PubMed:9119908 JSONTXT

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":73},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":74,"end":175},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":176,"end":364},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":365,"end":423},"obj":"DRI_Challenge"},{"id":"T5","span":{"begin":424,"end":454},"obj":"Token_Label.OUTSIDE"},{"id":"T6","span":{"begin":455,"end":522},"obj":"DRI_Challenge"},{"id":"T7","span":{"begin":523,"end":611},"obj":"DRI_Background"},{"id":"T8","span":{"begin":612,"end":797},"obj":"DRI_Background"},{"id":"T9","span":{"begin":798,"end":938},"obj":"DRI_Outcome"}],"text":"Deep prepiriform cortex modulates neuronal cell death in global ischemia.\nDeep prepiriform cortex has an important role in modulating neurotransmission during limbic seizures. We used pharmacologic blockade of non-N-methyl-D-aspartate (NMDA) receptors to study excitatory circuitry from the deep prepiriform cortex to the hippocampus during global ischemia in rat. NBQX, a potent non-NMDA glutamate receptor antagonist, was microinjected stereotactically into the deep prepiriform cortex before global ischemia for 10 min. Neuronal cell death in the hippocampus was evaluated quantitatively 72 h after ischemia. The NBQX-injected rats had a greater number of surviving cells in CA1 sector of hippocampus than did saline-injected controls or rats that received NBQX injections 1 mm from the target. Thus, excitatory amino acid-mediated circuitry emanating from deep prepiriform cortex modulates ischemic neuronal injury in the hippocampus."}