PubMed:9073544 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T2","span":{"begin":118,"end":254},"obj":"Sentence"},{"id":"T3","span":{"begin":255,"end":484},"obj":"Sentence"},{"id":"T4","span":{"begin":485,"end":723},"obj":"Sentence"},{"id":"T5","span":{"begin":724,"end":879},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T2","span":{"begin":118,"end":254},"obj":"Sentence"},{"id":"T3","span":{"begin":255,"end":484},"obj":"Sentence"},{"id":"T4","span":{"begin":485,"end":723},"obj":"Sentence"},{"id":"T5","span":{"begin":724,"end":879},"obj":"Sentence"}],"text":"T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.\nThe in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"cell_type"},{"id":"T2","span":{"begin":161,"end":206},"obj":"cell_type"},{"id":"T3","span":{"begin":255,"end":274},"obj":"cell_type"},{"id":"T4","span":{"begin":395,"end":411},"obj":"cell_type"},{"id":"T5","span":{"begin":581,"end":616},"obj":"cell_type"},{"id":"T6","span":{"begin":698,"end":722},"obj":"cell_type"},{"id":"T7","span":{"begin":783,"end":789},"obj":"protein"},{"id":"T8","span":{"begin":871,"end":878},"obj":"cell_type"}],"text":"T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.\nThe in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"S2","span":{"begin":118,"end":254},"obj":"Sentence"},{"id":"S3","span":{"begin":255,"end":484},"obj":"Sentence"},{"id":"S4","span":{"begin":485,"end":723},"obj":"Sentence"},{"id":"S5","span":{"begin":724,"end":879},"obj":"Sentence"}],"text":"T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.\nThe in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":280,"end":337},"obj":"NP"},{"id":"C2","span":{"begin":434,"end":472},"obj":"NP"},{"id":"C3","span":{"begin":500,"end":518},"obj":"NP"},{"id":"C4","span":{"begin":622,"end":636},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C1"}],"text":"T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.\nThe in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"cell_type"},{"id":"T2","span":{"begin":36,"end":65},"obj":"other_name"},{"id":"T3","span":{"begin":81,"end":107},"obj":"other_name"},{"id":"T4","span":{"begin":122,"end":130},"obj":"other_name"},{"id":"T5","span":{"begin":131,"end":157},"obj":"other_name"},{"id":"T6","span":{"begin":161,"end":206},"obj":"cell_type"},{"id":"T7","span":{"begin":223,"end":243},"obj":"mono_cell"},{"id":"T8","span":{"begin":255,"end":274},"obj":"cell_type"},{"id":"T9","span":{"begin":297,"end":332},"obj":"other_name"},{"id":"T10","span":{"begin":334,"end":336},"obj":"other_name"},{"id":"T11","span":{"begin":395,"end":411},"obj":"cell_type"},{"id":"T12","span":{"begin":434,"end":472},"obj":"multi_cell"},{"id":"T13","span":{"begin":504,"end":518},"obj":"multi_cell"},{"id":"T14","span":{"begin":545,"end":571},"obj":"other_name"},{"id":"T15","span":{"begin":581,"end":616},"obj":"cell_type"},{"id":"T16","span":{"begin":622,"end":624},"obj":"other_name"},{"id":"T17","span":{"begin":698,"end":722},"obj":"cell_type"},{"id":"T18","span":{"begin":740,"end":748},"obj":"multi_cell"},{"id":"T19","span":{"begin":777,"end":783},"obj":"other_name"},{"id":"T20","span":{"begin":783,"end":789},"obj":"protein_molecule"},{"id":"T21","span":{"begin":841,"end":867},"obj":"other_name"},{"id":"T22","span":{"begin":871,"end":878},"obj":"cell_type"}],"text":"T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.\nThe in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells."}