> top > docs > PubMed:9311830 > annotations

PubMed:9311830 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-20 protein denotes BHRF1
T2 206-217 cell_type denotes transformed
T3 221-241 cell_type denotes virus-infected cells
T4 404-409 protein denotes BHRF1
T5 414-464 protein denotes Epstein-Barr virus (EBV) early-lytic-cycle protein
T6 490-495 protein denotes Bcl-2
T7 503-525 protein denotes anti-apoptosis protein
T8 541-546 protein denotes BHRF1
T9 550-563 cell_line denotes MCF-Fas cells
T10 614-631 protein denotes anti-Fas antibody
T11 673-678 protein denotes BHRF1
T12 784-817 cell_type denotes lymphokine-activated killer cells
T13 834-839 protein denotes BHRF1
T14 851-864 cell_line denotes MCF-Fas cells
T15 932-937 protein denotes Bcl-2
T16 942-948 protein denotes Bcl-xL
T17 987-992 protein denotes BHRF1
T18 1011-1016 protein denotes Bcl-2
T19 1021-1027 protein denotes Bcl-xL
T20 1136-1162 protein denotes cytosolic phospholipase A2
T21 1167-1182 protein denotes caspase-3/CPP32
T22 1229-1265 protein denotes NF-kappaB-like transcription factors
T23 1290-1295 protein denotes BHRF1
T24 1299-1328 cell_type denotes EBV-infected epithelial cells
T25 1488-1493 protein denotes BHRF1
T26 1498-1503 protein denotes Bcl-2
T27 1509-1520 cell_line denotes B-cell line
T28 1522-1526 cell_line denotes BJAB
T29 1624-1643 cell_type denotes serum-starved cells
T30 1674-1679 protein denotes BHRF1
T31 1716-1721 protein denotes Bcl-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-81 Sentence denotes The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.
S2 82-300 Sentence denotes The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease.
S3 301-526 Sentence denotes To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein.
S4 527-659 Sentence denotes Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis.
S5 660-818 Sentence denotes In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells.
S6 819-949 Sentence denotes The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL.
S7 950-1266 Sentence denotes Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors.
S8 1267-1451 Sentence denotes A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas-induced cell death in order to maximize virus production.
S9 1452-1644 Sentence denotes Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells.
S10 1645-1790 Sentence denotes Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 15-20 NP denotes BHRF1
C2 32-41 NP denotes apoptosis
C3 309-314 NP denotes genes
C4 315-319 NP denotes that
C5 339-348 NP denotes apoptosis
C6 404-409 NP denotes BHRF1
C8 490-495 NP denotes Bcl-2
C7 411-495 NP denotes an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2
C9 541-546 NP denotes BHRF1
C10 550-563 NP denotes MCF-Fas cells
C11 673-678 NP denotes BHRF1
C12 689-700 NP denotes these cells
C13 754-758 NP denotes them
C14 819-830 NP denotes The ability
C15 834-839 NP denotes BHRF1
C16 851-864 NP denotes MCF-Fas cells
C17 924-928 NP denotes that
C19 932-937 NP denotes Bcl-2
C20 942-948 NP denotes Bcl-xL
C18 932-948 NP denotes Bcl-2 and Bcl-xL
C22 960-983 NP denotes the mechanism of action
C23 987-992 NP denotes BHRF1
C21 960-992 NP denotes the mechanism of action of BHRF1
C24 1003-1007 NP denotes that
C26 1011-1016 NP denotes Bcl-2
C27 1021-1027 NP denotes Bcl-xL
C25 1011-1027 NP denotes Bcl-2 and Bcl-xL
C28 1031-1033 NP denotes it
C29 1084-1134 NP denotes two enzymes participating in the apoptosis pathway
C30 1136-1182 NP denotes cytosolic phospholipase A2 and caspase-3/CPP32
C31 1290-1295 NP denotes BHRF1
C32 1488-1493 NP denotes BHRF1
C33 1498-1503 NP denotes Bcl-2
C34 1651-1670 NP denotes the protective role
C35 1674-1679 NP denotes BHRF1
C36 1688-1697 NP denotes apoptosis
C37 1708-1712 NP denotes that
C38 1716-1721 NP denotes Bcl-2
R1 C4 C3 coref-relat that,genes
R2 C5 C2 coref-ident apoptosis,apoptosis
R3 C6 C1 coref-ident BHRF1,BHRF1
R4 C7 C6 coref-appos an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2,BHRF1
R5 C9 C6 coref-ident BHRF1,BHRF1
R6 C11 C9 coref-ident BHRF1,BHRF1
R7 C12 C10 coref-ident these cells,MCF-Fas cells
R8 C13 C12 coref-pron them,these cells
R9 C15 C11 coref-ident BHRF1,BHRF1
R10 C16 C12 coref-ident MCF-Fas cells,these cells
R11 C17 C14 coref-pron that,The ability
R12 C19 C8 coref-ident Bcl-2,Bcl-2
R13 C23 C15 coref-ident BHRF1,BHRF1
R14 C24 C22 coref-pron that,the mechanism of action
R15 C26 C19 coref-ident Bcl-2,Bcl-2
R16 C27 C20 coref-ident Bcl-xL,Bcl-xL
R17 C25 C18 coref-ident Bcl-2 and Bcl-xL,Bcl-2 and Bcl-xL
R18 C28 C21 coref-pron it,the mechanism of action of BHRF1
R19 C30 C29 coref-appos cytosolic phospholipase A2 and caspase-3/CPP32,two enzymes participating in the apoptosis pathway
R20 C31 C23 coref-ident BHRF1,BHRF1
R21 C32 C31 coref-ident BHRF1,BHRF1
R22 C33 C26 coref-ident Bcl-2,Bcl-2
R23 C35 C32 coref-ident BHRF1,BHRF1
R24 C36 C5 coref-ident apoptosis,apoptosis
R25 C37 C34 coref-pron that,the protective role
R26 C38 C33 coref-ident Bcl-2,Bcl-2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-20 protein_molecule denotes BHRF1
T2 32-41 other_name denotes apoptosis
T3 115-138 other_name denotes host defense mechanisms
T4 206-217 cell_type denotes transformed
T5 221-241 cell_type denotes virus-infected cells
T6 339-348 other_name denotes apoptosis
T7 404-409 protein_molecule denotes BHRF1
T8 414-432 virus denotes Epstein-Barr virus
T9 434-437 virus denotes EBV
T10 490-495 protein_molecule denotes Bcl-2
T11 503-508 protein_family_or_group denotes anti-
T12 508-517 other_name denotes apoptosis
T13 541-546 protein_molecule denotes BHRF1
T14 550-563 cell_line denotes MCF-Fas cells
T15 614-631 protein_family_or_group denotes anti-Fas antibody
T16 636-648 other_name denotes TNF-mediated
T17 649-658 other_name denotes apoptosis
T18 673-678 protein_molecule denotes BHRF1
T19 706-731 other_name denotes monocyte-mediated killing
T20 784-817 cell_type denotes lymphokine-activated killer cells
T21 834-839 protein_molecule denotes BHRF1
T22 851-864 cell_line denotes MCF-Fas cells
T23 870-879 other_name denotes apoptosis
T24 932-937 protein_molecule denotes Bcl-2
T25 942-948 protein_molecule denotes Bcl-xL
T26 987-992 protein_molecule denotes BHRF1
T27 1011-1016 protein_molecule denotes Bcl-2
T28 1021-1027 protein_molecule denotes Bcl-xL
T29 1117-1126 other_name denotes apoptosis
T30 1136-1162 protein_molecule denotes cytosolic phospholipase A2
T31 1167-1182 protein_molecule denotes caspase-3/CPP32
T32 1229-1238 protein_complex denotes NF-kappaB
T33 1290-1295 protein_molecule denotes BHRF1
T34 1299-1302 virus denotes EBV
T35 1488-1493 protein_molecule denotes BHRF1
T36 1498-1503 protein_molecule denotes Bcl-2
T37 1509-1520 cell_line denotes B-cell line
T38 1522-1526 cell_line denotes BJAB
T39 1553-1570 other_name denotes anti-Fas-mediated
T40 1571-1580 other_name denotes apoptosis
T41 1624-1643 cell_type denotes serum-starved cells
T42 1674-1679 protein_molecule denotes BHRF1
T43 1688-1697 other_name denotes apoptosis
T44 1716-1721 protein_molecule denotes Bcl-2
T45 1771-1789 other_name denotes apoptotic stimulus