PubMed:9162091 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9162091","sourcedb":"PubMed","sourceid":"9162091","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9162091","text":"Involvement of phosphatidylinositol 3-kinase in NFAT activation in T cells.\nPhosphatidylinositol 3-kinase (PI3-K) has been implicated in the regulation of cell proliferation in many cell types. We have previously shown that in T cells the PI3-K inhibitor, wortmannin, interferes with activation of the mitogen-activated kinase, Erk2, after T cell receptor (TcR) stimulation. To further explore the involvement of PI3-K in T cell activation, we created a set of potentially dominant negative PI3-K constructs comprising individual or tandem domains of the regulatory p85 subunit and tested their effect on downstream signaling events like Erk2 activation and transcription from an NFAT (nuclear factor of activated T cells) element taken from the interleukin-2 promoter. Following TcR stimulation, activation of Erk2 was only inhibited by a previously described truncated form of p85 that cannot bind the catalytic subunit, but not by other constructs of p85. In contrast, several mutant p85 alleles had dramatic effects on NFAT activation. Most interestingly, the N-terminal SH2 domain had an inhibitory effect, whereas a mutant p85 containing only the two SH2 domains enhanced basal NFAT activity in a Ras-dependent manner. Ionomycin induced synergistic activation of NFAT in cells expressing p85 mutants that contained the C-terminal SH2 domain. Analysis of phosphotyrosine-containing proteins bound to truncated p85 constructs revealed cooperative binding of the two SH2 domains but no apparent differences between the N- and C-terminal SH2 domains. Wortmannin did not interfere with NFAT activation, although it inhibited PI3-K and Erk2 activation in the same experiment. These results suggest that PI3-K is involved in NFAT activation through a complex adaptor function of its regulatory subunit and that its lipid kinase activity is dispensable for this effect.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":15,"end":44},"obj":"NP"},{"id":"C2","span":{"begin":48,"end":63},"obj":"NP"},{"id":"C3","span":{"begin":67,"end":74},"obj":"NP"},{"id":"C4","span":{"begin":76,"end":113},"obj":"NP"},{"id":"C5","span":{"begin":227,"end":234},"obj":"NP"},{"id":"C6","span":{"begin":235,"end":254},"obj":"NP"},{"id":"C7","span":{"begin":256,"end":266},"obj":"NP"},{"id":"C8","span":{"begin":298,"end":326},"obj":"NP"},{"id":"C9","span":{"begin":328,"end":332},"obj":"NP"},{"id":"C10","span":{"begin":340,"end":373},"obj":"NP"},{"id":"C11","span":{"begin":413,"end":418},"obj":"NP"},{"id":"C13","span":{"begin":551,"end":577},"obj":"NP"},{"id":"C12","span":{"begin":452,"end":577},"obj":"NP"},{"id":"C14","span":{"begin":589,"end":594},"obj":"NP"},{"id":"C15","span":{"begin":638,"end":653},"obj":"NP"},{"id":"C16","span":{"begin":780,"end":795},"obj":"NP"},{"id":"C18","span":{"begin":811,"end":815},"obj":"NP"},{"id":"C17","span":{"begin":797,"end":815},"obj":"NP"},{"id":"C20","span":{"begin":879,"end":882},"obj":"NP"},{"id":"C19","span":{"begin":838,"end":882},"obj":"NP"},{"id":"C21","span":{"begin":883,"end":887},"obj":"NP"},{"id":"C22","span":{"begin":954,"end":957},"obj":"NP"},{"id":"C23","span":{"begin":1023,"end":1038},"obj":"NP"},{"id":"C24","span":{"begin":1149,"end":1168},"obj":"NP"},{"id":"C25","span":{"begin":1294,"end":1305},"obj":"NP"},{"id":"C26","span":{"begin":1306,"end":1310},"obj":"NP"},{"id":"C27","span":{"begin":1462,"end":1481},"obj":"NP"},{"id":"C28","span":{"begin":1518,"end":1551},"obj":"NP"},{"id":"C29","span":{"begin":1553,"end":1563},"obj":"NP"},{"id":"C30","span":{"begin":1587,"end":1602},"obj":"NP"},{"id":"C31","span":{"begin":1613,"end":1615},"obj":"NP"},{"id":"C32","span":{"begin":1703,"end":1708},"obj":"NP"},{"id":"C33","span":{"begin":1724,"end":1739},"obj":"NP"},{"id":"C35","span":{"begin":1778,"end":1781},"obj":"NP"},{"id":"C34","span":{"begin":1778,"end":1800},"obj":"NP"},{"id":"C36","span":{"begin":1810,"end":1813},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C3"},{"id":"R3","pred":"coref-appos","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-appos","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C4"},{"id":"R6","pred":"coref-pron","subj":"C14","obj":"C12"},{"id":"R7","pred":"coref-ident","subj":"C16","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C18","obj":"C9"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C15"},{"id":"R10","pred":"coref-ident","subj":"C20","obj":"C13"},{"id":"R11","pred":"coref-relat","subj":"C21","obj":"C19"},{"id":"R12","pred":"coref-ident","subj":"C22","obj":"C20"},{"id":"R13","pred":"coref-ident","subj":"C23","obj":"C2"},{"id":"R14","pred":"coref-relat","subj":"C26","obj":"C25"},{"id":"R15","pred":"coref-ident","subj":"C27","obj":"C24"},{"id":"R16","pred":"coref-ident","subj":"C28","obj":"C27"},{"id":"R17","pred":"coref-ident","subj":"C29","obj":"C6"},{"id":"R18","pred":"coref-ident","subj":"C30","obj":"C23"},{"id":"R19","pred":"coref-pron","subj":"C31","obj":"C29"},{"id":"R20","pred":"coref-ident","subj":"C32","obj":"C11"},{"id":"R21","pred":"coref-ident","subj":"C33","obj":"C30"},{"id":"R22","pred":"coref-pron","subj":"C35","obj":"C32"},{"id":"R23","pred":"coref-ident","subj":"C34","obj":"C22"},{"id":"R24","pred":"coref-pron","subj":"C36","obj":"C32"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C26","pred":"source","obj":"genia-medco-coref"},{"subj":"C27","pred":"source","obj":"genia-medco-coref"},{"subj":"C28","pred":"source","obj":"genia-medco-coref"},{"subj":"C29","pred":"source","obj":"genia-medco-coref"},{"subj":"C30","pred":"source","obj":"genia-medco-coref"},{"subj":"C31","pred":"source","obj":"genia-medco-coref"},{"subj":"C32","pred":"source","obj":"genia-medco-coref"},{"subj":"C33","pred":"source","obj":"genia-medco-coref"},{"subj":"C35","pred":"source","obj":"genia-medco-coref"},{"subj":"C34","pred":"source","obj":"genia-medco-coref"},{"subj":"C36","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":15,"end":44},"obj":"protein"},{"id":"T2","span":{"begin":48,"end":52},"obj":"protein"},{"id":"T3","span":{"begin":67,"end":74},"obj":"cell_type"},{"id":"T4","span":{"begin":76,"end":105},"obj":"protein"},{"id":"T5","span":{"begin":107,"end":112},"obj":"protein"},{"id":"T6","span":{"begin":227,"end":234},"obj":"cell_type"},{"id":"T7","span":{"begin":239,"end":244},"obj":"protein"},{"id":"T8","span":{"begin":302,"end":326},"obj":"protein"},{"id":"T9","span":{"begin":328,"end":332},"obj":"protein"},{"id":"T10","span":{"begin":340,"end":355},"obj":"protein"},{"id":"T11","span":{"begin":357,"end":360},"obj":"protein"},{"id":"T12","span":{"begin":413,"end":418},"obj":"protein"},{"id":"T13","span":{"begin":473,"end":507},"obj":"DNA"},{"id":"T14","span":{"begin":533,"end":547},"obj":"DNA"},{"id":"T15","span":{"begin":555,"end":577},"obj":"protein"},{"id":"T16","span":{"begin":638,"end":642},"obj":"protein"},{"id":"T17","span":{"begin":680,"end":730},"obj":"DNA"},{"id":"T18","span":{"begin":746,"end":768},"obj":"DNA"},{"id":"T19","span":{"begin":780,"end":783},"obj":"protein"},{"id":"T20","span":{"begin":811,"end":815},"obj":"protein"},{"id":"T21","span":{"begin":861,"end":882},"obj":"protein"},{"id":"T22","span":{"begin":904,"end":921},"obj":"protein"},{"id":"T23","span":{"begin":954,"end":957},"obj":"protein"},{"id":"T24","span":{"begin":987,"end":990},"obj":"protein"},{"id":"T25","span":{"begin":1023,"end":1027},"obj":"protein"},{"id":"T26","span":{"begin":1064,"end":1085},"obj":"protein"},{"id":"T27","span":{"begin":1122,"end":1132},"obj":"protein"},{"id":"T28","span":{"begin":1153,"end":1168},"obj":"protein"},{"id":"T29","span":{"begin":1184,"end":1188},"obj":"protein"},{"id":"T30","span":{"begin":1203,"end":1206},"obj":"protein"},{"id":"T31","span":{"begin":1269,"end":1273},"obj":"protein"},{"id":"T32","span":{"begin":1294,"end":1305},"obj":"protein"},{"id":"T33","span":{"begin":1325,"end":1346},"obj":"protein"},{"id":"T34","span":{"begin":1360,"end":1395},"obj":"protein"},{"id":"T35","span":{"begin":1415,"end":1429},"obj":"protein"},{"id":"T36","span":{"begin":1466,"end":1481},"obj":"protein"},{"id":"T37","span":{"begin":1522,"end":1551},"obj":"protein"},{"id":"T38","span":{"begin":1587,"end":1591},"obj":"protein"},{"id":"T39","span":{"begin":1626,"end":1631},"obj":"protein"},{"id":"T40","span":{"begin":1636,"end":1640},"obj":"protein"},{"id":"T41","span":{"begin":1703,"end":1708},"obj":"protein"},{"id":"T42","span":{"begin":1724,"end":1728},"obj":"protein"},{"id":"T43","span":{"begin":1782,"end":1800},"obj":"protein"},{"id":"T44","span":{"begin":1814,"end":1826},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"},{"subj":"T40","pred":"source","obj":"jnlpba-st-training"},{"subj":"T41","pred":"source","obj":"jnlpba-st-training"},{"subj":"T42","pred":"source","obj":"jnlpba-st-training"},{"subj":"T43","pred":"source","obj":"jnlpba-st-training"},{"subj":"T44","pred":"source","obj":"jnlpba-st-training"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"T2","span":{"begin":76,"end":193},"obj":"Sentence"},{"id":"T3","span":{"begin":194,"end":374},"obj":"Sentence"},{"id":"T4","span":{"begin":375,"end":769},"obj":"Sentence"},{"id":"T5","span":{"begin":770,"end":958},"obj":"Sentence"},{"id":"T6","span":{"begin":959,"end":1039},"obj":"Sentence"},{"id":"T7","span":{"begin":1040,"end":1224},"obj":"Sentence"},{"id":"T8","span":{"begin":1225,"end":1347},"obj":"Sentence"},{"id":"T9","span":{"begin":1348,"end":1552},"obj":"Sentence"},{"id":"T10","span":{"begin":1553,"end":1675},"obj":"Sentence"},{"id":"T11","span":{"begin":1676,"end":1867},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"T2","span":{"begin":76,"end":193},"obj":"Sentence"},{"id":"T3","span":{"begin":194,"end":374},"obj":"Sentence"},{"id":"T4","span":{"begin":375,"end":769},"obj":"Sentence"},{"id":"T5","span":{"begin":770,"end":958},"obj":"Sentence"},{"id":"T6","span":{"begin":959,"end":1039},"obj":"Sentence"},{"id":"T7","span":{"begin":1040,"end":1224},"obj":"Sentence"},{"id":"T8","span":{"begin":1225,"end":1347},"obj":"Sentence"},{"id":"T9","span":{"begin":1348,"end":1552},"obj":"Sentence"},{"id":"T10","span":{"begin":1553,"end":1675},"obj":"Sentence"},{"id":"T11","span":{"begin":1676,"end":1867},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"S2","span":{"begin":76,"end":193},"obj":"Sentence"},{"id":"S3","span":{"begin":194,"end":374},"obj":"Sentence"},{"id":"S4","span":{"begin":375,"end":769},"obj":"Sentence"},{"id":"S5","span":{"begin":770,"end":958},"obj":"Sentence"},{"id":"S6","span":{"begin":959,"end":1039},"obj":"Sentence"},{"id":"S7","span":{"begin":1040,"end":1224},"obj":"Sentence"},{"id":"S8","span":{"begin":1225,"end":1347},"obj":"Sentence"},{"id":"S9","span":{"begin":1348,"end":1552},"obj":"Sentence"},{"id":"S10","span":{"begin":1553,"end":1675},"obj":"Sentence"},{"id":"S11","span":{"begin":1676,"end":1867},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S11","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":15,"end":44},"obj":"protein_molecule"},{"id":"T2","span":{"begin":48,"end":52},"obj":"protein_family_or_group"},{"id":"T3","span":{"begin":67,"end":74},"obj":"cell_type"},{"id":"T4","span":{"begin":76,"end":105},"obj":"protein_molecule"},{"id":"T5","span":{"begin":107,"end":112},"obj":"protein_molecule"},{"id":"T6","span":{"begin":155,"end":173},"obj":"other_name"},{"id":"T7","span":{"begin":227,"end":234},"obj":"cell_type"},{"id":"T8","span":{"begin":239,"end":244},"obj":"protein_molecule"},{"id":"T9","span":{"begin":256,"end":266},"obj":"other_organic_compound"},{"id":"T10","span":{"begin":302,"end":326},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":328,"end":332},"obj":"protein_molecule"},{"id":"T12","span":{"begin":340,"end":355},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":357,"end":360},"obj":"protein_family_or_group"},{"id":"T14","span":{"begin":413,"end":418},"obj":"protein_molecule"},{"id":"T15","span":{"begin":422,"end":439},"obj":"other_name"},{"id":"T16","span":{"begin":473,"end":507},"obj":"DNA_molecule"},{"id":"T17","span":{"begin":533,"end":547},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":555,"end":577},"obj":"protein_subunit"},{"id":"T19","span":{"begin":605,"end":632},"obj":"other_name"},{"id":"T20","span":{"begin":638,"end":642},"obj":"protein_molecule"},{"id":"T21","span":{"begin":680,"end":684},"obj":"protein_family_or_group"},{"id":"T22","span":{"begin":686,"end":713},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":714,"end":721},"obj":"cell_type"},{"id":"T24","span":{"begin":746,"end":768},"obj":"DNA_domain_or_region"},{"id":"T25","span":{"begin":780,"end":783},"obj":"protein_family_or_group"},{"id":"T26","span":{"begin":811,"end":815},"obj":"protein_molecule"},{"id":"T27","span":{"begin":861,"end":882},"obj":"protein_subunit"},{"id":"T28","span":{"begin":904,"end":921},"obj":"protein_subunit"},{"id":"T29","span":{"begin":954,"end":957},"obj":"protein_subunit"},{"id":"T30","span":{"begin":987,"end":990},"obj":"protein_subunit"},{"id":"T31","span":{"begin":1023,"end":1027},"obj":"protein_family_or_group"},{"id":"T32","span":{"begin":1064,"end":1085},"obj":"protein_domain_or_region"},{"id":"T33","span":{"begin":1122,"end":1128},"obj":"protein_subunit"},{"id":"T34","span":{"begin":1129,"end":1132},"obj":"protein_subunit"},{"id":"T35","span":{"begin":1153,"end":1168},"obj":"protein_domain_or_region"},{"id":"T36","span":{"begin":1184,"end":1188},"obj":"protein_family_or_group"},{"id":"T37","span":{"begin":1203,"end":1206},"obj":"protein_molecule"},{"id":"T38","span":{"begin":1269,"end":1273},"obj":"protein_family_or_group"},{"id":"T39","span":{"begin":1294,"end":1297},"obj":"protein_subunit"},{"id":"T40","span":{"begin":1325,"end":1346},"obj":"protein_domain_or_region"},{"id":"T41","span":{"begin":1360,"end":1375},"obj":"amino_acid_monomer"},{"id":"T42","span":{"begin":1415,"end":1418},"obj":"protein_subunit"},{"id":"T43","span":{"begin":1466,"end":1481},"obj":"protein_domain_or_region"},{"id":"T44","span":{"begin":1587,"end":1591},"obj":"protein_family_or_group"},{"id":"T45","span":{"begin":1626,"end":1631},"obj":"protein_molecule"},{"id":"T46","span":{"begin":1636,"end":1640},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1703,"end":1708},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1724,"end":1728},"obj":"protein_family_or_group"},{"id":"T49","span":{"begin":1782,"end":1800},"obj":"protein_subunit"},{"id":"T50","span":{"begin":1814,"end":1826},"obj":"protein_molecule"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":340,"end":346},"obj":"Body_part"},{"id":"T2","span":{"begin":422,"end":428},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":67,"end":74},"obj":"Cell"},{"id":"T2","span":{"begin":227,"end":234},"obj":"Cell"},{"id":"T3","span":{"begin":340,"end":346},"obj":"Cell"},{"id":"T4","span":{"begin":422,"end":428},"obj":"Cell"},{"id":"T5","span":{"begin":714,"end":721},"obj":"Cell"},{"id":"T6","span":{"begin":1178,"end":1183},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0002324"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"},{"subj":"T4","pred":"source","obj":"CL-cell"},{"subj":"T5","pred":"source","obj":"CL-cell"},{"subj":"T6","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93ecb9","default":true},{"id":"jnlpba-st-training","color":"#ec9f93"},{"id":"sentences","color":"#93a1ec"},{"id":"pubmed-sentences-benchmark","color":"#bbec93"},{"id":"GENIAcorpus","color":"#ec93d5"},{"id":"Anatomy-UBERON","color":"#93ece9"},{"id":"CL-cell","color":"#eccf93"}]}]}}