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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-76 Sentence denotes Oxidant-regulation of gene expression in the chronically inflamed intestine.
T2 77-315 Sentence denotes It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.
T3 316-451 Sentence denotes Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.
T4 452-628 Sentence denotes Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.
T5 629-968 Sentence denotes This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).
T6 969-1098 Sentence denotes The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.
T7 1099-1354 Sentence denotes Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.
T1 0-76 Sentence denotes Oxidant-regulation of gene expression in the chronically inflamed intestine.
T2 77-315 Sentence denotes It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.
T3 316-451 Sentence denotes Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.
T4 452-628 Sentence denotes Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.
T5 629-968 Sentence denotes This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).
T6 969-1098 Sentence denotes The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.
T7 1099-1354 Sentence denotes Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 381-402 protein denotes transcription factors
T2 411-450 protein denotes nuclear transcription factor kappa beta
T3 452-483 protein denotes Nuclear transcription factor kB
T4 485-495 protein denotes NF-kappa B
T5 502-533 protein denotes ubiquitous transcription factor
T6 538-559 protein denotes pleiotropic regulator
T7 634-654 protein denotes transcription factor
T8 739-761 protein denotes inhibitor protein I-kB
T9 796-806 protein denotes NF-kappa B
T10 879-897 protein denotes adhesion molecules
T11 904-910 protein denotes ICAM-1
T12 912-918 protein denotes VCAM-1
T13 921-930 protein denotes cytokines
T14 932-935 protein denotes TNF
T15 937-941 protein denotes IL-1
T16 943-947 protein denotes IL-6
T17 953-960 protein denotes enzymes
T18 962-966 protein denotes iNOS
T19 1034-1043 protein denotes I-kappa B
T20 1075-1097 protein denotes 26S proteasome complex
T21 1166-1176 protein denotes NF-kappa B
T22 1304-1330 protein denotes pro-inflammatory mediators
T23 1335-1353 protein denotes adhesion molecules

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 411-450 NP denotes nuclear transcription factor kappa beta
C2 452-496 NP denotes Nuclear transcription factor kB (NF-kappa B)
C3 629-654 NP denotes This transcription factor
C4 735-738 NP denotes its
C5 796-806 NP denotes NF-kappa B
C6 830-832 NP denotes it
C7 1197-1235 NP denotes significant anti inflammatory activity
C8 1236-1241 NP denotes which
R1 C2 C1 coref-ident Nuclear transcription factor kB (NF-kappa B),nuclear transcription factor kappa beta
R2 C3 C2 coref-ident This transcription factor,Nuclear transcription factor kB (NF-kappa B)
R3 C4 C3 coref-pron its,This transcription factor
R4 C5 C3 coref-ident NF-kappa B,This transcription factor
R5 C6 C5 coref-pron it,NF-kappa B
R6 C8 C7 coref-relat which,significant anti inflammatory activity

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-76 Sentence denotes Oxidant-regulation of gene expression in the chronically inflamed intestine.
S2 77-315 Sentence denotes It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.
S3 316-451 Sentence denotes Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.
S4 452-628 Sentence denotes Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.
S5 629-968 Sentence denotes This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).
S6 969-1098 Sentence denotes The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.
S7 1099-1354 Sentence denotes Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 other_name denotes Oxidant-regulation
T2 22-37 other_name denotes gene expression
T3 45-75 body_part denotes chronically inflamed intestine
T4 123-147 other_name denotes chronic gut inflammation
T5 164-202 other_name denotes idiopathic inflammatory bowel diseases
T6 209-227 other_name denotes ulcerative colitis
T7 229-244 other_name denotes Crohn's disease
T8 288-314 other_organic_compound denotes leukocyte-derived oxidants
T9 316-324 other_organic_compound denotes Oxidants
T10 333-350 other_organic_compound denotes hydrogen peroxide
T11 381-402 protein_family_or_group denotes transcription factors
T12 411-450 protein_complex denotes nuclear transcription factor kappa beta
T13 452-483 protein_complex denotes Nuclear transcription factor kB
T14 485-495 protein_complex denotes NF-kappa B
T15 502-533 protein_family_or_group denotes ubiquitous transcription factor
T16 538-559 protein_family_or_group denotes pleiotropic regulator
T17 634-654 protein_family_or_group denotes transcription factor
T18 686-701 other_name denotes phosphorylation
T19 703-715 other_name denotes ubiquination
T20 720-731 other_name denotes degradation
T21 739-761 protein_molecule denotes inhibitor protein I-kB
T22 796-806 protein_complex denotes NF-kappa B
T23 816-823 cell_component denotes nucleus
T24 879-897 protein_family_or_group denotes adhesion molecules
T25 904-910 protein_molecule denotes ICAM-1
T26 912-918 protein_molecule denotes VCAM-1
T27 921-930 protein_family_or_group denotes cytokines
T28 932-935 protein_family_or_group denotes TNF
T29 937-941 protein_molecule denotes IL-1
T30 943-947 protein_molecule denotes IL-6
T31 953-960 protein_family_or_group denotes enzymes
T32 962-966 protein_molecule denotes iNOS
T33 985-996 other_name denotes degradation
T34 1004-1033 other_name denotes post-translationally modified
T35 1034-1043 protein_molecule denotes I-kappa B
T36 1075-1097 protein_complex denotes 26S proteasome complex
T37 1166-1176 protein_complex denotes NF-kappa B
T38 1209-1235 other_name denotes anti inflammatory activity
T39 1304-1330 protein_family_or_group denotes pro-inflammatory mediators
T40 1335-1353 protein_family_or_group denotes adhesion molecules