PubMed:9081693
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 18-36 | DNA | denotes | tissue factor gene |
| T2 | 40-61 | cell_type | denotes | human monocytic cells |
| T3 | 71-75 | protein | denotes | AP-1 |
| T4 | 77-91 | protein | denotes | NF-kappa B/Rel |
| T5 | 97-100 | protein | denotes | Sp1 |
| T6 | 166-179 | protein | denotes | Tissue factor |
| T7 | 199-225 | cell_type | denotes | peripheral blood monocytes |
| T8 | 327-334 | DNA | denotes | TF gene |
| T9 | 352-361 | cell_type | denotes | monocytes |
| T10 | 367-384 | DNA | denotes | human TF promoter |
| T11 | 438-442 | protein | denotes | AP-1 |
| T12 | 444-453 | protein | denotes | c-Rel/p65 |
| T13 | 455-460 | protein | denotes | Egr-1 |
| T14 | 466-469 | protein | denotes | Sp1 |
| T15 | 471-494 | protein | denotes | NF-kappa B/Rel proteins |
| T16 | 544-565 | protein | denotes | AP-1 and Sp1 proteins |
| T17 | 616-637 | protein | denotes | transcription factors |
| T18 | 667-674 | DNA | denotes | TF gene |
| T19 | 689-716 | cell_type | denotes | human monocytic THP-1 cells |
| T20 | 758-767 | DNA | denotes | Sp1 sites |
| T21 | 797-812 | cell_type | denotes | uninduced cells |
| T22 | 822-832 | DNA | denotes | AP-1 sites |
| T23 | 839-863 | protein | denotes | c-Fos/c-Jun heterodimers |
| T24 | 872-909 | cell_type | denotes | unstimulated and LPS-stimulated cells |
| T25 | 940-951 | DNA | denotes | TF promoter |
| T26 | 969-973 | protein | denotes | AP-1 |
| T27 | 988-1000 | DNA | denotes | kappa B site |
| T28 | 1012-1032 | DNA | denotes | LPS response element |
| T29 | 1082-1100 | DNA | denotes | proximal AP-1 site |
| T30 | 1109-1121 | DNA | denotes | kappa B site |
| T31 | 1170-1180 | DNA | denotes | AP-1 sites |
| T32 | 1292-1302 | DNA | denotes | AP-1 sites |
| T33 | 1339-1359 | DNA | denotes | LPS response element |
| T34 | 1363-1389 | cell_line | denotes | Drosophila Schneider cells |
| T35 | 1409-1414 | protein | denotes | c-Fos |
| T36 | 1416-1421 | protein | denotes | c-Jun |
| T37 | 1423-1428 | protein | denotes | c-Rel |
| T38 | 1434-1437 | protein | denotes | p65 |
| T39 | 1441-1446 | protein | denotes | c-Jun |
| T40 | 1451-1454 | protein | denotes | p65 |
| T41 | 1468-1491 | protein | denotes | transactivation domains |
| T42 | 1495-1500 | protein | denotes | c-Jun |
| T43 | 1505-1508 | protein | denotes | p65 |
| T44 | 1536-1541 | protein | denotes | c-Fos |
| T45 | 1541-1547 | protein | denotes | /c-Jun |
| T46 | 1549-1554 | protein | denotes | c-Rel |
| T47 | 1554-1558 | protein | denotes | /p65 |
| T48 | 1564-1567 | protein | denotes | Sp1 |
| T49 | 1577-1584 | DNA | denotes | TF gene |
| T50 | 1599-1620 | cell_type | denotes | human monocytic cells |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 40-61 | NP | denotes | human monocytic cells |
| C2 | 166-195 | NP | denotes | Tissue factor (TF) expression |
| C3 | 363-384 | NP | denotes | The human TF promoter |
| C4 | 412-469 | NP | denotes | the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1 |
| C5 | 610-637 | NP | denotes | these transcription factors |
| C6 | 814-832 | NP | denotes | The two AP-1 sites |
| C7 | 936-951 | NP | denotes | the TF promoter |
| C8 | 961-979 | NP | denotes | the two AP-1 sites |
| C9 | 984-1000 | NP | denotes | the kappa B site |
| C10 | 1008-1032 | NP | denotes | the LPS response element |
| C11 | 1105-1121 | NP | denotes | the kappa B site |
| C12 | 1132-1145 | NP | denotes | LPS induction |
| C13 | 1162-1180 | NP | denotes | the two AP-1 sites |
| C14 | 1228-1241 | NP | denotes | LPS induction |
| C15 | 1288-1302 | NP | denotes | the AP-1 sites |
| C16 | 1335-1359 | NP | denotes | the LPS response element |
| C17 | 1416-1421 | NP | denotes | c-Jun |
| C18 | 1434-1437 | NP | denotes | p65 |
| C19 | 1441-1446 | NP | denotes | c-Jun |
| C20 | 1451-1454 | NP | denotes | p65 |
| C21 | 1495-1500 | NP | denotes | c-Jun |
| C22 | 1505-1508 | NP | denotes | p65 |
| C23 | 1577-1595 | NP | denotes | TF gene expression |
| C24 | 1599-1620 | NP | denotes | human monocytic cells |
| R1 | C5 | C4 | coref-ident | these transcription factors,"the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1" |
| R2 | C7 | C3 | coref-ident | the TF promoter,The human TF promoter |
| R3 | C8 | C6 | coref-ident | the two AP-1 sites,The two AP-1 sites |
| R4 | C11 | C9 | coref-ident | the kappa B site,the kappa B site |
| R5 | C13 | C8 | coref-ident | the two AP-1 sites,the two AP-1 sites |
| R6 | C14 | C12 | coref-ident | LPS induction,LPS induction |
| R7 | C15 | C13 | coref-ident | the AP-1 sites,the two AP-1 sites |
| R8 | C16 | C10 | coref-ident | the LPS response element,the LPS response element |
| R9 | C19 | C17 | coref-ident | c-Jun,c-Jun |
| R10 | C20 | C18 | coref-ident | p65,p65 |
| R11 | C21 | C19 | coref-ident | c-Jun,c-Jun |
| R12 | C22 | C20 | coref-ident | p65,p65 |
| R13 | C23 | C2 | coref-ident | TF gene expression,Tissue factor (TF) expression |
| R14 | C24 | C1 | coref-ident | human monocytic cells,human monocytic cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-62 | Sentence | denotes | Regulation of the tissue factor gene in human monocytic cells. |
| S2 | 63-165 | Sentence | denotes | Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression. |
| S3 | 166-275 | Sentence | denotes | Tissue factor (TF) expression by peripheral blood monocytes during sepsis initiates intravascular thrombosis. |
| S4 | 276-362 | Sentence | denotes | Bacterial lipopolysaccharide (LPS) rapidly induces TF gene transcription in monocytes. |
| S5 | 363-470 | Sentence | denotes | The human TF promoter contains binding sites for the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1. |
| S6 | 471-566 | Sentence | denotes | NF-kappa B/Rel proteins have been shown to physically interact with both AP-1 and Sp1 proteins. |
| S7 | 567-717 | Sentence | denotes | In this study, we investigated the role of these transcription factors in uninduced and LPS-induced TF gene expression in human monocytic THP-1 cells. |
| S8 | 718-813 | Sentence | denotes | Deletional analysis indicated that five Sp1 sites mediated basal expression in uninduced cells. |
| S9 | 814-910 | Sentence | denotes | The two AP-1 sites bound c-Fos/c-Jun heterodimers in both unstimulated and LPS-stimulated cells. |
| S10 | 911-1033 | Sentence | denotes | Maximal LPS induction of the TF promoter required the two AP-1 sites and the kappa B site within the LPS response element. |
| S11 | 1034-1146 | Sentence | denotes | Disruption of the conserved spacing between the proximal AP-1 site and the kappa B site abolished LPS induction. |
| S12 | 1147-1303 | Sentence | denotes | Replacement of the two AP-1 sites with intrinsically bent DNA partially restored LPS induction, suggesting an additional structural role for the AP-1 sites. |
| S13 | 1304-1509 | Sentence | denotes | Synergistic transactivation of the LPS response element in Drosophila Schneider cells by coexpression of c-Fos, c-Jun, c-Rel, and p65 or c-Jun and p65 required the transactivation domains of c-Jun and p65. |
| S14 | 1510-1621 | Sentence | denotes | These data indicated that c-Fos/c-Jun, c-Rel/p65, and Sp1 regulate TF gene expression in human monocytic cells. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 18-36 | DNA_domain_or_region | denotes | tissue factor gene |
| T2 | 40-45 | cell_type | denotes | human |
| T3 | 46-61 | cell_type | denotes | monocytic cells |
| T4 | 71-75 | protein_molecule | denotes | AP-1 |
| T5 | 77-91 | protein_complex | denotes | NF-kappa B/Rel |
| T6 | 97-100 | protein_molecule | denotes | Sp1 |
| T7 | 127-145 | lipid | denotes | lipopolysaccharide |
| T8 | 166-179 | protein_family_or_group | denotes | Tissue factor |
| T9 | 199-225 | cell_type | denotes | peripheral blood monocytes |
| T10 | 250-274 | other_name | denotes | intravascular thrombosis |
| T11 | 286-304 | lipid | denotes | lipopolysaccharide |
| T12 | 306-309 | lipid | denotes | LPS |
| T13 | 327-334 | DNA_domain_or_region | denotes | TF gene |
| T14 | 352-361 | cell_type | denotes | monocytes |
| T15 | 367-384 | DNA_domain_or_region | denotes | human TF promoter |
| T16 | 438-442 | protein_molecule | denotes | AP-1 |
| T17 | 444-453 | protein_molecule | denotes | c-Rel/p65 |
| T18 | 455-460 | protein_molecule | denotes | Egr-1 |
| T19 | 466-469 | protein_molecule | denotes | Sp1 |
| T20 | 471-485 | protein_complex | denotes | NF-kappa B/Rel |
| T21 | 616-637 | protein_family_or_group | denotes | transcription factors |
| T22 | 655-658 | lipid | denotes | LPS |
| T23 | 667-674 | DNA_domain_or_region | denotes | TF gene |
| T24 | 689-716 | cell_type | denotes | human monocytic THP-1 cells |
| T25 | 758-761 | protein_molecule | denotes | Sp1 |
| T26 | 797-812 | cell_type | denotes | uninduced cells |
| T27 | 822-826 | protein_molecule | denotes | AP-1 |
| T28 | 839-844 | protein_molecule | denotes | c-Fos |
| T29 | 919-922 | lipid | denotes | LPS |
| T30 | 940-951 | DNA_domain_or_region | denotes | TF promoter |
| T31 | 969-973 | protein_molecule | denotes | AP-1 |
| T32 | 988-1000 | DNA_domain_or_region | denotes | kappa B site |
| T33 | 1012-1015 | lipid | denotes | LPS |
| T34 | 1082-1090 | DNA_domain_or_region | denotes | proximal |
| T35 | 1091-1095 | protein_molecule | denotes | AP-1 |
| T36 | 1109-1121 | DNA_domain_or_region | denotes | kappa B site |
| T37 | 1132-1135 | lipid | denotes | LPS |
| T38 | 1170-1174 | protein_molecule | denotes | AP-1 |
| T39 | 1228-1231 | lipid | denotes | LPS |
| T40 | 1292-1296 | protein_molecule | denotes | AP-1 |
| T41 | 1304-1331 | other_name | denotes | Synergistic transactivation |
| T42 | 1339-1342 | lipid | denotes | LPS |
| T43 | 1363-1373 | multi_cell | denotes | Drosophila |
| T44 | 1409-1414 | protein_molecule | denotes | c-Fos |
| T45 | 1416-1421 | protein_molecule | denotes | c-Jun |
| T46 | 1423-1428 | protein_molecule | denotes | c-Rel |
| T47 | 1434-1437 | protein_molecule | denotes | p65 |
| T48 | 1441-1446 | protein_molecule | denotes | c-Jun |
| T49 | 1451-1454 | protein_molecule | denotes | p65 |
| T50 | 1468-1491 | protein_domain_or_region | denotes | transactivation domains |
| T51 | 1495-1500 | protein_molecule | denotes | c-Jun |
| T52 | 1505-1508 | protein_molecule | denotes | p65 |
| T53 | 1536-1541 | protein_molecule | denotes | c-Fos |
| T54 | 1541-1547 | protein_molecule | denotes | /c-Jun |
| T55 | 1549-1554 | protein_molecule | denotes | c-Rel |
| T56 | 1554-1558 | protein_molecule | denotes | /p65 |
| T57 | 1564-1567 | protein_molecule | denotes | Sp1 |
| T58 | 1577-1584 | DNA_domain_or_region | denotes | TF gene |
| T59 | 1599-1604 | cell_type | denotes | human |
| T60 | 1605-1620 | cell_type | denotes | monocytic cells |