> top > docs > PubMed:9069290 > annotations

PubMed:9069290 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
T2 84-304 Sentence denotes For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria.
T3 305-417 Sentence denotes These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways.
T4 418-611 Sentence denotes In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the expression of proinflammatory molecules.
T5 612-756 Sentence denotes One means of understanding the role of p38 in these responses is to identify proteins with functions regulated by p38-catalysed phosphorylation.
T6 757-892 Sentence denotes Here we demonstrate a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors.
T7 893-1017 Sentence denotes We found that in monocytic cells, LPS increases the transactivation activity of MEF2C through p38-catalysed phosphorylation.
T8 1018-1092 Sentence denotes One consequence of MEF2C activation is increased c-jun gene transcription.
T9 1093-1233 Sentence denotes Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection.
T1 0-83 Sentence denotes Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
T2 84-304 Sentence denotes For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria.
T3 305-417 Sentence denotes These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways.
T4 418-611 Sentence denotes In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the expression of proinflammatory molecules.
T5 612-756 Sentence denotes One means of understanding the role of p38 in these responses is to identify proteins with functions regulated by p38-catalysed phosphorylation.
T6 757-892 Sentence denotes Here we demonstrate a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors.
T7 893-1017 Sentence denotes We found that in monocytic cells, LPS increases the transactivation activity of MEF2C through p38-catalysed phosphorylation.
T8 1018-1092 Sentence denotes One consequence of MEF2C activation is increased c-jun gene transcription.
T9 1093-1233 Sentence denotes Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-38 protein denotes transcription factor
T2 39-44 protein denotes MEF2C
T3 52-66 protein denotes MAP kinase p38
T4 390-400 protein denotes MAP kinase
T5 402-406 protein denotes MAPK
T6 441-449 protein denotes MAPK p38
T7 585-610 protein denotes proinflammatory molecules
T8 651-654 protein denotes p38
T9 726-729 protein denotes p38
T10 796-799 protein denotes p38
T11 828-866 protein denotes myocyte-enhancer factor 2 (MEF2) group
T12 870-891 protein denotes transcription factors
T13 910-925 cell_type denotes monocytic cells
T14 973-978 protein denotes MEF2C
T15 987-990 protein denotes p38
T16 1037-1042 protein denotes MEF2C
T17 1067-1077 DNA denotes c-jun gene
T18 1115-1118 protein denotes p38
T19 1193-1206 protein denotes c-Jun protein

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-83 Sentence denotes Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
S2 84-304 Sentence denotes For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria.
S3 305-417 Sentence denotes These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways.
S4 418-611 Sentence denotes In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the expression of proinflammatory molecules.
S5 612-756 Sentence denotes One means of understanding the role of p38 in these responses is to identify proteins with functions regulated by p38-catalysed phosphorylation.
S6 757-892 Sentence denotes Here we demonstrate a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors.
S7 893-1017 Sentence denotes We found that in monocytic cells, LPS increases the transactivation activity of MEF2C through p38-catalysed phosphorylation.
S8 1018-1092 Sentence denotes One consequence of MEF2C activation is increased c-jun gene transcription.
S9 1093-1233 Sentence denotes Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 14-44 NP denotes the transcription factor MEF2C
C1 0-44 NP denotes Activation of the transcription factor MEF2C
C3 48-66 NP denotes the MAP kinase p38
C4 88-121 NP denotes cells of the innate immune system
C5 169-173 NP denotes they
C6 229-253 NP denotes lipopolysaccharide (LPS)
C7 255-303 NP denotes the endotoxin secreted by Gram-negative bacteria
C8 437-449 NP denotes the MAPK p38
C9 508-526 NP denotes cellular responses
C10 552-555 NP denotes its
C11 651-654 NP denotes p38
C12 658-673 NP denotes these responses
C13 726-755 NP denotes p38-catalysed phosphorylation
C14 812-891 NP denotes a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors
C15 927-930 NP denotes LPS
C16 973-978 NP denotes MEF2C
C17 987-1016 NP denotes p38-catalysed phosphorylation
C18 1037-1053 NP denotes MEF2C activation
C19 1115-1118 NP denotes p38
R1 C5 C4 coref-pron they,cells of the innate immune system
R2 C7 C6 coref-appos the endotoxin secreted by Gram-negative bacteria,lipopolysaccharide (LPS)
R3 C8 C3 coref-ident the MAPK p38,the MAP kinase p38
R4 C10 C8 coref-pron its,the MAPK p38
R5 C11 C8 coref-ident p38,the MAPK p38
R6 C12 C9 coref-ident these responses,cellular responses
R7 C14 C2 coref-ident a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors,the transcription factor MEF2C
R8 C15 C6 coref-ident LPS,lipopolysaccharide (LPS)
R9 C16 C14 coref-ident MEF2C,a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors
R10 C17 C13 coref-ident p38-catalysed phosphorylation,p38-catalysed phosphorylation
R11 C18 C1 coref-ident MEF2C activation,Activation of the transcription factor MEF2C
R12 C19 C11 coref-ident p38,p38

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-38 protein_family_or_group denotes transcription factor
T2 39-44 protein_molecule denotes MEF2C
T3 52-62 protein_molecule denotes MAP kinase
T4 63-66 protein_molecule denotes p38
T5 70-82 other_name denotes inflammation
T6 101-121 body_part denotes innate immune system
T7 201-220 mono_cell denotes microbial pathogens
T8 229-247 lipid denotes lipopolysaccharide
T9 249-252 lipid denotes LPS
T10 281-303 mono_cell denotes Gram-negative bacteria
T11 338-371 other_name denotes intracellular signalling pathways
T12 390-400 protein_family_or_group denotes MAP kinase
T13 402-406 protein_family_or_group denotes MAPK
T14 441-449 protein_molecule denotes MAPK p38
T15 508-526 other_name denotes cellular responses
T16 534-543 other_name denotes infection
T17 585-610 protein_family_or_group denotes proinflammatory molecules
T18 651-654 protein_molecule denotes p38
T19 726-729 protein_molecule denotes p38
T20 796-799 protein_molecule denotes p38
T21 828-866 protein_family_or_group denotes myocyte-enhancer factor 2 (MEF2) group
T22 870-891 protein_family_or_group denotes transcription factors
T23 910-925 cell_type denotes monocytic cells
T24 927-930 lipid denotes LPS
T25 973-978 protein_molecule denotes MEF2C
T26 987-990 protein_molecule denotes p38
T27 1037-1042 protein_molecule denotes MEF2C
T28 1067-1077 DNA_domain_or_region denotes c-jun gene
T29 1115-1118 protein_molecule denotes p38
T30 1150-1162 other_name denotes inflammation
T31 1193-1206 protein_molecule denotes c-Jun protein
T32 1223-1232 other_name denotes infection