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PubMed:9147042 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 25-32 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis a
T2 25-32 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis a
T3 302-310 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T4 302-310 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T5 315-323 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis(x)
T6 315-323 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis(x)
T7 384-392 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T8 384-392 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T9 397-405 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis(x)
T10 397-405 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis(x)
T11 653-661 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T12 653-661 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T13 1270-1278 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T14 1270-1278 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T15 1534-1540 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T16 1579-1588 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis (a)
T17 1579-1588 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis (a)
T18 1827-1835 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T19 1827-1835 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 25-32 Glycan_Motif denotes Lewis a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T3 302-310 Glycan_Motif denotes Lewis(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T5 315-323 Glycan_Motif denotes Lewis(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T7 384-392 Glycan_Motif denotes Lewis(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T9 397-405 Glycan_Motif denotes Lewis(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T11 653-661 Glycan_Motif denotes Lewis(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T13 1270-1278 Glycan_Motif denotes Lewis(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T15 1534-1540 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T16 1579-1588 Glycan_Motif denotes Lewis (a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO
T18 1827-1835 Glycan_Motif denotes Lewis(a) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 25-32 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis a
T2 1579-1588 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis (a)

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
TextSentencer_T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
TextSentencer_T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
TextSentencer_T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
TextSentencer_T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
TextSentencer_T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
TextSentencer_T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
TextSentencer_T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
TextSentencer_T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
TextSentencer_T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
TextSentencer_T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
TextSentencer_T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
TextSentencer_T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.
T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.
T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 25-32 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis a
T2 25-32 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis a
T3 302-310 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T4 302-310 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T5 315-323 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis(x)
T6 315-323 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis(x)
T7 384-392 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T8 384-392 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T9 397-405 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis(x)
T10 397-405 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis(x)
T11 653-661 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T12 653-661 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T13 1270-1278 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T14 1270-1278 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)
T15 1534-1540 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T16 1579-1588 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis (a)
T17 1579-1588 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis (a)
T18 1827-1835 https://glytoucan.org/Structures/Glycans/G00047MO denotes Lewis(a)
T19 1827-1835 https://glytoucan.org/Structures/Glycans/G39023AU denotes Lewis(a)

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1493-1502 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximity

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 42-50 FMAID:165243 denotes selectin
_T2 42-50 FMAID:61795 denotes selectin
_T3 130-139 FMAID:165243 denotes selectins
_T4 130-139 FMAID:61795 denotes selectins
_T5 156-164 FMAID:67257 denotes proteins
_T6 156-164 FMAID:165447 denotes proteins
_T7 178-187 FMAID:167148 denotes leukocyte
_T8 178-187 FMAID:62852 denotes leukocyte
_T9 229-240 FMAID:63916 denotes endothelium
_T10 229-240 FMAID:162384 denotes endothelium
_T11 254-264 FMAID:62931 denotes L-selectin
_T12 254-264 FMAID:167265 denotes L-selectin
_T13 254-264 FMAID:62932 denotes L-selectin
_T14 254-264 FMAID:167267 denotes L-selectin
_T15 254-264 FMAID:167268 denotes L-selectin
_T16 254-264 FMAID:62933 denotes L-selectin
_T17 256-264 FMAID:165243 denotes selectin
_T18 256-264 FMAID:61795 denotes selectin
_T19 406-422 FMAID:82742 denotes oligosaccharides
_T20 406-422 FMAID:196731 denotes oligosaccharides
_T21 481-490 FMAID:165243 denotes selectins
_T22 481-490 FMAID:61795 denotes selectins
_T23 689-697 FMAID:165243 denotes selectin
_T24 689-697 FMAID:61795 denotes selectin
_T25 821-827 FMAID:196724 denotes sugars
_T26 1493-1502 FMAID:171415 denotes proximity
_T27 1493-1502 FMAID:30326 denotes proximity
_T28 1534-1540 FMAID:82790 denotes fucose
_T29 1534-1540 FMAID:196784 denotes fucose
_T30 1883-1888 FMAID:177242 denotes added
_T31 1938-1949 FMAID:258694 denotes s structure

uniprot-human

Id Subject Object Predicate Lexical cue
T1 254-264 http://www.uniprot.org/uniprot/P14151 denotes L-selectin

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 254-264 http://www.uniprot.org/uniprot/P18337 denotes L-selectin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1295-1302 http://purl.bioontology.org/ontology/STY/T033 denotes finding
T2 1521-1526 http://purl.bioontology.org/ontology/STY/T096 denotes group
T3 1799-1807 http://purl.bioontology.org/ontology/STY/T033 denotes findings
T4 1869-1875 http://purl.bioontology.org/ontology/STY/T096 denotes groups

GO-BP

Id Subject Object Predicate Lexical cue
T1 178-209 http://purl.obolibrary.org/obo/GO_1903238 denotes leukocyte tethering and rolling
T2 178-209 http://purl.obolibrary.org/obo/GO_1903237 denotes leukocyte tethering and rolling
T3 178-209 http://purl.obolibrary.org/obo/GO_1903236 denotes leukocyte tethering and rolling
T4 178-209 http://purl.obolibrary.org/obo/GO_0050901 denotes leukocyte tethering and rolling
T5 1237-1246 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T6 1376-1385 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T7 1513-1520 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate

GO-MF

Id Subject Object Predicate Lexical cue
T1 42-50 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T2 256-264 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T3 130-139 http://purl.obolibrary.org/obo/GO_0030246 denotes selectins
T4 481-490 http://purl.obolibrary.org/obo/GO_0030246 denotes selectins
T5 51-58 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T6 466-473 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 466-473 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 466-473 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 466-473 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 1265-1269 http://purl.obolibrary.org/obo/GO_0019013 denotes core

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 229-240 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1493-1502 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximity

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 25-30 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T2 302-307 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T3 315-320 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T4 384-389 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T5 397-402 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T6 653-658 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T7 1270-1275 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T8 1579-1584 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T9 1827-1832 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T10 315-322 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis(x
T11 397-404 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis(x

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 42-50 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T2 254-264 https://acgg.asia/db/lfdb/LfDB0142 denotes L-selectin
Lectin_T3 689-697 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T4 42-50 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T5 256-264 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T6 689-697 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T7 42-50 https://acgg.asia/db/lfdb/LfDB0043 denotes selectin
Lectin_T8 256-264 https://acgg.asia/db/lfdb/LfDB0043 denotes selectin
Lectin_T9 689-697 https://acgg.asia/db/lfdb/LfDB0043 denotes selectin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 315-322 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis(x
PD-GlycoEpitope-B_T2 397-404 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis(x
PD-GlycoEpitope-B_T3 25-32 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis a
PD-GlycoEpitope-B_T4 302-309 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis(a
PD-GlycoEpitope-B_T5 384-391 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis(a
PD-GlycoEpitope-B_T6 653-660 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis(a
PD-GlycoEpitope-B_T7 1270-1277 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis(a
PD-GlycoEpitope-B_T8 1579-1587 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis (a
PD-GlycoEpitope-B_T9 1827-1834 http://www.glycoepitope.jp/epitopes/EP0007 denotes Lewis(a

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 663-666 "http://rdf.glycoinfo.org/glycan/G59743JO" denotes Glc
GlycanIUPAC_T2 663-666 "http://rdf.glycoinfo.org/glycan/G22515CP" denotes Glc
GlycanIUPAC_T3 663-666 "http://rdf.glycoinfo.org/glycan/G50260YT" denotes Glc
GlycanIUPAC_T4 663-666 "http://rdf.glycoinfo.org/glycan/G59271KV" denotes Glc
GlycanIUPAC_T5 663-666 "http://rdf.glycoinfo.org/glycan/G41080ZB" denotes Glc
GlycanIUPAC_T6 663-666 "http://rdf.glycoinfo.org/glycan/G28051VF" denotes Glc
GlycanIUPAC_T7 663-666 "http://rdf.glycoinfo.org/glycan/G44775RL" denotes Glc
GlycanIUPAC_T8 663-666 "http://rdf.glycoinfo.org/glycan/G05723ZI" denotes Glc
GlycanIUPAC_T9 663-666 "http://rdf.glycoinfo.org/glycan/G80753ZP" denotes Glc
GlycanIUPAC_T10 663-666 "http://rdf.glycoinfo.org/glycan/G09675LS" denotes Glc
GlycanIUPAC_T11 663-666 "http://rdf.glycoinfo.org/glycan/G32374SR" denotes Glc
GlycanIUPAC_T12 663-666 "http://rdf.glycoinfo.org/glycan/G35562XQ" denotes Glc
GlycanIUPAC_T13 663-666 "http://rdf.glycoinfo.org/glycan/G79798HI" denotes Glc
GlycanIUPAC_T14 663-666 "http://rdf.glycoinfo.org/glycan/G60629WC" denotes Glc
GlycanIUPAC_T15 663-666 "http://rdf.glycoinfo.org/glycan/G28900GG" denotes Glc
GlycanIUPAC_T16 663-666 "http://rdf.glycoinfo.org/glycan/G80295GO" denotes Glc
GlycanIUPAC_T17 663-666 "http://rdf.glycoinfo.org/glycan/G78827BW" denotes Glc
GlycanIUPAC_T18 663-666 "http://rdf.glycoinfo.org/glycan/G04154TF" denotes Glc
GlycanIUPAC_T19 663-666 "http://rdf.glycoinfo.org/glycan/G52272JK" denotes Glc
GlycanIUPAC_T20 663-666 "http://rdf.glycoinfo.org/glycan/G04451ID" denotes Glc
GlycanIUPAC_T21 663-666 "http://rdf.glycoinfo.org/glycan/G93765AC" denotes Glc
GlycanIUPAC_T22 663-666 "http://rdf.glycoinfo.org/glycan/G37845XB" denotes Glc
GlycanIUPAC_T23 663-666 "http://rdf.glycoinfo.org/glycan/G91536UT" denotes Glc
GlycanIUPAC_T24 663-666 "http://rdf.glycoinfo.org/glycan/G39846RD" denotes Glc
GlycanIUPAC_T25 663-666 "http://rdf.glycoinfo.org/glycan/G16598ZE" denotes Glc
GlycanIUPAC_T26 663-666 "http://rdf.glycoinfo.org/glycan/G69175UD" denotes Glc
GlycanIUPAC_T27 663-666 "http://rdf.glycoinfo.org/glycan/G64029GC" denotes Glc
GlycanIUPAC_T28 663-666 "http://rdf.glycoinfo.org/glycan/G88005IG" denotes Glc
GlycanIUPAC_T29 663-666 "http://rdf.glycoinfo.org/glycan/G20950LN" denotes Glc
GlycanIUPAC_T30 663-666 "http://rdf.glycoinfo.org/glycan/G62915MH" denotes Glc
GlycanIUPAC_T31 663-666 "http://rdf.glycoinfo.org/glycan/G03187PO" denotes Glc
GlycanIUPAC_T32 663-666 "http://rdf.glycoinfo.org/glycan/G35637EX" denotes Glc
GlycanIUPAC_T33 663-666 "http://rdf.glycoinfo.org/glycan/G58694JL" denotes Glc
GlycanIUPAC_T34 663-666 "http://rdf.glycoinfo.org/glycan/G16024FW" denotes Glc
GlycanIUPAC_T35 663-666 "http://rdf.glycoinfo.org/glycan/G32353KL" denotes Glc
GlycanIUPAC_T36 663-666 "http://rdf.glycoinfo.org/glycan/G10359XP" denotes Glc
GlycanIUPAC_T37 663-666 "http://rdf.glycoinfo.org/glycan/G79996IH" denotes Glc
GlycanIUPAC_T38 663-666 "http://rdf.glycoinfo.org/glycan/G74945HO" denotes Glc
GlycanIUPAC_T39 663-666 "http://rdf.glycoinfo.org/glycan/G41472DW" denotes Glc
GlycanIUPAC_T40 663-666 "http://rdf.glycoinfo.org/glycan/G00508LN" denotes Glc
GlycanIUPAC_T41 663-666 "http://rdf.glycoinfo.org/glycan/G57307OS" denotes Glc
GlycanIUPAC_T42 663-666 "http://rdf.glycoinfo.org/glycan/G21068RB" denotes Glc
GlycanIUPAC_T43 663-666 "http://rdf.glycoinfo.org/glycan/G93716IA" denotes Glc
GlycanIUPAC_T44 663-666 "http://rdf.glycoinfo.org/glycan/G79555YY" denotes Glc
GlycanIUPAC_T45 663-666 "http://rdf.glycoinfo.org/glycan/G68618KX" denotes Glc
GlycanIUPAC_T46 663-666 "http://rdf.glycoinfo.org/glycan/G11806XO" denotes Glc
GlycanIUPAC_T47 663-666 "http://rdf.glycoinfo.org/glycan/G23375NF" denotes Glc
GlycanIUPAC_T48 663-666 "http://rdf.glycoinfo.org/glycan/G83211PN" denotes Glc
GlycanIUPAC_T49 663-666 "http://rdf.glycoinfo.org/glycan/G46248XJ" denotes Glc
GlycanIUPAC_T50 663-666 "http://rdf.glycoinfo.org/glycan/G50990UV" denotes Glc
GlycanIUPAC_T51 663-666 "http://rdf.glycoinfo.org/glycan/G11748CA" denotes Glc
GlycanIUPAC_T52 663-666 "http://rdf.glycoinfo.org/glycan/G47705VB" denotes Glc
GlycanIUPAC_T53 663-666 "http://rdf.glycoinfo.org/glycan/G56513MF" denotes Glc
GlycanIUPAC_T54 663-666 "http://rdf.glycoinfo.org/glycan/G29595MF" denotes Glc
GlycanIUPAC_T55 663-666 "http://rdf.glycoinfo.org/glycan/G79937GD" denotes Glc
GlycanIUPAC_T56 663-666 "http://rdf.glycoinfo.org/glycan/G83526PI" denotes Glc
GlycanIUPAC_T57 663-666 "http://rdf.glycoinfo.org/glycan/G72397QO" denotes Glc
GlycanIUPAC_T58 663-666 "http://rdf.glycoinfo.org/glycan/G19751JJ" denotes Glc
GlycanIUPAC_T59 663-666 "http://rdf.glycoinfo.org/glycan/G30236YV" denotes Glc
GlycanIUPAC_T60 663-666 "http://rdf.glycoinfo.org/glycan/G52603CJ" denotes Glc
GlycanIUPAC_T61 663-666 "http://rdf.glycoinfo.org/glycan/G69831UL" denotes Glc
GlycanIUPAC_T62 663-666 "http://rdf.glycoinfo.org/glycan/G70447JX" denotes Glc
GlycanIUPAC_T63 663-666 "http://rdf.glycoinfo.org/glycan/G19550WL" denotes Glc
GlycanIUPAC_T64 663-666 "http://rdf.glycoinfo.org/glycan/G76492IF" denotes Glc
GlycanIUPAC_T65 663-666 "http://rdf.glycoinfo.org/glycan/G30921DY" denotes Glc
GlycanIUPAC_T66 663-666 "http://rdf.glycoinfo.org/glycan/G93844OF" denotes Glc
GlycanIUPAC_T67 663-666 "http://rdf.glycoinfo.org/glycan/G60958XB" denotes Glc
GlycanIUPAC_T68 663-666 "http://rdf.glycoinfo.org/glycan/G89925BN" denotes Glc
GlycanIUPAC_T69 663-666 "http://rdf.glycoinfo.org/glycan/G04660BL" denotes Glc
GlycanIUPAC_T70 663-666 "http://rdf.glycoinfo.org/glycan/G57508FI" denotes Glc
GlycanIUPAC_T71 663-666 "http://rdf.glycoinfo.org/glycan/G89416JB" denotes Glc
GlycanIUPAC_T72 663-666 "http://rdf.glycoinfo.org/glycan/G04443UP" denotes Glc
GlycanIUPAC_T73 663-666 "http://rdf.glycoinfo.org/glycan/G18920XE" denotes Glc
GlycanIUPAC_T74 663-666 "http://rdf.glycoinfo.org/glycan/G16975IY" denotes Glc
GlycanIUPAC_T75 663-666 "http://rdf.glycoinfo.org/glycan/G91289IV" denotes Glc
GlycanIUPAC_T76 663-666 "http://rdf.glycoinfo.org/glycan/G80908PK" denotes Glc
GlycanIUPAC_T77 663-666 "http://rdf.glycoinfo.org/glycan/G58337HT" denotes Glc
GlycanIUPAC_T78 663-666 "http://rdf.glycoinfo.org/glycan/G50847CR" denotes Glc
GlycanIUPAC_T79 663-666 "http://rdf.glycoinfo.org/glycan/G58393QV" denotes Glc
GlycanIUPAC_T80 663-666 "http://rdf.glycoinfo.org/glycan/G71104BM" denotes Glc
GlycanIUPAC_T81 663-666 "http://rdf.glycoinfo.org/glycan/G34414DD" denotes Glc
GlycanIUPAC_T82 663-666 "http://rdf.glycoinfo.org/glycan/G23241IB" denotes Glc
GlycanIUPAC_T83 663-666 "http://rdf.glycoinfo.org/glycan/G86119OK" denotes Glc
GlycanIUPAC_T84 663-666 "http://rdf.glycoinfo.org/glycan/G90738SP" denotes Glc
GlycanIUPAC_T85 663-666 "http://rdf.glycoinfo.org/glycan/G79621UL" denotes Glc
GlycanIUPAC_T86 663-666 "http://rdf.glycoinfo.org/glycan/G25287AB" denotes Glc
GlycanIUPAC_T87 663-666 "http://rdf.glycoinfo.org/glycan/G96108DQ" denotes Glc
GlycanIUPAC_T88 663-666 "http://rdf.glycoinfo.org/glycan/G12678RQ" denotes Glc
GlycanIUPAC_T89 663-666 "http://rdf.glycoinfo.org/glycan/G81016FY" denotes Glc
GlycanIUPAC_T90 663-666 "http://rdf.glycoinfo.org/glycan/G60896QE" denotes Glc
GlycanIUPAC_T91 663-666 "http://rdf.glycoinfo.org/glycan/G28328IY" denotes Glc
GlycanIUPAC_T92 663-666 "http://rdf.glycoinfo.org/glycan/G98259SQ" denotes Glc
GlycanIUPAC_T93 663-666 "http://rdf.glycoinfo.org/glycan/G97961JO" denotes Glc
GlycanIUPAC_T94 663-666 "http://rdf.glycoinfo.org/glycan/G06186NU" denotes Glc
GlycanIUPAC_T95 663-666 "http://rdf.glycoinfo.org/glycan/G91012QA" denotes Glc
GlycanIUPAC_T96 663-666 "http://rdf.glycoinfo.org/glycan/G18124QU" denotes Glc
GlycanIUPAC_T97 663-666 "http://rdf.glycoinfo.org/glycan/G77966MT" denotes Glc
GlycanIUPAC_T98 663-666 "http://rdf.glycoinfo.org/glycan/G69065ZM" denotes Glc
GlycanIUPAC_T99 663-666 "http://rdf.glycoinfo.org/glycan/G56543CB" denotes Glc
GlycanIUPAC_T100 663-666 "http://rdf.glycoinfo.org/glycan/G48702OS" denotes Glc
GlycanIUPAC_T101 663-666 "http://rdf.glycoinfo.org/glycan/G49548NQ" denotes Glc
GlycanIUPAC_T102 663-666 "http://rdf.glycoinfo.org/glycan/G42469OA" denotes Glc
GlycanIUPAC_T103 663-666 "http://rdf.glycoinfo.org/glycan/G62090LW" denotes Glc
GlycanIUPAC_T104 663-666 "http://rdf.glycoinfo.org/glycan/G94606VT" denotes Glc
GlycanIUPAC_T105 663-666 "http://rdf.glycoinfo.org/glycan/G96937AI" denotes Glc
GlycanIUPAC_T106 663-666 "http://rdf.glycoinfo.org/glycan/G51498DQ" denotes Glc
GlycanIUPAC_T107 663-666 "http://rdf.glycoinfo.org/glycan/G94744IV" denotes Glc
GlycanIUPAC_T108 663-666 "http://rdf.glycoinfo.org/glycan/G82967ZA" denotes Glc
GlycanIUPAC_T109 821-827 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugars
GlycanIUPAC_T110 821-827 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugars
GlycanIUPAC_T111 821-827 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugars

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 229-240 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1493-1502 Body_part denotes proximity http://purl.obolibrary.org/obo/MAT_0000491

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 25-32 Glycan denotes Lewis a https://api.glycosmos.org/wurcs2image/latest/png/binary/G39023AU

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 25-32 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis a http://www.glycoepitope.jp/epitopes/EP0007
T2 1579-1588 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis (a) http://www.glycoepitope.jp/epitopes/EP0007

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 178-187 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 178-187 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T2 229-240 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1493-1502 Body_part denotes proximity http://purl.obolibrary.org/obo/MAT_0000491

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
TextSentencer_T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
TextSentencer_T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
TextSentencer_T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
TextSentencer_T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
TextSentencer_T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
TextSentencer_T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
TextSentencer_T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
TextSentencer_T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
TextSentencer_T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
TextSentencer_T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
TextSentencer_T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
TextSentencer_T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.
T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.
T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Solution conformation of Lewis a--derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions.
T2 126-241 Sentence denotes The selectins are a family of proteins that mediate leukocyte tethering and rolling along the vascular endothelium.
T3 242-339 Sentence denotes E-, P-, and L-selectin recognize various derivatives of the Lewis(a) and Lewis(x) trisaccharides.
T4 340-491 Sentence denotes The distribution of negative charges on the Lewis(a) and Lewis(x) oligosaccharides appears to be an important factor in their binding by the selectins.
T5 492-720 Sentence denotes Previous work exploring this electrostatic dependence found that a series of synthetic anionic trisaccharides, 3'-sulfo, 3'-phospho, 6'-sulfo, and 3',6'-disulfo Lewis(a)-(Glc), exhibited differing selectin inhibitory efficacies.
T6 721-938 Sentence denotes To explore the possibility that these differences arise from conformational differences between the sugars, the solution structures of these trisaccharides were determined using NMR and molecular dynamics simulations.
T7 939-1092 Sentence denotes Interproton distances and interglycosidic torsion angles were determined at 37 degrees C using NOESY buildup curves and 1D LRJ experiments, respectively.
T8 1093-1219 Sentence denotes Data from both experiments agreed well with predictions made from 2000 picosecond unrestrained molecular dynamics simulations.
T9 1220-1348 Sentence denotes We found that 3'-sulfation did not alter the core Lewis(a) conformation, a finding that reaffirms the results of previous study.
T10 1349-1460 Sentence denotes In addition, we found that sulfation at the 6' position also leaves the trisaccharide conformation unperturbed.
T11 1461-1599 Sentence denotes This is significant because the proximity of the 6'-sulfate group to the fucose ring might have altered the canonical Lewis (a) structure.
T12 1600-1778 Sentence denotes The disulfate exhibited greater flexibility than the other derivatives in dynamics simulations, but not so much as to affect NOE and heteronuclear coupling constant measurements.
T13 1779-1950 Sentence denotes Taken together, our findings support the use of Lewis(a) as a template onto which charged groups may be added without significantly altering the trisaccharide's structure.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 25-32 Glycan denotes Lewis a https://api.glycosmos.org/wurcs2image/latest/png/binary/G39023AU

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 25-32 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis a http://www.glycoepitope.jp/epitopes/EP0007
T2 1579-1588 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis (a) http://www.glycoepitope.jp/epitopes/EP0007

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 178-187 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T2 229-240 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 178-187 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738