> top > docs > PubMed:9278334 > annotations

PubMed:9278334 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
T2 89-214 Sentence denotes Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
T3 215-334 Sentence denotes This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
T4 335-478 Sentence denotes Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
T5 479-613 Sentence denotes In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
T6 614-865 Sentence denotes IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
T7 866-1113 Sentence denotes Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
T8 1114-1310 Sentence denotes By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
T9 1311-1482 Sentence denotes Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
T10 1483-1724 Sentence denotes These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.
T1 0-88 Sentence denotes Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
T2 89-214 Sentence denotes Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
T3 215-334 Sentence denotes This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
T4 335-478 Sentence denotes Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
T5 479-613 Sentence denotes In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
T6 614-865 Sentence denotes IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
T7 866-1113 Sentence denotes Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
T8 1114-1310 Sentence denotes By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
T9 1311-1482 Sentence denotes Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
T10 1483-1724 Sentence denotes These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-14 cell_type denotes Human monocyte
T2 26-37 protein denotes fibronectin
T3 47-56 protein denotes IFN-gamma
T4 89-108 protein denotes Leukocyte integrins
T5 345-353 protein denotes integrin
T6 567-576 protein denotes IFN-gamma
T7 614-623 protein denotes IFN-gamma
T8 741-752 protein denotes fibronectin
T9 756-805 protein denotes arginine-glycine-aspartate (RGD)-coated substrata
T10 843-864 cell_type denotes matrix-adherent cells
T11 959-970 protein denotes fibronectin
T12 1048-1070 RNA denotes IFN-gamma-induced mRNA
T13 1079-1112 protein denotes high affinity Fc gammaRI receptor
T14 1173-1177 RNA denotes mRNA
T15 1230-1266 protein denotes STAT1-containing DNA-binding complex
T16 1281-1309 DNA denotes Fc gammaRI promoter elements
T17 1356-1361 protein denotes STAT1
T18 1370-1386 protein denotes tyrosine kinases
T19 1387-1391 protein denotes JAK1
T20 1396-1400 protein denotes JAK2
T21 1431-1453 cell_type denotes RGD-adherent monocytes
T22 1468-1481 cell_type denotes control cells
T23 1532-1540 protein denotes integrin
T24 1594-1602 protein denotes cytokine

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-88 Sentence denotes Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
S2 89-214 Sentence denotes Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
S3 215-334 Sentence denotes This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
S4 335-478 Sentence denotes Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
S5 479-613 Sentence denotes In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
S6 614-865 Sentence denotes IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
S7 866-1113 Sentence denotes Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
S8 1114-1310 Sentence denotes By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
S9 1311-1482 Sentence denotes Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
S10 1483-1724 Sentence denotes These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 26-37 NP denotes fibronectin
C2 215-246 NP denotes This integrin-mediated adhesion
C3 382-400 NP denotes signaling pathways
C4 401-405 NP denotes that
C5 567-576 NP denotes IFN-gamma
C6 614-623 NP denotes IFN-gamma
C7 633-675 NP denotes a well-defined signal transduction pathway
C8 677-682 NP denotes which
C9 741-752 NP denotes fibronectin
C10 959-970 NP denotes fibronectin
C11 1048-1070 NP denotes IFN-gamma-induced mRNA
C12 1173-1177 NP denotes mRNA
C13 1226-1266 NP denotes the STAT1-containing DNA-binding complex
C14 1267-1271 NP denotes that
C15 1505-1522 NP denotes a novel mechanism
C16 1526-1531 NP denotes which
C17 1532-1563 NP denotes integrin-mediated cell adhesion
R1 C4 C3 coref-relat that,signaling pathways
R2 C6 C5 coref-ident IFN-gamma,IFN-gamma
R3 C8 C7 coref-relat which,a well-defined signal transduction pathway
R4 C9 C1 coref-ident fibronectin,fibronectin
R5 C10 C9 coref-ident fibronectin,fibronectin
R6 C12 C11 coref-ident mRNA,IFN-gamma-induced mRNA
R7 C14 C13 coref-relat that,the STAT1-containing DNA-binding complex
R8 C16 C15 coref-relat which,a novel mechanism
R9 C17 C2 coref-ident integrin-mediated cell adhesion,This integrin-mediated adhesion

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 cell_type denotes Human monocyte
T2 26-37 protein_family_or_group denotes fibronectin
T3 47-56 protein_molecule denotes IFN-gamma
T4 89-108 protein_family_or_group denotes Leukocyte integrins
T5 163-194 cell_component denotes extracellular matrix components
T6 256-272 other_name denotes leukocyte arrest
T7 311-333 other_name denotes inflammatory responses
T8 345-353 protein_family_or_group denotes integrin
T9 456-477 other_name denotes sites of inflammation
T10 545-562 other_name denotes monocyte adhesion
T11 567-576 protein_molecule denotes IFN-gamma
T12 580-612 other_name denotes intracellular signaling pathways
T13 614-623 protein_molecule denotes IFN-gamma
T14 719-737 other_name denotes monocyte adherence
T15 741-752 protein_family_or_group denotes fibronectin
T16 756-805 protein_family_or_group denotes arginine-glycine-aspartate (RGD)-coated substrata
T17 843-864 cell_type denotes matrix-adherent cells
T18 919-935 other_organic_compound denotes plastic surfaces
T19 959-970 protein_family_or_group denotes fibronectin
T20 974-977 peptide denotes RGD
T21 1048-1057 protein_molecule denotes IFN-gamma
T22 1079-1112 protein_molecule denotes high affinity Fc gammaRI receptor
T23 1117-1154 other_name denotes electrophoretic mobility shift assays
T24 1173-1177 RNA_family_or_group denotes mRNA
T25 1230-1266 protein_complex denotes STAT1-containing DNA-binding complex
T26 1281-1309 DNA_domain_or_region denotes Fc gammaRI promoter elements
T27 1356-1361 protein_molecule denotes STAT1
T28 1370-1386 protein_family_or_group denotes tyrosine kinases
T29 1387-1391 protein_molecule denotes JAK1
T30 1396-1400 protein_molecule denotes JAK2
T31 1431-1434 peptide denotes RGD
T32 1468-1481 cell_type denotes control cells
T33 1532-1540 protein_family_or_group denotes integrin
T34 1594-1602 protein_family_or_group denotes cytokine
T35 1660-1675 other_name denotes cellular events
T36 1687-1706 other_name denotes monocyte activation
T37 1711-1723 other_name denotes inflammation