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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 50-61 protein denotes Erk2 kinase
T2 76-100 cell_line denotes Lck-negative JCaM1 cells
T3 104-107 protein denotes Syk
T4 125-149 protein denotes protein-tyrosine kinases
T5 150-153 protein denotes Syk
T6 158-161 protein denotes Zap
T7 263-286 protein denotes T cell antigen receptor
T8 339-342 protein denotes Syk
T9 368-385 protein denotes Src family kinase
T10 386-389 protein denotes Lck
T11 413-416 protein denotes Zap
T12 456-459 protein denotes Syk
T13 467-491 cell_line denotes Lck-negative JCaM1 cells
T14 504-539 protein denotes T cell antigen receptor/CD3 complex
T15 577-609 protein denotes mitogen-activated protein kinase
T16 611-615 protein denotes MAPK
T17 645-680 protein denotes nuclear factor of activated T cells
T18 714-717 protein denotes Zap
T19 728-752 protein denotes protein-tyrosine kinases
T20 854-857 protein denotes Syk
T21 896-899 protein denotes Zap
T22 913-916 protein denotes Syk
T23 926-949 protein denotes T cell antigen receptor
T24 958-962 protein denotes MAPK
T25 1065-1068 protein denotes Syk
T26 1089-1093 protein denotes MAPK
T27 1138-1141 protein denotes Syk
T28 1153-1177 protein denotes autophosphorylation site
T29 1200-1222 protein denotes Src homology 2 domains
T30 1249-1303 protein denotes inhibitory N17-mutated dominant-negative Ras construct
T31 1314-1322 protein denotes F mutant
T32 1326-1329 protein denotes Syk
T33 1374-1391 protein denotes phospholipase Cy1
T34 1396-1399 protein denotes Vav
T35 1425-1438 protein denotes wild-type Syk
T36 1465-1468 protein denotes Syk
T37 1485-1488 protein denotes Zap
T38 1521-1544 protein denotes T cell antigen receptor
T39 1562-1565 protein denotes Lck

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 76-100 NP denotes Lck-negative JCaM1 cells
C2 104-107 NP denotes Syk
C3 259-286 NP denotes the T cell antigen receptor
C4 339-342 NP denotes Syk
C5 364-389 NP denotes the Src family kinase Lck
C6 413-416 NP denotes Zap
C7 456-459 NP denotes Syk
C8 463-491 NP denotes the Lck-negative JCaM1 cells
C9 714-717 NP denotes Zap
C10 854-857 NP denotes Syk
C11 896-899 NP denotes Zap
C13 1065-1068 NP denotes Syk
C12 1049-1102 NP denotes The capacity of Syk to reconstitute the MAPK response
C14 1138-1141 NP denotes Syk
C15 1227-1229 NP denotes it
C17 1326-1329 NP denotes Syk
C16 1305-1329 NP denotes A Y341-->F mutant of Syk
C18 1331-1336 NP denotes which
C19 1353-1356 NP denotes its
C20 1465-1468 NP denotes Syk
C21 1485-1488 NP denotes Zap
C22 1517-1544 NP denotes the T cell antigen receptor
C23 1562-1565 NP denotes Lck
R1 C4 C2 coref-ident Syk,Syk
R2 C7 C4 coref-ident Syk,Syk
R3 C8 C1 coref-ident the Lck-negative JCaM1 cells,Lck-negative JCaM1 cells
R4 C9 C6 coref-ident Zap,Zap
R5 C10 C7 coref-ident Syk,Syk
R6 C11 C9 coref-ident Zap,Zap
R7 C13 C10 coref-ident Syk,Syk
R8 C14 C13 coref-ident Syk,Syk
R9 C15 C12 coref-pron it,The capacity of Syk to reconstitute the MAPK response
R10 C17 C14 coref-ident Syk,Syk
R11 C18 C16 coref-relat which,A Y341-->F mutant of Syk
R12 C19 C16 coref-pron its,A Y341-->F mutant of Syk
R13 C20 C17 coref-ident Syk,Syk
R14 C21 C11 coref-ident Zap,Zap
R15 C22 C3 coref-ident the T cell antigen receptor,the T cell antigen receptor
R16 C23 C5 coref-ident Lck,the Src family kinase Lck

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-108 Sentence denotes Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk.
S2 109-287 Sentence denotes The two related protein-tyrosine kinases Syk and Zap are rapidly phosphorylated on tyrosine residues and enzymatically activated upon crosslinking of the T cell antigen receptor.
S3 288-417 Sentence denotes We have previously reported that the activation of Syk is less dependent on the Src family kinase Lck than the activation of Zap.
S4 418-700 Sentence denotes Here we report that overexpression of Syk in the Lck-negative JCaM1 cells enabled the T cell antigen receptor/CD3 complex to induce a normal activation of the mitogen-activated protein kinase (MAPK) pathway and expression of a nuclear factor of activated T cells reporter construct.
S5 701-840 Sentence denotes In contrast, Zap and other protein-tyrosine kinases were unable to reconstitute these signaling pathways when expressed at the same levels.
S6 841-908 Sentence denotes In parallel, Syk was phosphorylated on tyrosine, while Zap was not.
S7 909-1048 Sentence denotes The Syk-mediated T cell antigen receptor-induced MAPK activation was detectable within 1 min of receptor stimulation and peaked at 3-5 min.
S8 1049-1304 Sentence denotes The capacity of Syk to reconstitute the MAPK response required the catalytic activity of Syk, an intact autophosphorylation site (Y518 and Y519), both Src homology 2 domains and it was blocked by the inhibitory N17-mutated dominant-negative Ras construct.
S9 1305-1439 Sentence denotes A Y341-->F mutant of Syk, which is deficient in its interaction with phospholipase Cy1 and Vav, was less efficient than wild-type Syk.
S10 1440-1566 Sentence denotes Our results suggest that Syk, in contrast to Zap, can transduce signals from the T cell antigen receptor independently of Lck.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 other_name denotes Reconstitution
T2 18-49 other_name denotes T cell antigen receptor-induced
T3 50-61 protein_molecule denotes Erk2 kinase
T4 76-100 cell_line denotes Lck-negative JCaM1 cells
T5 104-107 protein_molecule denotes Syk
T6 125-133 protein_family_or_group denotes protein-
T7 133-141 amino_acid_monomer denotes tyrosine
T8 150-153 protein_molecule denotes Syk
T9 158-161 protein_molecule denotes Zap
T10 192-200 amino_acid_monomer denotes tyrosine
T11 263-286 protein_family_or_group denotes T cell antigen receptor
T12 339-342 protein_molecule denotes Syk
T13 368-385 protein_family_or_group denotes Src family kinase
T14 386-389 protein_molecule denotes Lck
T15 413-416 protein_molecule denotes Zap
T16 456-459 protein_molecule denotes Syk
T17 467-470 protein_molecule denotes Lck
T18 504-527 protein_family_or_group denotes T cell antigen receptor
T19 577-609 protein_family_or_group denotes mitogen-activated protein kinase
T20 611-615 protein_family_or_group denotes MAPK
T21 645-672 protein_molecule denotes nuclear factor of activated
T22 673-680 cell_type denotes T cells
T23 714-717 protein_molecule denotes Zap
T24 728-736 protein_family_or_group denotes protein-
T25 736-744 amino_acid_monomer denotes tyrosine
T26 787-805 other_name denotes signaling pathways
T27 854-857 protein_molecule denotes Syk
T28 880-888 amino_acid_monomer denotes tyrosine
T29 896-899 protein_molecule denotes Zap
T30 913-916 protein_molecule denotes Syk
T31 926-949 protein_family_or_group denotes T cell antigen receptor
T32 958-962 protein_family_or_group denotes MAPK
T33 1005-1025 other_name denotes receptor stimulation
T34 1065-1068 protein_molecule denotes Syk
T35 1089-1093 protein_family_or_group denotes MAPK
T36 1138-1141 protein_molecule denotes Syk
T37 1153-1177 protein_domain_or_region denotes autophosphorylation site
T38 1179-1183 amino_acid_monomer denotes Y518
T39 1188-1192 amino_acid_monomer denotes Y519
T40 1200-1222 protein_domain_or_region denotes Src homology 2 domains
T41 1249-1303 protein_molecule denotes inhibitory N17-mutated dominant-negative Ras construct
T42 1307-1311 amino_acid_monomer denotes Y341
T43 1314-1322 protein_molecule denotes F mutant
T44 1326-1329 protein_molecule denotes Syk
T45 1374-1391 protein_molecule denotes phospholipase Cy1
T46 1396-1399 protein_molecule denotes Vav
T47 1425-1434 protein_molecule denotes wild-type
T48 1435-1438 protein_molecule denotes Syk
T49 1465-1468 protein_molecule denotes Syk
T50 1485-1488 protein_molecule denotes Zap
T51 1521-1544 protein_family_or_group denotes T cell antigen receptor
T52 1562-1565 protein_molecule denotes Lck