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PubMed:9136080 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 39-98 DNA denotes human myeloid cell nuclear differentiation antigen promoter
T2 125-128 protein denotes Sp1
T3 140-145 protein denotes c-Myb
T4 149-153 protein denotes PU.1
T5 205-250 protein denotes human myeloid nuclear differentiation antigen
T6 252-256 protein denotes MNDA
T7 287-301 cell_type denotes maturing cells
T8 339-348 cell_type denotes monocytes
T9 353-365 cell_type denotes granulocytes
T10 460-464 protein denotes MNDA
T11 535-546 DNA denotes 1-kb region
T12 573-593 DNA denotes 5' flanking sequence
T13 692-708 cell_type denotes expressing cells
T14 724-734 cell_type denotes null cells
T15 776-789 DNA denotes 1-kb fragment
T16 832-836 protein denotes MNDA
T17 836-853 cell_type denotes -expressing cells
T18 859-879 cell_type denotes non-expressing cells
T19 961-979 DNA denotes consensus elements
T20 1042-1061 DNA denotes PU.1 consensus site
T21 1077-1101 DNA denotes transcription start site
T22 1119-1130 DNA denotes c-Myb sites
T23 1207-1223 DNA denotes deletion mutants
T24 1289-1299 DNA denotes -73 to -16
T25 1337-1348 DNA denotes c-Myb sites
T26 1373-1399 DNA denotes core Sp1 consensus element
T27 1401-1407 DNA denotes GC box
T28 1456-1469 DNA denotes 1-kb fragment
T29 1487-1496 DNA denotes PU.1 site
T30 1592-1603 DNA denotes Sp1 element
T31 1608-1632 DNA denotes transcription start site
T32 1646-1655 DNA denotes PU.1 site
T33 1703-1724 DNA denotes Sp1 consensus element
T34 1809-1812 protein denotes Sp1
T35 1847-1861 DNA denotes consensus site
T36 1867-1875 DNA denotes Sp1 site
T37 1901-1928 DNA denotes DNase I hypersensitive site
T38 1973-1982 DNA denotes chromatin
T39 2020-2028 DNA denotes Sp1 site
T40 2084-2120 DNA denotes myelomonocytic lineage specific gene

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 125-128 NP denotes Sp1
C2 201-257 NP denotes The human myeloid nuclear differentiation antigen (MNDA)
C3 460-464 NP denotes MNDA
C6 550-558 NP denotes the gene
C5 533-558 NP denotes A 1-kb region of the gene
C7 559-563 NP denotes that
C4 533-593 NP denotes A 1-kb region of the gene that includes 5' flanking sequence
C8 771-789 NP denotes this 1-kb fragment
C9 938-951 NP denotes This sequence
C11 1067-1101 NP denotes the major transcription start site
C10 1040-1101 NP denotes a PU.1 consensus site near the major transcription start site
C13 1173-1184 NP denotes this region
C12 1106-1184 NP denotes a cluster of c-Myb sites located several hundred bases upstream of this region
C14 1273-1300 NP denotes a short region (-73 to -16)
C15 1301-1305 NP denotes that
C16 1322-1348 NP denotes the cluster of c-Myb sites
C17 1369-1408 NP denotes the core Sp1 consensus element (GC box)
C18 1452-1469 NP denotes the 1-kb fragment
C19 1483-1496 NP denotes the PU.1 site
C20 1588-1603 NP denotes the Sp1 element
C21 1608-1632 NP denotes transcription start site
C22 1642-1655 NP denotes the PU.1 site
C23 1694-1724 NP denotes the core Sp1 consensus element
C24 1751-1759 NP denotes the site
C25 1809-1812 NP denotes Sp1
C26 1843-1861 NP denotes the consensus site
C27 1863-1875 NP denotes The Sp1 site
C28 2017-2028 NP denotes an Sp1 site
C29 2079-2120 NP denotes this myelomonocytic lineage specific gene
R1 C3 C2 coref-ident MNDA,The human myeloid nuclear differentiation antigen (MNDA)
R2 C6 C3 coref-ident the gene,MNDA
R3 C7 C5 coref-relat that,A 1-kb region of the gene
R4 C8 C4 coref-ident this 1-kb fragment,A 1-kb region of the gene that includes 5' flanking sequence
R5 C9 C8 coref-ident This sequence,this 1-kb fragment
R6 C13 C9 coref-ident this region,This sequence
R7 C15 C14 coref-relat that,a short region (-73 to -16)
R8 C16 C12 coref-ident the cluster of c-Myb sites,a cluster of c-Myb sites located several hundred bases upstream of this region
R9 C18 C8 coref-ident the 1-kb fragment,this 1-kb fragment
R10 C19 C10 coref-ident the PU.1 site,a PU.1 consensus site near the major transcription start site
R11 C20 C17 coref-ident the Sp1 element,the core Sp1 consensus element (GC box)
R12 C21 C11 coref-ident transcription start site,the major transcription start site
R13 C22 C19 coref-ident the PU.1 site,the PU.1 site
R14 C23 C17 coref-ident the core Sp1 consensus element,the core Sp1 consensus element (GC box)
R15 C25 C1 coref-ident Sp1,Sp1
R16 C26 C24 coref-ident the consensus site,the site
R17 C28 C27 coref-ident an Sp1 site,The Sp1 site
R18 C29 C6 coref-ident this myelomonocytic lineage specific gene,the gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-200 Sentence denotes Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression.
S2 201-366 Sentence denotes The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes.
S3 367-532 Sentence denotes Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fixed tissues.
S4 533-735 Sentence denotes A 1-kb region of the gene that includes 5' flanking sequence was reported earlier to contain functional promoter activity and was specifically demethylated in expressing cells in contrast to null cells.
S5 736-937 Sentence denotes Further analysis has revealed that this 1-kb fragment promotes higher reporter gene activity in MNDA-expressing cells than non-expressing cells, indicating cell-specific differences in transactivation.
S6 938-1185 Sentence denotes This sequence contains consensus elements consistent with myeloid-specific gene expression, including a PU.1 consensus site near the major transcription start site and a cluster of c-Myb sites located several hundred bases upstream of this region.
S7 1186-1349 Sentence denotes However, analysis of deletion mutants localized nearly all of the promoter activity to a short region (-73 to -16) that did not include the cluster of c-Myb sites.
S8 1350-1470 Sentence denotes A 4-bp mutation of the core Sp1 consensus element (GC box) (-20) reduced overall promoter activity of the 1-kb fragment.
S9 1471-1544 Sentence denotes Mutation of the PU.1 site did not significantly affect promoter activity.
S10 1545-1672 Sentence denotes Only a small region (-35 to +22) including the Sp1 element and transcription start site, but not the PU.1 site was footprinted.
S11 1673-1862 Sentence denotes The 4-bp mutation of the core Sp1 consensus element abolished footprinting at the site and an antibody super-shift reaction showed that Sp1 is one of the factors binding the consensus site.
S12 1863-1929 Sentence denotes The Sp1 site also co-localizes with a DNase I hypersensitive site.
S13 1930-2121 Sentence denotes The results indicate that DNA methylation, chromatin structure, and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 39-98 DNA_domain_or_region denotes human myeloid cell nuclear differentiation antigen promoter
T2 125-128 protein_molecule denotes Sp1
T3 140-145 protein_molecule denotes c-Myb
T4 149-153 protein_molecule denotes PU.1
T5 157-199 other_name denotes myelomonocytic lineage-specific expression
T6 205-250 protein_molecule denotes human myeloid nuclear differentiation antigen
T7 252-256 protein_molecule denotes MNDA
T8 287-301 cell_type denotes maturing cells
T9 309-331 other_name denotes myelomonocytic lineage
T10 339-348 cell_type denotes monocytes
T11 353-365 cell_type denotes granulocytes
T12 367-386 other_name denotes Epitope enhancement
T13 418-426 other_name denotes lineage-
T14 431-456 other_name denotes stage-specific expression
T15 460-464 protein_molecule denotes MNDA
T16 468-479 tissue denotes bone marrow
T17 500-531 tissue denotes paraffin-embedded fixed tissues
T18 535-546 DNA_domain_or_region denotes 1-kb region
T19 573-593 DNA_domain_or_region denotes 5' flanking sequence
T20 626-654 other_name denotes functional promoter activity
T21 692-708 cell_type denotes expressing cells
T22 724-734 cell_type denotes null cells
T23 776-789 DNA_domain_or_region denotes 1-kb fragment
T24 832-836 protein_molecule denotes MNDA
T25 836-853 cell_type denotes -expressing cells
T26 859-879 cell_type denotes non-expressing cells
T27 921-936 other_name denotes transactivation
T28 961-979 DNA_family_or_group denotes consensus elements
T29 996-1028 other_name denotes myeloid-specific gene expression
T30 1042-1061 DNA_domain_or_region denotes PU.1 consensus site
T31 1077-1101 DNA_domain_or_region denotes transcription start site
T32 1119-1130 DNA_domain_or_region denotes c-Myb sites
T33 1207-1223 DNA_family_or_group denotes deletion mutants
T34 1252-1269 other_name denotes promoter activity
T35 1289-1299 DNA_domain_or_region denotes -73 to -16
T36 1337-1348 DNA_domain_or_region denotes c-Myb sites
T37 1373-1399 DNA_domain_or_region denotes core Sp1 consensus element
T38 1401-1407 DNA_domain_or_region denotes GC box
T39 1431-1448 other_name denotes promoter activity
T40 1456-1469 DNA_domain_or_region denotes 1-kb fragment
T41 1487-1496 DNA_domain_or_region denotes PU.1 site
T42 1526-1543 other_name denotes promoter activity
T43 1592-1603 DNA_domain_or_region denotes Sp1 element
T44 1608-1632 DNA_domain_or_region denotes transcription start site
T45 1646-1655 DNA_domain_or_region denotes PU.1 site
T46 1703-1724 DNA_domain_or_region denotes Sp1 consensus element
T47 1767-1796 other_name denotes antibody super-shift reaction
T48 1809-1812 protein_molecule denotes Sp1
T49 1847-1861 DNA_domain_or_region denotes consensus site
T50 1867-1870 protein_molecule denotes Sp1
T51 1901-1928 DNA_domain_or_region denotes DNase I hypersensitive site
T52 1956-1971 other_name denotes DNA methylation
T53 1973-1982 DNA_family_or_group denotes chromatin
T54 1998-2013 other_name denotes transactivation
T55 2020-2023 protein_molecule denotes Sp1
T56 2084-2120 DNA_domain_or_region denotes myelomonocytic lineage specific gene