PubMed:9180266 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":70,"end":81},"obj":"protein"},{"id":"T2","span":{"begin":82,"end":87},"obj":"protein"},{"id":"T3","span":{"begin":89,"end":94},"obj":"protein"},{"id":"T4","span":{"begin":100,"end":138},"obj":"protein"},{"id":"T5","span":{"begin":159,"end":177},"obj":"protein"},{"id":"T6","span":{"begin":235,"end":249},"obj":"DNA"},{"id":"T7","span":{"begin":271,"end":276},"obj":"protein"},{"id":"T8","span":{"begin":358,"end":376},"obj":"protein"},{"id":"T9","span":{"begin":390,"end":416},"obj":"protein"},{"id":"T10","span":{"begin":464,"end":469},"obj":"protein"},{"id":"T11","span":{"begin":480,"end":513},"obj":"protein"},{"id":"T12","span":{"begin":557,"end":583},"obj":"protein"},{"id":"T13","span":{"begin":598,"end":603},"obj":"protein"},{"id":"T14","span":{"begin":636,"end":655},"obj":"DNA"},{"id":"T15","span":{"begin":702,"end":710},"obj":"DNA"},{"id":"T16","span":{"begin":753,"end":758},"obj":"protein"},{"id":"T17","span":{"begin":857,"end":868},"obj":"cell_type"}],"text":"Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1.\nElf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family. It can bind to DNA target sequences within a variety of cytokine genes. We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265. Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain. Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling. Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":66,"end":87},"obj":"NP"},{"id":"C2","span":{"begin":89,"end":94},"obj":"NP"},{"id":"C4","span":{"begin":98,"end":138},"obj":"NP"},{"id":"C5","span":{"begin":139,"end":143},"obj":"NP"},{"id":"C3","span":{"begin":98,"end":177},"obj":"NP"},{"id":"C6","span":{"begin":179,"end":181},"obj":"NP"},{"id":"C8","span":{"begin":271,"end":276},"obj":"NP"},{"id":"C9","span":{"begin":320,"end":325},"obj":"NP"},{"id":"C7","span":{"begin":271,"end":376},"obj":"NP"},{"id":"C10","span":{"begin":464,"end":469},"obj":"NP"},{"id":"C11","span":{"begin":478,"end":513},"obj":"NP"},{"id":"C12","span":{"begin":531,"end":536},"obj":"NP"},{"id":"C13","span":{"begin":598,"end":603},"obj":"NP"},{"id":"C14","span":{"begin":753,"end":758},"obj":"NP"},{"id":"C15","span":{"begin":780,"end":798},"obj":"NP"},{"id":"C16","span":{"begin":799,"end":804},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R4","pred":"coref-pron","subj":"C6","obj":"C3"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C2"},{"id":"R6","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R7","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R8","pred":"coref-relat","subj":"C12","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C10"},{"id":"R10","pred":"coref-ident","subj":"C14","obj":"C13"},{"id":"R11","pred":"coref-relat","subj":"C16","obj":"C15"}],"text":"Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1.\nElf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family. It can bind to DNA target sequences within a variety of cytokine genes. We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265. Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain. Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling. Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":88},"obj":"Sentence"},{"id":"S2","span":{"begin":89,"end":178},"obj":"Sentence"},{"id":"S3","span":{"begin":179,"end":250},"obj":"Sentence"},{"id":"S4","span":{"begin":251,"end":377},"obj":"Sentence"},{"id":"S5","span":{"begin":378,"end":584},"obj":"Sentence"},{"id":"S6","span":{"begin":585,"end":746},"obj":"Sentence"},{"id":"S7","span":{"begin":747,"end":869},"obj":"Sentence"}],"text":"Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1.\nElf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family. It can bind to DNA target sequences within a variety of cytokine genes. We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265. Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain. Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling. Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":24},"obj":"other_name"},{"id":"T2","span":{"begin":29,"end":62},"obj":"other_name"},{"id":"T3","span":{"begin":70,"end":81},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":82,"end":87},"obj":"protein_molecule"},{"id":"T5","span":{"begin":89,"end":94},"obj":"protein_molecule"},{"id":"T6","span":{"begin":100,"end":138},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":159,"end":170},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":235,"end":249},"obj":"DNA_family_or_group"},{"id":"T9","span":{"begin":271,"end":276},"obj":"protein_molecule"},{"id":"T10","span":{"begin":312,"end":319},"obj":"cell_component"},{"id":"T11","span":{"begin":358,"end":376},"obj":"protein_domain_or_region"},{"id":"T12","span":{"begin":390,"end":416},"obj":"protein_molecule"},{"id":"T13","span":{"begin":464,"end":469},"obj":"protein_molecule"},{"id":"T14","span":{"begin":480,"end":513},"obj":"protein_domain_or_region"},{"id":"T15","span":{"begin":557,"end":583},"obj":"protein_domain_or_region"},{"id":"T16","span":{"begin":598,"end":603},"obj":"protein_molecule"},{"id":"T17","span":{"begin":636,"end":655},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":702,"end":710},"obj":"DNA_domain_or_region"},{"id":"T19","span":{"begin":726,"end":745},"obj":"other_name"},{"id":"T20","span":{"begin":753,"end":758},"obj":"protein_molecule"},{"id":"T21","span":{"begin":780,"end":798},"obj":"other_name"},{"id":"T22","span":{"begin":857,"end":868},"obj":"cell_type"}],"text":"Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1.\nElf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family. It can bind to DNA target sequences within a variety of cytokine genes. We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265. Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain. Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling. Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes."}