Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-30 |
Sentence |
denotes |
Characterization of UT2 cells. |
T2 |
31-108 |
Sentence |
denotes |
The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase. |
T3 |
109-257 |
Sentence |
denotes |
In the liver 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is present not only in the endoplasmic reticulum but also in the peroxisomes. |
T4 |
258-481 |
Sentence |
denotes |
However, to date no information is available regarding the function of the peroxisomal HMG-CoA reductase in cholesterol/isoprenoid metabolism, and the structure of the peroxisomal HMG-CoA reductase has yet to be determined. |
T5 |
482-622 |
Sentence |
denotes |
We have identified a mammalian cell line that expresses only one HMG-CoA reductase protein and that is localized exclusively to peroxisomes. |
T6 |
623-758 |
Sentence |
denotes |
This cell line was obtained by growing UT2 cells (which lack the endoplasmic reticulum HMG-CoA reductase) in the absence of mevalonate. |
T7 |
759-873 |
Sentence |
denotes |
The cells exhibited a marked increase in a 90-kDa HMG-CoA reductase that was localized exclusively to peroxisomes. |
T8 |
874-1081 |
Sentence |
denotes |
The wild type Chinese hamster ovary cells contain two HMG-CoA reductase proteins, the well characterized 97-kDa protein, localized in the endoplasmic reticulum, and a 90-kDa protein localized in peroxisomes. |
T9 |
1082-1209 |
Sentence |
denotes |
The UT2 cells grown in the absence of mevalonate containing the up-regulated peroxisomal HMG-CoA reductase are designated UT2*. |
T10 |
1210-1296 |
Sentence |
denotes |
A detailed characterization and analysis of this cell line is presented in this study. |
T1 |
0-30 |
Sentence |
denotes |
Characterization of UT2 cells. |
T2 |
31-108 |
Sentence |
denotes |
The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase. |
T3 |
109-257 |
Sentence |
denotes |
In the liver 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is present not only in the endoplasmic reticulum but also in the peroxisomes. |
T4 |
258-481 |
Sentence |
denotes |
However, to date no information is available regarding the function of the peroxisomal HMG-CoA reductase in cholesterol/isoprenoid metabolism, and the structure of the peroxisomal HMG-CoA reductase has yet to be determined. |
T5 |
482-622 |
Sentence |
denotes |
We have identified a mammalian cell line that expresses only one HMG-CoA reductase protein and that is localized exclusively to peroxisomes. |
T6 |
623-758 |
Sentence |
denotes |
This cell line was obtained by growing UT2 cells (which lack the endoplasmic reticulum HMG-CoA reductase) in the absence of mevalonate. |
T7 |
759-873 |
Sentence |
denotes |
The cells exhibited a marked increase in a 90-kDa HMG-CoA reductase that was localized exclusively to peroxisomes. |
T8 |
874-1081 |
Sentence |
denotes |
The wild type Chinese hamster ovary cells contain two HMG-CoA reductase proteins, the well characterized 97-kDa protein, localized in the endoplasmic reticulum, and a 90-kDa protein localized in peroxisomes. |
T9 |
1082-1209 |
Sentence |
denotes |
The UT2 cells grown in the absence of mevalonate containing the up-regulated peroxisomal HMG-CoA reductase are designated UT2*. |
T10 |
1210-1296 |
Sentence |
denotes |
A detailed characterization and analysis of this cell line is presented in this study. |