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PubMed:9032265 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 81-101 gene:10153 denotes CCAAT binding factor
T1 136-151 disease:C0678128 denotes Friend leukemia
R1 T0 T1 associated_with CCAAT binding factor,Friend leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 34-59 DNA denotes ferritin heavy-chain gene
T2 81-106 protein denotes CCAAT binding factor NF-Y
T3 123-157 cell_line denotes heme-treated Friend leukemia cells
T4 213-243 DNA denotes ferritin H-chain gene promoter
T5 271-305 cell_line denotes heme-treated Friend leukemia cells
T6 307-311 cell_line denotes FLCs
T7 383-393 cell_line denotes cell lines
T8 421-429 protein denotes ferritin
T9 500-531 cell_type denotes differentiating erythroid cells
T10 587-597 protein denotes hemoglobin
T11 616-627 cell_type denotes macrophages
T12 771-795 DNA denotes ferritin H-gene promoter
T13 857-861 cell_line denotes FLCs
T14 867-880 DNA denotes reporter gene
T15 884-907 DNA denotes 77 nucleotides upstream
T16 915-923 DNA denotes TATA box
T17 930-941 DNA denotes cis element
T18 981-984 protein denotes HRF
T19 986-1008 protein denotes heme-responsive factor
T20 1058-1062 cell_line denotes FLCs
T21 1118-1131 DNA denotes CCAAT element
T22 1194-1215 DNA denotes ferritin H-chain gene
T23 1328-1331 protein denotes HRF
T24 1368-1385 cell_line denotes transfected cells
T25 1463-1466 protein denotes HRF
T26 1505-1525 protein denotes transcription factor
T27 1526-1530 protein denotes NF-Y
T28 1532-1536 protein denotes NF-Y
T29 1556-1564 protein denotes subunits
T30 1566-1567 protein denotes A
T31 1569-1570 protein denotes B
T32 1576-1577 protein denotes C
T33 1645-1674 protein denotes transdominant negative mutant
T34 1682-1695 protein denotes NF-YA subunit
T35 1740-1744 protein denotes heme
T36 1762-1766 protein denotes NF-Y
T37 1866-1879 protein denotes NF-YA subunit
T38 1908-1912 cell_line denotes FLCs

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9032265-0#81#101#gene10153 81-101 gene10153 denotes CCAAT binding factor
9032265-0#136#151#diseaseC0678128 136-151 diseaseC0678128 denotes Friend leukemia
9032265-10#55#60#gene4800 1866-1871 gene4800 denotes NF-YA
9032265-10#97#100#diseaseC0334287 1908-1911 diseaseC0334287 denotes FLC
9032265-5#56#59#gene7178 981-984 gene7178 denotes HRF
9032265-5#133#136#diseaseC0334287 1058-1061 diseaseC0334287 denotes FLC
81#101#gene10153136#151#diseaseC0678128 9032265-0#81#101#gene10153 9032265-0#136#151#diseaseC0678128 associated_with CCAAT binding factor,Friend leukemia
55#60#gene480097#100#diseaseC0334287 9032265-10#55#60#gene4800 9032265-10#97#100#diseaseC0334287 associated_with NF-YA,FLC
56#59#gene7178133#136#diseaseC0334287 9032265-5#56#59#gene7178 9032265-5#133#136#diseaseC0334287 associated_with HRF,FLC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-208 Sentence denotes Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation.
S2 209-363 Sentence denotes The ferritin H-chain gene promoter regulation was analyzed in heme-treated Friend leukemia cells (FLCs) and during monocyte-to-macrophage differentiation.
S3 364-487 Sentence denotes In the majority of cell lines studied, the regulation of ferritin expression was exerted mostly at the translational level.
S4 488-726 Sentence denotes However, in differentiating erythroid cells, which must incorporate high levels of iron to sustain hemoglobin synthesis, and in macrophages, which are involved in iron storage, transcriptional regulation seemed to be a relevant mechanism.
S5 727-924 Sentence denotes We show here that the minimum region of the ferritin H-gene promoter that is able to confer transcriptional regulation by heme in FLCs to a reporter gene is 77 nucleotides upstream of the TATA box.
S6 925-1113 Sentence denotes This cis element binds a protein complex referred to as HRF (heme-responsive factor), which is greatly enhanced both in heme-treated FLCs and during monocyte-to-macrophage differentiation.
S7 1114-1386 Sentence denotes The CCAAT element present in reverse orientation in this promoter region of the ferritin H-chain gene is necessary for binding and for gene activity, since a single point mutation is able to abolish the binding of HRF and the transcriptional activity in transfected cells.
S8 1387-1531 Sentence denotes By competition experiments and supershift assays, we identified the induced HRF as containing at least the ubiquitous transcription factor NF-Y.
S9 1532-1622 Sentence denotes NF-Y is formed by three subunits, A, B, and C, all of which are necessary for DNA binding.
S10 1623-1810 Sentence denotes Cotransfection with a transdominant negative mutant of the NF-YA subunit abolishes the transcriptional activation by heme, indicating that NF-Y plays an essential role in this activation.
S11 1811-1963 Sentence denotes We have also observed a differential expression of the NF-YA subunit in heme-treated and control FLCs and during monocyte-to-macrophage differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 30-59 NP denotes the ferritin heavy-chain gene
C2 77-106 NP denotes the CCAAT binding factor NF-Y
C3 123-157 NP denotes heme-treated Friend leukemia cells
C4 169-207 NP denotes monocyte-to-macrophage differentiation
C5 271-312 NP denotes heme-treated Friend leukemia cells (FLCs)
C6 324-362 NP denotes monocyte-to-macrophage differentiation
C7 500-531 NP denotes differentiating erythroid cells
C8 533-538 NP denotes which
C9 616-627 NP denotes macrophages
C10 629-634 NP denotes which
C12 745-795 NP denotes the minimum region of the ferritin H-gene promoter
C13 796-800 NP denotes that
C14 849-853 NP denotes heme
C11 745-880 NP denotes the minimum region of the ferritin H-gene promoter that is able to confer transcriptional regulation by heme in FLCs to a reporter gene
C15 948-965 NP denotes a protein complex
C16 981-1009 NP denotes HRF (heme-responsive factor)
C17 1011-1016 NP denotes which
C18 1045-1062 NP denotes heme-treated FLCs
C19 1074-1112 NP denotes monocyte-to-macrophage differentiation
C21 1190-1215 NP denotes the ferritin H-chain gene
C20 1166-1215 NP denotes this promoter region of the ferritin H-chain gene
C22 1328-1331 NP denotes HRF
C23 1490-1530 NP denotes the ubiquitous transcription factor NF-Y
C24 1532-1536 NP denotes NF-Y
C25 1550-1564 NP denotes three subunits
C26 1566-1577 NP denotes A, B, and C
C28 1586-1591 NP denotes which
C27 1579-1591 NP denotes all of which
C29 1678-1695 NP denotes the NF-YA subunit
C31 1740-1744 NP denotes heme
C30 1706-1744 NP denotes the transcriptional activation by heme
C32 1762-1766 NP denotes NF-Y
C33 1794-1809 NP denotes this activation
C34 1862-1879 NP denotes the NF-YA subunit
C35 1924-1962 NP denotes monocyte-to-macrophage differentiation
R1 C5 C3 coref-ident heme-treated Friend leukemia cells (FLCs),heme-treated Friend leukemia cells
R2 C6 C4 coref-ident monocyte-to-macrophage differentiation,monocyte-to-macrophage differentiation
R3 C8 C7 coref-relat which,differentiating erythroid cells
R4 C10 C9 coref-relat which,macrophages
R5 C13 C12 coref-relat that,the minimum region of the ferritin H-gene promoter
R6 C16 C15 coref-ident HRF (heme-responsive factor),a protein complex
R7 C17 C16 coref-relat which,HRF (heme-responsive factor)
R8 C18 C5 coref-ident heme-treated FLCs,heme-treated Friend leukemia cells (FLCs)
R9 C19 C6 coref-ident monocyte-to-macrophage differentiation,monocyte-to-macrophage differentiation
R10 C21 C1 coref-ident the ferritin H-chain gene,the ferritin heavy-chain gene
R11 C20 C11 coref-ident this promoter region of the ferritin H-chain gene,the minimum region of the ferritin H-gene promoter that is able to confer transcriptional regulation by heme in FLCs to a reporter gene
R12 C22 C16 coref-ident HRF,HRF (heme-responsive factor)
R13 C23 C2 coref-ident the ubiquitous transcription factor NF-Y,the CCAAT binding factor NF-Y
R14 C24 C23 coref-ident NF-Y,the ubiquitous transcription factor NF-Y
R15 C26 C25 coref-appos "A, B, and C",three subunits
R16 C28 C25 coref-relat which,three subunits
R17 C27 C25 coref-ident all of which,three subunits
R18 C31 C14 coref-ident heme,heme
R19 C32 C24 coref-ident NF-Y,NF-Y
R20 C33 C30 coref-ident this activation,the transcriptional activation by heme
R21 C34 C29 coref-ident the NF-YA subunit,the NF-YA subunit
R22 C35 C19 coref-ident monocyte-to-macrophage differentiation,monocyte-to-macrophage differentiation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 34-59 DNA_domain_or_region denotes ferritin heavy-chain gene
T2 81-101 protein_molecule denotes CCAAT binding factor
T3 102-106 protein_molecule denotes NF-Y
T4 123-157 cell_line denotes heme-treated Friend leukemia cells
T5 169-207 other_name denotes monocyte-to-macrophage differentiation
T6 213-243 DNA_domain_or_region denotes ferritin H-chain gene promoter
T7 271-305 cell_line denotes heme-treated Friend leukemia cells
T8 307-311 cell_line denotes FLCs
T9 324-362 other_name denotes monocyte-to-macrophage differentiation
T10 383-393 cell_line denotes cell lines
T11 421-429 protein_molecule denotes ferritin
T12 467-486 other_name denotes translational level
T13 500-531 cell_type denotes differentiating erythroid cells
T14 571-575 atom denotes iron
T15 587-597 protein_complex denotes hemoglobin
T16 616-627 cell_type denotes macrophages
T17 651-655 atom denotes iron
T18 665-691 other_name denotes transcriptional regulation
T19 771-779 protein_molecule denotes ferritin
T20 819-845 other_name denotes transcriptional regulation
T21 857-861 cell_line denotes FLCs
T22 867-880 DNA_family_or_group denotes reporter gene
T23 884-907 DNA_domain_or_region denotes 77 nucleotides upstream
T24 915-923 DNA_family_or_group denotes TATA box
T25 930-941 DNA_family_or_group denotes cis element
T26 981-984 protein_complex denotes HRF
T27 986-1008 protein_complex denotes heme-responsive factor
T28 1058-1062 cell_line denotes FLCs
T29 1074-1112 other_name denotes monocyte-to-macrophage differentiation
T30 1118-1131 DNA_domain_or_region denotes CCAAT element
T31 1194-1202 protein_molecule denotes ferritin
T32 1279-1293 other_name denotes point mutation
T33 1328-1331 protein_complex denotes HRF
T34 1340-1364 other_name denotes transcriptional activity
T35 1368-1385 cell_line denotes transfected cells
T36 1390-1413 other_name denotes competition experiments
T37 1418-1435 other_name denotes supershift assays
T38 1463-1466 protein_complex denotes HRF
T39 1505-1525 protein_family_or_group denotes transcription factor
T40 1526-1530 protein_molecule denotes NF-Y
T41 1532-1536 protein_molecule denotes NF-Y
T42 1556-1564 protein_subunit denotes subunits
T43 1566-1567 protein_subunit denotes A
T44 1569-1570 protein_subunit denotes B
T45 1576-1577 protein_subunit denotes C
T46 1645-1674 protein_molecule denotes transdominant negative mutant
T47 1682-1695 protein_subunit denotes NF-YA subunit
T48 1710-1736 other_name denotes transcriptional activation
T49 1740-1744 protein_molecule denotes heme
T50 1762-1766 protein_molecule denotes NF-Y
T51 1866-1879 protein_subunit denotes NF-YA subunit
T52 1908-1912 cell_line denotes FLCs
T53 1924-1962 other_name denotes monocyte-to-macrophage differentiation