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PubMed:9164948 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 67-74 cell_type denotes T cells
T2 104-141 protein denotes TCR alpha beta or -gamma delta chains
T3 190-213 protein denotes CD3 delta epsilon gamma
T4 218-235 protein denotes TCR zeta subunits
T5 247-250 protein denotes TCR
T6 394-401 cell_type denotes T cells
T7 654-668 protein denotes TCR zeta chain
T8 670-695 protein denotes NF kappaB family proteins
T9 701-725 protein denotes tyrosine kinase p56(lck)
T10 814-839 protein denotes NF kappaB family proteins
T11 869-872 protein denotes p65
T12 958-968 protein denotes zeta-chain
T13 1033-1046 protein denotes Th1 cytokines
T14 1048-1052 protein denotes IL-2
T15 1057-1066 protein denotes IFN-gamma
T16 1128-1142 protein denotes TCR zeta chain
T17 1147-1155 protein denotes p56(lck)
T18 1297-1307 protein denotes zeta-chain

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 80-98 NP denotes tumor-bearing mice
C2 340-390 NP denotes marked alterations in signal transduction elements
C3 429-447 NP denotes mice bearing tumor
C4 476-488 NP denotes The sequence
C5 492-497 NP denotes which
C6 498-515 NP denotes these alterations
C7 608-726 NP denotes alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck))
C8 730-768 NP denotes mice bearing MC38 colon adenocarcinoma
C9 799-839 NP denotes alterations in NF kappaB family proteins
C10 958-968 NP denotes zeta-chain
C11 970-983 NP denotes These defects
C12 1128-1142 NP denotes TCR zeta chain
C13 1297-1307 NP denotes zeta-chain
R8 C13 C12 coref-ident zeta-chain,TCR zeta chain
R1 C3 C1 coref-ident mice bearing tumor,tumor-bearing mice
R2 C5 C4 coref-relat which,The sequence
R3 C6 C2 coref-ident these alterations,marked alterations in signal transduction elements
R4 C7 C6 coref-ident "alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck))",these alterations
R5 C8 C3 coref-ident mice bearing MC38 colon adenocarcinoma,mice bearing tumor
R6 C11 C9 coref-ident These defects,alterations in NF kappaB family proteins
R7 C12 C10 coref-ident TCR zeta chain,zeta-chain

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-99 Sentence denotes Sequential development of structural and functional alterations in T cells from tumor-bearing mice.
S2 100-299 Sentence denotes The TCR alpha beta or -gamma delta chains bind the peptide ligand, whereas the associated CD3 delta epsilon gamma and TCR zeta subunits couple the TCR to intracellular signal transduction components.
S3 300-475 Sentence denotes Recently, several groups have described marked alterations in signal transduction elements in T cells from cancer patients or in mice bearing tumor for a few weeks (>26 days).
S4 476-535 Sentence denotes The sequence in which these alterations develop is unknown.
S5 536-769 Sentence denotes The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck)) in mice bearing MC38 colon adenocarcinoma.
S6 770-969 Sentence denotes The results demonstrate that alterations in NF kappaB family proteins, specifically the failure of p65 translocation to the nucleus, occur earlier and more frequently than the decrease in zeta-chain.
S7 970-1068 Sentence denotes These defects are paralleled by an impaired ability to produce Th1 cytokines (IL-2 and IFN-gamma).
S8 1069-1200 Sentence denotes These initial changes are followed by the eventual loss of TCR zeta chain and p56(lck) and a marked decrease in cytotoxic function.
S9 1201-1308 Sentence denotes An increased rate of lysosomal degradation is one of the mechanisms responsible for the loss of zeta-chain.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 41-63 other_name denotes functional alterations
T2 67-74 cell_type denotes T cells
T3 80-98 other_artificial_source denotes tumor-bearing mice
T4 151-165 other_name denotes peptide ligand
T5 190-213 protein_subunit denotes CD3 delta epsilon gamma
T6 218-235 protein_subunit denotes TCR zeta subunits
T7 247-250 protein_complex denotes TCR
T8 362-390 other_name denotes signal transduction elements
T9 394-401 cell_type denotes T cells
T10 407-422 multi_cell denotes cancer patients
T11 429-433 multi_cell denotes mice
T12 442-447 tissue denotes tumor
T13 623-652 other_name denotes signal transduction molecules
T14 654-668 protein_subunit denotes TCR zeta chain
T15 670-695 protein_family_or_group denotes NF kappaB family proteins
T16 701-725 protein_molecule denotes tyrosine kinase p56(lck)
T17 743-768 tissue denotes MC38 colon adenocarcinoma
T18 814-839 protein_family_or_group denotes NF kappaB family proteins
T19 869-872 protein_molecule denotes p65
T20 958-968 protein_subunit denotes zeta-chain
T21 1033-1036 protein_family_or_group denotes Th1
T22 1037-1046 protein_family_or_group denotes cytokines
T23 1048-1052 protein_molecule denotes IL-2
T24 1057-1066 protein_molecule denotes IFN-gamma
T25 1128-1142 protein_subunit denotes TCR zeta chain
T26 1147-1155 protein_molecule denotes p56(lck)
T27 1181-1199 other_name denotes cytotoxic function
T28 1297-1307 protein_subunit denotes zeta-chain