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PubMed:9211933 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 82-91 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 253-262 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 429-438 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 471-480 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054

sentences

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
T2 99-163 Sentence denotes Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
T3 164-271 Sentence denotes Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
T4 272-447 Sentence denotes This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
T5 448-724 Sentence denotes Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
T6 725-905 Sentence denotes Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
T7 906-1025 Sentence denotes In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
T8 1026-1094 Sentence denotes LPS stimulation increased the binding of c-Jun-containing complexes.
T9 1095-1260 Sentence denotes In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
T10 1261-1444 Sentence denotes The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
T11 1445-1628 Sentence denotes Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
T12 1629-1800 Sentence denotes These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.
T1 0-98 Sentence denotes Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
T2 99-163 Sentence denotes Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
T3 164-271 Sentence denotes Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
T4 272-447 Sentence denotes This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
T5 448-724 Sentence denotes Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
T6 725-905 Sentence denotes Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
T7 906-1025 Sentence denotes In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
T8 1026-1094 Sentence denotes LPS stimulation increased the binding of c-Jun-containing complexes.
T9 1095-1260 Sentence denotes In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
T10 1261-1444 Sentence denotes The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
T11 1445-1628 Sentence denotes Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
T12 1629-1800 Sentence denotes These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 36-72 DNA denotes tumor necrosis factor-alpha promoter
T2 76-97 cell_type denotes human monocytic cells
T3 113-118 protein denotes Egr-1
T4 120-125 protein denotes c-Jun
T5 131-140 protein denotes NF-kappaB
T6 141-162 protein denotes transcription factors
T7 180-207 protein denotes tumor necrosis factor-alpha
T8 209-218 protein denotes TNF-alpha
T9 253-270 cell_type denotes monocytic lineage
T10 312-342 DNA denotes cis-acting regulatory elements
T11 392-416 DNA denotes human TNF-alpha promoter
T12 429-446 cell_type denotes monocytic lineage
T13 471-492 cell_line denotes monocytic THP-1 cells
T14 510-518 DNA denotes plasmids
T15 549-567 DNA denotes TNF-alpha promoter
T16 578-595 DNA denotes enhancer elements
T17 609-631 DNA denotes -182 to -37 base pairs
T18 690-704 DNA denotes TNF-alpha gene
T19 754-762 DNA denotes region I
T20 764-779 DNA denotes -182 to -162 bp
T21 806-820 DNA denotes Sp1/Egr-1 site
T22 826-835 DNA denotes region II
T23 837-848 DNA denotes -119 to -88
T24 860-863 DNA denotes CRE
T25 868-904 DNA denotes NF-kappaB (designated kappaB3) sites
T26 922-927 cell_line denotes THP-1
T27 929-948 protein denotes CRE-binding protein
T28 974-989 protein denotes c-Jun complexes
T29 1016-1024 DNA denotes CRE site
T30 1067-1093 protein denotes c-Jun-containing complexes
T31 1155-1170 protein denotes nuclear factors
T32 1178-1201 DNA denotes Egr-1 and kappaB3 sites
T33 1228-1233 protein denotes Egr-1
T34 1238-1245 protein denotes p50/p65
T35 1265-1286 DNA denotes CRE and kappaB3 sites
T36 1290-1299 DNA denotes region II
T37 1350-1371 DNA denotes heterologous promoter
T38 1493-1518 DNA denotes CRE and the kappaB3 sites
T39 1600-1615 protein denotes c-Jun complexes
T40 1620-1627 protein denotes p50/p65
T41 1686-1704 DNA denotes TNF-alpha promoter
T42 1769-1799 DNA denotes cis-acting regulatory elements

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 32-72 NP denotes the tumor necrosis factor-alpha promoter
C2 113-118 NP denotes Egr-1
C3 180-219 NP denotes tumor necrosis factor-alpha (TNF-alpha)
C4 240-270 NP denotes cells of the monocytic lineage
C6 388-416 NP denotes the human TNF-alpha promoter
C5 350-416 NP denotes lipopolysaccharide (LPS) induction of the human TNF-alpha promoter
C7 420-446 NP denotes cells of monocytic lineage
C8 549-567 NP denotes TNF-alpha promoter
C9 578-607 NP denotes enhancer elements in a region
C10 638-642 NP denotes that
C11 686-704 NP denotes the TNF-alpha gene
C12 725-736 NP denotes Two regions
C14 860-904 NP denotes CRE and NF-kappaB (designated kappaB3) sites
C13 754-904 NP denotes region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites
C15 974-989 NP denotes c-Jun complexes
C16 1026-1041 NP denotes LPS stimulation
C17 1067-1093 NP denotes c-Jun-containing complexes
C18 1108-1123 NP denotes LPS stimulation
C19 1174-1201 NP denotes the Egr-1 and kappaB3 sites
C20 1203-1208 NP denotes which
C21 1228-1233 NP denotes Egr-1
C22 1238-1245 NP denotes p50/p65
C23 1261-1299 NP denotes The CRE and kappaB3 sites in region II
C24 1394-1398 NP denotes they
C25 1489-1518 NP denotes the CRE and the kappaB3 sites
C26 1540-1553 NP denotes LPS induction
C27 1600-1615 NP denotes c-Jun complexes
C28 1620-1627 NP denotes p50/p65
C30 1682-1704 NP denotes the TNF-alpha promoter
C29 1657-1704 NP denotes maximal LPS induction of the TNF-alpha promoter
R10 C21 C2 coref-ident Egr-1,Egr-1
R11 C23 C14 coref-ident The CRE and kappaB3 sites in region II,CRE and NF-kappaB (designated kappaB3) sites
R12 C24 C23 coref-pron they,The CRE and kappaB3 sites in region II
R13 C25 C23 coref-ident the CRE and the kappaB3 sites,The CRE and kappaB3 sites in region II
R14 C26 C5 coref-ident LPS induction,lipopolysaccharide (LPS) induction of the human TNF-alpha promoter
R15 C27 C17 coref-ident c-Jun complexes,c-Jun-containing complexes
R1 C6 C1 coref-ident the human TNF-alpha promoter,the tumor necrosis factor-alpha promoter
R2 C7 C4 coref-ident cells of monocytic lineage,cells of the monocytic lineage
R3 C8 C6 coref-ident TNF-alpha promoter,the human TNF-alpha promoter
R4 C10 C9 coref-relat that,enhancer elements in a region
R5 C11 C3 coref-ident the TNF-alpha gene,tumor necrosis factor-alpha (TNF-alpha)
R6 C13 C12 coref-ident "region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites",Two regions
R7 C17 C15 coref-ident c-Jun-containing complexes,c-Jun complexes
R8 C18 C16 coref-ident LPS stimulation,LPS stimulation
R9 C20 C19 coref-relat which,the Egr-1 and kappaB3 sites
R16 C28 C22 coref-ident p50/p65,p50/p65
R17 C30 C8 coref-ident the TNF-alpha promoter,TNF-alpha promoter
R18 C29 C26 coref-ident maximal LPS induction of the TNF-alpha promoter,LPS induction

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-98 Sentence denotes Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
S2 99-163 Sentence denotes Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
S3 164-271 Sentence denotes Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
S4 272-447 Sentence denotes This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
S5 448-724 Sentence denotes Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
S6 725-905 Sentence denotes Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
S7 906-1025 Sentence denotes In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
S8 1026-1094 Sentence denotes LPS stimulation increased the binding of c-Jun-containing complexes.
S9 1095-1260 Sentence denotes In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
S10 1261-1444 Sentence denotes The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
S11 1445-1628 Sentence denotes Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
S12 1629-1800 Sentence denotes These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 lipid denotes Lipopolysaccharide
T2 36-63 protein_molecule denotes tumor necrosis factor-alpha
T3 76-97 cell_type denotes human monocytic cells
T4 113-118 protein_molecule denotes Egr-1
T5 120-125 protein_molecule denotes c-Jun
T6 131-140 protein_complex denotes NF-kappaB
T7 141-162 protein_family_or_group denotes transcription factors
T8 180-207 protein_molecule denotes tumor necrosis factor-alpha
T9 209-218 protein_molecule denotes TNF-alpha
T10 253-270 cell_type denotes monocytic lineage
T11 312-342 DNA_family_or_group denotes cis-acting regulatory elements
T12 350-368 lipid denotes lipopolysaccharide
T13 370-373 lipid denotes LPS
T14 392-397 DNA_domain_or_region denotes human
T15 398-407 protein_molecule denotes TNF-alpha
T16 429-446 cell_type denotes monocytic lineage
T17 471-480 cell_line denotes monocytic
T18 481-492 cell_line denotes THP-1 cells
T19 510-518 DNA_family_or_group denotes plasmids
T20 549-558 protein_molecule denotes TNF-alpha
T21 578-595 DNA_domain_or_region denotes enhancer elements
T22 609-631 DNA_domain_or_region denotes -182 to -37 base pairs
T23 690-704 DNA_domain_or_region denotes TNF-alpha gene
T24 720-723 lipid denotes LPS
T25 754-762 DNA_domain_or_region denotes region I
T26 764-779 DNA_domain_or_region denotes -182 to -162 bp
T27 806-810 DNA_domain_or_region denotes Sp1/
T28 810-815 protein_molecule denotes Egr-1
T29 826-835 DNA_domain_or_region denotes region II
T30 837-848 DNA_domain_or_region denotes -119 to -88
T31 860-863 DNA_domain_or_region denotes CRE
T32 868-877 protein_complex denotes NF-kappaB
T33 922-927 cell_line denotes THP-1
T34 929-932 DNA_domain_or_region denotes CRE
T35 974-989 protein_complex denotes c-Jun complexes
T36 1016-1024 DNA_domain_or_region denotes CRE site
T37 1026-1029 lipid denotes LPS
T38 1067-1072 protein_molecule denotes c-Jun
T39 1108-1111 lipid denotes LPS
T40 1155-1170 protein_family_or_group denotes nuclear factors
T41 1228-1233 protein_molecule denotes Egr-1
T42 1238-1245 protein_complex denotes p50/p65
T43 1290-1299 DNA_domain_or_region denotes region II
T44 1326-1329 lipid denotes LPS
T45 1350-1371 DNA_domain_or_region denotes heterologous promoter
T46 1417-1443 other_name denotes transcriptional activation
T47 1493-1496 DNA_domain_or_region denotes CRE
T48 1505-1518 DNA_domain_or_region denotes kappaB3 sites
T49 1540-1543 lipid denotes LPS
T50 1600-1605 protein_molecule denotes c-Jun
T51 1620-1627 protein_complex denotes p50/p65
T52 1665-1668 lipid denotes LPS
T53 1686-1695 protein_molecule denotes TNF-alpha
T54 1769-1799 DNA_family_or_group denotes cis-acting regulatory elements

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 36-41 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 180-185 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 76-81 OrganismTaxon denotes human 9606
T2 392-397 OrganismTaxon denotes human 9606

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 36-41 Phenotype denotes tumor HP:0002664
T2 180-185 Phenotype denotes tumor HP:0002664