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PubMed:9305924 JSONTXT

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Goldhamster2_CellLineAnn

Id Subject Object Predicate Lexical cue
T1 20-23 CellLine denotes UT2
T2 663-666 CellLine denotes T2
T3 1087-1090 CellLine denotes T2
T4 1205-1209 CellLine denotes T2*.

sentences

Id Subject Object Predicate Lexical cue
T1 0-30 Sentence denotes Characterization of UT2 cells.
T2 31-108 Sentence denotes The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase.
T3 109-257 Sentence denotes In the liver 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is present not only in the endoplasmic reticulum but also in the peroxisomes.
T4 258-481 Sentence denotes However, to date no information is available regarding the function of the peroxisomal HMG-CoA reductase in cholesterol/isoprenoid metabolism, and the structure of the peroxisomal HMG-CoA reductase has yet to be determined.
T5 482-622 Sentence denotes We have identified a mammalian cell line that expresses only one HMG-CoA reductase protein and that is localized exclusively to peroxisomes.
T6 623-758 Sentence denotes This cell line was obtained by growing UT2 cells (which lack the endoplasmic reticulum HMG-CoA reductase) in the absence of mevalonate.
T7 759-873 Sentence denotes The cells exhibited a marked increase in a 90-kDa HMG-CoA reductase that was localized exclusively to peroxisomes.
T8 874-1081 Sentence denotes The wild type Chinese hamster ovary cells contain two HMG-CoA reductase proteins, the well characterized 97-kDa protein, localized in the endoplasmic reticulum, and a 90-kDa protein localized in peroxisomes.
T9 1082-1209 Sentence denotes The UT2 cells grown in the absence of mevalonate containing the up-regulated peroxisomal HMG-CoA reductase are designated UT2*.
T10 1210-1296 Sentence denotes A detailed characterization and analysis of this cell line is presented in this study.
T1 0-30 Sentence denotes Characterization of UT2 cells.
T2 31-108 Sentence denotes The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase.
T3 109-257 Sentence denotes In the liver 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is present not only in the endoplasmic reticulum but also in the peroxisomes.
T4 258-481 Sentence denotes However, to date no information is available regarding the function of the peroxisomal HMG-CoA reductase in cholesterol/isoprenoid metabolism, and the structure of the peroxisomal HMG-CoA reductase has yet to be determined.
T5 482-622 Sentence denotes We have identified a mammalian cell line that expresses only one HMG-CoA reductase protein and that is localized exclusively to peroxisomes.
T6 623-758 Sentence denotes This cell line was obtained by growing UT2 cells (which lack the endoplasmic reticulum HMG-CoA reductase) in the absence of mevalonate.
T7 759-873 Sentence denotes The cells exhibited a marked increase in a 90-kDa HMG-CoA reductase that was localized exclusively to peroxisomes.
T8 874-1081 Sentence denotes The wild type Chinese hamster ovary cells contain two HMG-CoA reductase proteins, the well characterized 97-kDa protein, localized in the endoplasmic reticulum, and a 90-kDa protein localized in peroxisomes.
T9 1082-1209 Sentence denotes The UT2 cells grown in the absence of mevalonate containing the up-regulated peroxisomal HMG-CoA reductase are designated UT2*.
T10 1210-1296 Sentence denotes A detailed characterization and analysis of this cell line is presented in this study.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 116-121 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 888-903 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 116-121 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 219-228 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 700-709 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T4 904-909 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T5 1024-1033 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 116-121 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097