 307-309 protein_molecule denotes CN
T11 329-332 other_organic_compound denotes CsA
T12 362-364 protein_molecule denotes CN
T13 377-399 cell_type denotes circulating leukocytes
T14 427-429 protein_molecule denotes CN
T15 444-468 cell_type denotes primary human leukocytes
T16 510-517 other_name denotes partial
T17 518-520 protein_molecule denotes CN
T18 539-566 other_name denotes downstream signaling events
T19 580-595 other_name denotes gene activation
T20 600-603 other_organic_compound denotes CsA
T21 637-654 other_organic_compound denotes calcium ionophore
T22 683-685 protein_molecule denotes CN
T23 767-784 other_name denotes dephosphorylation
T24 788-831 protein_family_or_group denotes nuclear factor of activated T cell proteins
T25 833-852 other_name denotes nuclear DNA binding
T26 870-905 DNA_molecule denotes transfected reporter gene construct
T27 949-958 protein_molecule denotes IFN-gamma
T28 998-1000 protein_molecule denotes CN
T29 1062-1086 other_name denotes lymphocyte proliferation
T30 1091-1100 protein_molecule denotes IFN-gamma
T31 1119-1155 cell_line denotes allogeneic mixed lymphocyte cultures
T32 1196-1198 protein_molecule denotes CN
T33 1247-1274 cell_type denotes primary human T lymphocytes
T34 1299-1301 protein_molecule denotes CN
T35 1323-1326 other_organic_compound denotes CsA
T36 1335-1343 multi_cell denotes patients
T37 1395-1410 DNA_family_or_group denotes lymphocyte gene
T38 1444-1461 other_name denotes immunosuppression