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PubMed:9206974 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-60 Sentence denotes Genes implicated in the pathogenesis of Alzheimer's disease.
TextSentencer_T2 61-158 Sentence denotes Both the early and late-onset Alzheimer's disease affect millions of people throughout the world.
TextSentencer_T3 159-245 Sentence denotes A number of molecules have been implicated in the pathogenesis of Alzheimer's disease.
TextSentencer_T4 246-334 Sentence denotes These include presenilin 1 and 2 (PS1 and PS2), a beta-amyloid peptide, and tau protein.
TextSentencer_T5 335-436 Sentence denotes Presenilin 1 and 2 genes implicated in the early-onset familial Alzheimer's disease have been cloned.
TextSentencer_T6 437-535 Sentence denotes Both PS1 and PS2 are integral membrane proteins and may function as receptors or channel proteins.
TextSentencer_T7 536-658 Sentence denotes Missense mutations in PS1 and PS2 genes have been found in families that cosegregate with early-onset Alzheimer's disease.
TextSentencer_T8 659-755 Sentence denotes Overexpression of the mutated PS1 gene produced amyloid plaques in the brain of transgenic mice.
TextSentencer_T9 756-932 Sentence denotes Secreted beta-amyloid protein similar to that in the senile plaques of Alzheimer's disease was found to be elevated in fibroblast media from subjects with PS1 or PS2 mutations.
TextSentencer_T10 933-1147 Sentence denotes Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss.
TextSentencer_T11 1148-1197 Sentence denotes The mutated PS2 gene enhanced apoptotic activity.
TextSentencer_T12 1198-1333 Sentence denotes This enhanced apoptotic activity may accelerate the process of neurodegeneration leading to an earlier age in the onset of the disease.
TextSentencer_T13 1334-1488 Sentence denotes Identification of lesions in the molecules that are important in the Alzheimer's disease should allow developing therapeutic approaches for its treatment.
T1 0-60 Sentence denotes Genes implicated in the pathogenesis of Alzheimer's disease.
T2 61-158 Sentence denotes Both the early and late-onset Alzheimer's disease affect millions of people throughout the world.
T3 159-245 Sentence denotes A number of molecules have been implicated in the pathogenesis of Alzheimer's disease.
T4 246-334 Sentence denotes These include presenilin 1 and 2 (PS1 and PS2), a beta-amyloid peptide, and tau protein.
T5 335-436 Sentence denotes Presenilin 1 and 2 genes implicated in the early-onset familial Alzheimer's disease have been cloned.
T6 437-535 Sentence denotes Both PS1 and PS2 are integral membrane proteins and may function as receptors or channel proteins.
T7 536-658 Sentence denotes Missense mutations in PS1 and PS2 genes have been found in families that cosegregate with early-onset Alzheimer's disease.
T8 659-755 Sentence denotes Overexpression of the mutated PS1 gene produced amyloid plaques in the brain of transgenic mice.
T9 756-932 Sentence denotes Secreted beta-amyloid protein similar to that in the senile plaques of Alzheimer's disease was found to be elevated in fibroblast media from subjects with PS1 or PS2 mutations.
T10 933-1147 Sentence denotes Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss.
T11 1148-1197 Sentence denotes The mutated PS2 gene enhanced apoptotic activity.
T12 1198-1333 Sentence denotes This enhanced apoptotic activity may accelerate the process of neurodegeneration leading to an earlier age in the onset of the disease.
T13 1334-1488 Sentence denotes Identification of lesions in the molecules that are important in the Alzheimer's disease should allow developing therapeutic approaches for its treatment.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 689-692 gene:5663 denotes PS1
T1 707-722 disease:C0333463 denotes amyloid plaques
T2 689-692 gene:5663 denotes PS1
T3 707-722 disease:C2936349 denotes amyloid plaques
T4 689-692 gene:338399 denotes PS1
T5 707-722 disease:C0333463 denotes amyloid plaques
T6 689-692 gene:338399 denotes PS1
T7 707-722 disease:C2936349 denotes amyloid plaques
R1 T0 T1 associated_with PS1,amyloid plaques
R2 T2 T3 associated_with PS1,amyloid plaques
R3 T4 T5 associated_with PS1,amyloid plaques
R4 T6 T7 associated_with PS1,amyloid plaques

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 730-735 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 1125-1130 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T309 986-1016 gene:351 denotes beta-amyloid precursor protein
T310 1102-1117 disease:C2936349 denotes amyloid plaques
T311 1135-1146 disease:C0002622 denotes memory loss
R1 T309 T310 associated_with beta-amyloid precursor protein,amyloid plaques
R2 T309 T311 associated_with beta-amyloid precursor protein,memory loss
R3 T309 T311 associated_with beta-amyloid precursor protein,memory loss

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 730-735 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 1125-1130 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain