PubMed:9136989
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 18-27 | protein | denotes | IFN-gamma |
| T2 | 36-57 | protein | denotes | HLA class II antigens |
| T3 | 83-95 | protein | denotes | HLA class II |
| T4 | 127-149 | cell_line | denotes | human Raji B cell line |
| T5 | 169-225 | protein | denotes | major histocompatibility complex (MHC) class II antigens |
| T6 | 245-282 | cell_type | denotes | professional antigen presenting cells |
| T7 | 284-288 | cell_type | denotes | APCs |
| T8 | 317-333 | protein | denotes | interferon-gamma |
| T9 | 335-344 | protein | denotes | IFN-gamma |
| T10 | 373-390 | cell_type | denotes | professional APCs |
| T11 | 397-408 | cell_type | denotes | fibroblasts |
| T12 | 462-464 | protein | denotes | IK |
| T13 | 500-509 | protein | denotes | IFN-gamma |
| T14 | 523-544 | protein | denotes | MHC class II antigens |
| T15 | 595-597 | protein | denotes | IK |
| T16 | 601-613 | protein | denotes | MHC class II |
| T17 | 750-767 | RNA | denotes | MHC class II mRNA |
| T18 | 784-807 | DNA | denotes | class II transactivator |
| T19 | 809-814 | DNA | denotes | CIITA |
| T20 | 855-864 | protein | denotes | IFN-gamma |
| T21 | 873-885 | protein | denotes | MHC class II |
| T22 | 914-924 | RNA | denotes | CIITA mRNA |
| T23 | 928-930 | protein | denotes | IK |
| T24 | 988-998 | RNA | denotes | CIITA mRNA |
| T25 | 1064-1074 | protein | denotes | IK protein |
| T26 | 1126-1147 | protein | denotes | MHC class II antigens |
| T27 | 1179-1181 | protein | denotes | IK |
| T28 | 1197-1202 | DNA | denotes | CIITA |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-68 | NP | denotes | Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression |
| C3 | 169-225 | NP | denotes | major histocompatibility complex (MHC) class II antigens |
| C2 | 151-225 | NP | denotes | The expression of major histocompatibility complex (MHC) class II antigens |
| C5 | 442-464 | NP | denotes | a new factor called IK |
| C6 | 465-470 | NP | denotes | which |
| C7 | 523-555 | NP | denotes | MHC class II antigens expression |
| C4 | 442-555 | NP | denotes | a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression |
| C8 | 595-597 | NP | denotes | IK |
| C9 | 601-624 | NP | denotes | MHC class II expression |
| C10 | 650-662 | NP | denotes | this protein |
| C11 | 737-778 | NP | denotes | constitutive MHC class II mRNA expression |
| C12 | 780-815 | NP | denotes | The class II transactivator (CIITA) |
| C13 | 1060-1074 | NP | denotes | the IK protein |
| C15 | 1126-1147 | NP | denotes | MHC class II antigens |
| C14 | 1095-1147 | NP | denotes | the constitutive expression of MHC class II antigens |
| C16 | 1179-1181 | NP | denotes | IK |
| C17 | 1197-1202 | NP | denotes | CIITA |
| R1 | C6 | C5 | coref-relat | which,a new factor called IK |
| R2 | C7 | C2 | coref-ident | MHC class II antigens expression,The expression of major histocompatibility complex (MHC) class II antigens |
| R3 | C4 | C1 | coref-ident | a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression,Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression |
| R4 | C8 | C4 | coref-ident | IK,a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression |
| R5 | C9 | C7 | coref-ident | MHC class II expression,MHC class II antigens expression |
| R6 | C10 | C8 | coref-ident | this protein,IK |
| R7 | C13 | C10 | coref-ident | the IK protein,this protein |
| R8 | C15 | C3 | coref-ident | MHC class II antigens,major histocompatibility complex (MHC) class II antigens |
| R9 | C14 | C11 | coref-ident | the constitutive expression of MHC class II antigens,constitutive MHC class II mRNA expression |
| R10 | C16 | C13 | coref-ident | IK,the IK protein |
| R11 | C17 | C12 | coref-ident | CIITA,The class II transactivator (CIITA) |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-150 | Sentence | denotes | Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line. |
| S2 | 151-410 | Sentence | denotes | The expression of major histocompatibility complex (MHC) class II antigens is constitutive in professional antigen presenting cells (APCs) but can also be induced by interferon-gamma (IFN-gamma) on the majority of the non professional APCs (e.g. fibroblasts). |
| S3 | 411-556 | Sentence | denotes | We have recently characterised a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression. |
| S4 | 557-779 | Sentence | denotes | Here, we demonstrate a novel role for IK in MHC class II expression since over-expression of this protein by stable transfection into human B cells led to a total disappearance of constitutive MHC class II mRNA expression. |
| S5 | 780-898 | Sentence | denotes | The class II transactivator (CIITA) is necessary for both constitutive and IFN-gamma induced MHC class II expressions. |
| S6 | 899-1013 | Sentence | denotes | Examination of CIITA mRNA in IK stably transfected clones revealed a marked reduction of CIITA mRNA transcription. |
| S7 | 1014-1230 | Sentence | denotes | Taken together these results demonstrate that the IK protein plays a key role in the constitutive expression of MHC class II antigens and that inhibition induced by IK is upstream of CIITA in this regulatory pathway. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-17 | other_organic_compound | denotes | Inhibitor (IK) of |
| T2 | 18-27 | protein_molecule | denotes | IFN-gamma |
| T3 | 36-57 | protein_family_or_group | denotes | HLA class II antigens |
| T4 | 83-95 | protein_family_or_group | denotes | HLA class II |
| T5 | 127-149 | cell_line | denotes | human Raji B cell line |
| T6 | 169-225 | protein_family_or_group | denotes | major histocompatibility complex (MHC) class II antigens |
| T7 | 245-282 | cell_type | denotes | professional antigen presenting cells |
| T8 | 284-288 | cell_type | denotes | APCs |
| T9 | 317-333 | protein_molecule | denotes | interferon-gamma |
| T10 | 335-344 | protein_molecule | denotes | IFN-gamma |
| T11 | 373-385 | cell_type | denotes | professional |
| T12 | 386-390 | cell_type | denotes | APCs |
| T13 | 397-408 | cell_type | denotes | fibroblasts |
| T14 | 462-464 | protein_molecule | denotes | IK |
| T15 | 500-509 | protein_molecule | denotes | IFN-gamma |
| T16 | 523-544 | protein_family_or_group | denotes | MHC class II antigens |
| T17 | 595-597 | protein_molecule | denotes | IK |
| T18 | 601-613 | protein_family_or_group | denotes | MHC class II |
| T19 | 737-749 | other_name | denotes | constitutive |
| T20 | 750-767 | RNA_domain_or_region | denotes | MHC class II mRNA |
| T21 | 784-807 | DNA_domain_or_region | denotes | class II transactivator |
| T22 | 809-814 | DNA_domain_or_region | denotes | CIITA |
| T23 | 855-864 | protein_molecule | denotes | IFN-gamma |
| T24 | 873-885 | protein_family_or_group | denotes | MHC class II |
| T25 | 914-919 | DNA_domain_or_region | denotes | CIITA |
| T26 | 928-930 | protein_molecule | denotes | IK |
| T27 | 988-993 | DNA_domain_or_region | denotes | CIITA |
| T28 | 1064-1066 | protein_molecule | denotes | IK |
| T29 | 1126-1147 | protein_family_or_group | denotes | MHC class II antigens |
| T30 | 1179-1181 | protein_molecule | denotes | IK |
| T31 | 1197-1202 | DNA_domain_or_region | denotes | CIITA |
| T32 | 1211-1229 | other_name | denotes | regulatory pathway |