> top > docs > PubMed:9143284 > annotations

PubMed:9143284 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 86-127 cell_type denotes persistently infected human T-lymphocytes
T2 169-193 DNA denotes reiterated DNA sequences
T3 201-211 DNA denotes E1a region
T4 226-254 cell_line denotes human T-lymphocyte cell line
T5 256-262 cell_line denotes Molt-4
T6 385-397 protein denotes Endonuclease
T7 520-536 DNA denotes DNA reiterations
T8 558-590 DNA denotes six-base-pair consensus sequence
T9 628-632 DNA denotes exon
T10 640-650 DNA denotes E1a region
T11 749-753 DNA denotes exon
T12 762-781 DNA denotes inserting sequences
T13 854-879 DNA denotes reiterated splicing sites
T14 1244-1248 cell_line denotes HeLa
T15 1250-1254 cell_line denotes A549
T16 1260-1268 cell_line denotes KB cells
T17 1316-1326 cell_line denotes CREF cells
T18 1454-1474 protein denotes early viral proteins
T19 1482-1491 DNA denotes viral DNA
T20 1499-1513 cell_type denotes infected cells
T21 1593-1603 cell_line denotes CREF cells
T22 1618-1634 DNA denotes E1a reiterations

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 65-82 NP denotes type 5 adenovirus
C1 26-82 NP denotes early region 1A reiteration mutants of type 5 adenovirus
C4 140-163 NP denotes type 5 adenovirus (Ad5)
C5 197-211 NP denotes the E1a region
C3 129-211 NP denotes Mutants of type 5 adenovirus (Ad5) with reiterated DNA sequences in the E1a region
C6 224-254 NP denotes a human T-lymphocyte cell line
C7 256-262 NP denotes Molt-4
C8 291-299 NP denotes H5sub304
C10 301-331 NP denotes a deletion/substitution mutant
C11 332-336 NP denotes that
C9 301-383 NP denotes a deletion/substitution mutant that has a wild-type phenotype in viral replication
C12 470-514 NP denotes the four representative mutants investigated
C13 556-590 NP denotes a six-base-pair consensus sequence
C14 592-604 NP denotes G(or C)CTGTG
C16 636-650 NP denotes the E1a region
C15 617-650 NP denotes the second exon of the E1a region
C17 738-753 NP denotes the second exon
C18 883-909 NP denotes the representative mutants
C19 1069-1072 NP denotes Ad5
C20 1191-1220 NP denotes These E1a reiteration mutants
C21 1270-1274 NP denotes they
C22 1304-1308 NP denotes they
C23 1316-1326 NP denotes CREF cells
C24 1593-1603 NP denotes CREF cells
R1 C4 C2 coref-ident type 5 adenovirus (Ad5),type 5 adenovirus
R2 C3 C1 coref-ident Mutants of type 5 adenovirus (Ad5) with reiterated DNA sequences in the E1a region,early region 1A reiteration mutants of type 5 adenovirus
R3 C7 C6 coref-appos Molt-4,a human T-lymphocyte cell line
R4 C11 C10 coref-relat that,a deletion/substitution mutant
R5 C9 C8 coref-appos a deletion/substitution mutant that has a wild-type phenotype in viral replication,H5sub304
R6 C14 C13 coref-appos G(or C)CTGTG,a six-base-pair consensus sequence
R7 C16 C5 coref-ident the E1a region,the E1a region
R8 C17 C15 coref-ident the second exon,the second exon of the E1a region
R9 C18 C12 coref-ident the representative mutants,the four representative mutants investigated
R10 C19 C4 coref-ident Ad5,type 5 adenovirus (Ad5)
R11 C20 C18 coref-ident These E1a reiteration mutants,the representative mutants
R12 C21 C20 coref-pron they,These E1a reiteration mutants
R13 C22 C20 coref-pron they,These E1a reiteration mutants
R14 C24 C23 coref-ident CREF cells,CREF cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-128 Sentence denotes Spontaneous occurrence of early region 1A reiteration mutants of type 5 adenovirus in persistently infected human T-lymphocytes.
S2 129-384 Sentence denotes Mutants of type 5 adenovirus (Ad5) with reiterated DNA sequences in the E1a region appeared in a human T-lymphocyte cell line, Molt-4, persistently infected with H5sub304, a deletion/substitution mutant that has a wild-type phenotype in viral replication.
S3 385-466 Sentence denotes Endonuclease analyses and DNA sequencing revealed DNA reiteration in each mutant.
S4 467-679 Sentence denotes In the four representative mutants investigated, the DNA reiterations all started within a six-base-pair consensus sequence, G(or C)CTGTG, located in the second exon of the E1a region (at nt 1333, 1367, or 1419).
S5 680-816 Sentence denotes There was not any DNA homology between the breakpoints in the second exon and the inserting sequences (starting at nt 532, 710, or 792).
S6 817-1010 Sentence denotes Northern analyses suggested that the reiterated splicing sites of the representative mutants were all used in RNA splicing, and the closest donor and recipient joints were used most frequently.
S7 1011-1190 Sentence denotes These observations imply that during persistent infection Ad5 underwent spontaneous mutations by sequence-specific breakage and nonhomologous end-end joining recombination events.
S8 1191-1358 Sentence denotes These E1a reiteration mutants could be propagated in HeLa, A549, and KB cells; they were genetically stable; and they killed CREF cells at a strikingly high frequency.
S9 1359-1514 Sentence denotes Preliminary observations tend to correlate this CREF cell killing with the accumulation of the early viral proteins and/or viral DNA in the infected cells.
S10 1515-1604 Sentence denotes This degree of cell damage was not observed in Ad5wt or H5sub304 infection of CREF cells.
S11 1605-1869 Sentence denotes The observed E1a reiterations provide a model to gain insight into understanding the evolutionary events of some, if not all, adenovirus types during many years of symbiotic, persistent relationship in human tonsils and adenoids and possibly other lymphoid organs.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-61 virus denotes early region 1A reiteration mutants
T2 65-82 virus denotes type 5 adenovirus
T3 86-127 cell_type denotes persistently infected human T-lymphocytes
T4 140-157 virus denotes type 5 adenovirus
T5 159-162 virus denotes Ad5
T6 169-193 DNA_domain_or_region denotes reiterated DNA sequences
T7 201-211 DNA_domain_or_region denotes E1a region
T8 226-254 cell_line denotes human T-lymphocyte cell line
T9 256-262 cell_line denotes Molt-4
T10 291-299 virus denotes H5sub304
T11 303-331 virus denotes deletion/substitution mutant
T12 343-362 other_name denotes wild-type phenotype
T13 366-383 other_name denotes viral replication
T14 385-397 protein_family_or_group denotes Endonuclease
T15 520-536 DNA_family_or_group denotes DNA reiterations
T16 558-590 DNA_domain_or_region denotes six-base-pair consensus sequence
T17 592-604 polynucleotide denotes G(or C)CTGTG
T18 628-632 DNA_domain_or_region denotes exon
T19 640-650 DNA_domain_or_region denotes E1a region
T20 749-753 DNA_domain_or_region denotes exon
T21 762-781 DNA_domain_or_region denotes inserting sequences
T22 854-879 DNA_domain_or_region denotes reiterated splicing sites
T23 1069-1072 virus denotes Ad5
T24 1139-1189 other_name denotes nonhomologous end-end joining recombination events
T25 1197-1220 virus denotes E1a reiteration mutants
T26 1244-1248 cell_line denotes HeLa
T27 1250-1254 cell_line denotes A549
T28 1260-1268 cell_line denotes KB cells
T29 1316-1326 cell_line denotes CREF cells
T30 1407-1424 other_name denotes CREF cell killing
T31 1454-1474 protein_family_or_group denotes early viral proteins
T32 1482-1491 DNA_domain_or_region denotes viral DNA
T33 1499-1513 cell_type denotes infected cells
T34 1562-1567 virus denotes Ad5wt
T35 1571-1579 virus denotes H5sub304
T36 1593-1603 cell_line denotes CREF cells
T37 1618-1634 DNA_domain_or_region denotes E1a reiterations
T38 1731-1747 virus denotes adenovirus types
T39 1807-1820 body_part denotes human tonsils
T40 1825-1833 body_part denotes adenoids
T41 1853-1868 body_part denotes lymphoid organs