PubMed:9118226 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":47,"end":64},"obj":"Cell"},{"id":"T2","span":{"begin":58,"end":64},"obj":"Cell"},{"id":"T3","span":{"begin":119,"end":136},"obj":"Cell"},{"id":"T4","span":{"begin":130,"end":136},"obj":"Cell"},{"id":"T5","span":{"begin":316,"end":323},"obj":"Cell"},{"id":"T6","span":{"begin":410,"end":428},"obj":"Cell"},{"id":"T7","span":{"begin":437,"end":454},"obj":"Cell"},{"id":"T8","span":{"begin":504,"end":521},"obj":"Cell"},{"id":"T9","span":{"begin":515,"end":521},"obj":"Cell"},{"id":"T10","span":{"begin":536,"end":552},"obj":"Cell"},{"id":"T11","span":{"begin":546,"end":552},"obj":"Cell"},{"id":"T12","span":{"begin":644,"end":654},"obj":"Cell"},{"id":"T13","span":{"begin":723,"end":739},"obj":"Cell"},{"id":"T14","span":{"begin":733,"end":739},"obj":"Cell"},{"id":"T15","span":{"begin":811,"end":817},"obj":"Cell"},{"id":"T16","span":{"begin":866,"end":883},"obj":"Cell"},{"id":"T17","span":{"begin":877,"end":883},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000798"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000798"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000798"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000789"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000798"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000789"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A12","pred":"cl_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL:0000893"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000789"},{"id":"A14","pred":"cl_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A15","pred":"cl_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A16","pred":"cl_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CL:0000798"},{"id":"A17","pred":"cl_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL:0000084"}],"text":"Notch activity influences the alphabeta versus gammadelta T cell lineage decision.\nThe choice between the alphabeta or gammadelta T cell fates is influenced by the production of functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage choice is not known. Here, we show that T cells that are heterozygous for a mutation of the Notch1 gene are more likely to develop as gammadelta T cells than as alphabeta T cells, implying that reduced Notch activity favors the gammadelta T cell fate over the alphabeta T cell fate. A constitutively activated form of Notch produces a reciprocal phenotype and induces thymocytes that have functional gammadeltaTCR gene rearrangements to adopt the alphabeta T cell fate. Our data indicate that Notch acts together with the newly formed T cell antigen receptor to direct the alphabeta versus gammadelta T cell lineage decision."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":58,"end":64},"obj":"Body_part"},{"id":"T2","span":{"begin":130,"end":136},"obj":"Body_part"},{"id":"T3","span":{"begin":515,"end":521},"obj":"Body_part"},{"id":"T4","span":{"begin":546,"end":552},"obj":"Body_part"},{"id":"T5","span":{"begin":644,"end":654},"obj":"Body_part"},{"id":"T6","span":{"begin":733,"end":739},"obj":"Body_part"},{"id":"T7","span":{"begin":811,"end":817},"obj":"Body_part"},{"id":"T8","span":{"begin":877,"end":883},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000893"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Notch activity influences the alphabeta versus gammadelta T cell lineage decision.\nThe choice between the alphabeta or gammadelta T cell fates is influenced by the production of functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage choice is not known. Here, we show that T cells that are heterozygous for a mutation of the Notch1 gene are more likely to develop as gammadelta T cells than as alphabeta T cells, implying that reduced Notch activity favors the gammadelta T cell fate over the alphabeta T cell fate. A constitutively activated form of Notch produces a reciprocal phenotype and induces thymocytes that have functional gammadeltaTCR gene rearrangements to adopt the alphabeta T cell fate. Our data indicate that Notch acts together with the newly formed T cell antigen receptor to direct the alphabeta versus gammadelta T cell lineage decision."}