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PubMed:9191057 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 10-18 protein denotes cyclin A
T2 72-99 cell_type denotes human primary T lymphocytes
T3 104-107 protein denotes CD2
T4 112-116 protein denotes CD28
T5 117-135 protein denotes adhesion molecules
T6 137-145 protein denotes Cyclin A
T7 366-374 protein denotes Cyclin A
T8 384-405 cell_type denotes primary T lymphocytes
T9 465-486 protein denotes monoclonal antibodies
T10 499-502 protein denotes CD2
T11 507-511 protein denotes CD28
T12 512-530 protein denotes adhesion molecules
T13 592-607 cell_type denotes accessory cells
T14 609-617 protein denotes Cyclin A
T15 666-674 protein denotes anti CD2
T16 677-681 protein denotes CD28
T17 705-713 protein denotes anti CD2
T18 717-726 protein denotes anti CD28
T19 816-846 DNA denotes transcription initiation sites
T20 879-900 DNA denotes protein binding sites
T21 977-982 protein denotes ATF-1
T22 987-1000 protein denotes NF-Y proteins
T23 1075-1083 protein denotes anti CD2
T24 1087-1096 protein denotes anti CD28
T25 1133-1141 protein denotes anti CD2
T26 1144-1153 protein denotes anti CD28
T27 1393-1401 protein denotes anti CD2
T28 1404-1413 protein denotes anti CD28

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-136 Sentence denotes Relief of cyclin A gene transcriptional inhibition during activation of human primary T lymphocytes via CD2 and CD28 adhesion molecules.
S2 137-226 Sentence denotes Cyclin A transcription is cell cycle regulated and induced by cell proliferative signals.
S3 227-406 Sentence denotes To understand the mechanisms underlined in this regulation in normal human cells, we have analysed in vivo protein-DNA interactions at the Cyclin A locus in primary T lymphocytes.
S4 407-608 Sentence denotes Stimulation of purified T lymphocytes by a combination of monoclonal antibodies directed at CD2 and CD28 adhesion molecules gives rise to a long lasting proliferation in the absence of accessory cells.
S5 609-751 Sentence denotes Cyclin A was observed after 4 days of costimulation with anti CD2 + CD28 whereas stimulation by anti CD2 or anti CD28 alone was not effective.
S6 752-944 Sentence denotes In vivo genomic DMS footprinting revealed upstream of the major transcription initiation sites, the presence of at least three protein binding sites, two of which were constitutively occupied.
S7 945-1001 Sentence denotes They bind in vitro respectively ATF-1 and NF-Y proteins.
S8 1002-1103 Sentence denotes The third site was occupied in quiescent cells or in cells stimulated by anti CD2 or anti CD28 alone.
S9 1104-1218 Sentence denotes The mitogenic combination of anti CD2 + anti CD28 released the footprint as cells were committed to proliferation.
S10 1219-1472 Sentence denotes Consistent with theses results, nuclear extracts prepared from quiescent cells formed a specific complex with this element, whereas extracts prepared from cells treated with anti CD2 + anti CD28 failed to do so after cells entered a proliferative state.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 72-99 NP denotes human primary T lymphocytes
C2 104-135 NP denotes CD2 and CD28 adhesion molecules
C3 384-405 NP denotes primary T lymphocytes
C4 499-530 NP denotes CD2 and CD28 adhesion molecules
C5 666-681 NP denotes anti CD2 + CD28
C7 705-713 NP denotes anti CD2
C8 717-726 NP denotes anti CD28
C6 705-732 NP denotes anti CD2 or anti CD28 alone
C9 864-900 NP denotes at least three protein binding sites
C12 902-905 NP denotes two
C13 909-914 NP denotes which
C11 902-914 NP denotes two of which
C10 902-943 NP denotes two of which were constitutively occupied
C14 945-949 NP denotes They
C15 1002-1016 NP denotes The third site
C16 1033-1048 NP denotes quiescent cells
C18 1075-1083 NP denotes anti CD2
C19 1087-1096 NP denotes anti CD28
C17 1075-1102 NP denotes anti CD2 or anti CD28 alone
C21 1133-1153 NP denotes anti CD2 + anti CD28
C20 1104-1153 NP denotes The mitogenic combination of anti CD2 + anti CD28
C22 1282-1297 NP denotes quiescent cells
C23 1329-1341 NP denotes this element
C24 1393-1413 NP denotes anti CD2 + anti CD28
R1 C3 C1 coref-ident primary T lymphocytes,human primary T lymphocytes
R2 C4 C2 coref-ident CD2 and CD28 adhesion molecules,CD2 and CD28 adhesion molecules
R3 C13 C12 coref-relat which,two
R4 C11 C9 coref-ident two of which,at least three protein binding sites
R5 C14 C10 coref-pron They,two of which were constitutively occupied
R6 C15 C9 coref-ident The third site,at least three protein binding sites
R7 C18 C7 coref-ident anti CD2,anti CD2
R8 C19 C8 coref-ident anti CD28,anti CD28
R9 C17 C6 coref-ident anti CD2 or anti CD28 alone,anti CD2 or anti CD28 alone
R10 C21 C5 coref-ident anti CD2 + anti CD28,anti CD2 + CD28
R11 C22 C16 coref-ident quiescent cells,quiescent cells
R12 C23 C20 coref-ident this element,The mitogenic combination of anti CD2 + anti CD28
R13 C24 C21 coref-ident anti CD2 + anti CD28,anti CD2 + anti CD28

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 10-18 protein_molecule denotes cyclin A
T2 72-99 cell_type denotes human primary T lymphocytes
T3 104-107 protein_molecule denotes CD2
T4 112-116 protein_molecule denotes CD28
T5 117-135 protein_family_or_group denotes adhesion molecules
T6 137-145 protein_molecule denotes Cyclin A
T7 199-225 other_name denotes cell proliferative signals
T8 334-358 other_name denotes protein-DNA interactions
T9 366-374 protein_molecule denotes Cyclin A
T10 384-405 cell_type denotes primary T lymphocytes
T11 465-486 protein_family_or_group denotes monoclonal antibodies
T12 499-502 protein_molecule denotes CD2
T13 507-511 protein_molecule denotes CD28
T14 512-530 protein_family_or_group denotes adhesion molecules
T15 592-607 cell_type denotes accessory cells
T16 609-617 protein_molecule denotes Cyclin A
T17 666-670 protein_family_or_group denotes anti
T18 671-674 protein_molecule denotes CD2
T19 677-681 protein_molecule denotes CD28
T20 705-709 protein_family_or_group denotes anti
T21 710-713 protein_molecule denotes CD2
T22 717-721 protein_family_or_group denotes anti
T23 722-726 protein_molecule denotes CD28
T24 752-784 other_name denotes In vivo genomic DMS footprinting
T25 816-846 DNA_domain_or_region denotes transcription initiation sites
T26 879-900 DNA_domain_or_region denotes protein binding sites
T27 977-982 protein_molecule denotes ATF-1
T28 987-1000 protein_molecule denotes NF-Y proteins
T29 1075-1079 protein_family_or_group denotes anti
T30 1080-1083 protein_molecule denotes CD2
T31 1087-1091 protein_family_or_group denotes anti
T32 1092-1096 protein_molecule denotes CD28
T33 1133-1137 protein_family_or_group denotes anti
T34 1138-1141 protein_molecule denotes CD2
T35 1144-1148 protein_family_or_group denotes anti
T36 1149-1153 protein_molecule denotes CD28
T37 1251-1267 cell_component denotes nuclear extracts
T38 1393-1397 protein_family_or_group denotes anti
T39 1398-1401 protein_molecule denotes CD2
T40 1404-1408 protein_family_or_group denotes anti
T41 1409-1413 protein_molecule denotes CD28
T42 1452-1471 other_name denotes proliferative state