PubMed:9130477 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	28-36	DNA	denotes	germline
T2	60-93	protein	denotes	B-cell-specific activator protein
T3	95-115	protein	denotes	Germline transcripts
T4	130-139	DNA	denotes	promoters
T5	156-184	DNA	denotes	immunoglobulin switch region
T6	287-296	protein	denotes	cytokines
T7	339-356	DNA	denotes	germline promoter
T8	366-379	DNA	denotes	binding sites
T9	384-417	protein	denotes	B-cell-specific activator protein
T10	419-423	protein	denotes	BSAP
T11	479-518	DNA	denotes	immunoglobulin heavy chain gene cluster
T12	520-524	protein	denotes	BSAP
T13	564-572	DNA	denotes	germline
T14	634-638	protein	denotes	BSAP
T15	701-718	DNA	denotes	germline promoter
T16	722-735	cell_type	denotes	human B cells
T17	761-765	protein	denotes	BSAP
T18	787-791	protein	denotes	IL-4
T19	816-820	protein	denotes	CD40
T20	860-868	DNA	denotes	germline
T21	884-888	protein	denotes	BSAP
T22	909-930	protein	denotes	transcription factors
T23	953-961	DNA	denotes	germline
T24	1082-1085	protein	denotes	IgE

Id	Subject	Object	Predicate	Lexical cue
C2	14-50	NP	denotes	human epsilon germline transcription
C1	0-50	NP	denotes	Regulation of human epsilon germline transcription
C3	60-93	NP	denotes	B-cell-specific activator protein
C4	384-424	NP	denotes	B-cell-specific activator protein (BSAP)
C5	520-524	NP	denotes	BSAP
C6	546-586	NP	denotes	the regulation of germline transcription
C7	634-638	NP	denotes	BSAP
C8	761-765	NP	denotes	BSAP
C9	846-882	NP	denotes	human epsilon germline transcription
C10	884-888	NP	denotes	BSAP
C11	905-930	NP	denotes	the transcription factors
C12	931-935	NP	denotes	that
C13	982-984	NP	denotes	it
C14	1036-1059	NP	denotes	two signalling pathways
C15	1060-1064	NP	denotes	that
R1	C4	C3	coref-ident	B-cell-specific activator protein (BSAP),B-cell-specific activator protein
R2	C5	C4	coref-ident	BSAP,B-cell-specific activator protein (BSAP)
R3	C6	C1	coref-ident	the regulation of germline transcription,Regulation of human epsilon germline transcription
R4	C7	C5	coref-ident	BSAP,BSAP
R5	C8	C7	coref-ident	BSAP,BSAP
R6	C9	C2	coref-ident	human epsilon germline transcription,human epsilon germline transcription
R7	C10	C8	coref-ident	BSAP,BSAP
R8	C12	C11	coref-relat	that,the transcription factors
R9	C13	C10	coref-pron	it,BSAP
R10	C15	C14	coref-relat	that,two signalling pathways

Id	Subject	Object	Predicate	Lexical cue
S1	0-94	Sentence	denotes	Regulation of human epsilon germline transcription: role of B-cell-specific activator protein.
S2	95-276	Sentence	denotes	Germline transcripts initiate from promoters upstream of the immunoglobulin switch region, and are necessary to target the appropriate switch region for recombination and switching.
S3	277-357	Sentence	denotes	Different cytokines activate transcription at the appropriate germline promoter.
S4	358-609	Sentence	denotes	Because binding sites for B-cell-specific activator protein (BSAP) are located upstream of several switch regions in the immunoglobulin heavy chain gene cluster, BSAP might play a role in the regulation of germline transcription and isotype switching.
S5	610-736	Sentence	denotes	We investigated whether BSAP plays a role in the transcriptional regulation of the epsilon germline promoter in human B cells.
S6	737-883	Sentence	denotes	Our results showed that BSAP plays a role in both IL-4-dependent induction and CD40-mediated upregulation of human epsilon germline transcription.
S7	884-1096	Sentence	denotes	BSAP is unique among the transcription factors that regulate epsilon germline expression, because it is B cell specific, and is at the merging point of two signalling pathways that are critical for IgE switching.

Id	Subject	Object	Predicate	Lexical cue
T1	14-27	other_name	denotes	human epsilon
T2	28-36	DNA_domain_or_region	denotes	germline
T3	60-93	protein_molecule	denotes	B-cell-specific activator protein
T4	95-115	protein_family_or_group	denotes	Germline transcripts
T5	130-139	DNA_domain_or_region	denotes	promoters
T6	156-184	DNA_domain_or_region	denotes	immunoglobulin switch region
T7	248-261	other_name	denotes	recombination
T8	287-296	protein_family_or_group	denotes	cytokines
T9	339-356	DNA_domain_or_region	denotes	germline promoter
T10	366-379	DNA_domain_or_region	denotes	binding sites
T11	384-417	protein_molecule	denotes	B-cell-specific activator protein
T12	419-423	protein_molecule	denotes	BSAP
T13	479-518	DNA_domain_or_region	denotes	immunoglobulin heavy chain gene cluster
T14	520-524	protein_molecule	denotes	BSAP
T15	564-572	DNA_domain_or_region	denotes	germline
T16	591-608	other_name	denotes	isotype switching
T17	634-638	protein_molecule	denotes	BSAP
T18	659-685	other_name	denotes	transcriptional regulation
T19	701-718	DNA_domain_or_region	denotes	germline promoter
T20	722-735	cell_type	denotes	human B cells
T21	761-765	protein_molecule	denotes	BSAP
T22	787-791	protein_molecule	denotes	IL-4
T23	816-820	protein_molecule	denotes	CD40
T24	846-859	other_name	denotes	human epsilon
T25	860-868	DNA_domain_or_region	denotes	germline
T26	884-888	protein_molecule	denotes	BSAP
T27	909-930	protein_family_or_group	denotes	transcription factors
T28	945-952	other_name	denotes	epsilon
T29	953-961	DNA_domain_or_region	denotes	germline
T30	1040-1059	other_name	denotes	signalling pathways
T31	1082-1085	protein_family_or_group	denotes	IgE