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PubMed:9070319 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 362-375 gene:3565 denotes interleukin-4
T1 520-543 disease:C0079731 denotes Burkitt lymphoma B cell
T2 362-375 gene:3565 denotes interleukin-4
T3 520-543 disease:C0006413 denotes Burkitt lymphoma B cell
T4 377-381 gene:3565 denotes IL-4
T5 520-543 disease:C0079731 denotes Burkitt lymphoma B cell
T6 377-381 gene:3565 denotes IL-4
T7 520-543 disease:C0006413 denotes Burkitt lymphoma B cell
T8 391-395 gene:958 denotes CD40
T9 520-543 disease:C0079731 denotes Burkitt lymphoma B cell
T10 391-395 gene:958 denotes CD40
T11 520-543 disease:C0006413 denotes Burkitt lymphoma B cell
R1 T0 T1 associated_with interleukin-4,Burkitt lymphoma B cell
R2 T2 T3 associated_with interleukin-4,Burkitt lymphoma B cell
R3 T4 T5 associated_with IL-4,Burkitt lymphoma B cell
R4 T6 T7 associated_with IL-4,Burkitt lymphoma B cell
R5 T8 T9 associated_with CD40,Burkitt lymphoma B cell
R6 T10 T11 associated_with CD40,Burkitt lymphoma B cell

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 17-39 protein denotes nuclear factor-kappa B
T2 52-60 DNA denotes germline
T3 90-124 cell_line denotes human Burkitt lymphoma B cell line
T4 126-148 protein denotes Nuclear factor-kappa B
T5 150-160 protein denotes NF-kappa B
T6 231-241 protein denotes NF-kappa B
T7 273-281 DNA denotes germline
T8 362-375 protein denotes interleukin-4
T9 377-381 protein denotes IL-4
T10 386-415 protein denotes anti-CD40 monoclonal antibody
T11 417-420 protein denotes mAb
T12 438-448 protein denotes NF-kappa B
T13 476-484 DNA denotes germline
T14 514-548 cell_line denotes human Burkitt lymphoma B cell line
T15 550-555 cell_line denotes DND39
T16 562-566 protein denotes IL-4
T17 576-584 protein denotes CD40 mAb
T18 607-636 protein denotes phosphatidylinositol 3-kinase
T19 638-648 protein denotes PI3-kinase
T20 686-702 protein denotes protein kinase C
T21 730-740 protein denotes NF-kappa B
T22 825-835 protein denotes PI3-kinase
T23 909-919 protein denotes NF-kappa B
T24 941-945 protein denotes IL-4
T25 947-960 protein denotes anti-CD40 mAb
T26 1022-1030 DNA denotes germline
T27 1113-1117 protein denotes IL-4
T28 1122-1135 protein denotes anti-CD40 mAb
T29 1166-1170 protein denotes IL-4
T30 1206-1210 protein denotes IL-4
T31 1227-1231 protein denotes CD40
T32 1239-1249 protein denotes NF-kappa B
T33 1303-1313 protein denotes PI3-kinase
T34 1339-1349 protein denotes NF-kappa B
T35 1397-1405 DNA denotes germline

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-125 Sentence denotes Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line.
S2 126-306 Sentence denotes Nuclear factor-kappa B (NF-kappa B) plays a broad role in gene regulation, but it is not evident whether NF-kappa B acts as a messenger system for germline C epsilon transcription.
S3 307-556 Sentence denotes We report here that the signaling cascade triggered by interleukin-4 (IL-4) or anti-CD40 monoclonal antibody (mAb) participates in NF-kappa B activation responsible for germline C epsilon transcription in a human Burkitt lymphoma B cell line, DND39.
S4 557-741 Sentence denotes Both IL-4 and anti-CD40 mAb induced activation of phosphatidylinositol 3-kinase (PI3-kinase), translocation of a zeta isoform of protein kinase C, and nuclear expression of NF-kappa B.
S5 742-836 Sentence denotes All such events were abrogated by treatment with LY294002, a specific inhibitor of PI3-kinase.
S6 837-983 Sentence denotes In addition, N-acetyl-L-cysteine (NAC), a potent antioxidant, decreased NF-kappa B activation caused by IL-4, anti-CD40 mAb, or their combination.
S7 984-1177 Sentence denotes NAC was also effective in diminishing germline C epsilon transcription, and its potency was higher in cultures costimulated with IL-4 and anti-CD40 mAb than in those stimulated with IL-4 alone.
S8 1178-1430 Sentence denotes These results indicate that IL-4 and ligation of CD40 induce NF-kappa B expression via at least a mechanism dependent on the PI3-kinase pathway and suggest that NF-kappa B sensitive to NAC may play a role in regulating germline C epsilon transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 52-84 NP denotes germline C epsilon transcription
C2 88-124 NP denotes a human Burkitt lymphoma B cell line
C3 126-161 NP denotes Nuclear factor-kappa B (NF-kappa B)
C4 231-241 NP denotes NF-kappa B
C5 273-305 NP denotes germline C epsilon transcription
C6 362-382 NP denotes interleukin-4 (IL-4)
C7 386-421 NP denotes anti-CD40 monoclonal antibody (mAb)
C8 438-459 NP denotes NF-kappa B activation
C9 476-508 NP denotes germline C epsilon transcription
C10 512-548 NP denotes a human Burkitt lymphoma B cell line
C11 550-555 NP denotes DND39
C12 562-566 NP denotes IL-4
C13 571-584 NP denotes anti-CD40 mAb
C15 607-649 NP denotes phosphatidylinositol 3-kinase (PI3-kinase)
C16 730-740 NP denotes NF-kappa B
C14 593-740 NP denotes activation of phosphatidylinositol 3-kinase (PI3-kinase), translocation of a zeta isoform of protein kinase C, and nuclear expression of NF-kappa B
C17 742-757 NP denotes All such events
C18 791-799 NP denotes LY294002
C20 825-835 NP denotes PI3-kinase
C19 801-835 NP denotes a specific inhibitor of PI3-kinase
C21 850-875 NP denotes N-acetyl-L-cysteine (NAC)
C22 877-897 NP denotes a potent antioxidant
C23 909-930 NP denotes NF-kappa B activation
C24 941-945 NP denotes IL-4
C25 947-960 NP denotes anti-CD40 mAb
C26 965-970 NP denotes their
C27 984-987 NP denotes NAC
C28 1022-1054 NP denotes germline C epsilon transcription
C29 1060-1063 NP denotes its
C30 1086-1094 NP denotes cultures
C31 1113-1117 NP denotes IL-4
C32 1122-1135 NP denotes anti-CD40 mAb
C33 1144-1149 NP denotes those
C34 1166-1170 NP denotes IL-4
C35 1206-1210 NP denotes IL-4
C36 1339-1349 NP denotes NF-kappa B
C37 1363-1366 NP denotes NAC
C38 1397-1429 NP denotes germline C epsilon transcription
R1 C4 C3 coref-ident NF-kappa B,Nuclear factor-kappa B (NF-kappa B)
R2 C5 C1 coref-ident germline C epsilon transcription,germline C epsilon transcription
R3 C9 C5 coref-ident germline C epsilon transcription,germline C epsilon transcription
R4 C10 C2 coref-ident a human Burkitt lymphoma B cell line,a human Burkitt lymphoma B cell line
R5 C11 C10 coref-appos DND39,a human Burkitt lymphoma B cell line
R6 C12 C6 coref-ident IL-4,interleukin-4 (IL-4)
R7 C13 C7 coref-ident anti-CD40 mAb,anti-CD40 monoclonal antibody (mAb)
R8 C16 C4 coref-ident NF-kappa B,NF-kappa B
R9 C17 C14 coref-ident All such events,"activation of phosphatidylinositol 3-kinase (PI3-kinase), translocation of a zeta isoform of protein kinase C, and nuclear expression of NF-kappa B"
R10 C20 C15 coref-ident PI3-kinase,phosphatidylinositol 3-kinase (PI3-kinase)
R11 C19 C18 coref-appos a specific inhibitor of PI3-kinase,LY294002
R12 C22 C21 coref-appos a potent antioxidant,N-acetyl-L-cysteine (NAC)
R13 C23 C8 coref-ident NF-kappa B activation,NF-kappa B activation
R14 C24 C12 coref-ident IL-4,IL-4
R15 C25 C13 coref-ident anti-CD40 mAb,anti-CD40 mAb
R16 C26 C24 coref-pron their,IL-4
R17 C26 C25 coref-pron their,anti-CD40 mAb
R18 C27 C21 coref-ident NAC,N-acetyl-L-cysteine (NAC)
R19 C28 C9 coref-ident germline C epsilon transcription,germline C epsilon transcription
R20 C29 C27 coref-pron its,NAC
R21 C31 C24 coref-ident IL-4,IL-4
R22 C32 C25 coref-ident anti-CD40 mAb,anti-CD40 mAb
R23 C33 C30 coref-pron those,cultures
R24 C34 C31 coref-ident IL-4,IL-4
R25 C35 C34 coref-ident IL-4,IL-4
R26 C36 C16 coref-ident NF-kappa B,NF-kappa B
R27 C37 C27 coref-ident NAC,NAC
R28 C38 C28 coref-ident germline C epsilon transcription,germline C epsilon transcription

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-39 protein_complex denotes nuclear factor-kappa B
T2 52-60 DNA_domain_or_region denotes germline
T3 90-124 cell_line denotes human Burkitt lymphoma B cell line
T4 126-148 protein_complex denotes Nuclear factor-kappa B
T5 150-160 protein_complex denotes NF-kappa B
T6 231-241 protein_complex denotes NF-kappa B
T7 273-281 DNA_domain_or_region denotes germline
T8 362-375 protein_molecule denotes interleukin-4
T9 377-381 protein_molecule denotes IL-4
T10 386-391 protein_molecule denotes anti-
T11 391-395 protein_molecule denotes CD40
T12 417-420 protein_family_or_group denotes mAb
T13 438-448 protein_complex denotes NF-kappa B
T14 476-484 DNA_domain_or_region denotes germline
T15 514-548 cell_line denotes human Burkitt lymphoma B cell line
T16 550-555 cell_line denotes DND39
T17 562-566 protein_molecule denotes IL-4
T18 576-580 protein_molecule denotes CD40
T19 607-636 protein_molecule denotes phosphatidylinositol 3-kinase
T20 638-648 protein_molecule denotes PI3-kinase
T21 686-702 protein_molecule denotes protein kinase C
T22 730-740 protein_complex denotes NF-kappa B
T23 791-799 other_organic_compound denotes LY294002
T24 825-835 protein_molecule denotes PI3-kinase
T25 850-869 amino_acid_monomer denotes N-acetyl-L-cysteine
T26 871-874 amino_acid_monomer denotes NAC
T27 909-919 protein_complex denotes NF-kappa B
T28 941-945 protein_molecule denotes IL-4
T29 947-952 protein_molecule denotes anti-
T30 952-956 protein_molecule denotes CD40
T31 984-987 amino_acid_monomer denotes NAC
T32 1022-1030 DNA_domain_or_region denotes germline
T33 1113-1117 protein_molecule denotes IL-4
T34 1122-1127 protein_molecule denotes anti-
T35 1127-1131 protein_molecule denotes CD40
T36 1166-1170 protein_molecule denotes IL-4
T37 1206-1210 protein_molecule denotes IL-4
T38 1227-1231 protein_molecule denotes CD40
T39 1239-1249 protein_complex denotes NF-kappa B
T40 1303-1313 protein_molecule denotes PI3-kinase
T41 1339-1349 protein_complex denotes NF-kappa B
T42 1363-1366 amino_acid_monomer denotes NAC
T43 1397-1405 DNA_domain_or_region denotes germline