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sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.
T2 133-230 Sentence denotes The leukocyte integrin genes CD11c and CD11b are expressed predominately in myelomonocytic cells.
T3 231-436 Sentence denotes In previous experiments, the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter were shown to be essential for Sp1-mediated activation of these genes.
T4 437-551 Sentence denotes In vivo genomic footprinting had also revealed cell-specific binding of protein, presumably Sp1, to these regions.
T5 552-689 Sentence denotes In this study, electrophoretic mobility shift analysis showed that the Sp1-related factor, Sp3, also binds at or near these same regions.
T6 690-857 Sentence denotes Cotransfection of Sp3 along with CD11c promoter-luciferase constructs into Sp-deficient Drosophila Schneider 2 cells showed that Sp3 could activate the CD11c promoter.
T7 858-979 Sentence denotes Deletion of both the -70 to -65 and -121 to -103 regions of the CD11c promoter resulted in the loss of activation by Sp3.
T8 980-1087 Sentence denotes Both sites showed activation by Sp3; however, the -70 to -65 region was more responsive to Sp3 than to Sp1.
T9 1088-1197 Sentence denotes Similar transfection analysis of the -66 to -59 region of the CD11b promoter showed Sp3-dependent expression.
T10 1198-1346 Sentence denotes Further, cotransfection analysis in Drosophila cells showed that Sp3, as was previously shown for Sp1, also synergizes with c-Jun to activate CD11c.
T11 1347-1535 Sentence denotes Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo.
T1 0-132 Sentence denotes Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.
T2 133-230 Sentence denotes The leukocyte integrin genes CD11c and CD11b are expressed predominately in myelomonocytic cells.
T3 231-436 Sentence denotes In previous experiments, the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter were shown to be essential for Sp1-mediated activation of these genes.
T4 437-551 Sentence denotes In vivo genomic footprinting had also revealed cell-specific binding of protein, presumably Sp1, to these regions.
T5 552-689 Sentence denotes In this study, electrophoretic mobility shift analysis showed that the Sp1-related factor, Sp3, also binds at or near these same regions.
T6 690-857 Sentence denotes Cotransfection of Sp3 along with CD11c promoter-luciferase constructs into Sp-deficient Drosophila Schneider 2 cells showed that Sp3 could activate the CD11c promoter.
T7 858-979 Sentence denotes Deletion of both the -70 to -65 and -121 to -103 regions of the CD11c promoter resulted in the loss of activation by Sp3.
T8 980-1087 Sentence denotes Both sites showed activation by Sp3; however, the -70 to -65 region was more responsive to Sp3 than to Sp1.
T9 1088-1197 Sentence denotes Similar transfection analysis of the -66 to -59 region of the CD11b promoter showed Sp3-dependent expression.
T10 1198-1346 Sentence denotes Further, cotransfection analysis in Drosophila cells showed that Sp3, as was previously shown for Sp1, also synergizes with c-Jun to activate CD11c.
T11 1347-1535 Sentence denotes Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes Sp3
T2 47-71 DNA denotes leukocyte integrin genes
T3 72-77 DNA denotes CD11C
T4 82-87 DNA denotes CD11B
T5 126-131 DNA denotes CD11C
T6 137-161 DNA denotes leukocyte integrin genes
T7 162-167 DNA denotes CD11c
T8 172-177 DNA denotes CD11b
T9 260-295 DNA denotes -70 to -65 and -121 to -103 regions
T10 303-317 DNA denotes CD11c promoter
T11 326-343 DNA denotes -66 to -59 region
T12 351-365 DNA denotes CD11b promoter
T13 397-401 protein denotes Sp1-
T14 529-532 protein denotes Sp1
T15 623-641 protein denotes Sp1-related factor
T16 643-646 protein denotes Sp3
T17 708-711 protein denotes Sp3
T18 723-759 DNA denotes CD11c promoter-luciferase constructs
T19 765-806 cell_line denotes Sp-deficient Drosophila Schneider 2 cells
T20 819-822 protein denotes Sp3
T21 842-856 DNA denotes CD11c promoter
T22 879-914 DNA denotes -70 to -65 and -121 to -103 regions
T23 922-936 DNA denotes CD11c promoter
T24 975-978 protein denotes Sp3
T25 1012-1015 protein denotes Sp3
T26 1030-1047 DNA denotes -70 to -65 region
T27 1071-1074 protein denotes Sp3
T28 1083-1086 protein denotes Sp1
T29 1125-1142 DNA denotes -66 to -59 region
T30 1150-1164 DNA denotes CD11b promoter
T31 1172-1175 protein denotes Sp3
T32 1234-1250 cell_line denotes Drosophila cells
T33 1263-1266 protein denotes Sp3
T34 1296-1299 protein denotes Sp1
T35 1322-1327 protein denotes c-Jun
T36 1340-1345 DNA denotes CD11c
T37 1397-1400 protein denotes Sp3
T38 1419-1441 cell_line denotes myelomocytic cell line
T39 1443-1447 cell_line denotes HL60
T40 1463-1466 protein denotes Sp3
T41 1501-1526 DNA denotes CD11c and CD11b promoters

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-132 Sentence denotes Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.
S2 133-230 Sentence denotes The leukocyte integrin genes CD11c and CD11b are expressed predominately in myelomonocytic cells.
S3 231-436 Sentence denotes In previous experiments, the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter were shown to be essential for Sp1-mediated activation of these genes.
S4 437-551 Sentence denotes In vivo genomic footprinting had also revealed cell-specific binding of protein, presumably Sp1, to these regions.
S5 552-689 Sentence denotes In this study, electrophoretic mobility shift analysis showed that the Sp1-related factor, Sp3, also binds at or near these same regions.
S6 690-857 Sentence denotes Cotransfection of Sp3 along with CD11c promoter-luciferase constructs into Sp-deficient Drosophila Schneider 2 cells showed that Sp3 could activate the CD11c promoter.
S7 858-979 Sentence denotes Deletion of both the -70 to -65 and -121 to -103 regions of the CD11c promoter resulted in the loss of activation by Sp3.
S8 980-1087 Sentence denotes Both sites showed activation by Sp3; however, the -70 to -65 region was more responsive to Sp3 than to Sp1.
S9 1088-1197 Sentence denotes Similar transfection analysis of the -66 to -59 region of the CD11b promoter showed Sp3-dependent expression.
S10 1198-1346 Sentence denotes Further, cotransfection analysis in Drosophila cells showed that Sp3, as was previously shown for Sp1, also synergizes with c-Jun to activate CD11c.
S11 1347-1535 Sentence denotes Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-3 NP denotes Sp3
C2 43-87 NP denotes the leukocyte integrin genes CD11C and CD11B
C3 108-113 NP denotes c-Jun
C4 126-131 NP denotes CD11C
C5 133-177 NP denotes The leukocyte integrin genes CD11c and CD11b
C8 299-317 NP denotes the CD11c promoter
C7 256-317 NP denotes the -70 to -65 and -121 to -103 regions of the CD11c promoter
C9 322-365 NP denotes the -66 to -59 region of the CD11b promoter
C6 256-365 NP denotes the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter
C10 424-435 NP denotes these genes
C11 509-516 NP denotes protein
C12 529-532 NP denotes Sp1
C13 537-550 NP denotes these regions
C14 619-641 NP denotes the Sp1-related factor
C15 643-646 NP denotes Sp3
C16 670-688 NP denotes these same regions
C17 708-711 NP denotes Sp3
C18 765-806 NP denotes Sp-deficient Drosophila Schneider 2 cells
C19 819-822 NP denotes Sp3
C20 838-856 NP denotes the CD11c promoter
C22 918-936 NP denotes the CD11c promoter
C21 870-936 NP denotes both the -70 to -65 and -121 to -103 regions of the CD11c promoter
C23 975-978 NP denotes Sp3
C24 980-990 NP denotes Both sites
C25 1012-1016 NP denotes Sp3;
C26 1071-1074 NP denotes Sp3
C27 1083-1086 NP denotes Sp1
C28 1121-1164 NP denotes the -66 to -59 region of the CD11b promoter
C29 1234-1250 NP denotes Drosophila cells
C30 1263-1266 NP denotes Sp3
C31 1296-1299 NP denotes Sp1
C32 1322-1327 NP denotes c-Jun
C33 1340-1345 NP denotes CD11c
C34 1347-1368 NP denotes Antisense experiments
C35 1369-1373 NP denotes that
C36 1415-1441 NP denotes the myelomocytic cell line
C37 1443-1447 NP denotes HL60
C38 1463-1466 NP denotes Sp3
R1 C5 C2 coref-ident The leukocyte integrin genes CD11c and CD11b,the leukocyte integrin genes CD11C and CD11B
R2 C10 C5 coref-ident these genes,The leukocyte integrin genes CD11c and CD11b
R3 C12 C11 coref-appos Sp1,protein
R4 C13 C6 coref-ident these regions,the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter
R5 C14 C1 coref-ident the Sp1-related factor,Sp3
R6 C15 C14 coref-appos Sp3,the Sp1-related factor
R7 C16 C6 coref-ident these same regions,the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter
R8 C17 C14 coref-ident Sp3,the Sp1-related factor
R9 C19 C17 coref-ident Sp3,Sp3
R10 C20 C8 coref-ident the CD11c promoter,the CD11c promoter
R11 C22 C20 coref-ident the CD11c promoter,the CD11c promoter
R12 C21 C7 coref-ident both the -70 to -65 and -121 to -103 regions of the CD11c promoter,the -70 to -65 and -121 to -103 regions of the CD11c promoter
R13 C23 C19 coref-ident Sp3,Sp3
R14 C24 C21 coref-ident Both sites,both the -70 to -65 and -121 to -103 regions of the CD11c promoter
R15 C25 C23 coref-ident Sp3;,Sp3
R16 C26 C25 coref-ident Sp3,Sp3;
R17 C27 C11 coref-ident Sp1,protein
R18 C28 C9 coref-ident the -66 to -59 region of the CD11b promoter,the -66 to -59 region of the CD11b promoter
R19 C29 C18 coref-ident Drosophila cells,Sp-deficient Drosophila Schneider 2 cells
R20 C30 C26 coref-ident Sp3,Sp3
R21 C31 C27 coref-ident Sp1,Sp1
R22 C32 C3 coref-ident c-Jun,c-Jun
R23 C33 C4 coref-ident CD11c,CD11C
R24 C35 C34 coref-relat that,Antisense experiments
R25 C37 C36 coref-appos HL60,the myelomocytic cell line
R26 C38 C30 coref-ident Sp3,Sp3

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_molecule denotes Sp3
T2 13-39 other_name denotes transcriptional activation
T3 47-71 DNA_family_or_group denotes leukocyte integrin genes
T4 72-77 DNA_domain_or_region denotes CD11C
T5 82-87 DNA_domain_or_region denotes CD11B
T6 126-131 DNA_domain_or_region denotes CD11C
T7 137-161 DNA_family_or_group denotes leukocyte integrin genes
T8 162-167 DNA_domain_or_region denotes CD11c
T9 172-177 DNA_domain_or_region denotes CD11b
T10 303-308 DNA_domain_or_region denotes CD11c
T11 326-343 DNA_domain_or_region denotes -66 to -59 region
T12 351-356 DNA_domain_or_region denotes CD11b
T13 397-401 protein_family_or_group denotes Sp1-
T14 437-465 other_name denotes In vivo genomic footprinting
T15 529-532 protein_molecule denotes Sp1
T16 567-606 other_name denotes electrophoretic mobility shift analysis
T17 623-626 protein_molecule denotes Sp1
T18 643-646 protein_molecule denotes Sp3
T19 690-704 other_name denotes Cotransfection
T20 708-711 protein_molecule denotes Sp3
T21 723-728 DNA_domain_or_region denotes CD11c
T22 737-748 protein_molecule denotes -luciferase
T23 765-806 cell_line denotes Sp-deficient Drosophila Schneider 2 cells
T24 819-822 protein_molecule denotes Sp3
T25 842-847 DNA_domain_or_region denotes CD11c
T26 922-927 DNA_domain_or_region denotes CD11c
T27 975-978 protein_molecule denotes Sp3
T28 1012-1015 protein_molecule denotes Sp3
T29 1030-1047 DNA_domain_or_region denotes -70 to -65 region
T30 1071-1074 protein_molecule denotes Sp3
T31 1083-1086 protein_molecule denotes Sp1
T32 1096-1117 other_name denotes transfection analysis
T33 1125-1142 DNA_domain_or_region denotes -66 to -59 region
T34 1150-1155 DNA_domain_or_region denotes CD11b
T35 1172-1175 protein_molecule denotes Sp3
T36 1207-1230 other_name denotes cotransfection analysis
T37 1234-1250 cell_line denotes Drosophila cells
T38 1263-1266 protein_molecule denotes Sp3
T39 1296-1299 protein_molecule denotes Sp1
T40 1322-1327 protein_molecule denotes c-Jun
T41 1340-1345 DNA_domain_or_region denotes CD11c
T42 1347-1368 other_name denotes Antisense experiments
T43 1386-1396 other_name denotes endogenous
T44 1397-1400 protein_molecule denotes Sp3
T45 1419-1441 cell_line denotes myelomocytic cell line
T46 1443-1447 cell_line denotes HL60
T47 1463-1466 protein_molecule denotes Sp3

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 778-788 OrganismTaxon denotes Drosophila 2081351|32281|7215
T4 1234-1244 OrganismTaxon denotes Drosophila 2081351|32281|7215

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 47-56 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T2 137-146 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 47-56 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T2 137-146 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738