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sentences

Id Subject Object Predicate Lexical cue
T1 0-190 Sentence denotes Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
T2 191-422 Sentence denotes Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
T3 423-725 Sentence denotes Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.
T4 726-857 Sentence denotes Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.
T5 858-1009 Sentence denotes Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.
T6 1010-1266 Sentence denotes Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.
T7 1267-1472 Sentence denotes While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.
T8 1473-1657 Sentence denotes In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.
T9 1658-1796 Sentence denotes Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.
T10 1797-1950 Sentence denotes These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.
T1 0-190 Sentence denotes Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
T2 191-422 Sentence denotes Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
T3 423-725 Sentence denotes Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.
T4 726-857 Sentence denotes Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.
T5 858-1009 Sentence denotes Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.
T6 1010-1266 Sentence denotes Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.
T7 1267-1472 Sentence denotes While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.
T8 1473-1657 Sentence denotes In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.
T9 1658-1796 Sentence denotes Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.
T10 1797-1950 Sentence denotes These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 402-413 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T2 402-406 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1833-1839 gene:4851 denotes NOTCH1
T1 1840-1851 disease:C0596263 denotes oncogenesis
R1 T0 T1 associated_with NOTCH1,oncogenesis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 19-25 protein denotes NOTCH1
T2 45-65 DNA denotes primary binding site
T3 70-80 protein denotes RBP-Jkappa
T4 84-114 protein denotes nuclear localization sequences
T5 152-162 protein denotes RBP-Jkappa
T6 214-243 protein denotes NOTCH1 transmembrane receptor
T7 283-289 protein denotes NOTCH1
T8 441-447 protein denotes NOTCH1
T9 527-547 protein denotes extracellular domain
T10 549-555 protein denotes DeltaE
T11 583-603 protein denotes intracellular domain
T12 605-608 protein denotes ICN
T13 685-695 protein denotes RBP-Jkappa
T14 765-796 protein denotes transcription factor RBP-Jkappa
T15 823-856 cell_line denotes human and murine T-ALL cell lines
T16 917-940 protein denotes RBP-Jkappa-binding site
T17 952-980 protein denotes NOTCH1 ankyrin repeat region
T18 988-1008 protein denotes intracellular domain
T19 1043-1066 protein denotes RBP-Jkappa-binding site
T20 1090-1110 protein denotes intracellular domain
T21 1189-1199 protein denotes RBP-Jkappa
T22 1273-1276 protein denotes ICN
T23 1312-1318 protein denotes DeltaE
T24 1529-1559 protein denotes nuclear localization sequences
T25 1635-1656 protein denotes membrane-bound DeltaE
T26 1708-1729 protein denotes membrane-bound DeltaE
T27 1779-1795 protein denotes intranuclear ICN
T28 1833-1839 protein denotes NOTCH1
T29 1921-1931 protein denotes RBP-Jkappa
T30 1935-1949 DNA denotes promoter sites

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9111040-1#23#29#gene4851 214-220 gene4851 denotes NOTCH1
9111040-1#30#52#gene8829 221-243 gene8829 denotes transmembrane receptor
9111040-1#92#98#gene4851 283-289 gene4851 denotes NOTCH1
9111040-1#125#155#diseaseC0023493 316-346 diseaseC0023493 denotes human T cell leukemia/lymphoma
9111040-1#157#162#diseaseC0023493 348-353 diseaseC0023493 denotes T-ALL
9111040-1#183#188#diseaseC0023493 374-379 diseaseC0023493 denotes T-ALL
9111040-1#125#155#diseaseC0023493 316-346 diseaseC0023493 denotes human T cell leukemia/lymphoma
9111040-1#157#162#diseaseC0023493 348-353 diseaseC0023493 denotes T-ALL
9111040-1#183#188#diseaseC0023493 374-379 diseaseC0023493 denotes T-ALL
9111040-1#125#155#diseaseC0023493 316-346 diseaseC0023493 denotes human T cell leukemia/lymphoma
9111040-1#157#162#diseaseC0023493 348-353 diseaseC0023493 denotes T-ALL
9111040-1#183#188#diseaseC0023493 374-379 diseaseC0023493 denotes T-ALL
9111040-9#36#42#gene4851 1833-1839 gene4851 denotes NOTCH1
9111040-9#43#54#diseaseC0596263 1840-1851 diseaseC0596263 denotes oncogenesis
23#29#gene4851125#155#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
23#29#gene4851157#162#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
23#29#gene4851183#188#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
23#29#gene4851125#155#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
23#29#gene4851157#162#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
23#29#gene4851183#188#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
23#29#gene4851125#155#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
23#29#gene4851157#162#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
23#29#gene4851183#188#diseaseC0023493 9111040-1#23#29#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
30#52#gene8829125#155#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#125#155#diseaseC0023493 associated_with transmembrane receptor,human T cell leukemia/lymphoma
30#52#gene8829157#162#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#157#162#diseaseC0023493 associated_with transmembrane receptor,T-ALL
30#52#gene8829183#188#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#183#188#diseaseC0023493 associated_with transmembrane receptor,T-ALL
30#52#gene8829125#155#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#125#155#diseaseC0023493 associated_with transmembrane receptor,human T cell leukemia/lymphoma
30#52#gene8829157#162#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#157#162#diseaseC0023493 associated_with transmembrane receptor,T-ALL
30#52#gene8829183#188#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#183#188#diseaseC0023493 associated_with transmembrane receptor,T-ALL
30#52#gene8829125#155#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#125#155#diseaseC0023493 associated_with transmembrane receptor,human T cell leukemia/lymphoma
30#52#gene8829157#162#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#157#162#diseaseC0023493 associated_with transmembrane receptor,T-ALL
30#52#gene8829183#188#diseaseC0023493 9111040-1#30#52#gene8829 9111040-1#183#188#diseaseC0023493 associated_with transmembrane receptor,T-ALL
92#98#gene4851125#155#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
92#98#gene4851157#162#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
92#98#gene4851183#188#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
92#98#gene4851125#155#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
92#98#gene4851157#162#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
92#98#gene4851183#188#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
92#98#gene4851125#155#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#125#155#diseaseC0023493 associated_with NOTCH1,human T cell leukemia/lymphoma
92#98#gene4851157#162#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#157#162#diseaseC0023493 associated_with NOTCH1,T-ALL
92#98#gene4851183#188#diseaseC0023493 9111040-1#92#98#gene4851 9111040-1#183#188#diseaseC0023493 associated_with NOTCH1,T-ALL
36#42#gene485143#54#diseaseC0596263 9111040-9#36#42#gene4851 9111040-9#43#54#diseaseC0596263 associated_with NOTCH1,oncogenesis

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 19-25 NP denotes NOTCH1
C2 70-80 NP denotes RBP-Jkappa
C3 152-162 NP denotes RBP-Jkappa
C4 210-243 NP denotes the NOTCH1 transmembrane receptor
C5 283-289 NP denotes NOTCH1
C7 477-488 NP denotes the protein
C8 523-556 NP denotes the extracellular domain (DeltaE)
C9 579-609 NP denotes the intracellular domain (ICN)
C6 449-609 NP denotes two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN)
C10 726-746 NP denotes Both truncated forms
C11 761-796 NP denotes the transcription factor RBP-Jkappa
C12 984-1008 NP denotes the intracellular domain
C13 1024-1066 NP denotes a second, stronger RBP-Jkappa-binding site
C14 1068-1073 NP denotes which
C15 1086-1110 NP denotes the intracellular domain
C16 1189-1199 NP denotes RBP-Jkappa
C17 1273-1276 NP denotes ICN
C18 1312-1318 NP denotes DeltaE
C19 1635-1656 NP denotes membrane-bound DeltaE
C20 1658-1684 NP denotes Transcriptional activation
C21 1708-1729 NP denotes membrane-bound DeltaE
C22 1762-1766 NP denotes that
C23 1779-1795 NP denotes intranuclear ICN
C24 1921-1931 NP denotes RBP-Jkappa
R1 C3 C2 coref-ident RBP-Jkappa,RBP-Jkappa
R2 C5 C1 coref-ident NOTCH1,NOTCH1
R3 C7 C4 coref-ident the protein,the NOTCH1 transmembrane receptor
R4 C10 C6 coref-ident Both truncated forms,two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN)
R5 C11 C3 coref-ident the transcription factor RBP-Jkappa,RBP-Jkappa
R6 C12 C9 coref-ident the intracellular domain,the intracellular domain (ICN)
R7 C14 C13 coref-relat which,"a second, stronger RBP-Jkappa-binding site"
R8 C15 C12 coref-ident the intracellular domain,the intracellular domain
R9 C16 C11 coref-ident RBP-Jkappa,the transcription factor RBP-Jkappa
R10 C17 C15 coref-ident ICN,the intracellular domain
R11 C18 C8 coref-ident DeltaE,the extracellular domain (DeltaE)
R12 C21 C19 coref-ident membrane-bound DeltaE,membrane-bound DeltaE
R13 C22 C20 coref-pron that,Transcriptional activation
R14 C23 C17 coref-ident intranuclear ICN,ICN
R15 C24 C16 coref-ident RBP-Jkappa,RBP-Jkappa

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-190 Sentence denotes Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
S2 191-422 Sentence denotes Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
S3 423-725 Sentence denotes Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.
S4 726-857 Sentence denotes Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.
S5 858-1009 Sentence denotes Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.
S6 1010-1266 Sentence denotes Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.
S7 1267-1472 Sentence denotes While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.
S8 1473-1657 Sentence denotes In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.
S9 1658-1796 Sentence denotes Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.
S10 1797-1950 Sentence denotes These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 19-25 protein_molecule denotes NOTCH1
T2 45-65 DNA_domain_or_region denotes primary binding site
T3 70-80 protein_molecule denotes RBP-Jkappa
T4 152-162 protein_molecule denotes RBP-Jkappa
T5 214-220 protein_molecule denotes NOTCH1
T6 283-289 protein_molecule denotes NOTCH1
T7 316-346 other_name denotes human T cell leukemia/lymphoma
T8 348-353 other_name denotes T-ALL
T9 374-379 other_name denotes T-ALL
T10 402-413 tissue denotes bone marrow
T11 417-421 multi_cell denotes mice
T12 441-447 protein_molecule denotes NOTCH1
T13 527-547 protein_domain_or_region denotes extracellular domain
T14 549-555 protein_molecule denotes DeltaE
T15 583-603 protein_domain_or_region denotes intracellular domain
T16 605-608 protein_domain_or_region denotes ICN
T17 685-695 protein_molecule denotes RBP-Jkappa
T18 765-785 protein_molecule denotes transcription factor
T19 786-796 protein_molecule denotes RBP-Jkappa
T20 917-927 protein_molecule denotes RBP-Jkappa
T21 952-958 protein_molecule denotes NOTCH1
T22 988-1008 protein_domain_or_region denotes intracellular domain
T23 1043-1053 protein_molecule denotes RBP-Jkappa
T24 1090-1110 protein_domain_or_region denotes intracellular domain
T25 1189-1199 protein_domain_or_region denotes RBP-Jkappa
T26 1239-1265 other_name denotes transcriptional activation
T27 1273-1276 protein_domain_or_region denotes ICN
T28 1303-1310 cell_component denotes nucleus
T29 1312-1318 protein_molecule denotes DeltaE
T30 1445-1471 other_name denotes transcriptional activation
T31 1605-1631 other_name denotes transcriptional activation
T32 1635-1649 protein_molecule denotes membrane-bound
T33 1650-1656 protein_molecule denotes DeltaE
T34 1708-1722 protein_molecule denotes membrane-bound
T35 1723-1729 protein_molecule denotes DeltaE
T36 1779-1791 protein_domain_or_region denotes intranuclear
T37 1792-1795 protein_domain_or_region denotes ICN
T38 1833-1839 protein_molecule denotes NOTCH1
T39 1856-1882 other_name denotes transcriptional activation
T40 1921-1931 protein_molecule denotes RBP-Jkappa
T41 1935-1949 DNA_domain_or_region denotes promoter sites

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 402-413 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 329-337 Phenotype denotes leukemia HP:0001909
T2 338-346 Phenotype denotes lymphoma HP:0002665

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 322-337 Disease denotes T cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T2 338-346 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062
T3 348-353 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T5 374-379 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T7 840-845 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 316-321 OrganismTaxon denotes human 9606
T2 417-421 OrganismTaxon denotes mice 10088
T3 823-828 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 221-234 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T2 322-328 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 402-413 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T4 527-540 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 583-596 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 988-1001 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 1090-1103 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T8 1124-1137 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T9 1303-1310 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T11 1332-1343 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T12 1348-1365 Body_part denotes nuclear membranes http://purl.obolibrary.org/obo/GO_0031965
T13 1635-1643 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T16 1708-1716 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 322-328 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 650-664 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010