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PubMed:9212053 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-33 protein denotes Gs(alpha)
T2 61-77 protein denotes adenylyl cyclase
T3 137-146 protein denotes G protein
T4 148-157 protein denotes G(S)alpha
T5 302-311 protein denotes G(S)alpha
T6 509-518 protein denotes G(S)alpha
T7 540-556 protein denotes adenylyl cyclase
T8 622-635 cell_line denotes HEK 293 cells
T9 671-680 protein denotes G(S)alpha
T10 701-736 DNA denotes inducible metallothionein promoters
T11 863-872 protein denotes G(S)alpha
T12 898-907 protein denotes G(S)alpha
T13 986-995 protein denotes G(S)alpha
T14 1096-1105 protein denotes G(S)alpha
T15 1204-1213 protein denotes G(S)alpha
T16 1336-1373 protein denotes cAMP response element binding protein
T17 1408-1437 DNA denotes cAMP-dependent reporter genes
T18 1489-1498 protein denotes G(S)alpha
T19 1665-1674 protein denotes G(S)alpha
T20 1731-1751 DNA denotes cAMP-dependent genes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 24-33 NP denotes Gs(alpha)
C2 57-105 NP denotes the adenylyl cyclase signal transduction cascade
C4 121-146 NP denotes the stimulatory G protein
C5 148-157 NP denotes G(S)alpha
C3 107-157 NP denotes Expression of the stimulatory G protein, G(S)alpha
C6 191-204 NP denotes human tissues
C7 302-322 NP denotes G(S)alpha expression
C8 425-439 NP denotes the hypothesis
C9 440-444 NP denotes that
C10 495-518 NP denotes expression of G(S)alpha
C11 536-569 NP denotes the adenylyl cyclase (AC) cascade
C12 671-680 NP denotes G(S)alpha
C13 768-821 NP denotes varying concentrations (0-125 microM) of zinc sulfate
C14 822-826 NP denotes that
C15 863-883 NP denotes G(S)alpha expression
C16 898-918 NP denotes G(S)alpha expression
C17 986-1006 NP denotes G(S)alpha expression
C18 1033-1046 NP denotes human tissues
C20 1096-1116 NP denotes G(S)alpha expression
C19 1083-1116 NP denotes induction of G(S)alpha expression
C21 1162-1179 NP denotes cAMP accumulation
C23 1204-1224 NP denotes G(S)alpha expression
C22 1191-1224 NP denotes induction of G(S)alpha expression
C24 1252-1276 NP denotes the accumulation of cAMP
C25 1408-1437 NP denotes cAMP-dependent reporter genes
C26 1489-1509 NP denotes G(S)alpha expression
C27 1558-1572 NP denotes the AC cascade
C28 1665-1685 NP denotes G(S)alpha expression
C29 1723-1751 NP denotes certain cAMP-dependent genes
R1 C4 C1 coref-ident the stimulatory G protein,Gs(alpha)
R2 C5 C4 coref-appos G(S)alpha,the stimulatory G protein
R3 C7 C3 coref-ident G(S)alpha expression,"Expression of the stimulatory G protein, G(S)alpha"
R4 C9 C8 coref-relat that,the hypothesis
R5 C10 C7 coref-ident expression of G(S)alpha,G(S)alpha expression
R6 C11 C2 coref-ident the adenylyl cyclase (AC) cascade,the adenylyl cyclase signal transduction cascade
R7 C12 C4 coref-ident G(S)alpha,the stimulatory G protein
R8 C14 C13 coref-relat that,varying concentrations (0-125 microM) of zinc sulfate
R9 C15 C10 coref-ident G(S)alpha expression,expression of G(S)alpha
R10 C16 C15 coref-ident G(S)alpha expression,G(S)alpha expression
R11 C17 C16 coref-ident G(S)alpha expression,G(S)alpha expression
R12 C18 C6 coref-ident human tissues,human tissues
R13 C20 C17 coref-ident G(S)alpha expression,G(S)alpha expression
R14 C23 C20 coref-ident G(S)alpha expression,G(S)alpha expression
R15 C22 C19 coref-ident induction of G(S)alpha expression,induction of G(S)alpha expression
R16 C24 C21 coref-ident the accumulation of cAMP,cAMP accumulation
R17 C26 C23 coref-ident G(S)alpha expression,G(S)alpha expression
R18 C27 C11 coref-ident the AC cascade,the adenylyl cyclase (AC) cascade
R19 C28 C26 coref-ident G(S)alpha expression,G(S)alpha expression
R20 C29 C25 coref-ident certain cAMP-dependent genes,cAMP-dependent reporter genes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-106 Sentence denotes Increased expression of Gs(alpha) enhances activation of the adenylyl cyclase signal transduction cascade.
S2 107-242 Sentence denotes Expression of the stimulatory G protein, G(S)alpha, can vary over a 3-fold range in human tissues and in rodent central nervous system.
S3 243-387 Sentence denotes In fact, the offspring of alcoholics have higher levels of G(S)alpha expression in certain tissues compared with the offspring of nonalcoholics.
S4 388-570 Sentence denotes The aim of this research was to test the hypothesis that a causal relationship exists between the level of expression of G(S)alpha and induction of the adenylyl cyclase (AC) cascade.
S5 571-737 Sentence denotes The methodology employed transient transfection of HEK 293 cells with a cDNA for the 52-kDa form of G(S)alpha under regulation by inducible metallothionein promoters.
S6 738-884 Sentence denotes Transfectants were exposed to varying concentrations (0-125 microM) of zinc sulfate that produced a 3-fold range of membrane G(S)alpha expression.
S7 885-1061 Sentence denotes The range of G(S)alpha expression produced was found to mimic a physiologically relevant spectrum of G(S)alpha expression in membranes derived from human tissues and rat brain.
S8 1062-1180 Sentence denotes It was observed that induction of G(S)alpha expression increased constitutive as well as stimulated cAMP accumulation.
S9 1181-1438 Sentence denotes Moreover, induction of G(S)alpha expression increased events distal to the accumulation of cAMP including the phosphorylation of the transcription factor, cAMP response element binding protein and transcriptional activation of cAMP-dependent reporter genes.
S10 1439-1614 Sentence denotes In summary, these studies show that the amount of G(S)alpha expression has a marked impact on the level of activity of the AC cascade from the membrane through to the nucleus.
S11 1615-1752 Sentence denotes It is hypothesized that individuals who differ in G(S)alpha expression may also differ in the expression of certain cAMP-dependent genes.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Increased expression
T2 24-33 protein_molecule denotes Gs(alpha)
T3 61-77 protein_complex denotes adenylyl cyclase
T4 78-105 other_name denotes signal transduction cascade
T5 137-146 protein_family_or_group denotes G protein
T6 148-157 protein_molecule denotes G(S)alpha
T7 191-204 tissue denotes human tissues
T8 212-241 body_part denotes rodent central nervous system
T9 269-279 multi_cell denotes alcoholics
T10 302-311 protein_molecule denotes G(S)alpha
T11 334-341 tissue denotes tissues
T12 373-386 multi_cell denotes nonalcoholics
T13 509-518 protein_molecule denotes G(S)alpha
T14 540-556 protein_complex denotes adenylyl cyclase
T15 622-635 cell_line denotes HEK 293 cells
T16 671-680 protein_molecule denotes G(S)alpha
T17 701-736 DNA_domain_or_region denotes inducible metallothionein promoters
T18 809-821 inorganic denotes zinc sulfate
T19 854-862 other_name denotes membrane
T20 863-872 protein_molecule denotes G(S)alpha
T21 898-907 protein_molecule denotes G(S)alpha
T22 986-995 protein_molecule denotes G(S)alpha
T23 1010-1019 cell_component denotes membranes
T24 1033-1046 tissue denotes human tissues
T25 1051-1060 body_part denotes rat brain
T26 1096-1105 protein_molecule denotes G(S)alpha
T27 1162-1166 nucleotide denotes cAMP
T28 1204-1213 protein_molecule denotes G(S)alpha
T29 1291-1306 other_name denotes phosphorylation
T30 1336-1373 protein_family_or_group denotes cAMP response element binding protein
T31 1408-1437 DNA_family_or_group denotes cAMP-dependent reporter genes
T32 1489-1498 protein_molecule denotes G(S)alpha
T33 1562-1572 other_name denotes AC cascade
T34 1582-1590 cell_component denotes membrane
T35 1606-1613 cell_component denotes nucleus
T36 1665-1674 protein_molecule denotes G(S)alpha
T37 1731-1735 nucleotide denotes cAMP