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PubMed:9108409 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
T2 125-307 Sentence denotes Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis.
T3 308-468 Sentence denotes The development of chronic eosinophilic inflammation is dependent on interleukin-5 (IL-5), a selective eosinophil-activating factor, produced by helper T cells.
T4 469-609 Sentence denotes To delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.
T5 610-736 Sentence denotes GC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).
T6 737-830 Sentence denotes Induction of IL-5 mRNA upon TCR and IL-2R stimulation was totally inhibited by dexamethasone.
T7 831-1205 Sentence denotes Human IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.
T8 1206-1357 Sentence denotes Electrophoretic mobility shift assay analysis suggested that AP-1 and NF-kappaB are among the possible targets of GC actions on TCR-stimulated T cells.
T9 1358-1429 Sentence denotes NF-AT and NF-kappaB were not significantly induced by IL-2 stimulation.
T10 1430-1678 Sentence denotes Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.
T1 0-124 Sentence denotes Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
T2 125-307 Sentence denotes Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis.
T3 308-468 Sentence denotes The development of chronic eosinophilic inflammation is dependent on interleukin-5 (IL-5), a selective eosinophil-activating factor, produced by helper T cells.
T4 469-609 Sentence denotes To delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.
T5 610-736 Sentence denotes GC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).
T6 737-830 Sentence denotes Induction of IL-5 mRNA upon TCR and IL-2R stimulation was totally inhibited by dexamethasone.
T7 831-1205 Sentence denotes Human IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.
T8 1206-1357 Sentence denotes Electrophoretic mobility shift assay analysis suggested that AP-1 and NF-kappaB are among the possible targets of GC actions on TCR-stimulated T cells.
T9 1358-1429 Sentence denotes NF-AT and NF-kappaB were not significantly induced by IL-2 stimulation.
T10 1430-1678 Sentence denotes Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 25-38 protein denotes interleukin-5
T2 52-89 cell_line denotes allergen-specific human T-cell clones
T3 377-390 protein denotes interleukin-5
T4 392-396 protein denotes IL-5
T5 401-439 protein denotes selective eosinophil-activating factor
T6 453-467 cell_type denotes helper T cells
T7 517-521 protein denotes IL-5
T8 548-584 cell_line denotes allergen-specific CD4+ T-cell clones
T9 636-640 protein denotes IL-5
T10 689-704 protein denotes T-cell receptor
T11 706-709 protein denotes TCR
T12 714-727 protein denotes IL-2 receptor
T13 729-734 protein denotes IL-2R
T14 750-759 RNA denotes IL-5 mRNA
T15 765-768 protein denotes TCR
T16 773-778 protein denotes IL-2R
T17 837-841 protein denotes IL-5
T18 901-914 cell_line denotes T-cell clones
T19 941-944 protein denotes TCR
T20 948-953 protein denotes IL-2R
T21 1048-1078 DNA denotes 500-bp human IL-5 gene segment
T22 1087-1098 DNA denotes 5' upstream
T23 1129-1167 DNA denotes activation-inducible enhancer elements
T24 1267-1271 protein denotes AP-1
T25 1276-1285 protein denotes NF-kappaB
T26 1334-1356 cell_type denotes TCR-stimulated T cells
T27 1358-1363 protein denotes NF-AT
T28 1368-1377 protein denotes NF-kappaB
T29 1412-1416 protein denotes IL-2
T30 1469-1473 protein denotes IL-5
T31 1488-1506 cell_type denotes human CD4+ T cells
T32 1542-1545 protein denotes TCR
T33 1550-1555 protein denotes IL-2R
T34 1663-1667 protein denotes IL-5

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 108-123 NP denotes glucocorticoids
C2 125-145 NP denotes Glucocorticoids (GC)
C3 377-397 NP denotes interleukin-5 (IL-5)
C4 399-439 NP denotes a selective eosinophil-activating factor
C5 548-608 NP denotes allergen-specific CD4+ T-cell clones from asthmatic patients
C6 610-612 NP denotes GC
C7 654-667 NP denotes T-cell clones
C8 765-790 NP denotes TCR and IL-2R stimulation
C9 816-829 NP denotes dexamethasone
C10 901-914 NP denotes T-cell clones
C11 934-965 NP denotes either TCR or IL-2R stimulation
C12 999-1012 NP denotes dexamethasone
C13 1202-1204 NP denotes GC
C14 1276-1285 NP denotes NF-kappaB
C15 1368-1377 NP denotes NF-kappaB
C16 1455-1457 NP denotes GC
C17 1520-1540 NP denotes two distinct stimuli
C18 1542-1567 NP denotes TCR and IL-2R stimulation
C19 1596-1598 NP denotes GC
R1 C2 C1 coref-ident Glucocorticoids (GC),glucocorticoids
R2 C4 C3 coref-appos a selective eosinophil-activating factor,interleukin-5 (IL-5)
R3 C6 C2 coref-ident GC,Glucocorticoids (GC)
R4 C7 C5 coref-ident T-cell clones,allergen-specific CD4+ T-cell clones from asthmatic patients
R5 C10 C7 coref-ident T-cell clones,T-cell clones
R6 C11 C8 coref-ident either TCR or IL-2R stimulation,TCR and IL-2R stimulation
R7 C12 C9 coref-ident dexamethasone,dexamethasone
R8 C13 C6 coref-ident GC,GC
R9 C15 C14 coref-ident NF-kappaB,NF-kappaB
R10 C16 C13 coref-ident GC,GC
R11 C17 C8 coref-ident two distinct stimuli,TCR and IL-2R stimulation
R12 C18 C17 coref-appos TCR and IL-2R stimulation,two distinct stimuli
R13 C19 C16 coref-ident GC,GC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-124 Sentence denotes Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
S2 125-307 Sentence denotes Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis.
S3 308-468 Sentence denotes The development of chronic eosinophilic inflammation is dependent on interleukin-5 (IL-5), a selective eosinophil-activating factor, produced by helper T cells.
S4 469-609 Sentence denotes To delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.
S5 610-736 Sentence denotes GC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).
S6 737-830 Sentence denotes Induction of IL-5 mRNA upon TCR and IL-2R stimulation was totally inhibited by dexamethasone.
S7 831-1205 Sentence denotes Human IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.
S8 1206-1357 Sentence denotes Electrophoretic mobility shift assay analysis suggested that AP-1 and NF-kappaB are among the possible targets of GC actions on TCR-stimulated T cells.
S9 1358-1429 Sentence denotes NF-AT and NF-kappaB were not significantly induced by IL-2 stimulation.
S10 1430-1678 Sentence denotes Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 25-38 protein_molecule denotes interleukin-5
T2 52-89 cell_line denotes allergen-specific human T-cell clones
T3 108-123 lipid denotes glucocorticoids
T4 125-140 lipid denotes Glucocorticoids
T5 142-144 lipid denotes GC
T6 216-233 other_name denotes allergic diseases
T7 249-261 other_name denotes eosinophilia
T8 270-284 other_name denotes chronic asthma
T9 289-306 other_name denotes atopic dermatitis
T10 327-360 other_name denotes chronic eosinophilic inflammation
T11 377-390 protein_molecule denotes interleukin-5
T12 392-396 protein_molecule denotes IL-5
T13 401-439 protein_family_or_group denotes selective eosinophil-activating factor
T14 453-467 cell_type denotes helper T cells
T15 511-516 other_name denotes human
T16 517-521 protein_molecule denotes IL-5
T17 548-584 cell_line denotes allergen-specific CD4+ T-cell clones
T18 590-608 multi_cell denotes asthmatic patients
T19 610-612 lipid denotes GC
T20 636-640 protein_molecule denotes IL-5
T21 689-704 protein_family_or_group denotes T-cell receptor
T22 706-709 protein_family_or_group denotes TCR
T23 714-727 protein_molecule denotes IL-2 receptor
T24 729-734 protein_molecule denotes IL-2R
T25 750-754 protein_molecule denotes IL-5
T26 765-768 protein_family_or_group denotes TCR
T27 773-778 protein_molecule denotes IL-2R
T28 816-829 lipid denotes dexamethasone
T29 837-841 protein_molecule denotes IL-5
T30 901-914 cell_line denotes T-cell clones
T31 941-944 protein_family_or_group denotes TCR
T32 948-953 protein_molecule denotes IL-2R
T33 999-1012 lipid denotes dexamethasone
T34 1048-1060 DNA_domain_or_region denotes 500-bp human
T35 1061-1065 protein_molecule denotes IL-5
T36 1087-1098 DNA_domain_or_region denotes 5' upstream
T37 1129-1167 DNA_family_or_group denotes activation-inducible enhancer elements
T38 1202-1204 lipid denotes GC
T39 1206-1251 other_name denotes Electrophoretic mobility shift assay analysis
T40 1267-1271 protein_molecule denotes AP-1
T41 1276-1285 protein_complex denotes NF-kappaB
T42 1320-1322 lipid denotes GC
T43 1334-1337 protein_family_or_group denotes TCR
T44 1358-1363 protein_molecule denotes NF-AT
T45 1368-1377 protein_complex denotes NF-kappaB
T46 1412-1416 protein_molecule denotes IL-2
T47 1455-1457 lipid denotes GC
T48 1469-1473 protein_molecule denotes IL-5
T49 1488-1506 cell_type denotes human CD4+ T cells
T50 1542-1545 protein_family_or_group denotes TCR
T51 1550-1555 protein_molecule denotes IL-2R
T52 1596-1598 lipid denotes GC
T53 1619-1636 other_name denotes allergic diseases
T54 1656-1662 other_name denotes T-cell
T55 1663-1667 protein_molecule denotes IL-5