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sentences

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
T2 150-328 Sentence denotes The Jak1, Jak2, Jak3, and Fes tyrosine kinases have been demonstrated to undergo tyrosine phosphorylation in response to interleukin (IL)-4 stimulation in different cell systems.
T3 329-491 Sentence denotes However, it is not clear which, if any, of these kinases are responsible for initiating IL-4-induced tyrosine phosphorylation of intracellular substrates in vivo.
T4 492-714 Sentence denotes In the present study, we have utilized a mutant Jak1-deficient HeLa cell line, E1C3, and its parental Jak1-expressing counterpart, 1D4, to analyze the role of Jak1 in mediating IL-4-induced tyrosine phosphorylation events.
T5 715-848 Sentence denotes IL-4 treatment rapidly induced tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and IRS-2 in 1D4 but not in E1C3 cells.
T6 849-997 Sentence denotes IL-4-mediated tyrosine phosphorylation of Stat6 was pronounced in 1D4 cells, while no IL-4-induced Stat6 phosphorylation was detected in E1C3 cells.
T7 998-1223 Sentence denotes IL-4 also induced Stat6 DNA binding activity from lysates of 1D4 but not E1C3 cells utilizing a radiolabeled immunoglobulin heavy chain germline epsilon promotor sequence (Iepsilon) in an electrophoretic mobility shift assay.
T8 1224-1350 Sentence denotes Reconstitution of Jak1 expression in E1C3 cells restored the ability of IL-4 to induce IRS and Stat6 tyrosine phosphorylation.
T9 1351-1527 Sentence denotes These results provide evidence that Jak1 expression is required for mediating tyrosine phosphorylation and activation of crucial molecules involved in IL-4 signal transduction.
T1 0-149 Sentence denotes Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
T2 150-328 Sentence denotes The Jak1, Jak2, Jak3, and Fes tyrosine kinases have been demonstrated to undergo tyrosine phosphorylation in response to interleukin (IL)-4 stimulation in different cell systems.
T3 329-491 Sentence denotes However, it is not clear which, if any, of these kinases are responsible for initiating IL-4-induced tyrosine phosphorylation of intracellular substrates in vivo.
T4 492-714 Sentence denotes In the present study, we have utilized a mutant Jak1-deficient HeLa cell line, E1C3, and its parental Jak1-expressing counterpart, 1D4, to analyze the role of Jak1 in mediating IL-4-induced tyrosine phosphorylation events.
T5 715-848 Sentence denotes IL-4 treatment rapidly induced tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and IRS-2 in 1D4 but not in E1C3 cells.
T6 849-997 Sentence denotes IL-4-mediated tyrosine phosphorylation of Stat6 was pronounced in 1D4 cells, while no IL-4-induced Stat6 phosphorylation was detected in E1C3 cells.
T7 998-1223 Sentence denotes IL-4 also induced Stat6 DNA binding activity from lysates of 1D4 but not E1C3 cells utilizing a radiolabeled immunoglobulin heavy chain germline epsilon promotor sequence (Iepsilon) in an electrophoretic mobility shift assay.
T8 1224-1350 Sentence denotes Reconstitution of Jak1 expression in E1C3 cells restored the ability of IL-4 to induce IRS and Stat6 tyrosine phosphorylation.
T9 1351-1527 Sentence denotes These results provide evidence that Jak1 expression is required for mediating tyrosine phosphorylation and activation of crucial molecules involved in IL-4 signal transduction.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes Jak1
T2 123-128 protein denotes Stat6
T3 129-148 protein denotes signaling molecules
T4 154-196 protein denotes Jak1, Jak2, Jak3, and Fes tyrosine kinases
T5 271-289 protein denotes interleukin (IL)-4
T6 458-482 protein denotes intracellular substrates
T7 533-569 cell_line denotes mutant Jak1-deficient HeLa cell line
T8 571-575 cell_line denotes E1C3
T9 585-621 cell_line denotes parental Jak1-expressing counterpart
T10 623-626 cell_line denotes 1D4
T11 651-655 protein denotes Jak1
T12 774-808 protein denotes insulin receptor substrate (IRS)-1
T13 813-818 protein denotes IRS-2
T14 822-825 cell_line denotes 1D4
T15 837-847 cell_line denotes E1C3 cells
T16 849-853 protein denotes IL-4
T17 891-896 protein denotes Stat6
T18 915-924 cell_line denotes 1D4 cells
T19 935-939 protein denotes IL-4
T20 948-953 protein denotes Stat6
T21 986-996 cell_line denotes E1C3 cells
T22 998-1002 protein denotes IL-4
T23 1016-1021 protein denotes Stat6
T24 1059-1062 cell_line denotes 1D4
T25 1071-1081 cell_line denotes E1C3 cells
T26 1094-1168 DNA denotes radiolabeled immunoglobulin heavy chain germline epsilon promotor sequence
T27 1170-1178 DNA denotes Iepsilon
T28 1242-1246 protein denotes Jak1
T29 1261-1271 cell_line denotes E1C3 cells
T30 1296-1300 protein denotes IL-4
T31 1311-1314 DNA denotes IRS
T32 1319-1324 protein denotes Stat6
T33 1387-1391 protein denotes Jak1
T34 1502-1506 protein denotes IL-4

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-149 Sentence denotes Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
S2 150-328 Sentence denotes The Jak1, Jak2, Jak3, and Fes tyrosine kinases have been demonstrated to undergo tyrosine phosphorylation in response to interleukin (IL)-4 stimulation in different cell systems.
S3 329-491 Sentence denotes However, it is not clear which, if any, of these kinases are responsible for initiating IL-4-induced tyrosine phosphorylation of intracellular substrates in vivo.
S4 492-714 Sentence denotes In the present study, we have utilized a mutant Jak1-deficient HeLa cell line, E1C3, and its parental Jak1-expressing counterpart, 1D4, to analyze the role of Jak1 in mediating IL-4-induced tyrosine phosphorylation events.
S5 715-848 Sentence denotes IL-4 treatment rapidly induced tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and IRS-2 in 1D4 but not in E1C3 cells.
S6 849-997 Sentence denotes IL-4-mediated tyrosine phosphorylation of Stat6 was pronounced in 1D4 cells, while no IL-4-induced Stat6 phosphorylation was detected in E1C3 cells.
S7 998-1223 Sentence denotes IL-4 also induced Stat6 DNA binding activity from lysates of 1D4 but not E1C3 cells utilizing a radiolabeled immunoglobulin heavy chain germline epsilon promotor sequence (Iepsilon) in an electrophoretic mobility shift assay.
S8 1224-1350 Sentence denotes Reconstitution of Jak1 expression in E1C3 cells restored the ability of IL-4 to induce IRS and Stat6 tyrosine phosphorylation.
S9 1351-1527 Sentence denotes These results provide evidence that Jak1 expression is required for mediating tyrosine phosphorylation and activation of crucial molecules involved in IL-4 signal transduction.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-15 NP denotes Jak1 expression
C2 42-148 NP denotes interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules
C3 150-196 NP denotes The Jak1, Jak2, Jak3, and Fes tyrosine kinases
C4 372-385 NP denotes these kinases
C5 531-569 NP denotes a mutant Jak1-deficient HeLa cell line
C6 571-575 NP denotes E1C3
C8 581-584 NP denotes its
C7 581-621 NP denotes its parental Jak1-expressing counterpart
C9 623-626 NP denotes 1D4
C10 822-825 NP denotes 1D4
C11 837-847 NP denotes E1C3 cells
C12 915-924 NP denotes 1D4 cells
C13 986-996 NP denotes E1C3 cells
C14 998-1002 NP denotes IL-4
C15 1059-1062 NP denotes 1D4
C16 1071-1081 NP denotes E1C3 cells
C17 1242-1257 NP denotes Jak1 expression
C18 1261-1271 NP denotes E1C3 cells
C19 1296-1300 NP denotes IL-4
C20 1311-1349 NP denotes IRS and Stat6 tyrosine phosphorylation
C21 1387-1402 NP denotes Jak1 expression
R1 C4 C3 coref-ident these kinases,"The Jak1, Jak2, Jak3, and Fes tyrosine kinases"
R2 C6 C5 coref-appos E1C3,a mutant Jak1-deficient HeLa cell line
R3 C8 C5 coref-pron its,a mutant Jak1-deficient HeLa cell line
R4 C9 C7 coref-appos 1D4,its parental Jak1-expressing counterpart
R5 C10 C7 coref-ident 1D4,its parental Jak1-expressing counterpart
R6 C11 C5 coref-ident E1C3 cells,a mutant Jak1-deficient HeLa cell line
R7 C12 C10 coref-ident 1D4 cells,1D4
R8 C13 C11 coref-ident E1C3 cells,E1C3 cells
R9 C15 C12 coref-ident 1D4,1D4 cells
R10 C16 C13 coref-ident E1C3 cells,E1C3 cells
R11 C17 C1 coref-ident Jak1 expression,Jak1 expression
R12 C18 C16 coref-ident E1C3 cells,E1C3 cells
R13 C19 C14 coref-ident IL-4,IL-4
R14 C20 C2 coref-ident IRS and Stat6 tyrosine phosphorylation,interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules
R15 C21 C17 coref-ident Jak1 expression,Jak1 expression

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes Jak1
T2 42-63 other_name denotes interleukin-4-induced
T3 64-72 amino_acid_monomer denotes tyrosine
T4 123-128 protein_molecule denotes Stat6
T5 129-148 protein_family_or_group denotes signaling molecules
T6 231-239 amino_acid_monomer denotes tyrosine
T7 271-289 protein_molecule denotes interleukin (IL)-4
T8 417-429 other_name denotes IL-4-induced
T9 430-438 amino_acid_monomer denotes tyrosine
T10 458-482 protein_family_or_group denotes intracellular substrates
T11 533-539 cell_line denotes mutant
T12 540-544 protein_molecule denotes Jak1
T13 571-575 cell_line denotes E1C3
T14 585-593 cell_line denotes parental
T15 594-598 protein_molecule denotes Jak1
T16 623-626 cell_line denotes 1D4
T17 651-655 protein_molecule denotes Jak1
T18 669-681 other_name denotes IL-4-induced
T19 682-690 amino_acid_monomer denotes tyrosine
T20 746-754 amino_acid_monomer denotes tyrosine
T21 774-808 protein_family_or_group denotes insulin receptor substrate (IRS)-1
T22 813-818 protein_molecule denotes IRS-2
T23 822-825 cell_line denotes 1D4
T24 837-847 cell_line denotes E1C3 cells
T25 849-853 protein_molecule denotes IL-4
T26 863-871 amino_acid_monomer denotes tyrosine
T27 891-896 protein_molecule denotes Stat6
T28 915-924 cell_line denotes 1D4 cells
T29 935-939 protein_molecule denotes IL-4
T30 948-953 protein_molecule denotes Stat6
T31 986-996 cell_line denotes E1C3 cells
T32 998-1002 protein_molecule denotes IL-4
T33 1016-1021 protein_molecule denotes Stat6
T34 1048-1055 cell_component denotes lysates
T35 1059-1062 cell_line denotes 1D4
T36 1071-1081 cell_line denotes E1C3 cells
T37 1094-1168 DNA_domain_or_region denotes radiolabeled immunoglobulin heavy chain germline epsilon promotor sequence
T38 1170-1178 DNA_domain_or_region denotes Iepsilon
T39 1186-1222 other_name denotes electrophoretic mobility shift assay
T40 1242-1246 protein_molecule denotes Jak1
T41 1261-1271 cell_line denotes E1C3 cells
T42 1296-1300 protein_molecule denotes IL-4
T43 1311-1314 DNA_molecule denotes IRS
T44 1319-1324 protein_molecule denotes Stat6
T45 1325-1333 amino_acid_monomer denotes tyrosine
T46 1387-1391 protein_molecule denotes Jak1
T47 1429-1437 amino_acid_monomer denotes tyrosine
T48 1502-1506 protein_molecule denotes IL-4

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 458-471 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1143-1150 Cell denotes epsilon http://purl.obolibrary.org/obo/CL:0003025