PubMed:9285527
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-40 | protein | denotes | carboxyl-terminal cytoplasmic domain |
| T2 | 44-48 | protein | denotes | CD36 |
| T3 | 112-121 | protein | denotes | NF-kappaB |
| T4 | 134-161 | protein | denotes | tumor necrosis factor-alpha |
| T5 | 223-231 | cell_type | denotes | monocyte |
| T6 | 231-243 | cell_type | denotes | -macrophages |
| T7 | 393-410 | protein | denotes | glycoprotein CD36 |
| T8 | 483-503 | cell_type | denotes | monocyte-macrophages |
| T9 | 551-555 | protein | denotes | CD36 |
| T10 | 620-624 | protein | denotes | CD36 |
| T11 | 637-671 | cell_type | denotes | Chinese hampster ovary (CHO) cells |
| T12 | 743-763 | protein | denotes | transcription factor |
| T13 | 764-773 | protein | denotes | NF-kappaB |
| T14 | 858-876 | DNA | denotes | NF-kappaB sequence |
| T15 | 901-925 | cell_line | denotes | CD36-producing CHO cells |
| T16 | 935-959 | protein | denotes | proinflammatory cytokine |
| T17 | 960-987 | protein | denotes | tumor necrosis factor-alpha |
| T18 | 989-998 | protein | denotes | TNF-alpha |
| T19 | 1069-1073 | protein | denotes | CD36 |
| T20 | 1101-1129 | protein | denotes | human CD36-specific antibody |
| T21 | 1130-1134 | protein | denotes | OKM5 |
| T22 | 1174-1183 | protein | denotes | NF-kappaB |
| T23 | 1224-1261 | protein | denotes | carboxyl-terminal cytoplasmic segment |
| T24 | 1265-1269 | protein | denotes | CD36 |
| T25 | 1305-1315 | protein | denotes | human CD36 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-162 | Sentence | denotes | The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor necrosis factor-alpha. |
| S2 | 163-370 | Sentence | denotes | The binding of oxidized low-density lipoprotein (Ox LDL) by monocyte-macrophages causes pleiotropic effects, including changes in gene expression, and is thought to represent an early event in atherogenesis. |
| S3 | 371-587 | Sentence | denotes | The integral membrane glycoprotein CD36 appears to play a physiological role in binding and uptake of Ox LDL by monocyte-macrophages, although the molecular events associated with CD36-Ox LDL interaction are unknown. |
| S4 | 588-774 | Sentence | denotes | To approach this issue, we used CD36 transfected Chinese hampster ovary (CHO) cells, exposed them to Ox LDL, and determined changes in the activity of the transcription factor NF-kappaB. |
| S5 | 775-1000 | Sentence | denotes | We report here that Ox LDL enhanced DNA binding activity of nuclear extracts to an NF-kappaB sequence following activation of CD36-producing CHO cells with the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). |
| S6 | 1001-1135 | Sentence | denotes | This enhanced DNA binding activity was inhibited by coincubation of CD36 transfected cells with the human CD36-specific antibody OKM5. |
| S7 | 1136-1270 | Sentence | denotes | We also determined that activation of NF-kappaB DNA binding activity required an intact carboxyl-terminal cytoplasmic segment on CD36. |
| S8 | 1271-1374 | Sentence | denotes | Our results support the idea that human CD36 mediates signal transduction events in response to Ox LDL. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 44-48 | NP | denotes | CD36 |
| C2 | 112-130 | NP | denotes | NF-kappaB activity |
| C3 | 178-219 | NP | denotes | oxidized low-density lipoprotein (Ox LDL) |
| C4 | 223-243 | NP | denotes | monocyte-macrophages |
| C5 | 371-410 | NP | denotes | The integral membrane glycoprotein CD36 |
| C6 | 473-479 | NP | denotes | Ox LDL |
| C7 | 483-503 | NP | denotes | monocyte-macrophages |
| C8 | 620-671 | NP | denotes | CD36 transfected Chinese hampster ovary (CHO) cells |
| C9 | 681-685 | NP | denotes | them |
| C10 | 689-695 | NP | denotes | Ox LDL |
| C11 | 723-773 | NP | denotes | the activity of the transcription factor NF-kappaB |
| C12 | 795-801 | NP | denotes | Ox LDL |
| C13 | 1069-1091 | NP | denotes | CD36 transfected cells |
| C14 | 1291-1299 | NP | denotes | the idea |
| C15 | 1300-1304 | NP | denotes | that |
| C16 | 1367-1373 | NP | denotes | Ox LDL |
| R1 | C5 | C1 | coref-ident | The integral membrane glycoprotein CD36,CD36 |
| R2 | C6 | C3 | coref-ident | Ox LDL,oxidized low-density lipoprotein (Ox LDL) |
| R3 | C7 | C4 | coref-ident | monocyte-macrophages,monocyte-macrophages |
| R4 | C9 | C8 | coref-pron | them,CD36 transfected Chinese hampster ovary (CHO) cells |
| R5 | C10 | C6 | coref-ident | Ox LDL,Ox LDL |
| R6 | C11 | C2 | coref-ident | the activity of the transcription factor NF-kappaB,NF-kappaB activity |
| R7 | C12 | C10 | coref-ident | Ox LDL,Ox LDL |
| R8 | C13 | C8 | coref-ident | CD36 transfected cells,CD36 transfected Chinese hampster ovary (CHO) cells |
| R9 | C15 | C14 | coref-relat | that,the idea |
| R10 | C16 | C12 | coref-ident | Ox LDL,Ox LDL |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-40 | protein_domain_or_region | denotes | carboxyl-terminal cytoplasmic domain |
| T2 | 44-48 | protein_molecule | denotes | CD36 |
| T3 | 74-97 | lipid | denotes | low-density lipoprotein |
| T4 | 112-121 | protein_complex | denotes | NF-kappaB |
| T5 | 134-161 | protein_molecule | denotes | tumor necrosis factor-alpha |
| T6 | 187-210 | lipid | denotes | low-density lipoprotein |
| T7 | 212-218 | lipid | denotes | Ox LDL |
| T8 | 223-231 | cell_type | denotes | monocyte |
| T9 | 231-243 | cell_type | denotes | -macrophages |
| T10 | 251-270 | other_name | denotes | pleiotropic effects |
| T11 | 356-369 | other_name | denotes | atherogenesis |
| T12 | 393-405 | protein_molecule | denotes | glycoprotein |
| T13 | 406-410 | protein_molecule | denotes | CD36 |
| T14 | 473-479 | lipid | denotes | Ox LDL |
| T15 | 483-492 | cell_type | denotes | monocyte- |
| T16 | 492-503 | cell_type | denotes | macrophages |
| T17 | 551-555 | protein_molecule | denotes | CD36 |
| T18 | 555-562 | lipid | denotes | -Ox LDL |
| T19 | 620-624 | protein_molecule | denotes | CD36 |
| T20 | 637-671 | cell_type | denotes | Chinese hampster ovary (CHO) cells |
| T21 | 689-695 | lipid | denotes | Ox LDL |
| T22 | 743-763 | protein_family_or_group | denotes | transcription factor |
| T23 | 764-773 | protein_complex | denotes | NF-kappaB |
| T24 | 795-801 | lipid | denotes | Ox LDL |
| T25 | 835-851 | cell_component | denotes | nuclear extracts |
| T26 | 858-867 | protein_complex | denotes | NF-kappaB |
| T27 | 901-905 | protein_molecule | denotes | CD36 |
| T28 | 935-959 | protein_family_or_group | denotes | proinflammatory cytokine |
| T29 | 960-987 | protein_molecule | denotes | tumor necrosis factor-alpha |
| T30 | 989-998 | protein_molecule | denotes | TNF-alpha |
| T31 | 1069-1073 | protein_molecule | denotes | CD36 |
| T32 | 1101-1106 | protein_family_or_group | denotes | human |
| T33 | 1107-1111 | protein_molecule | denotes | CD36 |
| T34 | 1130-1134 | protein_molecule | denotes | OKM5 |
| T35 | 1174-1183 | protein_complex | denotes | NF-kappaB |
| T36 | 1224-1261 | protein_domain_or_region | denotes | carboxyl-terminal cytoplasmic segment |
| T37 | 1265-1269 | protein_molecule | denotes | CD36 |
| T38 | 1305-1310 | protein_molecule | denotes | human |
| T39 | 1311-1315 | protein_molecule | denotes | CD36 |
| T40 | 1325-1351 | other_name | denotes | signal transduction events |
| T41 | 1367-1373 | lipid | denotes | Ox LDL |