PubMed:9271588 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	30-34	protein	denotes	CD21
T2	57-71	DNA	denotes	viral promoter
T3	76-85	protein	denotes	NF-kappaB
T4	176-202	cell_type	denotes	normal human B lymphocytes
T5	207-211	protein	denotes	CD21
T6	217-240	protein	denotes	CR2 complement receptor
T7	308-326	cell_type	denotes	noncycling B cells
T8	404-408	protein	denotes	CD21
T9	421-442	cell_type	denotes	resting human B cells
T10	465-474	protein	denotes	NF-kappaB
T11	475-495	protein	denotes	transcription factor
T12	581-607	DNA	denotes	viral latent gene promoter
T13	683-692	protein	denotes	NF-kappaB

Id	Subject	Object	Predicate	Lexical cue
S1	0-96	Sentence	denotes	Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.
S2	97-241	Sentence	denotes	Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor.
S3	242-608	Sentence	denotes	Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter.
S4	609-767	Sentence	denotes	Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection.

Id	Subject	Object	Predicate	Lexical cue
C1	30-34	NP	denotes	CD21
C2	97-121	NP	denotes	Epstein-Barr virus (EBV)
C3	123-153	NP	denotes	an oncogenic human herpesvirus
C4	207-211	NP	denotes	CD21
C5	213-240	NP	denotes	the CR2 complement receptor
C6	253-267	NP	denotes	the mechanisms
C7	268-272	NP	denotes	that
C8	280-283	NP	denotes	EBV
C9	359-379	NP	denotes	a sequence of events
C10	383-388	NP	denotes	which
C11	404-408	NP	denotes	CD21
C12	461-495	NP	denotes	the NF-kappaB transcription factor
C13	497-502	NP	denotes	which
C14	565-567	NP	denotes	Wp
C15	569-607	NP	denotes	the initial viral latent gene promoter
C16	615-618	NP	denotes	EBV
C17	630-633	NP	denotes	its
C18	680-734	NP	denotes	an NF-kappaB-dependent intracellular signaling pathway
C19	735-740	NP	denotes	which
R1	C3	C2	coref-appos	an oncogenic human herpesvirus,Epstein-Barr virus (EBV)
R2	C4	C1	coref-ident	CD21,CD21
R3	C5	C4	coref-appos	the CR2 complement receptor,CD21
R4	C7	C6	coref-relat	that,the mechanisms
R5	C8	C2	coref-ident	EBV,Epstein-Barr virus (EBV)
R6	C10	C9	coref-relat	which,a sequence of events
R7	C11	C4	coref-ident	CD21,CD21
R8	C13	C12	coref-relat	which,the NF-kappaB transcription factor
R9	C15	C14	coref-appos	the initial viral latent gene promoter,Wp
R10	C16	C8	coref-ident	EBV,EBV
R11	C17	C16	coref-pron	its,EBV
R12	C19	C18	coref-relat	which,an NF-kappaB-dependent intracellular signaling pathway

Id	Subject	Object	Predicate	Lexical cue
T1	0-18	virus	denotes	Epstein-Barr virus
T2	30-34	protein_molecule	denotes	CD21
T3	57-71	DNA_domain_or_region	denotes	viral promoter
T4	76-85	protein_complex	denotes	NF-kappaB
T5	97-115	virus	denotes	Epstein-Barr virus
T6	117-120	virus	denotes	EBV
T7	126-153	virus	denotes	oncogenic human herpesvirus
T8	176-202	cell_type	denotes	normal human B lymphocytes
T9	207-211	protein_molecule	denotes	CD21
T10	217-240	protein_molecule	denotes	CR2 complement receptor
T11	280-283	virus	denotes	EBV
T12	308-326	cell_type	denotes	noncycling B cells
T13	389-392	virus	denotes	EBV
T14	404-408	protein_molecule	denotes	CD21
T15	421-442	cell_type	denotes	resting human B cells
T16	465-474	protein_complex	denotes	NF-kappaB
T17	475-495	protein_family_or_group	denotes	transcription factor
T18	581-607	DNA_domain_or_region	denotes	viral latent gene promoter
T19	615-618	virus	denotes	EBV
T20	683-692	protein_complex	denotes	NF-kappaB