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sentences

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
T2 123-311 Sentence denotes Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.
T3 312-513 Sentence denotes Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.
T4 514-825 Sentence denotes To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.
T5 826-960 Sentence denotes We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.
T6 961-1221 Sentence denotes In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.
T7 1222-1372 Sentence denotes Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.
T8 1373-1507 Sentence denotes We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.
T1 0-122 Sentence denotes Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
T2 123-311 Sentence denotes Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.
T3 312-513 Sentence denotes Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.
T4 514-825 Sentence denotes To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.
T5 826-960 Sentence denotes We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.
T6 961-1221 Sentence denotes In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.
T7 1222-1372 Sentence denotes Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.
T8 1373-1507 Sentence denotes We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-27 protein denotes HSF2-beta
T2 37-42 protein denotes hemin
T3 111-121 cell_line denotes K562 cells
T4 229-245 DNA denotes heat shock genes
T5 263-273 cell_line denotes K562 cells
T6 343-347 protein denotes HSF2
T7 396-406 protein denotes HSF2-alpha
T8 411-420 protein denotes HSF2-beta
T9 556-566 protein denotes HSF2-alpha
T10 571-580 protein denotes HSF2-beta
T11 623-627 protein denotes HSF2
T12 644-648 protein denotes HSF2
T13 800-810 protein denotes HSF2-alpha
T14 815-824 protein denotes HSF2-beta
T15 851-861 cell_line denotes K562 cells
T16 867-885 protein denotes HSF2-alpha isoform
T17 917-921 protein denotes HSF2
T18 979-988 protein denotes HSF2-beta
T19 1031-1052 protein denotes endogenous HSF2-alpha
T20 1114-1130 DNA denotes heat shock genes
T21 1172-1182 protein denotes HSF2-alpha
T22 1206-1211 protein denotes hemin
T23 1239-1244 protein denotes hemin
T24 1269-1275 protein denotes globin
T25 1362-1371 protein denotes HSF2-beta
T26 1389-1398 protein denotes HSF2-beta
T27 1431-1435 protein denotes HSF2
T28 1496-1506 cell_line denotes K562 cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 18-27 NP denotes HSF2-beta
C2 82-107 NP denotes erythroid differentiation
C3 111-121 NP denotes K562 cells
C4 138-185 NP denotes heat shock factor 2 (HSF2) DNA binding activity
C5 204-245 NP denotes induced transcription of heat shock genes
C6 285-310 NP denotes erythroid differentiation
C7 343-347 NP denotes HSF2
C10 396-406 NP denotes HSF2-alpha
C11 411-420 NP denotes HSF2-beta
C9 396-420 NP denotes HSF2-alpha and HSF2-beta
C8 360-420 NP denotes two alternatively spliced isoforms, HSF2-alpha and HSF2-beta
C12 422-427 NP denotes whose
C13 556-589 NP denotes HSF2-alpha and HSF2-beta isoforms
C14 623-627 NP denotes HSF2
C15 640-657 NP denotes the HSF2 isoforms
C16 698-742 NP denotes the hemin-mediated erythroid differentiation
C18 800-810 NP denotes HSF2-alpha
C19 815-824 NP denotes HSF2-beta
C17 800-824 NP denotes HSF2-alpha and HSF2-beta
C20 863-885 NP denotes the HSF2-alpha isoform
C21 917-921 NP denotes HSF2
C22 979-988 NP denotes HSF2-beta
C23 1005-1011 NP denotes levels
C24 1022-1027 NP denotes those
C25 1054-1092 NP denotes the hemin-induced DNA binding activity
C26 1097-1130 NP denotes transcription of heat shock genes
C27 1172-1182 NP denotes HSF2-alpha
C28 1362-1371 NP denotes HSF2-beta
C29 1389-1398 NP denotes HSF2-beta
C31 1496-1506 NP denotes K562 cells
C30 1452-1506 NP denotes hemin-mediated erythroid differentiation of K562 cells
R1 C6 C2 coref-ident erythroid differentiation,erythroid differentiation
R2 C11 C1 coref-ident HSF2-beta,HSF2-beta
R3 C9 C8 coref-appos HSF2-alpha and HSF2-beta,"two alternatively spliced isoforms, HSF2-alpha and HSF2-beta"
R4 C12 C9 coref-relat whose,HSF2-alpha and HSF2-beta
R5 C13 C8 coref-ident HSF2-alpha and HSF2-beta isoforms,"two alternatively spliced isoforms, HSF2-alpha and HSF2-beta"
R6 C14 C7 coref-ident HSF2,HSF2
R7 C15 C13 coref-ident the HSF2 isoforms,HSF2-alpha and HSF2-beta isoforms
R8 C16 C6 coref-ident the hemin-mediated erythroid differentiation,erythroid differentiation
R9 C18 C10 coref-ident HSF2-alpha,HSF2-alpha
R10 C19 C11 coref-ident HSF2-beta,HSF2-beta
R11 C17 C15 coref-ident HSF2-alpha and HSF2-beta,the HSF2 isoforms
R12 C20 C18 coref-ident the HSF2-alpha isoform,HSF2-alpha
R13 C21 C14 coref-ident HSF2,HSF2
R14 C22 C19 coref-ident HSF2-beta,HSF2-beta
R15 C24 C23 coref-pron those,levels
R16 C25 C4 coref-ident the hemin-induced DNA binding activity,heat shock factor 2 (HSF2) DNA binding activity
R17 C26 C5 coref-ident transcription of heat shock genes,induced transcription of heat shock genes
R18 C27 C20 coref-ident HSF2-alpha,the HSF2-alpha isoform
R19 C29 C28 coref-ident HSF2-beta,HSF2-beta
R20 C31 C3 coref-ident K562 cells,K562 cells
R21 C30 C16 coref-ident hemin-mediated erythroid differentiation of K562 cells,the hemin-mediated erythroid differentiation

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-122 Sentence denotes Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
S2 123-311 Sentence denotes Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.
S3 312-513 Sentence denotes Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.
S4 514-825 Sentence denotes To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.
S5 826-960 Sentence denotes We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.
S6 961-1221 Sentence denotes In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.
S7 1222-1372 Sentence denotes Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.
S8 1373-1507 Sentence denotes We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-27 protein_molecule denotes HSF2-beta
T2 37-42 protein_molecule denotes hemin
T3 82-107 other_name denotes erythroid differentiation
T4 111-121 cell_line denotes K562 cells
T5 229-245 DNA_family_or_group denotes heat shock genes
T6 263-273 cell_line denotes K562 cells
T7 285-310 other_name denotes erythroid differentiation
T8 343-347 protein_molecule denotes HSF2
T9 396-406 protein_molecule denotes HSF2-alpha
T10 411-420 protein_molecule denotes HSF2-beta
T11 556-566 protein_molecule denotes HSF2-alpha
T12 571-580 protein_molecule denotes HSF2-beta
T13 623-627 protein_molecule denotes HSF2
T14 644-648 protein_molecule denotes HSF2
T15 717-742 other_name denotes erythroid differentiation
T16 800-810 protein_molecule denotes HSF2-alpha
T17 815-824 protein_molecule denotes HSF2-beta
T18 851-861 cell_line denotes K562 cells
T19 867-877 protein_molecule denotes HSF2-alpha
T20 917-921 protein_molecule denotes HSF2
T21 979-988 protein_molecule denotes HSF2-beta
T22 1031-1041 protein_molecule denotes endogenous
T23 1042-1052 protein_molecule denotes HSF2-alpha
T24 1114-1130 DNA_family_or_group denotes heat shock genes
T25 1172-1182 protein_molecule denotes HSF2-alpha
T26 1206-1211 protein_molecule denotes hemin
T27 1239-1244 protein_molecule denotes hemin
T28 1269-1275 protein_complex denotes globin
T29 1298-1323 other_name denotes erythroid differentiation
T30 1362-1371 protein_molecule denotes HSF2-beta
T31 1389-1398 protein_molecule denotes HSF2-beta
T32 1431-1435 protein_molecule denotes HSF2
T33 1452-1466 other_name denotes hemin-mediated
T34 1467-1492 other_name denotes erythroid differentiation
T35 1496-1506 cell_line denotes K562 cells

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 541-546 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-61 Phenotype denotes shock HP:0031273
T2 143-148 Phenotype denotes shock HP:0031273
T3 234-239 Phenotype denotes shock HP:0031273
T4 1119-1124 Phenotype denotes shock HP:0031273