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PubMed:9129050 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.
T2 82-275 Sentence denotes Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins.
T3 276-510 Sentence denotes Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many of these genes depend on the activation of transcription factors, such as NF-kappaB, for inducible expression.
T4 511-645 Sentence denotes We therefore investigated whether NF-kappaB/Rel proteins are expressed in human neutrophils, as well as their fate on cell activation.
T5 646-877 Sentence denotes We now report that dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel are present in neutrophils and that the greater part of these protein complexes is physically associated with cytoplasmic IkappaB-alpha in resting cells.
T6 878-1277 Sentence denotes Following neutrophil stimulation with proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe) that induce the production of cytokines and chemokines in these cells, NF-kappaB/Rel proteins translocated to nuclear fractions, resulting in a transient induction of NF-kappaB DNA binding activity, as determined in gel mobility shift assays.
T7 1278-1389 Sentence denotes The onset of both processes was found to be closely paralleled by, and dependent on, IkappaB-alpha degradation.
T8 1390-1550 Sentence denotes Proinflammatory neutrophil stimuli also promoted the accumulation of IkappaB-alpha mRNA transcripts, resulting in the reexpression of the IkappaB-alpha protein.
T9 1551-1799 Sentence denotes To our knowledge, this constitutes the first indication that NF-kappaB activation may underlie the action of proinflammatory stimuli towards human neutrophil gene expression and, as such, adds a new facet to our understanding of neutrophil biology.
T1 0-81 Sentence denotes Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.
T2 82-275 Sentence denotes Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins.
T3 276-510 Sentence denotes Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many of these genes depend on the activation of transcription factors, such as NF-kappaB, for inducible expression.
T4 511-645 Sentence denotes We therefore investigated whether NF-kappaB/Rel proteins are expressed in human neutrophils, as well as their fate on cell activation.
T5 646-877 Sentence denotes We now report that dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel are present in neutrophils and that the greater part of these protein complexes is physically associated with cytoplasmic IkappaB-alpha in resting cells.
T6 878-1277 Sentence denotes Following neutrophil stimulation with proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe) that induce the production of cytokines and chemokines in these cells, NF-kappaB/Rel proteins translocated to nuclear fractions, resulting in a transient induction of NF-kappaB DNA binding activity, as determined in gel mobility shift assays.
T7 1278-1389 Sentence denotes The onset of both processes was found to be closely paralleled by, and dependent on, IkappaB-alpha degradation.
T8 1390-1550 Sentence denotes Proinflammatory neutrophil stimuli also promoted the accumulation of IkappaB-alpha mRNA transcripts, resulting in the reexpression of the IkappaB-alpha protein.
T9 1551-1799 Sentence denotes To our knowledge, this constitutes the first indication that NF-kappaB activation may underlie the action of proinflammatory stimuli towards human neutrophil gene expression and, as such, adds a new facet to our understanding of neutrophil biology.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-27 protein denotes NF-kappaB
T2 63-80 cell_type denotes human neutrophils
T3 82-103 cell_type denotes Activated neutrophils
T4 194-203 protein denotes cytokines
T5 208-218 protein denotes chemokines
T6 360-371 cell_type denotes neutrophils
T7 443-464 protein denotes transcription factors
T8 474-483 protein denotes NF-kappaB
T9 545-567 protein denotes NF-kappaB/Rel proteins
T10 585-602 cell_type denotes human neutrophils
T11 686-699 protein denotes p50 NFkappaB1
T12 701-709 protein denotes p65 RelA
T13 718-723 protein denotes c-Rel
T14 739-750 cell_type denotes neutrophils
T15 786-803 protein denotes protein complexes
T16 834-859 protein denotes cytoplasmic IkappaB-alpha
T17 976-1003 protein denotes tumor necrosis factor-alpha
T18 1005-1014 protein denotes TNF-alpha
T19 1065-1074 protein denotes cytokines
T20 1079-1089 protein denotes chemokines
T21 1106-1128 protein denotes NF-kappaB/Rel proteins
T22 1202-1211 protein denotes NF-kappaB
T23 1363-1376 protein denotes IkappaB-alpha
T24 1390-1416 cell_type denotes Proinflammatory neutrophil
T25 1459-1489 RNA denotes IkappaB-alpha mRNA transcripts
T26 1528-1549 protein denotes IkappaB-alpha protein
T27 1612-1621 protein denotes NF-kappaB
T28 1780-1798 cell_type denotes neutrophil biology

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 63-80 NP denotes human neutrophils
C2 153-163 NP denotes many genes
C3 194-203 NP denotes cytokines
C4 208-218 NP denotes chemokines
C5 360-371 NP denotes neutrophils
C6 403-414 NP denotes these genes
C7 545-567 NP denotes NF-kappaB/Rel proteins
C8 585-602 NP denotes human neutrophils
C9 615-620 NP denotes their
C10 665-723 NP denotes dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel
C11 739-750 NP denotes neutrophils
C12 780-803 NP denotes these protein complexes
C13 916-1034 NP denotes proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe)
C14 1035-1039 NP denotes that
C15 1065-1074 NP denotes cytokines
C16 1079-1089 NP denotes chemokines
C17 1093-1104 NP denotes these cells
C18 1106-1128 NP denotes NF-kappaB/Rel proteins
C19 1390-1424 NP denotes Proinflammatory neutrophil stimuli
C20 1586-1606 NP denotes the first indication
C21 1607-1611 NP denotes that
C22 1660-1683 NP denotes proinflammatory stimuli
R1 C6 C2 coref-ident these genes,many genes
R2 C8 C1 coref-ident human neutrophils,human neutrophils
R3 C9 C7 coref-pron their,NF-kappaB/Rel proteins
R4 C11 C5 coref-ident neutrophils,neutrophils
R5 C12 C10 coref-ident these protein complexes,"dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel"
R6 C14 C13 coref-relat that,"proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe)"
R7 C15 C3 coref-ident cytokines,cytokines
R8 C16 C4 coref-ident chemokines,chemokines
R9 C17 C11 coref-ident these cells,neutrophils
R10 C18 C7 coref-ident NF-kappaB/Rel proteins,NF-kappaB/Rel proteins
R11 C21 C20 coref-relat that,the first indication
R12 C22 C19 coref-ident proinflammatory stimuli,Proinflammatory neutrophil stimuli

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-81 Sentence denotes Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.
S2 82-275 Sentence denotes Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins.
S3 276-510 Sentence denotes Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many of these genes depend on the activation of transcription factors, such as NF-kappaB, for inducible expression.
S4 511-645 Sentence denotes We therefore investigated whether NF-kappaB/Rel proteins are expressed in human neutrophils, as well as their fate on cell activation.
S5 646-877 Sentence denotes We now report that dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel are present in neutrophils and that the greater part of these protein complexes is physically associated with cytoplasmic IkappaB-alpha in resting cells.
S6 878-1277 Sentence denotes Following neutrophil stimulation with proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe) that induce the production of cytokines and chemokines in these cells, NF-kappaB/Rel proteins translocated to nuclear fractions, resulting in a transient induction of NF-kappaB DNA binding activity, as determined in gel mobility shift assays.
S7 1278-1389 Sentence denotes The onset of both processes was found to be closely paralleled by, and dependent on, IkappaB-alpha degradation.
S8 1390-1550 Sentence denotes Proinflammatory neutrophil stimuli also promoted the accumulation of IkappaB-alpha mRNA transcripts, resulting in the reexpression of the IkappaB-alpha protein.
S9 1551-1799 Sentence denotes To our knowledge, this constitutes the first indication that NF-kappaB activation may underlie the action of proinflammatory stimuli towards human neutrophil gene expression and, as such, adds a new facet to our understanding of neutrophil biology.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-27 protein_complex denotes NF-kappaB
T2 39-59 other_name denotes inflammatory stimuli
T3 63-80 cell_type denotes human neutrophils
T4 82-103 cell_type denotes Activated neutrophils
T5 194-203 protein_family_or_group denotes cytokines
T6 208-218 protein_family_or_group denotes chemokines
T7 338-356 other_name denotes gene transcription
T8 360-371 cell_type denotes neutrophils
T9 443-464 protein_family_or_group denotes transcription factors
T10 474-483 protein_complex denotes NF-kappaB
T11 545-554 protein_complex denotes NF-kappaB
T12 585-590 cell_type denotes human
T13 591-602 cell_type denotes neutrophils
T14 686-699 protein_molecule denotes p50 NFkappaB1
T15 701-709 protein_subunit denotes p65 RelA
T16 718-723 protein_subunit denotes c-Rel
T17 739-750 cell_type denotes neutrophils
T18 786-803 protein_family_or_group denotes protein complexes
T19 834-859 protein_molecule denotes cytoplasmic IkappaB-alpha
T20 888-910 other_name denotes neutrophil stimulation
T21 916-940 other_name denotes proinflammatory agonists
T22 950-968 lipid denotes lipopolysaccharide
T23 970-973 lipid denotes LPS
T24 976-1003 protein_molecule denotes tumor necrosis factor-alpha
T25 1005-1014 protein_molecule denotes TNF-alpha
T26 1021-1033 peptide denotes fMet-Leu-Phe
T27 1065-1074 protein_family_or_group denotes cytokines
T28 1079-1089 protein_family_or_group denotes chemokines
T29 1106-1115 protein_complex denotes NF-kappaB
T30 1145-1162 cell_component denotes nuclear fractions
T31 1202-1211 protein_complex denotes NF-kappaB
T32 1251-1276 other_name denotes gel mobility shift assays
T33 1363-1376 protein_molecule denotes IkappaB-alpha
T34 1390-1416 cell_type denotes Proinflammatory neutrophil
T35 1459-1489 RNA_molecule denotes IkappaB-alpha mRNA transcripts
T36 1528-1549 protein_molecule denotes IkappaB-alpha protein
T37 1612-1621 protein_complex denotes NF-kappaB
T38 1660-1683 other_name denotes proinflammatory stimuli
T39 1692-1724 other_name denotes human neutrophil gene expression
T40 1780-1798 cell_type denotes neutrophil biology