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PubMed:9121455 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 11-17 protein denotes NFATx1
T2 45-84 protein denotes calcineurin-regulated inhibitory domain
T3 90-125 protein denotes nuclear factor of activated T cells
T4 127-131 protein denotes NFAT
T5 143-156 DNA denotes cytokine gene
T6 171-178 cell_type denotes T cells
T7 187-206 DNA denotes cis-acting elements
T8 222-231 DNA denotes promoters
T9 243-257 DNA denotes cytokine genes
T10 259-265 protein denotes NFATx1
T11 319-346 cell_type denotes peripheral blood leukocytes
T12 378-389 protein denotes NFAT family
T13 393-414 protein denotes transcription factors
T14 453-459 protein denotes NFATx1
T15 522-528 protein denotes NFATx1
T16 611-640 protein denotes central Rel similarity region
T17 716-733 protein denotes N-terminal domain
T18 741-758 protein denotes C-terminal domain
T19 787-830 protein denotes intrinsic transcriptional activation motifs
T20 876-895 protein denotes inhibitory sequence
T21 907-924 protein denotes N-terminal domain
T22 1007-1018 protein denotes calcineurin
T23 1022-1062 protein denotes calcium-calmodulin-dependent phosphatase
T24 1082-1093 protein denotes calcineurin
T25 1114-1131 protein denotes N-terminal domain
T26 1135-1141 protein denotes NFATx1
T27 1145-1167 protein denotes multiple docking sites
T28 1236-1242 protein denotes NFATx1
T29 1296-1307 protein denotes 60 residues
T30 1353-1366 protein denotes NFAT proteins
T31 1409-1415 protein denotes NFATx1
T32 1430-1441 protein denotes 60 residues
T33 1560-1577 protein denotes N-terminal domain
T34 1618-1624 protein denotes NFATx1
T35 1741-1752 protein denotes calcineurin
T36 1776-1787 protein denotes phosphatase

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 11-39 NP denotes NFATx1 nuclear translocation
C2 259-265 NP denotes NFATx1
C3 267-272 NP denotes which
C4 453-459 NP denotes NFATx1
C5 607-610 NP denotes its
C7 712-715 NP denotes its
C6 712-733 NP denotes its N-terminal domain
C8 737-740 NP denotes its
C10 903-906 NP denotes its
C9 903-924 NP denotes its N-terminal domain
C11 1007-1018 NP denotes calcineurin
C12 1020-1062 NP denotes a calcium-calmodulin-dependent phosphatase
C13 1082-1093 NP denotes calcineurin
C15 1135-1141 NP denotes NFATx1
C14 1110-1141 NP denotes the N-terminal domain of NFATx1
C16 1236-1242 NP denotes NFATx1
C17 1320-1326 NP denotes motifs
C18 1327-1331 NP denotes that
C19 1409-1415 NP denotes NFATx1
C21 1451-1454 NP denotes its
C20 1451-1476 NP denotes its nuclear translocation
C22 1556-1577 NP denotes the N-terminal domain
C23 1664-1667 NP denotes its
C24 1703-1719 NP denotes a protein module
C25 1720-1724 NP denotes that
C26 1741-1752 NP denotes calcineurin
C27 1772-1775 NP denotes its
R1 C3 C2 coref-relat which,NFATx1
R2 C4 C2 coref-ident NFATx1,NFATx1
R3 C5 C4 coref-pron its,NFATx1
R4 C7 C4 coref-pron its,NFATx1
R5 C8 C4 coref-pron its,NFATx1
R6 C10 C4 coref-pron its,NFATx1
R7 C9 C6 coref-ident its N-terminal domain,its N-terminal domain
R8 C12 C11 coref-appos a calcium-calmodulin-dependent phosphatase,calcineurin
R9 C13 C11 coref-ident calcineurin,calcineurin
R10 C15 C4 coref-ident NFATx1,NFATx1
R11 C14 C9 coref-ident the N-terminal domain of NFATx1,its N-terminal domain
R12 C16 C15 coref-ident NFATx1,NFATx1
R13 C18 C17 coref-relat that,motifs
R14 C19 C16 coref-ident NFATx1,NFATx1
R15 C21 C19 coref-pron its,NFATx1
R16 C20 C1 coref-ident its nuclear translocation,NFATx1 nuclear translocation
R17 C22 C14 coref-ident the N-terminal domain,the N-terminal domain of NFATx1
R18 C23 C19 coref-pron its,NFATx1
R19 C25 C24 coref-relat that,a protein module
R20 C26 C13 coref-ident calcineurin,calcineurin
R21 C27 C19 coref-pron its,NFATx1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-85 Sentence denotes Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain.
S2 86-258 Sentence denotes The nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of several cytokine genes.
S3 259-415 Sentence denotes NFATx1, which is preferentially expressed in the thymus and peripheral blood leukocytes, is one of four members of the NFAT family of transcription factors.
S4 416-507 Sentence denotes We have performed domain analysis of NFATx1 by examining the effects of deletion mutations.
S5 508-847 Sentence denotes We found that NFATx1 DNA binding activity and interaction with AP-1 polypeptides were dependent on its central Rel similarity region and that transcriptional activation was reduced by deletions of either its N-terminal domain or its C-terminal domain, suggesting the presence of intrinsic transcriptional activation motifs in both regions.
S6 848-925 Sentence denotes We also identified a potent inhibitory sequence within its N-terminal domain.
S7 926-1063 Sentence denotes We show that the inactivation of the inhibition was dependent on the activity of calcineurin, a calcium-calmodulin-dependent phosphatase.
S8 1064-1243 Sentence denotes We also show that calcineurin associated with the N-terminal domain of NFATx1 at multiple docking sites and caused a reduction of size, indicative of dephosphorylation, in NFATx1.
S9 1244-1367 Sentence denotes We have mapped the inhibitory activity to less than 60 residues, containing motifs that are conserved in all NFAT proteins.
S10 1368-1510 Sentence denotes Finally, we demonstrate that deletion in NFATx1 of the mapped 60 residues leads to its nuclear translocation independent of calcium signaling.
S11 1511-1797 Sentence denotes Our results support the model proposing that the N-terminal domain confers calcium-signaling dependence on NFATx1 transactivation activity by regulating its intracellular localization through a protein module that associates with calcineurin and is a target of its phosphatase activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 11-17 protein_molecule denotes NFATx1
T2 45-56 protein_molecule denotes calcineurin
T3 90-125 protein_family_or_group denotes nuclear factor of activated T cells
T4 127-131 protein_family_or_group denotes NFAT
T5 143-156 DNA_family_or_group denotes cytokine gene
T6 171-178 cell_type denotes T cells
T7 187-206 DNA_family_or_group denotes cis-acting elements
T8 222-231 DNA_family_or_group denotes promoters
T9 243-257 DNA_family_or_group denotes cytokine genes
T10 259-265 protein_molecule denotes NFATx1
T11 319-346 cell_type denotes peripheral blood leukocytes
T12 378-382 protein_family_or_group denotes NFAT
T13 393-414 protein_family_or_group denotes transcription factors
T14 434-449 other_name denotes domain analysis
T15 453-459 protein_molecule denotes NFATx1
T16 488-506 other_name denotes deletion mutations
T17 522-528 protein_molecule denotes NFATx1
T18 571-588 peptide denotes AP-1 polypeptides
T19 611-640 protein_domain_or_region denotes central Rel similarity region
T20 650-676 other_name denotes transcriptional activation
T21 716-733 protein_domain_or_region denotes N-terminal domain
T22 741-758 protein_domain_or_region denotes C-terminal domain
T23 797-823 other_name denotes transcriptional activation
T24 876-895 protein_domain_or_region denotes inhibitory sequence
T25 907-924 protein_domain_or_region denotes N-terminal domain
T26 1007-1018 protein_molecule denotes calcineurin
T27 1022-1062 protein_family_or_group denotes calcium-calmodulin-dependent phosphatase
T28 1082-1093 protein_molecule denotes calcineurin
T29 1114-1131 protein_domain_or_region denotes N-terminal domain
T30 1135-1141 protein_molecule denotes NFATx1
T31 1145-1167 protein_domain_or_region denotes multiple docking sites
T32 1214-1231 other_name denotes dephosphorylation
T33 1236-1242 protein_molecule denotes NFATx1
T34 1296-1307 protein_domain_or_region denotes 60 residues
T35 1353-1366 protein_family_or_group denotes NFAT proteins
T36 1409-1415 protein_molecule denotes NFATx1
T37 1430-1441 protein_domain_or_region denotes 60 residues
T38 1492-1499 atom denotes calcium
T39 1560-1577 protein_domain_or_region denotes N-terminal domain
T40 1586-1593 atom denotes calcium
T41 1618-1624 protein_molecule denotes NFATx1
T42 1668-1694 other_name denotes intracellular localization
T43 1741-1752 protein_molecule denotes calcineurin
T44 1776-1787 protein_family_or_group denotes phosphatase