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PubMed:9091577 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-50 protein denotes Signal transducer and activator of transcription-3
T2 52-57 protein denotes STAT3
T3 98-121 cell_type denotes self-renewing B-1 cells
T4 167-180 cell_type denotes B lymphocytes
T5 182-190 protein denotes Cytokine
T6 195-217 protein denotes growth factor receptor
T7 290-366 protein denotes cytosolic signal transducers and activators of transcription (STAT) proteins
T8 454-481 DNA denotes specific promoter sequences
T9 483-488 protein denotes STAT3
T10 539-542 protein denotes Abl
T11 544-547 protein denotes Src
T12 578-590 cell_type denotes normal cells
T13 592-607 cell_type denotes B-1 lymphocytes
T14 627-639 cell_type denotes CD5+ B cells
T15 775-784 cell_type denotes B-1 cells
T16 926-941 cell_type denotes B-1 lymphocytes
T17 965-988 protein denotes nuclear activated STAT3
T18 1016-1060 cell_type denotes unmanipulated conventional (B-2) lymphocytes
T19 1075-1080 protein denotes STAT3
T20 1106-1115 cell_type denotes B-2 cells
T21 1197-1202 protein denotes STAT3
T22 1392-1395 protein denotes sIg
T23 1400-1413 protein denotes STAT proteins
T24 1459-1463 protein denotes STAT
T25 1477-1495 protein denotes cytokine receptors
T26 1552-1561 cell_type denotes B-2 cells
T27 1567-1574 protein denotes anti-Ig
T28 1609-1612 protein denotes CD5
T29 1648-1653 protein denotes STAT3
T30 1679-1684 protein denotes STAT3
T31 1718-1727 cell_type denotes B-1 cells
T32 1735-1740 protein denotes STAT3

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-58 NP denotes Signal transducer and activator of transcription-3 (STAT3)
C2 90-121 NP denotes normal, self-renewing B-1 cells
C3 154-180 NP denotes conventional B lymphocytes
C4 282-366 NP denotes latent, cytosolic signal transducers and activators of transcription (STAT) proteins
C5 368-373 NP denotes which
C6 412-416 NP denotes they
C7 592-607 NP denotes B-1 lymphocytes
C8 612-639 NP denotes self-renewing, CD5+ B cells
C9 640-644 NP denotes that
C10 775-784 NP denotes B-1 cells
C11 926-941 NP denotes B-1 lymphocytes
C12 965-988 NP denotes nuclear activated STAT3
C13 990-995 NP denotes which
C14 1016-1060 NP denotes unmanipulated conventional (B-2) lymphocytes
C15 1106-1115 NP denotes B-2 cells
C16 1197-1202 NP denotes STAT3
C17 1369-1413 NP denotes novel coupling between sIg and STAT proteins
C18 1414-1418 NP denotes that
C19 1539-1561 NP denotes conventional B-2 cells
C20 1567-1574 NP denotes anti-Ig
C21 1576-1623 NP denotes a treatment sufficient to induce CD5 expression
C22 1679-1684 NP denotes STAT3
C23 1718-1727 NP denotes B-1 cells
C24 1735-1740 NP denotes STAT3
C25 1809-1812 NP denotes its
R1 C5 C4 coref-relat which,"latent, cytosolic signal transducers and activators of transcription (STAT) proteins"
R2 C6 C4 coref-pron they,"latent, cytosolic signal transducers and activators of transcription (STAT) proteins"
R3 C7 C2 coref-ident B-1 lymphocytes,"normal, self-renewing B-1 cells"
R4 C9 C8 coref-relat that,"self-renewing, CD5+ B cells"
R5 C10 C7 coref-ident B-1 cells,B-1 lymphocytes
R6 C11 C10 coref-ident B-1 lymphocytes,B-1 cells
R7 C13 C12 coref-relat which,nuclear activated STAT3
R8 C14 C3 coref-ident unmanipulated conventional (B-2) lymphocytes,conventional B lymphocytes
R9 C15 C14 coref-ident B-2 cells,unmanipulated conventional (B-2) lymphocytes
R10 C16 C1 coref-ident STAT3,Signal transducer and activator of transcription-3 (STAT3)
R11 C18 C17 coref-relat that,novel coupling between sIg and STAT proteins
R12 C19 C15 coref-ident conventional B-2 cells,B-2 cells
R13 C21 C20 coref-appos a treatment sufficient to induce CD5 expression,anti-Ig
R14 C22 C16 coref-ident STAT3,STAT3
R15 C23 C11 coref-ident B-1 cells,B-1 lymphocytes
R16 C24 C22 coref-ident STAT3,STAT3
R17 C25 C24 coref-pron its,STAT3

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-181 Sentence denotes Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes.
S2 182-482 Sentence denotes Cytokine and growth factor receptor engagement leads to the rapid phosphorylation and activation of latent, cytosolic signal transducers and activators of transcription (STAT) proteins, which then translocate to the nucleus where they regulate transcriptional events from specific promoter sequences.
S3 483-591 Sentence denotes STAT3 expression in particular has been associated with Abl, Src, and HTLV-1 transformation of normal cells.
S4 592-765 Sentence denotes B-1 lymphocytes are self-renewing, CD5+ B cells that display a propensity for malignant transformation and are the normal counterpart to human chronic lymphocytic leukemias.
S5 766-900 Sentence denotes Further, B-1 cells are characterized by aberrant intracellular signaling, including hyperresponsiveness to phorbol ester PKC agonists.
S6 901-1061 Sentence denotes Here we demonstrate that B-1 lymphocytes constitutively express nuclear activated STAT3, which is not expressed by unmanipulated conventional (B-2) lymphocytes.
S7 1062-1183 Sentence denotes In contrast, STAT3 activation is induced in B-2 cells after antigen receptor engagement in a delayed fashion (after 3 h).
S8 1184-1496 Sentence denotes Induction of STAT3 is inhibited by both the serine/threonine protein kinase inhibitor H-7 and the immunosuppressive drug rapamycin and requires de novo protein synthesis, demonstrating novel coupling between sIg and STAT proteins that differs from the classical paradigm for STAT induction by cytokine receptors.
S9 1497-1728 Sentence denotes The inability of prolonged stimulation of conventional B-2 cells with anti-Ig, a treatment sufficient to induce CD5 expression, to result in sustained STAT3 activation suggests that STAT3 is a specific nuclear marker for B-1 cells.
S10 1729-1925 Sentence denotes Thus, STAT3 may play a role in B cell antigen-specific signaling responses, and its constitutive activation is associated with a normal cell population exhibiting intrinsic proliferative behavior.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-50 protein_molecule denotes Signal transducer and activator of transcription-3
T2 52-57 protein_molecule denotes STAT3
T3 98-121 cell_type denotes self-renewing B-1 cells
T4 167-180 cell_type denotes B lymphocytes
T5 182-190 protein_family_or_group denotes Cytokine
T6 195-217 protein_family_or_group denotes growth factor receptor
T7 242-263 other_name denotes rapid phosphorylation
T8 290-366 protein_family_or_group denotes cytosolic signal transducers and activators of transcription (STAT) proteins
T9 398-405 cell_component denotes nucleus
T10 454-481 DNA_family_or_group denotes specific promoter sequences
T11 483-488 protein_molecule denotes STAT3
T12 539-542 protein_molecule denotes Abl
T13 544-547 protein_family_or_group denotes Src
T14 553-574 other_name denotes HTLV-1 transformation
T15 578-590 cell_type denotes normal cells
T16 592-607 cell_type denotes B-1 lymphocytes
T17 627-639 cell_type denotes CD5+ B cells
T18 670-694 other_name denotes malignant transformation
T19 729-764 other_name denotes human chronic lymphocytic leukemias
T20 775-784 cell_type denotes B-1 cells
T21 806-838 other_name denotes aberrant intracellular signaling
T22 873-899 other_organic_compound denotes phorbol ester PKC agonists
T23 926-941 cell_type denotes B-1 lymphocytes
T24 965-982 protein_molecule denotes nuclear activated
T25 983-988 protein_molecule denotes STAT3
T26 1016-1060 cell_type denotes unmanipulated conventional (B-2) lymphocytes
T27 1075-1080 protein_molecule denotes STAT3
T28 1106-1115 cell_type denotes B-2 cells
T29 1197-1202 protein_molecule denotes STAT3
T30 1228-1273 other_organic_compound denotes serine/threonine protein kinase inhibitor H-7
T31 1282-1304 other_organic_compound denotes immunosuppressive drug
T32 1305-1314 other_organic_compound denotes rapamycin
T33 1392-1395 protein_family_or_group denotes sIg
T34 1400-1413 protein_family_or_group denotes STAT proteins
T35 1459-1463 protein_family_or_group denotes STAT
T36 1477-1495 protein_family_or_group denotes cytokine receptors
T37 1552-1561 cell_type denotes B-2 cells
T38 1567-1574 protein_family_or_group denotes anti-Ig
T39 1609-1612 protein_molecule denotes CD5
T40 1648-1653 protein_molecule denotes STAT3
T41 1679-1684 protein_molecule denotes STAT3
T42 1718-1727 cell_type denotes B-1 cells
T43 1735-1740 protein_molecule denotes STAT3
T44 1760-1803 other_name denotes B cell antigen-specific signaling responses
T45 1858-1880 other_name denotes normal cell population
T46 1892-1924 other_name denotes intrinsic proliferative behavior