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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.
T2 76-228 Sentence denotes The expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B.
T3 229-545 Sentence denotes Because surfactant protein (SP) A is involved in local host defense in the lung and alters immune cell function by modulating the expression of proinflammatory cytokines as well as surface proteins involved in inflammation, we hypothesized that SP-A exerts its action, at least in part, via activation of NF-kappa B.
T4 546-670 Sentence denotes We used gel shift assays to determine whether SP-A activated NF-kappa B in the THP-1 cell line, a human monocytic cell line.
T5 671-828 Sentence denotes Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml occurred within 30 min of SP-A treatment, peaked at 60 min, and then declined.
T6 829-957 Sentence denotes This activation is inhibited by known inhibitors of NF-kappa B or by simultaneous treatment of the cells with surfactant lipids.
T7 958-1070 Sentence denotes Moreover, the NF-kappa B inhibitors blocked SP-A-dependent increases in tumor necrosis factor-alpha mRNA levels.
T8 1071-1293 Sentence denotes These observations suggest a mechanism by which SP-A plays a role in the pathogenesis of some lung conditions and point to potential therapeutic measures that could be used to prevent SP-A induced inflammation in the lung.
T1 0-75 Sentence denotes Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.
T2 76-228 Sentence denotes The expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B.
T3 229-545 Sentence denotes Because surfactant protein (SP) A is involved in local host defense in the lung and alters immune cell function by modulating the expression of proinflammatory cytokines as well as surface proteins involved in inflammation, we hypothesized that SP-A exerts its action, at least in part, via activation of NF-kappa B.
T4 546-670 Sentence denotes We used gel shift assays to determine whether SP-A activated NF-kappa B in the THP-1 cell line, a human monocytic cell line.
T5 671-828 Sentence denotes Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml occurred within 30 min of SP-A treatment, peaked at 60 min, and then declined.
T6 829-957 Sentence denotes This activation is inhibited by known inhibitors of NF-kappa B or by simultaneous treatment of the cells with surfactant lipids.
T7 958-1070 Sentence denotes Moreover, the NF-kappa B inhibitors blocked SP-A-dependent increases in tumor necrosis factor-alpha mRNA levels.
T8 1071-1293 Sentence denotes These observations suggest a mechanism by which SP-A plays a role in the pathogenesis of some lung conditions and point to potential therapeutic measures that could be used to prevent SP-A induced inflammation in the lung.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-20 protein denotes Surfactant protein A
T2 31-41 protein denotes NF-kappa B
T3 49-74 cell_line denotes THP-1 monocytic cell line
T4 174-227 protein denotes transcriptional regulator nuclear factor (NF)-kappa B
T5 237-262 protein denotes surfactant protein (SP) A
T6 373-398 protein denotes proinflammatory cytokines
T7 410-426 protein denotes surface proteins
T8 474-478 protein denotes SP-A
T9 534-544 protein denotes NF-kappa B
T10 592-596 protein denotes SP-A
T11 607-617 protein denotes NF-kappa B
T12 625-640 cell_line denotes THP-1 cell line
T13 644-669 cell_line denotes human monocytic cell line
T14 685-695 protein denotes NF-kappa B
T15 699-710 cell_line denotes THP-1 cells
T16 714-718 protein denotes SP-A
T17 776-780 protein denotes SP-A
T18 881-891 protein denotes NF-kappa B
T19 972-993 protein denotes NF-kappa B inhibitors
T20 1002-1006 protein denotes SP-A
T21 1030-1062 RNA denotes tumor necrosis factor-alpha mRNA
T22 1119-1123 protein denotes SP-A
T23 1255-1259 protein denotes SP-A

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-75 Sentence denotes Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.
S2 76-228 Sentence denotes The expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B.
S3 229-545 Sentence denotes Because surfactant protein (SP) A is involved in local host defense in the lung and alters immune cell function by modulating the expression of proinflammatory cytokines as well as surface proteins involved in inflammation, we hypothesized that SP-A exerts its action, at least in part, via activation of NF-kappa B.
S4 546-670 Sentence denotes We used gel shift assays to determine whether SP-A activated NF-kappa B in the THP-1 cell line, a human monocytic cell line.
S5 671-828 Sentence denotes Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml occurred within 30 min of SP-A treatment, peaked at 60 min, and then declined.
S6 829-957 Sentence denotes This activation is inhibited by known inhibitors of NF-kappa B or by simultaneous treatment of the cells with surfactant lipids.
S7 958-1070 Sentence denotes Moreover, the NF-kappa B inhibitors blocked SP-A-dependent increases in tumor necrosis factor-alpha mRNA levels.
S8 1071-1293 Sentence denotes These observations suggest a mechanism by which SP-A plays a role in the pathogenesis of some lung conditions and point to potential therapeutic measures that could be used to prevent SP-A induced inflammation in the lung.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-20 NP denotes Surfactant protein A
C3 45-74 NP denotes the THP-1 monocytic cell line
C2 31-74 NP denotes NF-kappa B in the THP-1 monocytic cell line
C4 94-104 NP denotes many genes
C5 109-114 NP denotes which
C6 140-152 NP denotes inflammation
C7 170-227 NP denotes the transcriptional regulator nuclear factor (NF)-kappa B
C8 237-262 NP denotes surfactant protein (SP) A
C9 300-308 NP denotes the lung
C10 439-451 NP denotes inflammation
C11 474-478 NP denotes SP-A
C12 486-489 NP denotes its
C13 534-544 NP denotes NF-kappa B
C14 592-596 NP denotes SP-A
C17 621-640 NP denotes the THP-1 cell line
C16 621-640 NP denotes the THP-1 cell line
C18 642-669 NP denotes a human monocytic cell line
C15 607-669 NP denotes NF-kappa B in the THP-1 cell line, a human monocytic cell line
C19 671-749 NP denotes Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml
C20 829-844 NP denotes This activation
C22 881-891 NP denotes NF-kappa B
C21 861-891 NP denotes known inhibitors of NF-kappa B
C23 968-993 NP denotes the NF-kappa B inhibitors
C24 1098-1109 NP denotes a mechanism
C25 1113-1118 NP denotes which
C26 1119-1123 NP denotes SP-A
C27 1194-1224 NP denotes potential therapeutic measures
C28 1225-1229 NP denotes that
C29 1284-1292 NP denotes the lung
R1 C5 C4 coref-relat which,many genes
R2 C8 C1 coref-ident surfactant protein (SP) A,Surfactant protein A
R3 C10 C6 coref-ident inflammation,inflammation
R4 C11 C8 coref-ident SP-A,surfactant protein (SP) A
R5 C12 C11 coref-pron its,SP-A
R6 C13 C7 coref-ident NF-kappa B,the transcriptional regulator nuclear factor (NF)-kappa B
R7 C14 C11 coref-ident SP-A,SP-A
R8 C16 C3 coref-ident the THP-1 cell line,the THP-1 monocytic cell line
R9 C18 C17 coref-appos a human monocytic cell line,the THP-1 cell line
R10 C15 C2 coref-ident "NF-kappa B in the THP-1 cell line, a human monocytic cell line",NF-kappa B in the THP-1 monocytic cell line
R11 C20 C19 coref-ident This activation,Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml
R12 C22 C13 coref-ident NF-kappa B,NF-kappa B
R13 C23 C21 coref-ident the NF-kappa B inhibitors,known inhibitors of NF-kappa B
R14 C25 C24 coref-relat which,a mechanism
R15 C26 C14 coref-ident SP-A,SP-A
R16 C28 C27 coref-relat that,potential therapeutic measures
R17 C29 C9 coref-ident the lung,the lung

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 protein_molecule denotes Surfactant protein A
T2 31-41 protein_complex denotes NF-kappa B
T3 49-74 cell_line denotes THP-1 monocytic cell line
T4 140-152 other_name denotes inflammation
T5 174-227 protein_complex denotes transcriptional regulator nuclear factor (NF)-kappa B
T6 237-262 protein_molecule denotes surfactant protein (SP) A
T7 304-308 body_part denotes lung
T8 320-340 other_name denotes immune cell function
T9 373-398 protein_family_or_group denotes proinflammatory cytokines
T10 410-426 protein_family_or_group denotes surface proteins
T11 439-451 other_name denotes inflammation
T12 474-478 protein_molecule denotes SP-A
T13 534-544 protein_complex denotes NF-kappa B
T14 592-596 protein_molecule denotes SP-A
T15 607-617 protein_complex denotes NF-kappa B
T16 625-640 cell_line denotes THP-1 cell line
T17 644-669 cell_line denotes human monocytic cell line
T18 685-695 protein_complex denotes NF-kappa B
T19 699-710 cell_line denotes THP-1 cells
T20 714-718 protein_molecule denotes SP-A
T21 776-780 protein_molecule denotes SP-A
T22 881-891 protein_complex denotes NF-kappa B
T23 939-956 lipid denotes surfactant lipids
T24 972-982 protein_complex denotes NF-kappa B
T25 1002-1006 protein_molecule denotes SP-A
T26 1030-1062 RNA_molecule denotes tumor necrosis factor-alpha mRNA
T27 1119-1123 protein_molecule denotes SP-A
T28 1165-1169 body_part denotes lung
T29 1194-1224 other_name denotes potential therapeutic measures
T30 1255-1259 protein_molecule denotes SP-A
T31 1268-1280 other_name denotes inflammation
T32 1288-1292 body_part denotes lung