PubMed:9271438 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9271438","sourcedb":"PubMed","sourceid":"9271438","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9271438","text":"The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity.\nThe von Hippel-Lindau tumor suppressor gene (VHL) has a critical role in the pathogenesis of clear-cell renal cell carcinoma (RCC), as VHL mutations have been found in both von Hippel-Lindau disease-associated and sporadic RCCs. Recent studies suggest that vascular endothelial growth factor (VEGF) mRNA is upregulated in RCC- and von Hippel-Lindau disease-associated tumors. We have therefore assessed the effect of the VHL gene product on VEGF expression. VEGF promoter-luciferase constructs were transiently cotransfected with a wild-type VHL (wt-VHL) vector in several cell lines, including 293 embryonic kidney and RCC cell lines. wt-VHL protein inhibited VEGF promoter activity in a dose-dependent manner up to 5- to 10-fold. Deletion analysis defined a 144-bp region of the VEGF promoter necessary for VHL repression. This VHL-responsive element is GC rich and specifically binds the transcription factor Sp1 in crude nuclear extracts. In Drosophila cells, cotransfected VHL represses Sp1-mediated activation but not basal activity of the VEGF promoter. We next demonstrated in coimmunoprecipitates that VHL and Sp1 were part of the same complex and, by using a glutathione-S-transferase-VHL fusion protein and purified Sp1, that VHL and Sp1 directly interact. Furthermore, endogenous VEGF mRNA levels were suppressed in permanent RCC cell lines expressing wt-VHL, and nuclear run-on studies indicated that VHL regulation of VEGF occurs at least partly at the transcriptional level. These observations support a new mechanism for VHL-mediated transcriptional repression via a direct inhibitory action on Sp1 and suggest that loss of Sp1 inhibition may be important in the pathogenesis of von Hippel-Lindau disease and RCC.","tracks":[{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":4,"end":27},"obj":"Modifier:D006623"},{"id":"T2","span":{"begin":140,"end":163},"obj":"Modifier:D006623"},{"id":"T3","span":{"begin":229,"end":260},"obj":"SpecificDisease:C538445"},{"id":"T4","span":{"begin":262,"end":265},"obj":"SpecificDisease:D002292"},{"id":"T5","span":{"begin":309,"end":363},"obj":"CompositeMention:D006623"},{"id":"T6","span":{"begin":458,"end":510},"obj":"CompositeMention:D006623"},{"id":"T7","span":{"begin":756,"end":759},"obj":"Modifier:D002292"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"Modifier:D002292"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease:D006623"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease:D002292"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T2","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T3","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T4","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T5","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T6","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T7","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T8","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T9","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T10","pred":"source","obj":"NCBIDiseaseCorpus"}]},{"project":"NCBI-Disease-Develop","denotations":[{"id":"T330","span":{"begin":4,"end":27},"obj":"Modifier"},{"id":"T331","span":{"begin":140,"end":163},"obj":"Modifier"},{"id":"T332","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T333","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T334","span":{"begin":309,"end":363},"obj":"CompositeMention"},{"id":"T335","span":{"begin":458,"end":510},"obj":"CompositeMention"},{"id":"T336","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T337","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T338","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T339","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"id":"A330","pred":"database_id","subj":"T330","obj":"D006623"},{"id":"A331","pred":"database_id","subj":"T331","obj":"D006623"},{"id":"A332","pred":"database_id","subj":"T332","obj":"C538445"},{"id":"A333","pred":"database_id","subj":"T333","obj":"D002292"},{"id":"A334","pred":"database_id","subj":"T334","obj":"D006623"},{"id":"A335","pred":"database_id","subj":"T335","obj":"D006623"},{"id":"A336","pred":"database_id","subj":"T336","obj":"D002292"},{"id":"A337","pred":"database_id","subj":"T337","obj":"D002292"},{"id":"A338","pred":"database_id","subj":"T338","obj":"D006623"},{"id":"A339","pred":"database_id","subj":"T339","obj":"D002292"},{"subj":"T330","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T331","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T332","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T333","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T334","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T335","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T336","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T337","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T338","pred":"source","obj":"NCBI-Disease-Develop"},{"subj":"T339","pred":"source","obj":"NCBI-Disease-Develop"}]},{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T330","span":{"begin":4,"end":27},"obj":"Modifier"},{"id":"T331","span":{"begin":140,"end":163},"obj":"Modifier"},{"id":"T332","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T333","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T334","span":{"begin":309,"end":363},"obj":"CompositeMention"},{"id":"T335","span":{"begin":458,"end":510},"obj":"CompositeMention"},{"id":"T336","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T337","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T338","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T339","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"id":"A330","pred":"database_id","subj":"T330","obj":"D006623"},{"id":"A331","pred":"database_id","subj":"T331","obj":"D006623"},{"id":"A332","pred":"database_id","subj":"T332","obj":"C538445"},{"id":"A333","pred":"database_id","subj":"T333","obj":"D002292"},{"id":"A334","pred":"database_id","subj":"T334","obj":"D006623"},{"id":"A335","pred":"database_id","subj":"T335","obj":"D006623"},{"id":"A336","pred":"database_id","subj":"T336","obj":"D002292"},{"id":"A337","pred":"database_id","subj":"T337","obj":"D002292"},{"id":"A338","pred":"database_id","subj":"T338","obj":"D006623"},{"id":"A339","pred":"database_id","subj":"T339","obj":"D002292"},{"subj":"T330","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T331","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T332","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T333","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T334","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T335","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T336","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T337","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T338","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T339","pred":"source","obj":"NCBI-Disease-Corpus-All"}]},{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"}]},{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":359,"end":362},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"}]},{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":4,"end":38},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":140,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":229,"end":266},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T7","span":{"begin":467,"end":492},"obj":"Modifier"},{"id":"T8","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T9","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T10","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"}]},{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":140,"end":185},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":229,"end":266},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"}]},{"project":"ncbi-valid","denotations":[{"id":"T1","span":{"begin":4,"end":27},"obj":"Modifier"},{"id":"T2","span":{"begin":140,"end":163},"obj":"Modifier"},{"id":"T3","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":309,"end":363},"obj":"CompositeMention"},{"id":"T6","span":{"begin":458,"end":510},"obj":"CompositeMention"},{"id":"T7","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid"},{"subj":"T2","pred":"source","obj":"ncbi-valid"},{"subj":"T3","pred":"source","obj":"ncbi-valid"},{"subj":"T4","pred":"source","obj":"ncbi-valid"},{"subj":"T5","pred":"source","obj":"ncbi-valid"},{"subj":"T6","pred":"source","obj":"ncbi-valid"},{"subj":"T7","pred":"source","obj":"ncbi-valid"},{"subj":"T8","pred":"source","obj":"ncbi-valid"},{"subj":"T9","pred":"source","obj":"ncbi-valid"},{"subj":"T10","pred":"source","obj":"ncbi-valid"}]},{"project":"ncbi-valid-gpt-nr-ng","denotations":[{"id":"T1","span":{"begin":229,"end":266},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":309,"end":345},"obj":"CompositeMention"},{"id":"T3","span":{"begin":350,"end":358},"obj":"Modifier"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":467,"end":503},"obj":"CompositeMention"},{"id":"T7","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gpt-nr-ng"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gpt-nr-ng"}]},{"project":"ncbi-valid-gpt-nr-g","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":345},"obj":"Modifier"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":462},"obj":"Modifier"},{"id":"T6","span":{"begin":467,"end":503},"obj":"Modifier"},{"id":"T7","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gpt-nr-g"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gpt-nr-g"}]},{"project":"ncbi-valid-gpt-r-ng","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":350,"end":358},"obj":"Modifier"},{"id":"T5","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":458,"end":510},"obj":"CompositeMention"},{"id":"T7","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gpt-r-ng"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gpt-r-ng"}]},{"project":"ncbi-valid-gpt-r-g","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"Modifier"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T6","span":{"begin":467,"end":492},"obj":"Modifier"},{"id":"T7","span":{"begin":504,"end":510},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T9","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T10","span":{"begin":1831,"end":1864},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gpt-r-g"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gpt-r-g"}]},{"project":"ncbi-valid-gemini-nr-ng","denotations":[{"id":"T1","span":{"begin":4,"end":27},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":467,"end":510},"obj":"CompositeMention"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gemini-nr-ng"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gemini-nr-ng"}]},{"project":"ncbi-valid-gemini-nr-g","denotations":[{"id":"T1","span":{"begin":4,"end":27},"obj":"Modifier"},{"id":"T2","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":334,"end":345},"obj":"Modifier"},{"id":"T6","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T8","span":{"begin":504,"end":510},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T10","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gemini-nr-g"},{"subj":"T11","pred":"source","obj":"ncbi-valid-gemini-nr-g"}]},{"project":"ncbi-valid-gemini-r-g","denotations":[{"id":"T1","span":{"begin":4,"end":21},"obj":"Modifier"},{"id":"T2","span":{"begin":140,"end":157},"obj":"Modifier"},{"id":"T3","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T8","span":{"begin":467,"end":492},"obj":"Modifier"},{"id":"T9","span":{"begin":504,"end":510},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T11","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T11","pred":"source","obj":"ncbi-valid-gemini-r-g"},{"subj":"T12","pred":"source","obj":"ncbi-valid-gemini-r-g"}]},{"project":"ncbi-valid-deepseek-nr-ng","denotations":[{"id":"T1","span":{"begin":4,"end":38},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":39,"end":43},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":67,"end":70},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":82,"end":125},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":140,"end":174},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":175,"end":179},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":181,"end":184},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":229,"end":266},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":359,"end":362},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":393,"end":427},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":429,"end":433},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T14","span":{"begin":557,"end":560},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":594,"end":618},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":668,"end":677},"obj":"SpecificDisease"},{"id":"T17","span":{"begin":678,"end":681},"obj":"SpecificDisease"},{"id":"T18","span":{"begin":683,"end":689},"obj":"SpecificDisease"},{"id":"T19","span":{"begin":731,"end":751},"obj":"SpecificDisease"},{"id":"T20","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T21","span":{"begin":775,"end":778},"obj":"SpecificDisease"},{"id":"T22","span":{"begin":797,"end":801},"obj":"SpecificDisease"},{"id":"T23","span":{"begin":917,"end":921},"obj":"SpecificDisease"},{"id":"T24","span":{"begin":945,"end":948},"obj":"SpecificDisease"},{"id":"T25","span":{"begin":966,"end":969},"obj":"SpecificDisease"},{"id":"T26","span":{"begin":1048,"end":1051},"obj":"SpecificDisease"},{"id":"T27","span":{"begin":1114,"end":1117},"obj":"SpecificDisease"},{"id":"T28","span":{"begin":1182,"end":1186},"obj":"SpecificDisease"},{"id":"T29","span":{"begin":1247,"end":1250},"obj":"SpecificDisease"},{"id":"T30","span":{"begin":1363,"end":1366},"obj":"SpecificDisease"},{"id":"T31","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T32","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T9","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T10","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T11","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T12","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T13","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T14","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T15","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T16","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T17","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T18","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T19","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T20","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T21","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T22","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T23","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T24","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T25","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T26","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T27","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T28","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T29","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T30","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T31","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"},{"subj":"T32","pred":"source","obj":"ncbi-valid-deepseek-nr-ng"}]},{"project":"ncbi-valid-deepseek-nr-g","denotations":[{"id":"T1","span":{"begin":4,"end":27},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":140,"end":163},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":181,"end":184},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":359,"end":362},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":429,"end":433},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":557,"end":560},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":577,"end":581},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":594,"end":598},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":678,"end":681},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T14","span":{"begin":775,"end":778},"obj":"SpecificDisease"},{"id":"T15","span":{"begin":797,"end":801},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":917,"end":921},"obj":"SpecificDisease"},{"id":"T17","span":{"begin":945,"end":948},"obj":"SpecificDisease"},{"id":"T18","span":{"begin":1048,"end":1051},"obj":"SpecificDisease"},{"id":"T19","span":{"begin":1114,"end":1117},"obj":"SpecificDisease"},{"id":"T20","span":{"begin":1128,"end":1131},"obj":"SpecificDisease"},{"id":"T21","span":{"begin":1182,"end":1186},"obj":"SpecificDisease"},{"id":"T22","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T23","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T7","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T8","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T9","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T10","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T11","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T12","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T13","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T14","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T15","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T16","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T17","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T18","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T19","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T20","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T21","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T22","pred":"source","obj":"ncbi-valid-deepseek-nr-g"},{"subj":"T23","pred":"source","obj":"ncbi-valid-deepseek-nr-g"}]},{"project":"ncbi-valid-deepseek-r-ng","denotations":[{"id":"T1","span":{"begin":4,"end":43},"obj":"CompositeMention"},{"id":"T2","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":350,"end":358},"obj":"Modifier"},{"id":"T6","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":756,"end":759},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-deepseek-r-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-deepseek-r-ng"}]},{"project":"ncbi-valid-deepseek-r-g","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"Modifier"},{"id":"T4","span":{"begin":350,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T6","span":{"begin":1831,"end":1864},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-deepseek-r-g"},{"subj":"T2","pred":"source","obj":"ncbi-valid-deepseek-r-g"},{"subj":"T3","pred":"source","obj":"ncbi-valid-deepseek-r-g"},{"subj":"T4","pred":"source","obj":"ncbi-valid-deepseek-r-g"},{"subj":"T5","pred":"source","obj":"ncbi-valid-deepseek-r-g"},{"subj":"T6","pred":"source","obj":"ncbi-valid-deepseek-r-g"}]},{"project":"ncbi-valid-gemini-r-ng","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":335,"end":345},"obj":"Modifier"},{"id":"T5","span":{"begin":350,"end":358},"obj":"Modifier"},{"id":"T6","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":458,"end":461},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":493,"end":503},"obj":"Modifier"},{"id":"T10","span":{"begin":504,"end":510},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T12","span":{"begin":1474,"end":1477},"obj":"SpecificDisease"},{"id":"T13","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T11","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T12","pred":"source","obj":"ncbi-valid-gemini-r-ng"},{"subj":"T13","pred":"source","obj":"ncbi-valid-gemini-r-ng"}]},{"project":"ncbi-valid-gemini-r-m","denotations":[{"id":"T1","span":{"begin":4,"end":21},"obj":"Modifier"},{"id":"T2","span":{"begin":140,"end":157},"obj":"Modifier"},{"id":"T3","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":309,"end":334},"obj":"Modifier"},{"id":"T6","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T8","span":{"begin":467,"end":492},"obj":"Modifier"},{"id":"T9","span":{"begin":504,"end":510},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T11","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T12","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T11","pred":"source","obj":"ncbi-valid-gemini-r-m"},{"subj":"T12","pred":"source","obj":"ncbi-valid-gemini-r-m"}]},{"project":"ncbi-valid-gpt-r-m","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"Modifier"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":461},"obj":"Modifier"},{"id":"T6","span":{"begin":467,"end":492},"obj":"Modifier"},{"id":"T7","span":{"begin":756,"end":759},"obj":"Modifier"},{"id":"T8","span":{"begin":1474,"end":1477},"obj":"Modifier"},{"id":"T9","span":{"begin":1831,"end":1856},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1861,"end":1864},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T2","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T3","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T4","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T5","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T6","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T7","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T8","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T9","pred":"source","obj":"ncbi-valid-gpt-r-m"},{"subj":"T10","pred":"source","obj":"ncbi-valid-gpt-r-m"}]},{"project":"ncbi-valid-deepseek-r-m","denotations":[{"id":"T1","span":{"begin":229,"end":260},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":262,"end":265},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":309,"end":334},"obj":"Modifier"},{"id":"T4","span":{"begin":359,"end":363},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":458,"end":462},"obj":"Modifier"},{"id":"T6","span":{"begin":467,"end":492},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":756,"end":759},"obj":"SpecificDisease"},{"id":"T8","span":{"begin":1831,"end":1864},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T2","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T3","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T4","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T5","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T6","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T7","pred":"source","obj":"ncbi-valid-deepseek-r-m"},{"subj":"T8","pred":"source","obj":"ncbi-valid-deepseek-r-m"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NCBIDiseaseCorpus","color":"#ec9e93","default":true},{"id":"NCBI-Disease-Develop","color":"#93a1ec"},{"id":"NCBI-Disease-Corpus-All","color":"#bbec93"},{"id":"NCBI-Disease-Corpus-2stage-All","color":"#ec93d5"},{"id":"NCBI-Disease-Corpus-rezarta-All","color":"#93ece8"},{"id":"NCBI-Disease-Corpus-4oGuideline-All","color":"#ecce93"},{"id":"NCBI-Disease-Corpus-Simple-All","color":"#b493ec"},{"id":"ncbi-valid","color":"#93ec9a"},{"id":"ncbi-valid-gpt-nr-ng","color":"#ec93a5"},{"id":"ncbi-valid-gpt-nr-g","color":"#93bfec"},{"id":"ncbi-valid-gpt-r-ng","color":"#d9ec93"},{"id":"ncbi-valid-gpt-r-g","color":"#e593ec"},{"id":"ncbi-valid-gemini-nr-ng","color":"#93eccb"},{"id":"ncbi-valid-gemini-nr-g","color":"#ecb093"},{"id":"ncbi-valid-gemini-r-g","color":"#9693ec"},{"id":"ncbi-valid-deepseek-nr-ng","color":"#a9ec93"},{"id":"ncbi-valid-deepseek-nr-g","color":"#ec93c3"},{"id":"ncbi-valid-deepseek-r-ng","color":"#93ddec"},{"id":"ncbi-valid-deepseek-r-g","color":"#ece193"},{"id":"ncbi-valid-gemini-r-ng","color":"#c793ec"},{"id":"ncbi-valid-gemini-r-m","color":"#93ecad"},{"id":"ncbi-valid-gpt-r-m","color":"#ec9393"},{"id":"ncbi-valid-deepseek-r-m","color":"#93adec"}]}]}}