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sentences

Id Subject Object Predicate Lexical cue
T1 0-49 Sentence denotes STAT3 is a serine kinase target in T lymphocytes.
T2 50-125 Sentence denotes Interleukin 2 and T cell antigen receptor signals converge upon serine 727.
T3 126-248 Sentence denotes Interleukin 2 (IL-2) induces tyrosine phosphorylation of STATs 3 and 5 (signal transducer and activator of transcription).
T4 249-376 Sentence denotes We now show that IL-2 regulation of STAT3 proteins in T cells is a complex response involving activation of two forms of STAT3:
T5 377-447 Sentence denotes 90-kDa STAT3alpha and an 83-kDa carboxyl-terminal truncated STAT3beta.
T6 448-554 Sentence denotes The phosphorylation of STAT proteins on serine residues is also required for competent STAT transcription.
T7 555-627 Sentence denotes A critical serine phosphorylation site in STAT3alpha is at position 727.
T8 628-825 Sentence denotes In this study we have produced an antisera specific for STAT3alpha proteins phosphorylated on serine 727 and used this to monitor the phosphorylation of this residue during T lymphocyte activation.
T9 826-973 Sentence denotes Our results show that phosphorylation of STAT3alpha on serine 727 is not constitutive in quiescent T cells but can be induced by the cytokine IL-2.
T10 974-1218 Sentence denotes Interestingly, triggering of the T cell antigen receptor complex or activation of protein kinase C with phorbol esters also induces phosphorylation of serine 727 but without simultaneously inducing STAT3 tyrosine phosphorylation or DNA binding.
T11 1219-1365 Sentence denotes Hence, the present results show that STAT3 serine phosphorylation can be regulated independently of the tyrosine phosphorylation of this molecule.
T12 1366-1510 Sentence denotes IL-2 and T cell antigen receptor complex induction of STAT3alpha serine 727 phosphorylation is dependent on the activity of the MEK/ERK pathway.
T13 1511-1606 Sentence denotes Previous studies have identified H-7-sensitive kinase pathways that regulate STAT3 DNA binding.
T14 1607-1681 Sentence denotes We show that H-7-sensitive pathways regulate STAT3 DNA binding in T cells.
T15 1682-1811 Sentence denotes Nevertheless, we show that H-7-sensitive kinases do not regulate STAT3 tyrosine phosphorylation or phosphorylation of serine 727.
T16 1812-1985 Sentence denotes These results thus show that STAT3 proteins are targets for multiple kinase pathways in T cells and can integrate signals from both cytokine receptors and antigen receptors.
T1 0-49 Sentence denotes STAT3 is a serine kinase target in T lymphocytes.
T2 50-125 Sentence denotes Interleukin 2 and T cell antigen receptor signals converge upon serine 727.
T3 126-248 Sentence denotes Interleukin 2 (IL-2) induces tyrosine phosphorylation of STATs 3 and 5 (signal transducer and activator of transcription).
T4 249-376 Sentence denotes We now show that IL-2 regulation of STAT3 proteins in T cells is a complex response involving activation of two forms of STAT3:
T5 377-447 Sentence denotes 90-kDa STAT3alpha and an 83-kDa carboxyl-terminal truncated STAT3beta.
T6 448-554 Sentence denotes The phosphorylation of STAT proteins on serine residues is also required for competent STAT transcription.
T7 555-627 Sentence denotes A critical serine phosphorylation site in STAT3alpha is at position 727.
T8 628-825 Sentence denotes In this study we have produced an antisera specific for STAT3alpha proteins phosphorylated on serine 727 and used this to monitor the phosphorylation of this residue during T lymphocyte activation.
T9 826-973 Sentence denotes Our results show that phosphorylation of STAT3alpha on serine 727 is not constitutive in quiescent T cells but can be induced by the cytokine IL-2.
T10 974-1218 Sentence denotes Interestingly, triggering of the T cell antigen receptor complex or activation of protein kinase C with phorbol esters also induces phosphorylation of serine 727 but without simultaneously inducing STAT3 tyrosine phosphorylation or DNA binding.
T11 1219-1365 Sentence denotes Hence, the present results show that STAT3 serine phosphorylation can be regulated independently of the tyrosine phosphorylation of this molecule.
T12 1366-1510 Sentence denotes IL-2 and T cell antigen receptor complex induction of STAT3alpha serine 727 phosphorylation is dependent on the activity of the MEK/ERK pathway.
T13 1511-1606 Sentence denotes Previous studies have identified H-7-sensitive kinase pathways that regulate STAT3 DNA binding.
T14 1607-1681 Sentence denotes We show that H-7-sensitive pathways regulate STAT3 DNA binding in T cells.
T15 1682-1811 Sentence denotes Nevertheless, we show that H-7-sensitive kinases do not regulate STAT3 tyrosine phosphorylation or phosphorylation of serine 727.
T16 1812-1985 Sentence denotes These results thus show that STAT3 proteins are targets for multiple kinase pathways in T cells and can integrate signals from both cytokine receptors and antigen receptors.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes STAT3
T2 11-31 protein denotes serine kinase target
T3 35-48 cell_type denotes T lymphocytes
T4 50-63 protein denotes Interleukin 2
T5 68-91 protein denotes T cell antigen receptor
T6 126-139 protein denotes Interleukin 2
T7 141-145 protein denotes IL-2
T8 183-196 protein denotes STATs 3 and 5
T9 266-270 protein denotes IL-2
T10 285-299 protein denotes STAT3 proteins
T11 303-310 cell_type denotes T cells
T12 370-375 protein denotes STAT3
T13 384-394 protein denotes STAT3alpha
T14 402-446 protein denotes 83-kDa carboxyl-terminal truncated STAT3beta
T15 471-484 protein denotes STAT proteins
T16 535-539 protein denotes STAT
T17 566-593 protein denotes serine phosphorylation site
T18 597-607 protein denotes STAT3alpha
T19 684-703 protein denotes STAT3alpha proteins
T20 867-877 protein denotes STAT3alpha
T21 915-932 cell_type denotes quiescent T cells
T22 959-972 protein denotes cytokine IL-2
T23 1007-1038 protein denotes T cell antigen receptor complex
T24 1056-1072 protein denotes protein kinase C
T25 1172-1177 protein denotes STAT3
T26 1256-1261 protein denotes STAT3
T27 1366-1370 protein denotes IL-2
T28 1375-1406 protein denotes T cell antigen receptor complex
T29 1420-1430 protein denotes STAT3alpha
T30 1494-1497 protein denotes MEK
T31 1497-1501 protein denotes /ERK
T32 1588-1593 protein denotes STAT3
T33 1652-1657 protein denotes STAT3
T34 1673-1680 cell_type denotes T cells
T35 1709-1730 protein denotes H-7-sensitive kinases
T36 1747-1752 protein denotes STAT3
T37 1841-1855 protein denotes STAT3 proteins
T38 1900-1907 cell_type denotes T cells
T39 1944-1962 protein denotes cytokine receptors
T40 1967-1984 protein denotes antigen receptors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-49 Sentence denotes STAT3 is a serine kinase target in T lymphocytes.
S2 50-125 Sentence denotes Interleukin 2 and T cell antigen receptor signals converge upon serine 727.
S3 126-248 Sentence denotes Interleukin 2 (IL-2) induces tyrosine phosphorylation of STATs 3 and 5 (signal transducer and activator of transcription).
S4 249-447 Sentence denotes We now show that IL-2 regulation of STAT3 proteins in T cells is a complex response involving activation of two forms of STAT3: 90-kDa STAT3alpha and an 83-kDa carboxyl-terminal truncated STAT3beta.
S5 448-554 Sentence denotes The phosphorylation of STAT proteins on serine residues is also required for competent STAT transcription.
S6 555-627 Sentence denotes A critical serine phosphorylation site in STAT3alpha is at position 727.
S7 628-825 Sentence denotes In this study we have produced an antisera specific for STAT3alpha proteins phosphorylated on serine 727 and used this to monitor the phosphorylation of this residue during T lymphocyte activation.
S8 826-973 Sentence denotes Our results show that phosphorylation of STAT3alpha on serine 727 is not constitutive in quiescent T cells but can be induced by the cytokine IL-2.
S9 974-1218 Sentence denotes Interestingly, triggering of the T cell antigen receptor complex or activation of protein kinase C with phorbol esters also induces phosphorylation of serine 727 but without simultaneously inducing STAT3 tyrosine phosphorylation or DNA binding.
S10 1219-1365 Sentence denotes Hence, the present results show that STAT3 serine phosphorylation can be regulated independently of the tyrosine phosphorylation of this molecule.
S11 1366-1510 Sentence denotes IL-2 and T cell antigen receptor complex induction of STAT3alpha serine 727 phosphorylation is dependent on the activity of the MEK/ERK pathway.
S12 1511-1606 Sentence denotes Previous studies have identified H-7-sensitive kinase pathways that regulate STAT3 DNA binding.
S13 1607-1681 Sentence denotes We show that H-7-sensitive pathways regulate STAT3 DNA binding in T cells.
S14 1682-1811 Sentence denotes Nevertheless, we show that H-7-sensitive kinases do not regulate STAT3 tyrosine phosphorylation or phosphorylation of serine 727.
S15 1812-1985 Sentence denotes These results thus show that STAT3 proteins are targets for multiple kinase pathways in T cells and can integrate signals from both cytokine receptors and antigen receptors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 35-48 NP denotes T lymphocytes
C2 114-124 NP denotes serine 727
C3 303-310 NP denotes T cells
C4 357-375 NP denotes two forms of STAT3
C5 377-446 NP denotes 90-kDa STAT3alpha and an 83-kDa carboxyl-terminal truncated STAT3beta
C7 722-732 NP denotes serine 727
C6 659-732 NP denotes an antisera specific for STAT3alpha proteins phosphorylated on serine 727
C8 742-746 NP denotes this
C9 826-837 NP denotes Our results
C10 881-891 NP denotes serine 727
C11 1125-1135 NP denotes serine 727
C12 1172-1202 NP denotes STAT3 tyrosine phosphorylation
C13 1226-1245 NP denotes the present results
C14 1319-1364 NP denotes the tyrosine phosphorylation of this molecule
C15 1544-1573 NP denotes H-7-sensitive kinase pathways
C16 1574-1578 NP denotes that
C17 1673-1680 NP denotes T cells
C18 1747-1777 NP denotes STAT3 tyrosine phosphorylation
C19 1800-1810 NP denotes serine 727
C20 1900-1907 NP denotes T cells
R1 C3 C1 coref-ident T cells,T lymphocytes
R2 C5 C4 coref-appos 90-kDa STAT3alpha and an 83-kDa carboxyl-terminal truncated STAT3beta,two forms of STAT3
R3 C7 C2 coref-ident serine 727,serine 727
R4 C8 C6 coref-pron this,an antisera specific for STAT3alpha proteins phosphorylated on serine 727
R5 C10 C7 coref-ident serine 727,serine 727
R6 C11 C10 coref-ident serine 727,serine 727
R7 C13 C9 coref-ident the present results,Our results
R8 C14 C12 coref-ident the tyrosine phosphorylation of this molecule,STAT3 tyrosine phosphorylation
R9 C16 C15 coref-relat that,H-7-sensitive kinase pathways
R10 C17 C3 coref-ident T cells,T cells
R11 C18 C14 coref-ident STAT3 tyrosine phosphorylation,the tyrosine phosphorylation of this molecule
R12 C19 C11 coref-ident serine 727,serine 727
R13 C20 C17 coref-ident T cells,T cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes STAT3
T2 11-31 protein_family_or_group denotes serine kinase target
T3 35-48 cell_type denotes T lymphocytes
T4 50-63 protein_molecule denotes Interleukin 2
T5 68-91 protein_family_or_group denotes T cell antigen receptor
T6 114-124 amino_acid_monomer denotes serine 727
T7 126-139 protein_molecule denotes Interleukin 2
T8 141-145 protein_molecule denotes IL-2
T9 155-163 amino_acid_monomer denotes tyrosine
T10 266-270 protein_molecule denotes IL-2
T11 285-290 protein_molecule denotes STAT3
T12 303-310 cell_type denotes T cells
T13 370-375 protein_molecule denotes STAT3
T14 384-394 protein_molecule denotes STAT3alpha
T15 402-436 protein_molecule denotes 83-kDa carboxyl-terminal truncated
T16 437-446 protein_molecule denotes STAT3beta
T17 471-484 protein_family_or_group denotes STAT proteins
T18 488-503 amino_acid_monomer denotes serine residues
T19 535-539 protein_family_or_group denotes STAT
T20 566-572 amino_acid_monomer denotes serine
T21 597-607 protein_molecule denotes STAT3alpha
T22 614-626 amino_acid_monomer denotes position 727
T23 684-703 protein_family_or_group denotes STAT3alpha proteins
T24 722-728 amino_acid_monomer denotes serine
T25 801-824 other_name denotes T lymphocyte activation
T26 848-863 other_name denotes phosphorylation
T27 867-877 protein_molecule denotes STAT3alpha
T28 881-887 amino_acid_monomer denotes serine
T29 915-932 cell_type denotes quiescent T cells
T30 959-967 protein_molecule denotes cytokine
T31 968-972 protein_molecule denotes IL-2
T32 1007-1038 protein_complex denotes T cell antigen receptor complex
T33 1056-1072 protein_molecule denotes protein kinase C
T34 1078-1092 other_organic_compound denotes phorbol esters
T35 1125-1131 amino_acid_monomer denotes serine
T36 1172-1177 protein_molecule denotes STAT3
T37 1178-1186 amino_acid_monomer denotes tyrosine
T38 1256-1261 protein_molecule denotes STAT3
T39 1262-1268 amino_acid_monomer denotes serine
T40 1323-1331 amino_acid_monomer denotes tyrosine
T41 1366-1370 protein_molecule denotes IL-2
T42 1375-1406 protein_complex denotes T cell antigen receptor complex
T43 1420-1430 protein_molecule denotes STAT3alpha
T44 1431-1437 amino_acid_monomer denotes serine
T45 1494-1497 protein_family_or_group denotes MEK
T46 1497-1501 protein_molecule denotes /ERK
T47 1544-1573 other_name denotes H-7-sensitive kinase pathways
T48 1588-1593 protein_molecule denotes STAT3
T49 1620-1642 other_name denotes H-7-sensitive pathways
T50 1652-1657 protein_molecule denotes STAT3
T51 1673-1680 cell_type denotes T cells
T52 1709-1730 protein_family_or_group denotes H-7-sensitive kinases
T53 1747-1752 protein_molecule denotes STAT3
T54 1753-1761 amino_acid_monomer denotes tyrosine
T55 1800-1806 amino_acid_monomer denotes serine
T56 1841-1846 protein_molecule denotes STAT3
T57 1872-1896 other_name denotes multiple kinase pathways
T58 1900-1907 cell_type denotes T cells
T59 1944-1962 protein_family_or_group denotes cytokine receptors
T60 1967-1984 protein_family_or_group denotes antigen receptors

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 35-48 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T2 68-74 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 801-813 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T4 1007-1013 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T5 1375-1381 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 35-48 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T2 68-74 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T3 303-310 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 801-813 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T5 803-813 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T6 925-932 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T7 1007-1013 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T8 1375-1381 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T9 1673-1680 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T10 1900-1907 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084