PubMed:9295317 / 2469-2956 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T22","span":{"begin":109,"end":120},"obj":"Cell"},{"id":"T23","span":{"begin":140,"end":151},"obj":"Cell"},{"id":"T24","span":{"begin":252,"end":264},"obj":"Cell"}],"attributes":[{"id":"A22","pred":"cl_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CL:0000510"},{"id":"A23","pred":"cl_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CL:0000510"},{"id":"A24","pred":"cl_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CL:0000510"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"sentences","denotations":[{"id":"T16","span":{"begin":0,"end":487},"obj":"Sentence"},{"id":"T16","span":{"begin":0,"end":487},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T14","span":{"begin":30,"end":38},"obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"id":"T15","span":{"begin":293,"end":305},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T16","span":{"begin":309,"end":325},"obj":"http://purl.obolibrary.org/obo/MAT_0000047"},{"id":"T17","span":{"begin":456,"end":459},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"GlyCosmos15-CL","denotations":[{"id":"T22","span":{"begin":109,"end":120},"obj":"Cell"},{"id":"T23","span":{"begin":140,"end":151},"obj":"Cell"},{"id":"T24","span":{"begin":252,"end":264},"obj":"Cell"}],"attributes":[{"id":"A22","pred":"cl_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CL:0000510"},{"id":"A23","pred":"cl_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CL:0000510"},{"id":"A24","pred":"cl_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CL:0000510"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T15","span":{"begin":315,"end":332},"obj":"Body_part"},{"id":"T16","span":{"begin":407,"end":413},"obj":"Body_part"},{"id":"T17","span":{"begin":456,"end":486},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0001983"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001213"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001962"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"GlyCosmos15-MAT","denotations":[{"id":"T9","span":{"begin":30,"end":38},"obj":"Body_part"},{"id":"T10","span":{"begin":293,"end":305},"obj":"Body_part"},{"id":"T11","span":{"begin":309,"end":325},"obj":"Body_part"},{"id":"T12","span":{"begin":456,"end":459},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A11","pred":"mat_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MAT_0000047"},{"id":"A12","pred":"mat_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"sentences","denotations":[{"id":"T16","span":{"begin":0,"end":487},"obj":"Sentence"},{"id":"T16","span":{"begin":0,"end":487},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T15","span":{"begin":0,"end":487},"obj":"Sentence"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T15","span":{"begin":315,"end":332},"obj":"Body_part"},{"id":"T16","span":{"begin":407,"end":413},"obj":"Body_part"},{"id":"T17","span":{"begin":456,"end":486},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0001983"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001213"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001962"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}

{"project":"Anatomy-MAT","denotations":[{"id":"T9","span":{"begin":30,"end":38},"obj":"Body_part"},{"id":"T10","span":{"begin":293,"end":305},"obj":"Body_part"},{"id":"T11","span":{"begin":309,"end":325},"obj":"Body_part"},{"id":"T12","span":{"begin":456,"end":459},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A11","pred":"mat_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MAT_0000047"},{"id":"A12","pred":"mat_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"text":"Our findings suggest that (i) stemness in the crypt is not defined by instructive interactions involving the Paneth cell; (ii) expressing a Paneth cell fate may require that precursors migrate to the crypt base; (iii) antimicrobial factors produced by Paneth cells are not required to prevent colonization of small intestinal crypts; and (iv) this lineage does not function to maintain the asymmetric crypt-villus distribution of components of the diffuse gut-associated lymphoid tissue."}