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PubMed:9032271 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
T2 105-255 Sentence denotes Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
T3 256-352 Sentence denotes Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
T4 353-492 Sentence denotes Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
T5 493-579 Sentence denotes The transduction pathways that lead to I kappaB inactivation remain poorly understood.
T6 580-748 Sentence denotes In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
T7 749-988 Sentence denotes We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
T8 989-1153 Sentence denotes Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
T9 1154-1375 Sentence denotes As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
T10 1376-1531 Sentence denotes In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
T11 1532-1622 Sentence denotes Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
T12 1623-1834 Sentence denotes We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
T13 1835-2009 Sentence denotes Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
T14 2010-2177 Sentence denotes Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
T15 2178-2331 Sentence denotes In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.
T1 0-104 Sentence denotes Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
T2 105-255 Sentence denotes Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
T3 256-352 Sentence denotes Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
T4 353-492 Sentence denotes Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
T5 493-579 Sentence denotes The transduction pathways that lead to I kappaB inactivation remain poorly understood.
T6 580-748 Sentence denotes In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
T7 749-988 Sentence denotes We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
T8 989-1153 Sentence denotes Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
T9 1154-1375 Sentence denotes As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
T10 1376-1531 Sentence denotes In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
T11 1532-1622 Sentence denotes Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
T12 1623-1834 Sentence denotes We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
T13 1835-2009 Sentence denotes Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
T14 2010-2177 Sentence denotes Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
T15 2178-2331 Sentence denotes In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-38 cell_line denotes mutant cell line
T2 62-71 protein denotes NF-kappaB
T3 221-242 protein denotes nuclear factor kappaB
T4 244-253 protein denotes NF-kappaB
T5 287-295 protein denotes I kappaB
T6 297-306 protein denotes NF-kappaB
T7 389-397 protein denotes I kappaB
T8 417-426 protein denotes NF-kappaB
T9 532-540 protein denotes I kappaB
T10 640-682 cell_line denotes 70/Z3-derived 1.3E2 murine pre-B cell line
T11 707-716 protein denotes NF-kappaB
T12 843-856 protein denotes interleukin-1
T13 861-880 RNA denotes double-stranded RNA
T14 882-896 protein denotes I kappaB alpha
T15 1011-1025 protein denotes I kappaB alpha
T16 1044-1047 protein denotes p50
T17 1051-1055 protein denotes relA
T18 1083-1092 protein denotes NF-kappaB
T19 1213-1221 protein denotes I kappaB
T20 1287-1298 cell_line denotes 1.3E2 cells
T21 1495-1503 protein denotes I kappaB
T22 1525-1530 cell_line denotes 1.3E2
T23 1564-1569 cell_line denotes 1.3E2
T24 1606-1621 cell_line denotes wild-type 70Z/3
T25 1647-1718 protein denotes human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator
T26 1727-1736 protein denotes NF-kappaB
T27 1749-1754 cell_line denotes 1.3E2
T28 1867-1885 protein denotes I kappaB molecules
T29 1887-1900 protein denotes I kappaB beta
T30 1929-1945 protein denotes I kappaB epsilon
T31 1971-1976 cell_line denotes 1.3E2
T32 2039-2044 cell_line denotes 1.3E2
T33 2050-2078 protein denotes cellular transduction mutant
T34 2167-2176 protein denotes NF-kappaB
T35 2267-2281 protein denotes I kappaB alpha
T36 2283-2296 protein denotes I kappaB beta
T37 2302-2318 protein denotes I kappaB epsilon

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
S2 105-255 Sentence denotes Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
S3 256-352 Sentence denotes Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
S4 353-492 Sentence denotes Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
S5 493-579 Sentence denotes The transduction pathways that lead to I kappaB inactivation remain poorly understood.
S6 580-748 Sentence denotes In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
S7 749-988 Sentence denotes We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
S8 989-1153 Sentence denotes Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
S9 1154-1375 Sentence denotes As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
S10 1376-1531 Sentence denotes In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
S11 1532-1622 Sentence denotes Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
S12 1623-1834 Sentence denotes We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
S13 1835-2009 Sentence denotes Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
S14 2010-2177 Sentence denotes Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
S15 2178-2331 Sentence denotes In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 20-38 NP denotes a mutant cell line
C3 39-43 NP denotes that
C4 62-71 NP denotes NF-kappaB
C1 20-103 NP denotes a mutant cell line that does not activate NF-kappaB in response to multiple stimuli
C5 221-254 NP denotes nuclear factor kappaB (NF-kappaB)
C7 272-275 NP denotes its
C6 272-285 NP denotes its inhibitor
C8 287-295 NP denotes I kappaB
C9 297-306 NP denotes NF-kappaB
C10 389-397 NP denotes I kappaB
C11 417-426 NP denotes NF-kappaB
C12 462-464 NP denotes it
C13 475-478 NP denotes its
C14 493-518 NP denotes The transduction pathways
C15 519-523 NP denotes that
C17 617-634 NP denotes a cellular mutant
C18 636-682 NP denotes the 70/Z3-derived 1.3E2 murine pre-B cell line
C19 684-688 NP denotes that
C20 707-716 NP denotes NF-kappaB
C16 617-747 NP denotes a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli
C21 882-896 NP denotes I kappaB alpha
C22 970-987 NP denotes serines 32 and 36
C23 1011-1025 NP denotes I kappaB alpha
C24 1044-1055 NP denotes p50 or relA
C26 1083-1092 NP denotes NF-kappaB
C25 1057-1092 NP denotes the two major subunits of NF-kappaB
C27 1096-1110 NP denotes this cell line
C28 1213-1227 NP denotes I kappaB alpha
C29 1231-1248 NP denotes serines 32 and 36
C30 1250-1265 NP denotes all the stimuli
C31 1266-1270 NP denotes that
C32 1287-1298 NP denotes 1.3E2 cells
C33 1389-1449 NP denotes stimuli such as hyperosmotic shock or phosphatase inhibitors
C34 1451-1456 NP denotes which
C35 1525-1530 NP denotes 1.3E2
C36 1564-1569 NP denotes 1.3E2
C37 1643-1718 NP denotes the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator
C38 1749-1754 NP denotes 1.3E2
C39 1772-1790 NP denotes this viral protein
C40 1857-1885 NP denotes two other I kappaB molecules
C41 1887-1945 NP denotes I kappaB beta and the recently identified I kappaB epsilon
C42 1967-1986 NP denotes the 1.3E2 cell line
C43 2039-2044 NP denotes 1.3E2
C44 2102-2108 NP denotes a step
C45 2109-2113 NP denotes that
C46 2167-2176 NP denotes NF-kappaB
C47 2231-2253 NP denotes the signaling pathways
C48 2254-2258 NP denotes that
C49 2267-2281 NP denotes I kappaB alpha
R1 C3 C2 coref-relat that,a mutant cell line
R2 C5 C4 coref-ident nuclear factor kappaB (NF-kappaB),NF-kappaB
R3 C7 C5 coref-pron its,nuclear factor kappaB (NF-kappaB)
R4 C8 C6 coref-appos I kappaB,its inhibitor
R5 C9 C5 coref-ident NF-kappaB,nuclear factor kappaB (NF-kappaB)
R6 C10 C6 coref-ident I kappaB,its inhibitor
R7 C11 C9 coref-ident NF-kappaB,NF-kappaB
R8 C12 C11 coref-pron it,NF-kappaB
R9 C13 C11 coref-pron its,NF-kappaB
R10 C15 C14 coref-relat that,The transduction pathways
R11 C18 C17 coref-appos the 70/Z3-derived 1.3E2 murine pre-B cell line,a cellular mutant
R12 C19 C17 coref-relat that,a cellular mutant
R13 C20 C11 coref-ident NF-kappaB,NF-kappaB
R14 C16 C1 coref-ident "a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli",a mutant cell line that does not activate NF-kappaB in response to multiple stimuli
R15 C23 C21 coref-ident I kappaB alpha,I kappaB alpha
R16 C26 C20 coref-ident NF-kappaB,NF-kappaB
R17 C25 C24 coref-appos the two major subunits of NF-kappaB,p50 or relA
R18 C27 C16 coref-ident this cell line,"a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli"
R19 C28 C23 coref-ident I kappaB alpha,I kappaB alpha
R20 C29 C22 coref-ident serines 32 and 36,serines 32 and 36
R21 C31 C30 coref-relat that,all the stimuli
R22 C34 C33 coref-relat which,stimuli such as hyperosmotic shock or phosphatase inhibitors
R23 C35 C32 coref-ident 1.3E2,1.3E2 cells
R24 C36 C35 coref-ident 1.3E2,1.3E2
R25 C38 C36 coref-ident 1.3E2,1.3E2
R26 C39 C37 coref-ident this viral protein,the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator
R27 C41 C40 coref-appos I kappaB beta and the recently identified I kappaB epsilon,two other I kappaB molecules
R28 C42 C38 coref-ident the 1.3E2 cell line,1.3E2
R29 C43 C42 coref-ident 1.3E2,the 1.3E2 cell line
R30 C45 C44 coref-relat that,a step
R31 C46 C26 coref-ident NF-kappaB,NF-kappaB
R32 C48 C47 coref-relat that,the signaling pathways
R33 C49 C28 coref-ident I kappaB alpha,I kappaB alpha

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-38 cell_line denotes mutant cell line
T2 62-71 protein_complex denotes NF-kappaB
T3 150-162 other_name denotes inflammation
T4 221-242 protein_complex denotes nuclear factor kappaB
T5 244-253 protein_complex denotes NF-kappaB
T6 287-295 protein_molecule denotes I kappaB
T7 297-306 protein_complex denotes NF-kappaB
T8 342-351 cell_component denotes cytoplasm
T9 389-397 protein_molecule denotes I kappaB
T10 417-426 protein_complex denotes NF-kappaB
T11 497-518 other_name denotes transduction pathways
T12 532-540 protein_molecule denotes I kappaB
T13 640-682 cell_line denotes 70/Z3-derived 1.3E2 murine pre-B cell line
T14 707-716 protein_complex denotes NF-kappaB
T15 789-807 lipid denotes lipopolysaccharide
T16 809-814 other_organic_compound denotes Taxol
T17 816-841 other_organic_compound denotes phorbol myristate acetate
T18 843-856 protein_molecule denotes interleukin-1
T19 861-880 RNA_family_or_group denotes double-stranded RNA
T20 882-890 protein_molecule denotes I kappaB
T21 1011-1019 protein_molecule denotes I kappaB
T22 1044-1047 protein_subunit denotes p50
T23 1051-1055 protein_subunit denotes relA
T24 1083-1092 protein_complex denotes NF-kappaB
T25 1130-1152 other_name denotes phosphorylation defect
T26 1184-1209 other_name denotes inducible phosphorylation
T27 1213-1221 protein_molecule denotes I kappaB
T28 1287-1298 cell_line denotes 1.3E2 cells
T29 1328-1339 other_organic_compound denotes antioxidant
T30 1340-1367 other_organic_compound denotes pyrrolidine dithiocarbamate
T31 1369-1373 other_organic_compound denotes PDTC
T32 1405-1423 other_name denotes hyperosmotic shock
T33 1427-1449 other_organic_compound denotes phosphatase inhibitors
T34 1461-1465 other_organic_compound denotes PDTC
T35 1495-1503 protein_molecule denotes I kappaB
T36 1525-1530 cell_line denotes 1.3E2
T37 1564-1569 cell_line denotes 1.3E2
T38 1606-1621 cell_line denotes wild-type 70Z/3
T39 1647-1681 virus denotes human T-cell leukemia virus type 1
T40 1683-1689 virus denotes HTLV-1
T41 1699-1702 protein_molecule denotes Tax
T42 1727-1736 protein_complex denotes NF-kappaB
T43 1749-1754 cell_line denotes 1.3E2
T44 1816-1833 other_name denotes defective pathway
T45 1867-1875 protein_molecule denotes I kappaB
T46 1887-1895 protein_molecule denotes I kappaB
T47 1929-1937 protein_molecule denotes I kappaB
T48 1971-1976 cell_line denotes 1.3E2
T49 2039-2044 cell_line denotes 1.3E2
T50 2050-2078 protein_family_or_group denotes cellular transduction mutant
T51 2167-2176 protein_complex denotes NF-kappaB
T52 2267-2275 protein_molecule denotes I kappaB
T53 2283-2291 protein_molecule denotes I kappaB
T54 2302-2310 protein_molecule denotes I kappaB
T55 2319-2330 other_name denotes degradation