PubMed:9111141 JSON TXT

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GlyCosmos6-Glycan-Motif-Image

GlyCosmos6-Glycan-Motif-Structure

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":135,"end":141},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T2","span":{"begin":150,"end":156},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T3","span":{"begin":759,"end":765},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T4","span":{"begin":988,"end":994},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T5","span":{"begin":1006,"end":1012},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T6","span":{"begin":1215,"end":1226},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T7","span":{"begin":1257,"end":1263},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T8","span":{"begin":1275,"end":1281},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T9","span":{"begin":1302,"end":1325},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T10","span":{"begin":1302,"end":1325},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T11","span":{"begin":1381,"end":1387},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T12","span":{"begin":1658,"end":1664},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T13","span":{"begin":1876,"end":1882},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"},{"id":"T14","span":{"begin":2139,"end":2145},"obj":"https://glytoucan.org/Structures/Glycans/G03277YI"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

Glycosmos6-MAT

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"http://purl.obolibrary.org/obo/MAT_0000085"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

sentences

mondo_disease

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":615,"end":620},"obj":"Disease"},{"id":"T2","span":{"begin":849,"end":854},"obj":"Disease"},{"id":"T3","span":{"begin":1757,"end":1762},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0011636"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0011636"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0011636"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

Anatomy-MAT

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000085"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-Glycan

Glycan-GlyCosmos

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":143,"end":149},"obj":"Glycan"},{"id":"T2","span":{"begin":999,"end":1005},"obj":"Glycan"},{"id":"T3","span":{"begin":1268,"end":1274},"obj":"Glycan"},{"id":"T4","span":{"begin":1374,"end":1380},"obj":"Glycan"},{"id":"T5","span":{"begin":1651,"end":1657},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A6","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A7","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A8","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A9","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"},{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A10","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-CL

{"project":"GlyCosmos15-CL","denotations":[{"id":"T1","span":{"begin":58,"end":70},"obj":"Cell"},{"id":"T2","span":{"begin":233,"end":245},"obj":"Cell"},{"id":"T3","span":{"begin":485,"end":497},"obj":"Cell"},{"id":"T4","span":{"begin":923,"end":935},"obj":"Cell"},{"id":"T5","span":{"begin":1995,"end":2006},"obj":"Cell"},{"id":"T6","span":{"begin":2194,"end":2200},"obj":"Cell"},{"id":"T7","span":{"begin":2216,"end":2225},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000738"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-UBERON

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":1603,"end":1618},"obj":"Body_part"},{"id":"T3","span":{"begin":2194,"end":2200},"obj":"Body_part"},{"id":"T4","span":{"begin":2216,"end":2225},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001744"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000738"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-Taxon

{"project":"GlyCosmos15-Taxon","denotations":[{"id":"T1","span":{"begin":103,"end":108},"obj":"Organism"},{"id":"T3","span":{"begin":262,"end":266},"obj":"Organism"},{"id":"T4","span":{"begin":545,"end":550},"obj":"Organism"},{"id":"T6","span":{"begin":1775,"end":1779},"obj":"Organism"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10088"},{"id":"A2","pred":"db_id","subj":"T1","obj":"10090"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"id":"A4","pred":"db_id","subj":"T4","obj":"10088"},{"id":"A5","pred":"db_id","subj":"T4","obj":"10090"},{"id":"A6","pred":"db_id","subj":"T6","obj":"10088"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-Sentences

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T2","span":{"begin":118,"end":267},"obj":"Sentence"},{"id":"T3","span":{"begin":268,"end":341},"obj":"Sentence"},{"id":"T4","span":{"begin":342,"end":559},"obj":"Sentence"},{"id":"T5","span":{"begin":560,"end":699},"obj":"Sentence"},{"id":"T6","span":{"begin":700,"end":831},"obj":"Sentence"},{"id":"T7","span":{"begin":832,"end":970},"obj":"Sentence"},{"id":"T8","span":{"begin":971,"end":1203},"obj":"Sentence"},{"id":"T9","span":{"begin":1204,"end":1494},"obj":"Sentence"},{"id":"T10","span":{"begin":1495,"end":1714},"obj":"Sentence"},{"id":"T11","span":{"begin":1715,"end":1780},"obj":"Sentence"},{"id":"T12","span":{"begin":1781,"end":1859},"obj":"Sentence"},{"id":"T13","span":{"begin":1860,"end":1954},"obj":"Sentence"},{"id":"T14","span":{"begin":1955,"end":2245},"obj":"Sentence"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-Lectin-Jamboree

{"project":"GlyCosmos15-Lectin-Jamboree","denotations":[{"id":"T1","span":{"begin":615,"end":618},"obj":"Lectin"},{"id":"T2","span":{"begin":849,"end":852},"obj":"Lectin"},{"id":"T3","span":{"begin":1757,"end":1760},"obj":"Lectin"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"GL_004263"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"GL_004263"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"GL_004263"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-FMA

{"project":"GlyCosmos15-FMA","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":56,"end":70},"obj":"Body_part"},{"id":"T3","span":{"begin":231,"end":245},"obj":"Body_part"},{"id":"T4","span":{"begin":483,"end":497},"obj":"Body_part"},{"id":"T5","span":{"begin":921,"end":935},"obj":"Body_part"},{"id":"T6","span":{"begin":1603,"end":1618},"obj":"Body_part"},{"id":"T7","span":{"begin":1993,"end":2006},"obj":"Body_part"},{"id":"T8","span":{"begin":2216,"end":2225},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"FMA:7196"},{"id":"A2","pred":"db_id","subj":"T2","obj":"FMA:83032"},{"id":"A3","pred":"db_id","subj":"T3","obj":"FMA:83032"},{"id":"A4","pred":"db_id","subj":"T4","obj":"FMA:83032"},{"id":"A5","pred":"db_id","subj":"T5","obj":"FMA:83032"},{"id":"A6","pred":"db_id","subj":"T6","obj":"FMA:55220"},{"id":"A7","pred":"db_id","subj":"T7","obj":"FMA:83032"},{"id":"A8","pred":"db_id","subj":"T8","obj":"FMA:62852"}],"namespaces":[{"prefix":"FMA","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

GlyCosmos15-MAT

{"project":"GlyCosmos15-MAT","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000085"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

NCBITAXON

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":103,"end":108},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":262,"end":266},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":545,"end":550},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1775,"end":1779},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10088"},{"id":"A2","pred":"db_id","subj":"T1","obj":"10090"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"id":"A4","pred":"db_id","subj":"T4","obj":"10088"},{"id":"A5","pred":"db_id","subj":"T4","obj":"10090"},{"id":"A6","pred":"db_id","subj":"T6","obj":"10088"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

Anatomy-UBERON

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":49,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":1603,"end":1618},"obj":"Body_part"},{"id":"T3","span":{"begin":2194,"end":2200},"obj":"Body_part"},{"id":"T4","span":{"begin":2216,"end":2225},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001744"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000738"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}

CL-cell

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":58,"end":70},"obj":"Cell"},{"id":"T2","span":{"begin":233,"end":245},"obj":"Cell"},{"id":"T3","span":{"begin":485,"end":497},"obj":"Cell"},{"id":"T4","span":{"begin":923,"end":935},"obj":"Cell"},{"id":"T5","span":{"begin":1995,"end":2006},"obj":"Cell"},{"id":"T6","span":{"begin":2194,"end":2200},"obj":"Cell"},{"id":"T7","span":{"begin":2216,"end":2225},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0017005"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000738"}],"text":"Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.\nThe gangliosides G(M1b), GalNAc-G(M1b) and G(D1alpha) are typical compounds of concanavalin A stimulated splenic T lymphoblasts of CBA/J inbred mice. Their structural characterization has been described in previous studies. The intention of this work was the comparative TLC immunostaining analysis of the glycosphingolipid composition of lectin stimulated splenic T lymphoblasts obtained from six genetically different inbred mouse strains. The strains examined were AKR, BALB/c, C57BL/6, CBA/J, DBA/2 and WHT/Ht, which are commonly used for biochemical and immunological studies. The neutral glycosphingolipid GgOse4Cer, the precursor for G(M1b)-type gangliosides, was expressed by all six strains investigated. AKR, C57BL/6 and DBA/2 showed high and BALB/c, CBA/J and WHT/Ht diminished expression in T lymphoblasts, based on single cell calculation. The gangliosides G(M1b) and GalNAc-G(M1b), elongation products of GgOse4Cer, displayed strain-specific differences in their intensities, which were found to correlate with the intensities of GgOse4Cer expression of the same strains. Concerning sialic acid substitution of gangliosides, G(M1b) and GalNAc-G(M1b) predominantly carry N-acetylneuraminic acid, whereas choleragenoid receptors G(M1a) and Gal-GalNAc-G(M1b), which are also expressed by all six strains, are characterized by dominance of N-glycolylneuraminic acid. Two highly polar gangliosides, designated with X and Y, which have not been previously recognized in murine lymphoid tissue, were detected by positive anti-GalNAc-G(M1b) antibody and choleragenoid binding, respectively. Both gangliosides were restricted to AKR, DBA/2 and C57BL/6 mice. The other three strains BALB/c, CBA/J and WHT/Ht are lacking these structures. In summary, the G(M1b)-type pathway is quite active in all six strains analysed in this study. Strain-specific genetic variations in T lymphoblast gangliosides were observed with the occurrence of gangliosides X and Y. This study and data from other groups strongly indicate for G(M1b)-type gangliosides a functional association with T cell activation and leukocyte mediated reactions."}