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sentences

Id Subject Object Predicate Lexical cue
T1 0-161 Sentence denotes Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.
T2 162-633 Sentence denotes We have purified a previously unknown glycoprotein (designated gp-340) from human bronchioalveolar lung washings from a patient with alveolar proteinosis. gp-340 was identified by its calcium-dependent binding to lung surfactant protein D (SP-D) and by its molecular mass of 340 kDa in the reduced state on SDS-polyacrylamide gel electrophoresis (PAGE). gp-340 was purified from the 10,000 x g pellet of the lavage fluid by ion-exchange and gel permeation chromatography.
T3 634-722 Sentence denotes On SDS-PAGE, gp-340 showed an apparent molecular mass of 290 kDa in the unreduced state.
T4 723-832 Sentence denotes On gel chromatography under non-dissociating conditions, the apparent molecular mass of gp-340 was >1000 kDa.
T5 833-1011 Sentence denotes The presence of N-linked glycosylation was shown by digestion with N-glycosidase F, which reduced the apparent molecular mass of gp-340 under reducing condition to about 300 kDa.
T6 1012-1100 Sentence denotes Partial amino acid sequence data showed the presence of scavenger-receptor type domains.
T7 1101-1225 Sentence denotes Monoclonal and polyclonal antibodies were raised against gp-340, and their specificities were confirmed by Western blotting.
T8 1226-1380 Sentence denotes The antibodies were used for immunohistochemical localization of gp-340 in the lung, where it was found on the surface of and within alveolar macrophages.
T9 1381-1531 Sentence denotes Direct binding between gp-340 and SP-D took place at physiological ionic strength, required the presence of calcium, and was not inhibited by maltose.
T10 1532-1664 Sentence denotes The binding between SP-D and mannan also required the presence of calcium, but this interaction was completely inhibited by maltose.
T11 1665-1821 Sentence denotes The same binding pattern was seen between gp-340 and recombinant human SP-D composed of the trimeric neck region and three carbohydrate recognition domains.
T12 1822-2057 Sentence denotes These findings indicate that the binding between gp-340 and SP-D is a protein-protein interaction rather than a lectin-carbohydrate interaction and that the binding to gp-340 takes place via the carbohydrate recognition domain of SP-D.
T13 2058-2193 Sentence denotes We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D.
T1 0-161 Sentence denotes Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.
T2 162-633 Sentence denotes We have purified a previously unknown glycoprotein (designated gp-340) from human bronchioalveolar lung washings from a patient with alveolar proteinosis. gp-340 was identified by its calcium-dependent binding to lung surfactant protein D (SP-D) and by its molecular mass of 340 kDa in the reduced state on SDS-polyacrylamide gel electrophoresis (PAGE). gp-340 was purified from the 10,000 x g pellet of the lavage fluid by ion-exchange and gel permeation chromatography.
T3 634-722 Sentence denotes On SDS-PAGE, gp-340 showed an apparent molecular mass of 290 kDa in the unreduced state.
T4 723-832 Sentence denotes On gel chromatography under non-dissociating conditions, the apparent molecular mass of gp-340 was >1000 kDa.
T5 833-1011 Sentence denotes The presence of N-linked glycosylation was shown by digestion with N-glycosidase F, which reduced the apparent molecular mass of gp-340 under reducing condition to about 300 kDa.
T6 1012-1100 Sentence denotes Partial amino acid sequence data showed the presence of scavenger-receptor type domains.
T7 1101-1225 Sentence denotes Monoclonal and polyclonal antibodies were raised against gp-340, and their specificities were confirmed by Western blotting.
T8 1226-1380 Sentence denotes The antibodies were used for immunohistochemical localization of gp-340 in the lung, where it was found on the surface of and within alveolar macrophages.
T9 1381-1531 Sentence denotes Direct binding between gp-340 and SP-D took place at physiological ionic strength, required the presence of calcium, and was not inhibited by maltose.
T10 1532-1664 Sentence denotes The binding between SP-D and mannan also required the presence of calcium, but this interaction was completely inhibited by maltose.
T11 1665-1821 Sentence denotes The same binding pattern was seen between gp-340 and recombinant human SP-D composed of the trimeric neck region and three carbohydrate recognition domains.
T12 1822-2057 Sentence denotes These findings indicate that the binding between gp-340 and SP-D is a protein-protein interaction rather than a lectin-carbohydrate interaction and that the binding to gp-340 takes place via the carbohydrate recognition domain of SP-D.
T13 2058-2193 Sentence denotes We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 118-122 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T2 261-265 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T3 375-379 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T4 1305-1309 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T5 1766-1770 http://purl.obolibrary.org/obo/MAT_0000297 denotes neck

DisGeNET

Id Subject Object Predicate Lexical cue
T0 225-231 gene:1755 denotes gp-340
T1 295-315 disease:C0034050 denotes alveolar proteinosis
R1 T0 T1 associated_with gp-340,alveolar proteinosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9153228-1#63#69#gene1755 225-231 gene1755 denotes gp-340
9153228-1#155#161#gene1755 317-323 gene1755 denotes gp-340
9153228-1#240#244#gene6441 402-406 gene6441 denotes SP-D
9153228-1#307#310#gene10993 469-472 gene10993 denotes SDS
9153228-1#354#360#gene1755 516-522 gene1755 denotes gp-340
9153228-1#133#153#diseaseC0034050 295-315 diseaseC0034050 denotes alveolar proteinosis
63#69#gene1755133#153#diseaseC0034050 9153228-1#63#69#gene1755 9153228-1#133#153#diseaseC0034050 associated_with gp-340,alveolar proteinosis
155#161#gene1755133#153#diseaseC0034050 9153228-1#155#161#gene1755 9153228-1#133#153#diseaseC0034050 associated_with gp-340,alveolar proteinosis
240#244#gene6441133#153#diseaseC0034050 9153228-1#240#244#gene6441 9153228-1#133#153#diseaseC0034050 associated_with SP-D,alveolar proteinosis
307#310#gene10993133#153#diseaseC0034050 9153228-1#307#310#gene10993 9153228-1#133#153#diseaseC0034050 associated_with SDS,alveolar proteinosis
354#360#gene1755133#153#diseaseC0034050 9153228-1#354#360#gene1755 9153228-1#133#153#diseaseC0034050 associated_with gp-340,alveolar proteinosis

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1523-1530 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT
T2 1656-1663 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 118-122 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 261-265 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T3 375-379 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T4 1305-1309 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T5 1766-1770 Body_part denotes neck http://purl.obolibrary.org/obo/MAT_0000297

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 402-406 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T2 1415-1419 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T3 1552-1556 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T4 1736-1740 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T5 1882-1886 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T6 2052-2056 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T7 2188-2192 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1523-1530 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT
T2 1656-1663 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 295-315 Phenotype denotes alveolar proteinosis HP:0006517

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1359-1379 Cell denotes alveolar macrophages http://purl.obolibrary.org/obo/CL:0000583

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 118-133 Body_part denotes lung surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T2 261-265 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 375-390 Body_part denotes lung surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T4 556-562 Body_part denotes pellet http://purl.obolibrary.org/obo/UBERON_0036018
T5 577-582 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314
T6 1305-1309 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 1368-1379 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T8 1766-1770 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 54-63 Organism denotes scavenger 30848
T2 238-243 Organism denotes human 9606
T3 282-289 Organism denotes patient 9606
T4 1068-1077 Organism denotes scavenger 30848
T5 1730-1735 Organism denotes human 9606
T6 2105-2114 Organism denotes scavenger 30848

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-161 Sentence denotes Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.
T2 162-633 Sentence denotes We have purified a previously unknown glycoprotein (designated gp-340) from human bronchioalveolar lung washings from a patient with alveolar proteinosis. gp-340 was identified by its calcium-dependent binding to lung surfactant protein D (SP-D) and by its molecular mass of 340 kDa in the reduced state on SDS-polyacrylamide gel electrophoresis (PAGE). gp-340 was purified from the 10,000 x g pellet of the lavage fluid by ion-exchange and gel permeation chromatography.
T3 634-722 Sentence denotes On SDS-PAGE, gp-340 showed an apparent molecular mass of 290 kDa in the unreduced state.
T4 723-832 Sentence denotes On gel chromatography under non-dissociating conditions, the apparent molecular mass of gp-340 was >1000 kDa.
T5 833-1011 Sentence denotes The presence of N-linked glycosylation was shown by digestion with N-glycosidase F, which reduced the apparent molecular mass of gp-340 under reducing condition to about 300 kDa.
T6 1012-1100 Sentence denotes Partial amino acid sequence data showed the presence of scavenger-receptor type domains.
T7 1101-1225 Sentence denotes Monoclonal and polyclonal antibodies were raised against gp-340, and their specificities were confirmed by Western blotting.
T8 1226-1380 Sentence denotes The antibodies were used for immunohistochemical localization of gp-340 in the lung, where it was found on the surface of and within alveolar macrophages.
T9 1381-1531 Sentence denotes Direct binding between gp-340 and SP-D took place at physiological ionic strength, required the presence of calcium, and was not inhibited by maltose.
T10 1532-1664 Sentence denotes The binding between SP-D and mannan also required the presence of calcium, but this interaction was completely inhibited by maltose.
T11 1665-1821 Sentence denotes The same binding pattern was seen between gp-340 and recombinant human SP-D composed of the trimeric neck region and three carbohydrate recognition domains.
T12 1822-2193 Sentence denotes These findings indicate that the binding between gp-340 and SP-D is a protein-protein interaction rather than a lectin-carbohydrate interaction and that the binding to gp-340 takes place via the carbohydrate recognition domain of SP-D. We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D.

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-161 Sentence denotes Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.
T2 162-633 Sentence denotes We have purified a previously unknown glycoprotein (designated gp-340) from human bronchioalveolar lung washings from a patient with alveolar proteinosis. gp-340 was identified by its calcium-dependent binding to lung surfactant protein D (SP-D) and by its molecular mass of 340 kDa in the reduced state on SDS-polyacrylamide gel electrophoresis (PAGE). gp-340 was purified from the 10,000 x g pellet of the lavage fluid by ion-exchange and gel permeation chromatography.
T3 634-722 Sentence denotes On SDS-PAGE, gp-340 showed an apparent molecular mass of 290 kDa in the unreduced state.
T4 723-832 Sentence denotes On gel chromatography under non-dissociating conditions, the apparent molecular mass of gp-340 was >1000 kDa.
T5 833-1011 Sentence denotes The presence of N-linked glycosylation was shown by digestion with N-glycosidase F, which reduced the apparent molecular mass of gp-340 under reducing condition to about 300 kDa.
T6 1012-1100 Sentence denotes Partial amino acid sequence data showed the presence of scavenger-receptor type domains.
T7 1101-1225 Sentence denotes Monoclonal and polyclonal antibodies were raised against gp-340, and their specificities were confirmed by Western blotting.
T8 1226-1380 Sentence denotes The antibodies were used for immunohistochemical localization of gp-340 in the lung, where it was found on the surface of and within alveolar macrophages.
T9 1381-1531 Sentence denotes Direct binding between gp-340 and SP-D took place at physiological ionic strength, required the presence of calcium, and was not inhibited by maltose.
T10 1532-1664 Sentence denotes The binding between SP-D and mannan also required the presence of calcium, but this interaction was completely inhibited by maltose.
T11 1665-1821 Sentence denotes The same binding pattern was seen between gp-340 and recombinant human SP-D composed of the trimeric neck region and three carbohydrate recognition domains.
T12 1822-2193 Sentence denotes These findings indicate that the binding between gp-340 and SP-D is a protein-protein interaction rather than a lectin-carbohydrate interaction and that the binding to gp-340 takes place via the carbohydrate recognition domain of SP-D. We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 118-122 Body_part denotes lung FMA:7195
T2 261-265 Body_part denotes lung FMA:7195
T3 295-303 Body_part denotes alveolar FMA:264783
T4 375-379 Body_part denotes lung FMA:7195
T5 1305-1309 Body_part denotes lung FMA:7195
T6 1359-1379 Body_part denotes alveolar macrophages FMA:83023
T7 1766-1770 Body_part denotes neck FMA:7155

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 118-122 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 261-265 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T3 375-379 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T4 1305-1309 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T5 1766-1770 Body_part denotes neck http://purl.obolibrary.org/obo/MAT_0000297

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 54-63 OrganismTaxon denotes scavenger 30848
T2 238-243 OrganismTaxon denotes human 9606
T3 282-289 OrganismTaxon denotes patient 9606
T4 1068-1077 OrganismTaxon denotes scavenger 30848
T5 1730-1735 OrganismTaxon denotes human 9606
T6 2105-2114 OrganismTaxon denotes scavenger 30848

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 118-133 Body_part denotes lung surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T2 261-265 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 375-390 Body_part denotes lung surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T4 556-562 Body_part denotes pellet http://purl.obolibrary.org/obo/UBERON_0036018
T5 577-582 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314
T6 1305-1309 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 1368-1379 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T8 1766-1770 Body_part denotes neck http://purl.obolibrary.org/obo/UBERON_0000974

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 295-315 Phenotype denotes alveolar proteinosis HP:0006517

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1359-1379 Cell denotes alveolar macrophages http://purl.obolibrary.org/obo/CL:0000583