> top > docs > PubMed:9061006 > annotations

PubMed:9061006 JSONTXT

Annnotations TAB JSON ListView MergeView

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 72-82 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T2 213-225 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T3 215-225 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T4 1353-1363 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-56 protein denotes mitogen-activated protein kinase
T2 597-618 protein denotes transcription factors
T3 619-629 protein denotes NF-kappa B
T4 634-638 protein denotes AP-1
T5 979-1012 protein denotes mitogen-activated protein kinases
T6 1013-1017 protein denotes erk1
T7 1022-1026 protein denotes erk2
T8 1255-1259 protein denotes erk2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-94 Sentence denotes Redox regulation of the mitogen-activated protein kinase pathway during lymphocyte activation.
S2 95-414 Sentence denotes We have previously demonstrated an obligatory requirement for intracellular reactive oxygen species generation during T lymphocyte activation, and have proposed that intracellular reactive oxygen species may act as signalling agents in the regulation of certain cellular processes, for example, during cell cycle entry.
S3 415-553 Sentence denotes To test this hypothesis, we have been interested to determine which, if any, cell cycle entry events are affected by oxidative signalling.
S4 554-864 Sentence denotes In earlier studies, we have identified the transcription factors NF-kappa B and AP-1 as molecular targets for oxidative signalling processes during cell cycle entry, and have shown that oxidative signalling is involved in the regulation of early changes in gene expression during the G0 to G1 phase transition.
S5 865-1129 Sentence denotes To extend these initial observations, we have examined the effect of antioxidant treatment on the activity of the mitogen-activated protein kinases erk1 and erk2, as members of a signal transduction pathway known to directly regulate transcription factor function.
S6 1130-1375 Sentence denotes Using as a probe cysteamine, an aminothiol compound with both antioxidant and antiproliferative activity, we have identified erk2, a key element of the MAP kinase pathway, as being responsive to oxidative signalling during lymphocyte activation.
S7 1376-1689 Sentence denotes These observations provide further evidence to suggest a role for intracellular oxidant generation as a regulatory mechanism during cell cycle entry, and establish a link between oxidative signalling and other aspects of the intracellular signalling network that is activated in response to mitogenic stimulation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 20-64 NP denotes the mitogen-activated protein kinase pathway
C2 72-93 NP denotes lymphocyte activation
C3 397-413 NP denotes cell cycle entry
C4 532-552 NP denotes oxidative signalling
C5 702-718 NP denotes cell cycle entry
C6 740-760 NP denotes oxidative signalling
C7 1139-1157 NP denotes a probe cysteamine
C8 1159-1234 NP denotes an aminothiol compound with both antioxidant and antiproliferative activity
C9 1255-1259 NP denotes erk2
C11 1278-1300 NP denotes the MAP kinase pathway
C10 1261-1300 NP denotes a key element of the MAP kinase pathway
C12 1325-1345 NP denotes oxidative signalling
C13 1353-1374 NP denotes lymphocyte activation
C14 1508-1524 NP denotes cell cycle entry
C15 1555-1575 NP denotes oxidative signalling
C16 1597-1633 NP denotes the intracellular signalling network
C17 1634-1638 NP denotes that
R1 C5 C3 coref-ident cell cycle entry,cell cycle entry
R2 C6 C4 coref-ident oxidative signalling,oxidative signalling
R3 C8 C7 coref-appos an aminothiol compound with both antioxidant and antiproliferative activity,a probe cysteamine
R4 C11 C1 coref-ident the MAP kinase pathway,the mitogen-activated protein kinase pathway
R5 C10 C9 coref-appos a key element of the MAP kinase pathway,erk2
R6 C12 C6 coref-ident oxidative signalling,oxidative signalling
R7 C13 C2 coref-ident lymphocyte activation,lymphocyte activation
R8 C14 C5 coref-ident cell cycle entry,cell cycle entry
R9 C15 C12 coref-ident oxidative signalling,oxidative signalling
R10 C17 C16 coref-relat that,the intracellular signalling network

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-56 protein_family_or_group denotes mitogen-activated protein kinase
T2 72-93 other_name denotes lymphocyte activation
T3 215-236 other_name denotes lymphocyte activation
T4 261-298 other_organic_compound denotes intracellular reactive oxygen species
T5 397-413 other_name denotes cell cycle entry
T6 492-508 other_name denotes cell cycle entry
T7 597-618 protein_family_or_group denotes transcription factors
T8 619-629 protein_complex denotes NF-kappa B
T9 634-638 protein_molecule denotes AP-1
T10 702-718 other_name denotes cell cycle entry
T11 811-826 other_name denotes gene expression
T12 838-863 other_name denotes G0 to G1 phase transition
T13 979-1012 protein_family_or_group denotes mitogen-activated protein kinases
T14 1013-1017 protein_molecule denotes erk1
T15 1022-1026 protein_molecule denotes erk2
T16 1044-1071 other_name denotes signal transduction pathway
T17 1099-1128 other_name denotes transcription factor function
T18 1147-1157 other_organic_compound denotes cysteamine
T19 1162-1181 other_organic_compound denotes aminothiol compound
T20 1192-1203 other_name denotes antioxidant
T21 1208-1234 other_name denotes antiproliferative activity
T22 1255-1259 protein_molecule denotes erk2
T23 1353-1374 other_name denotes lymphocyte activation
T24 1480-1500 other_name denotes regulatory mechanism
T25 1508-1524 other_name denotes cell cycle entry
T26 1601-1633 other_name denotes intracellular signalling network
T27 1667-1688 other_name denotes mitogenic stimulation

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 72-82 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T2 157-170 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 213-225 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T4 261-274 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 357-375 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995
T6 397-407 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T7 492-502 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T8 702-712 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T9 1353-1363 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T10 1442-1455 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T11 1508-1518 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T12 1601-1614 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622