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PubMed:9261181 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 74-83 Cell denotes Th2 cells http://purl.obolibrary.org/obo/CL:0000546
T2 233-242 Cell denotes Th1 cells http://purl.obolibrary.org/obo/CL:0000545
T3 425-439 Cell denotes T helper cells http://purl.obolibrary.org/obo/CL:0000912
T4 818-827 Cell denotes Th2 cells http://purl.obolibrary.org/obo/CL:0000546
T5 932-941 Cell denotes Th2 cells http://purl.obolibrary.org/obo/CL:0000546
T6 975-984 Cell denotes Th1 cells http://purl.obolibrary.org/obo/CL:0000545
T7 1095-1115 Cell denotes naive CD4(+) T cells http://purl.obolibrary.org/obo/CL:0000895
T8 1130-1136 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T9 1217-1226 Cell denotes Th2 cells http://purl.obolibrary.org/obo/CL:0000546
T10 1254-1263 Cell denotes Th1 cells http://purl.obolibrary.org/obo/CL:0000545
T11 1296-1305 Cell denotes Th2 cells http://purl.obolibrary.org/obo/CL:0000546
T12 1315-1324 Cell denotes Th1 cells http://purl.obolibrary.org/obo/CL:0000545

sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
T2 148-306 Sentence denotes Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.
T3 307-541 Sentence denotes Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2-specific gene expression remains to be elucidated.
T4 542-710 Sentence denotes We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines.
T5 711-828 Sentence denotes Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells.
T6 829-1064 Sentence denotes Whereas mutations in the GATA-3 site abolished antigen- or cAMP-stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.
T7 1065-1355 Sentence denotes During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.
T8 1356-1459 Sentence denotes Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses.
T9 1460-1580 Sentence denotes Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.
T1 0-147 Sentence denotes Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
T2 148-306 Sentence denotes Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.
T3 307-541 Sentence denotes Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2-specific gene expression remains to be elucidated.
T4 542-710 Sentence denotes We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines.
T5 711-828 Sentence denotes Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells.
T6 829-1064 Sentence denotes Whereas mutations in the GATA-3 site abolished antigen- or cAMP-stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.
T7 1065-1355 Sentence denotes During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.
T8 1356-1459 Sentence denotes Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses.
T9 1460-1580 Sentence denotes Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-27 protein denotes Transcription factor GATA-3
T2 59-83 cell_line denotes murine Th1 and Th2 cells
T3 128-146 DNA denotes interleukin-5 gene
T4 148-161 protein denotes Interleukin-5
T5 163-167 protein denotes IL-5
T6 191-220 cell_type denotes CD4(+) T helper 2 (Th2) cells
T7 233-242 cell_type denotes Th1 cells
T8 418-439 cell_type denotes CD4(+) T helper cells
T9 441-444 cell_type denotes Th1
T10 449-452 cell_type denotes Th2
T11 592-612 protein denotes transcription factor
T12 613-619 protein denotes GATA-3
T13 623-636 DNA denotes IL-5 promoter
T14 651-661 cell_line denotes EL-4 cells
T15 682-709 protein denotes Th1- and Th2-type cytokines
T16 754-760 protein denotes GATA-3
T17 795-799 protein denotes IL-5
T18 808-827 cell_type denotes bona fide Th2 cells
T19 854-860 protein denotes GATA-3
T20 965-971 protein denotes GATA-3
T21 975-984 cell_type denotes Th1 cells
T22 993-1035 cell_line denotes non-lymphoid, non-IL-5-producing cell line
T23 1050-1063 DNA denotes IL-5 promoter
T24 1095-1115 cell_type denotes naive CD4(+) T cells
T25 1163-1169 protein denotes GATA-3
T26 1217-1226 cell_type denotes Th2 cells
T27 1254-1263 cell_type denotes Th1 cells
T28 1269-1305 cell_type denotes antigen- or cAMP-activated Th2 cells
T29 1315-1324 cell_type denotes Th1 cells
T30 1340-1354 protein denotes GATA-3 protein
T31 1362-1368 protein denotes GATA-3
T32 1419-1422 cell_type denotes Th1
T33 1427-1438 cell_type denotes Th2 subsets
T34 1474-1480 protein denotes GATA-3

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-27 NP denotes Transcription factor GATA-3
C2 148-168 NP denotes Interleukin-5 (IL-5)
C3 170-175 NP denotes which
C4 233-242 NP denotes Th1 cells
C5 299-305 NP denotes asthma
C6 326-334 NP denotes evidence
C7 335-339 NP denotes that
C8 399-439 NP denotes the two subsets of CD4(+) T helper cells
C9 441-452 NP denotes Th1 and Th2
C10 651-661 NP denotes EL-4 cells
C11 663-668 NP denotes which
C12 754-760 NP denotes GATA-3
C13 1254-1263 NP denotes Th1 cells
C14 1362-1368 NP denotes GATA-3
C15 1536-1542 NP denotes asthma
R1 C3 C2 coref-relat which,Interleukin-5 (IL-5)
R2 C7 C6 coref-relat that,evidence
R3 C9 C8 coref-appos Th1 and Th2,the two subsets of CD4(+) T helper cells
R4 C11 C10 coref-relat which,EL-4 cells
R5 C12 C1 coref-ident GATA-3,Transcription factor GATA-3
R6 C13 C4 coref-ident Th1 cells,Th1 cells
R7 C14 C12 coref-ident GATA-3,GATA-3
R8 C15 C5 coref-ident asthma,asthma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-147 Sentence denotes Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
S2 148-306 Sentence denotes Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.
S3 307-541 Sentence denotes Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2-specific gene expression remains to be elucidated.
S4 542-710 Sentence denotes We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines.
S5 711-828 Sentence denotes Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells.
S6 829-1064 Sentence denotes Whereas mutations in the GATA-3 site abolished antigen- or cAMP-stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.
S7 1065-1355 Sentence denotes During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.
S8 1356-1459 Sentence denotes Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses.
S9 1460-1580 Sentence denotes Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-27 protein_molecule denotes Transcription factor GATA-3
T2 97-120 other_name denotes Th2-specific expression
T3 128-146 DNA_domain_or_region denotes interleukin-5 gene
T4 148-161 protein_molecule denotes Interleukin-5
T5 163-167 protein_molecule denotes IL-5
T6 191-220 cell_type denotes CD4(+) T helper 2 (Th2) cells
T7 233-242 cell_type denotes Th1 cells
T8 283-295 other_name denotes eosinophilia
T9 299-305 other_name denotes asthma
T10 418-439 cell_type denotes CD4(+) T helper cells
T11 441-444 cell_type denotes Th1
T12 449-452 cell_type denotes Th2
T13 592-612 protein_family_or_group denotes transcription factor
T14 613-619 protein_molecule denotes GATA-3
T15 623-627 protein_molecule denotes IL-5
T16 651-661 cell_line denotes EL-4 cells
T17 754-760 protein_molecule denotes GATA-3
T18 795-799 protein_molecule denotes IL-5
T19 808-827 cell_type denotes bona fide Th2 cells
T20 854-860 protein_molecule denotes GATA-3
T21 965-971 protein_molecule denotes GATA-3
T22 975-984 cell_type denotes Th1 cells
T23 993-1011 cell_line denotes non-lymphoid, non-
T24 1011-1015 protein_molecule denotes IL-5
T25 1050-1054 protein_molecule denotes IL-5
T26 1095-1115 cell_type denotes naive CD4(+) T cells
T27 1130-1161 other_artificial_source denotes T cell receptor transgenic mice
T28 1163-1169 protein_molecule denotes GATA-3
T29 1217-1226 cell_type denotes Th2 cells
T30 1254-1263 cell_type denotes Th1 cells
T31 1269-1295 cell_type denotes antigen- or cAMP-activated
T32 1296-1305 cell_type denotes Th2 cells
T33 1315-1324 cell_type denotes Th1 cells
T34 1340-1346 protein_molecule denotes GATA-3
T35 1362-1368 protein_molecule denotes GATA-3
T36 1419-1422 cell_type denotes Th1
T37 1427-1438 cell_type denotes Th2 subsets
T38 1442-1458 other_name denotes immune responses
T39 1474-1480 protein_molecule denotes GATA-3
T40 1536-1542 other_name denotes asthma
T41 1553-1579 other_name denotes hypereosinophilic diseases

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 283-295 Disease denotes eosinophilia http://purl.obolibrary.org/obo/MONDO_0015691
T2 299-305 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T3 1536-1542 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T4 1553-1579 Disease denotes hypereosinophilic diseases http://purl.obolibrary.org/obo/MONDO_0015691

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 283-295 Phenotype denotes eosinophilia HP:0001880
T2 299-305 Phenotype denotes asthma HP:0002099
T3 1536-1542 Phenotype denotes asthma HP:0002099

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1157-1161 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1130-1136 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084